Development of Influenza B Universal Vaccine Candidates Using the “Mosaic” Hemagglutinin Approach

Original Antigenic Sin: How First Exposure Shapes Lifelong Anti–Influenza Virus Immune Responses

(2019) Ali Zhang et al.   JOURNAL OF IMMUNOLOGY

Broadly cross-reactive, non-neutralizing antibodies against the influenza B virus hemagglutinin demonstrate effector function dependent protection against lethal viral challenge in mice

(2019) Guha Asthagiri Arunkumar et al.   JOURNAL OF VIROLOGY

Cross-lineage protection by human antibodies binding the influenza B hemagglutinin

(2019) Yi Liu et al.   Nature Communications

Native Human Monoclonal Antibodies with Potent Cross-Lineage Neutralization of Influenza B Viruses

(2018) Adam Vigil et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Universal influenza virus vaccines and therapeutics: where do we stand with influenza B virus?

(2018) Jessica Tan et al.   CURRENT OPINION IN IMMUNOLOGY

Literature review of the epidemiology of influenza B disease in 15 countries in the Asia-Pacific region

(2018) Lance Jennings et al.   Influenza and Other Respiratory Viruses

Heterogeneous estimates of influenza virus types A and B in the elderly: Results of a meta-regression analysis

(2018) Donatella Panatto et al.   Influenza and Other Respiratory Viruses

The influenza B virus hemagglutinin head domain is less tolerant to transposon mutagenesis than that of the influenza A virus

(2018) Benjamin O. Fulton et al.   JOURNAL OF VIROLOGY

From Original Antigenic Sin to the Universal Influenza Virus Vaccine

(2018) Carole Henry et al.   TRENDS IN IMMUNOLOGY

Change in the efficacy of influenza vaccination after repeated inoculation under antigenic mismatch: A systematic review and meta-analysis

(2018) Nobuhisa Morimoto et al.   VACCINE

Update: Influenza Activity in the United States During the 2017–18 Season and Composition of the 2018–19 Influenza Vaccine

(2018) Rebecca Garten et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

Antibody Responses toward the Major Antigenic Sites of Influenza B Virus Hemagglutinin in Mice, Ferrets, and Humans

(2018) Weina Sun et al.   JOURNAL OF VIROLOGY

Universal influenza virus vaccines that target the conserved hemagglutinin stalk and conserved sites in the head domain

(2018) Florian Krammer et al.   JOURNAL OF INFECTIOUS DISEASES

Primary Human Influenza B Virus Infection Induces Cross-Lineage Hemagglutinin Stalk–Specific Antibodies Mediating Antibody-Dependent Cellular Cytoxicity

(2017) Rory D de Vries et al.   JOURNAL OF INFECTIOUS DISEASES

Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

(2017) Megan E. Ermler et al.   JOURNAL OF VIROLOGY

A multimechanistic antibody targeting the receptor binding site potently cross-protects against influenza B viruses

(2017) Chenguang Shen et al.   Science Translational Medicine

Influenza virus-specific antibody dependent cellular cytoxicity induced by vaccination or natural infection

(2017) Rory D. de Vries et al.   VACCINE

Rationale for two influenza B lineages in seasonal vaccines: A meta-regression study on immunogenicity and controlled field trials

(2017) W.E.P. Beyer et al.   VACCINE

Analysis of Anti-Influenza Virus Neuraminidase Antibodies in Children, Adults, and the Elderly by ELISA and Enzyme Inhibition: Evidence for Original Antigenic Sin

(2017) Madhusudan Rajendran et al.   mBio

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

(2017) Henning Jacobsen et al.   mBio

A broadly protective therapeutic antibody against influenza B virus with two mechanisms of action

(2017) Ning Chai et al.   Nature Communications

Broadly protective murine monoclonal antibodies against influenza B virus target highly conserved neuraminidase epitopes

(2017) Teddy John Wohlbold et al.   Nature Microbiology

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

(2017) Raffael Nachbagauer et al.   npj Vaccines

Influenza A Viruses Expressing Intra- or Intergroup Chimeric Hemagglutinins

(2016) Chi-Jene Chen et al.   JOURNAL OF VIROLOGY

Hospitalization for Influenza A Versus B

(2016) D. Tran et al.   PEDIATRICS

Influenza A surface glycosylation and vaccine design

(2016) Chung-Yi Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimal activation of Fc-mediated effector functions by influenza virus hemagglutinin antibodies requires two points of contact

(2016) Paul E. Leon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epitope specificity plays a critical role in regulating antibody-dependent cell-mediated cytotoxicity against influenza A virus

(2016) Wenqian He et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Age Dependence and Isotype Specificity of Influenza Virus Hemagglutinin Stalk-Reactive Antibodies in Humans

