Article
Immunology
Tracy A. Becerra-Culqui, Darios Getahun, Vicki Chiu, Lina S. Sy, Hung Fu Tseng
Summary: This study investigated the association between prenatal influenza vaccination or infection and autism spectrum disorder (ASD) in offspring. The findings showed no association between prenatal influenza vaccination or infection and ASD risk in children.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Immunology
Jai S. Bolton, Hannah Klim, Judith Wellens, Matthew Edmans, Uri Obolski, Craig P. Thompson
Summary: The antigenic drift theory posits that influenza evolves through gradual mutations, while the competing theory of antigenic thrift suggests that immune selection targets epitopes of limited variability, constraining the virus' variability. Both theories aim to explain the dominance of a single or limited number of influenza strains each season, despite the potential for multiple strains to co-circulate based on mutation in multiple epitopes.
Review
Biochemical Research Methods
Yang Wang, Cynthia Y. Tang, Xiu-Feng Wan
Summary: Antigenic characterization of emerging and re-emerging viruses is crucial for vaccine development and disease prevention, but faces challenges such as high virus quantity requirements, antigenic mismatch between vaccine strains and circulating viruses.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Immunology
Weijia Xiong, Tim K. Tsang, Ranawaka A. P. M. Perera, Nancy H. L. Leung, Vicky J. Fang, Ian G. Barr, J. S. Malik Peiris, Benjamin J. Cowling
Summary: We explored the biphasic pattern of antibody titers waning after influenza vaccination in children. Using blood samples, we found evidence for a faster waning in the first 1-2 years, followed by a slower decline in the longer term. Children with higher postvaccination titers showed faster antibody decay.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Immunology
Nicki L. Boddington, Isabelle Pearson, Heather Whitaker, Punam Mangtani, Richard G. Pebody
Summary: This systematic review found that the effectiveness of influenza vaccine against hospitalization in children varies by influenza subtype and vaccine type, with an overall seasonal IVE of 53.3%. IVE was highest against influenza A/H1N1pdm09 and lowest against influenza A/H3N2.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Immunology
Meng-Hsuan Sung, Ye Shen, Andreas Handel, Justin Bahl, Ted M. Ross
Summary: The study revealed distinct vaccine-elicited immune responses between adults and teenagers when vaccinated repeatedly in consecutive years. A mixture pattern of changes in both directions was observed in adults when stratified by prior vaccinations. Additionally, an interactive effect of age and BMI on the HAI composite scores was identified in the overall population and adults.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Hiroshi Yokomichi, Mie Mochizuki, Sayaka Horiuchi, Megumi Kushima, Ryoji Shinohara, Reiji Kojima, Tadao Ooka, Yuka Akiyama, Kunio Miyake, Sanae Otawa, Zentaro Yamagata
Summary: We examined the association between influenza vaccination history by age 2 and influenza virus infection at ages 3 and 4, finding that vaccination at ages 1 and/or 2 reduced infection risk by 30%-32% at age 3 and 17%-24% at age 4. The risk of recurrent infection at ages 3 and 4 increased with the number of prior infections by age 2. Additionally, one-season-prior influenza vaccination reduced infection risk at age 3 by 25%-42%. We concluded that influenza vaccination has a protective effect and recommends annual vaccination.
PREVENTIVE MEDICINE
(2023)
Article
Cell Biology
Jiahao Zhang, Xiaomin Wang, Yiqun Chen, Hejia Ye, Shiping Ding, Tao Zhang, Yi Liu, Huanan Li, Lihong Huang, Wenbao Qi, Ming Liao
Summary: This study identified the predominant HA immune-escape mutations of H9N2 influenza viruses and assessed their antigenic and pathogenic impacts. The R164Q and I220T mutations were found to increase viral replication in avian and mammalian cells, as well as in mice.
Article
Microbiology
Jiong Wang, Dongmei Li, Sheldon Perry, Shannon P. Hilchey, Alexander Wiltse, John J. Treanor, Mark Y. Sangster, Martin S. Zand
Summary: Different H5 priming histories can significantly impact the antibody responses to subsequent H5 vaccination. Long-term priming can enhance antibody responses, and there is a specific association with the initial H5 exposure, reflecting influenza virus immune imprinting. Antibody responses are strongest against the first priming H5 strain, and broad anti-H5 IgG responses are stronger against strains with a small antigenic distance from the initial priming strain.
Article
Immunology
Huy Quang Quach, Krista M. Goergen, Diane E. Grill, Iana H. Haralambieva, Inna G. Ovsyannikova, Gregory A. Poland, Richard B. Kennedy
Summary: This study identified shared gene expression pathways in response to influenza and vaccinia virus stimulation in different immune cells. The immune response signaling pathways identified can be targeted for the development of broad therapeutics and vaccines.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Jessica R. Shartouny, Anice C. Lowen
Summary: The current influenza vaccines have limitations that prevent them from being completely effective, but the recent deployment of mRNA vaccines for SARS-CoV-2 provides an opportunity to evaluate a new platform for influenza vaccines. Shifting global influenza vaccination efforts to an mRNA-based system could potentially lead to better control over the product and immune responses, and aid in the development of a universal vaccine.
JOURNAL OF GENERAL VIROLOGY
(2022)
Article
Immunology
Lena Hansen, Fan Zhou, Hakon Amdam, Mai-Chi Trieu, Rebecca Jane Cox
Summary: The study showed that adjuvanted influenza vaccine can induce durable NA-specific antibody responses, which can be further boosted by TIVs. Each subsequent vaccination increases durable titers and contributes to maintaining the durability of functional antibody titers. However, high levels of pre-existing antibodies may negatively affect the magnitude of fold-increase in repeatedly vaccinated individuals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Adam Palanica, Jouhyun Jeon
Summary: This research examines the demographic characteristics, psychological perceptions, and vaccination-related opinions and experiences of a large Canadian sample who had received mixed doses of COVID-19 vaccines. The results showed that individuals who received an adenoviral vector vaccine experienced more and more severe side effects compared to those who received an mRNA vaccine. Additionally, participants who received Moderna as their second dose experienced the highest number and most severe side effects.
Article
Virology
Mi Liu, Jingze Liu, Wenjun Song, Yousong Peng, Xiao Ding, Lizong Deng, Taijiao Jiang
Summary: This study developed a model to predict antigenic relationships and identify antigenic clusters for H1N1pdm viruses, which performed well in predicting antigenic variants. Mapping the antigenic clusters revealed different patterns of antigenic evolution and localized epidemic for H1N1pdm compared to former seasonal H1N1. The model provides a rapid determination method for antigenic variants and further analysis can aid vaccine recommendations and influenza surveillance for H1N1pdm.
Article
Public, Environmental & Occupational Health
Francesca Licata, Concetta Paola Pelullo, Giorgia Della Polla, Emma Antonia Citrino, Aida Bianco
Summary: This study investigated the practices, knowledge, and attitudes of Italian healthcare workers (HCWs) regarding influenza vaccination during pregnancy. The findings revealed that a significant number of HCWs had misconceptions about the risks of vaccines and lacked up-to-date knowledge. These findings are valuable for promoting evidence-based recommendations among HCWs.
FRONTIERS IN PUBLIC HEALTH
(2023)