(2016) Raffael Nachbagauer et al.   mBio

Broadly Neutralizing Hemagglutinin Stalk-Specific Antibodies Induce Potent Phagocytosis of Immune Complexes by Neutrophils in an Fc-Dependent Manner

(2016) Caitlin E. Mullarkey et al.   mBio

Antibodies with ‘Original Antigenic Sin’ Properties Are Valuable Components of Secondary Immune Responses to Influenza Viruses

(2016) Susanne L. Linderman et al.   PLoS Pathogens

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

Comparing Clinical Characteristics Between Hospitalized Adults With Laboratory-Confirmed Influenza A and B Virus Infection

(2014) S. Su et al.   CLINICAL INFECTIOUS DISEASES

Influenza season in Réunion dominated by influenza B virus circulation associated with numerous cases of severe disease, France, 2014

(2014) E Brottet et al.   Eurosurveillance

Influenza-Specific Antibody-Dependent Cellular Cytotoxicity: Toward a Universal Influenza Vaccine

(2014) Sinthujan Jegaskanda et al.   JOURNAL OF IMMUNOLOGY

Influenza A/Subtype and B/Lineage Effectiveness Estimates for the 2011–2012 Trivalent Vaccine: Cross-Season and Cross-Lineage Protection With Unchanged Vaccine

(2014) Danuta M. Skowronski et al.   JOURNAL OF INFECTIOUS DISEASES

Broadly neutralizing hemagglutinin stalk–specific antibodies require FcγR interactions for protection against influenza virus in vivo

(2014) David J DiLillo et al.   NATURE MEDICINE

Playing Hide and Seek: How Glycosylation of the Influenza Virus Hemagglutinin Can Modulate the Immune Response to Infection

(2014) Michelle Tate et al.   Viruses-Basel

The Burden of Influenza B: A Structured Literature Review

(2013) W. Paul Glezen et al.   AMERICAN JOURNAL OF PUBLIC HEALTH

Comparing influenza vaccine efficacy against mismatched and matched strains: a systematic review and meta-analysis

(2013) Andrea C Tricco et al.   BMC Medicine

H3 Stalk-Based Chimeric Hemagglutinin Influenza Virus Constructs Protect Mice from H7N9 Challenge

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

N-Linked Glycosylation of the Hemagglutinin Protein Influences Virulence and Antigenicity of the 1918 Pandemic and Seasonal H1N1 Influenza A Viruses

(2013) X. Sun et al.   JOURNAL OF VIROLOGY

Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

(2013) I. Margine et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Substitutions Near the Receptor Binding Site Determine Major Antigenic Change During Influenza Virus Evolution

(2013) B. F. Koel et al.   SCIENCE

Neutralizing Antibodies Against Previously Encountered Influenza Virus Strains Increase over Time: A Longitudinal Analysis

(2013) M. S. Miller et al.   Science Translational Medicine

Human Monoclonal Antibodies Broadly Neutralizing against Influenza B Virus

(2013) Mayo Yasugi et al.   PLoS Pathogens

Expression of Functional Recombinant Hemagglutinin and Neuraminidase Proteins from the Novel H7N9 Influenza Virus Using the Baculovirus Expression System

(2013) Irina Margine et al.   Jove-Journal of Visualized Experiments

Surveillance of Influenza in Indonesia, 2003-2007

(2012) Herman Kosasih et al.   Influenza and Other Respiratory Viruses

Excess Mortality Associated With Influenza A and B Virus in Hong Kong, 1998–2009

(2012) Peng Wu et al.   JOURNAL OF INFECTIOUS DISEASES

Influenza Viruses Expressing Chimeric Hemagglutinins: Globular Head and Stalk Domains Derived from Different Subtypes

(2012) R. Hai et al.   JOURNAL OF VIROLOGY

A Carboxy-Terminal Trimerization Domain Stabilizes Conformational Epitopes on the Stalk Domain of Soluble Recombinant Hemagglutinin Substrates

(2012) Florian Krammer et al.   PLoS One

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Complement-Dependent Lysis of Influenza A Virus-Infected Cells by Broadly Cross-Reactive Human Monoclonal Antibodies

(2011) M. Terajima et al.   JOURNAL OF VIROLOGY

Generation of Recombinant Influenza Virus from Plasmid DNA

(2010) Luis Martínez-Sobrido et al.   Jove-Journal of Visualized Experiments

Original Antigenic Sin Responses to Influenza Viruses

(2009) J. H. Kim et al.   JOURNAL OF IMMUNOLOGY

Crystal Structure of Unliganded Influenza B Virus Hemagglutinin

(2008) Q. Wang et al.   JOURNAL OF VIROLOGY