Antibiotic use in critical illness

Surviving Sepsis Campaign: International Guidelines for Management of Sepsis and Septic Shock: 2016

(2017) Andrew Rhodes et al.   INTENSIVE CARE MEDICINE

Prognostic Value of Timing of Antibiotic Administration in Patients With Septic Shock Treated With Early Quantitative Resuscitation

(2015) Seung Mok Ryoo et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Time to Appropriate Antibiotic Therapy Is an Independent Determinant of Postinfection ICU and Hospital Lengths of Stay in Patients With Sepsis*

(2015) David Zhang et al.   CRITICAL CARE MEDICINE

Retrospective evaluation of recurrent secondary septic peritonitis in dogs (2000-2011): 41 cases

(2015) Dominic M. Barfield et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Antibiotic Treatment Strategies for Community-Acquired Pneumonia in Adults

(2015) Douwe F. Postma et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optimizing Antimicrobial Therapy of Sepsis and Septic Shock: Focus on Antibiotic Combination Therapy

(2015) Gloria Vazquez-Grande et al.   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

The effect of pathophysiology on pharmacokinetics in the critically ill patient — Concepts appraised by the example of antimicrobial agents

(2014) Stijn I. Blot et al.   ADVANCED DRUG DELIVERY REVIEWS

Empiric Antibiotic Treatment Reduces Mortality in Severe Sepsis and Septic Shock From the First Hour

(2014) Ricard Ferrer et al.   CRITICAL CARE MEDICINE

How severe is antibiotic pharmacokinetic variability in critically ill patients and what can be done about it?

(2014) T.W. Felton et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial

(2014) Marc Leone et al.   INTENSIVE CARE MEDICINE

Impact of appropriate empirical antimicrobial therapy on outcome of dogs with septic peritonitis

(2014) Amy E. Dickinson et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions

(2014) Jason A Roberts et al.   LANCET INFECTIOUS DISEASES

β-Lactam Monotherapy vs β-Lactam–Macrolide Combination Treatment in Moderately Severe Community-Acquired Pneumonia

(2014) Nicolas Garin et al.   JAMA Internal Medicine

Safety and feasibility of antibiotic de-escalation in bacteremic pneumonia

(2014) Faisal Khasawneh et al.   Infection and Drug Resistance

Protein Binding of β-Lactam Antibiotics in Critically Ill Patients: Can We Successfully Predict Unbound Concentrations?

(2013) Gloria Wong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock

(2013) J. Garnacho-Montero et al.   INTENSIVE CARE MEDICINE

Vancomycin pharmacodynamics and survival in patients with methicillin-resistant Staphylococcus aureus-associated septic shock

(2013) Sheryl Zelenitsky et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Augmented renal clearance is a common finding with worse clinical outcome in critically ill patients receiving antimicrobial therapy

(2013) Barbara O.M. Claus et al.   JOURNAL OF CRITICAL CARE

In vitro bacterial isolate susceptibility to empirically selected antimicrobials in 111 dogs with bacterial pneumonia

(2013) Alexandre Proulx et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

An alternate pathophysiologic paradigm of sepsis and septic shock

(2013) Anand Kumar   Virulence

Role of biomarkers in the management of antibiotic therapy: an expert panel review II: clinical use of biomarkers for initiation or discontinuation of antibiotic therapy

(2013) Jean-Pierre Quenot et al.   Annals of Intensive Care

Role of biomarkers in the management of antibiotic therapy: an expert panel review: I – currently available biomarkers for clinical use in acute infections

(2013) Anne-Marie Dupuy et al.   Annals of Intensive Care

Clinical Outcomes With Extended or Continuous Versus Short-term Intravenous Infusion of Carbapenems and Piperacillin/Tazobactam: A Systematic Review and Meta-analysis

(2012) Matthew E. Falagas et al.   CLINICAL INFECTIOUS DISEASES

Continuous Infusion of Beta-Lactam Antibiotics in Severe Sepsis: A Multicenter Double-Blind, Randomized Controlled Trial

(2012) J. M. Dulhunty et al.   CLINICAL INFECTIOUS DISEASES

Antibiotic strategies in severe nosocomial sepsis

(2012) Sarah Heenen et al.   CRITICAL CARE MEDICINE

Using the rate of bacterial clearance determined by real-time polymerase chain reaction as a timely surrogate marker to evaluate the appropriateness of antibiotic usage in critical patients with Acinetobacter baumannii bacteremia*

(2012) Yu-Chung Chuang et al.   CRITICAL CARE MEDICINE

Comparative Activity of Carbapenem Testing (COMPACT) study in Germany

(2012) Giuseppe Valenza et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Effect of Empirical Treatment With Moxifloxacin and Meropenem vs Meropenem on Sepsis-Related Organ Dysfunction in Patients With Severe Sepsis

(2012) Frank M. Brunkhorst   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Continuous beta-lactam infusion in critically ill patients: the clinical evidence

(2012) Mohd H Abdul-Aziz et al.   Annals of Intensive Care

Therapeutic drug monitoring of antimicrobials

(2011) Jason A. Roberts et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Subtherapeutic Initial β-Lactam Concentrations in Select Critically Ill Patients

(2011) Andrew A. Udy et al.   CHEST

Implications of augmented renal clearance in critically ill patients

(2011) Andrew A. Udy et al.   Nature Reviews Nephrology

Potent Synergy and Sustained Bactericidal Activity of a Vancomycin-Colistin Combination versus Multidrug-Resistant Strains of Acinetobacter baumannii

(2010) N. C. Gordon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A survival benefit of combination antibiotic therapy for serious infections associated with sepsis and septic shock is contingent only on the risk of death: A meta-analytic/meta-regression study

(2010) Anand Kumar et al.   CRITICAL CARE MEDICINE

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

(2010) Anand Kumar et al.   CRITICAL CARE MEDICINE

Therapeutic drug monitoring of β-lactams in critically ill patients: proof of concept

(2010) Jason A. Roberts et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Interpreting culture and susceptibility data in critical care: perks and pitfalls

(2010) Dawn Merton Boothe   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Potential risks, prognostic indicators, and diagnostic and treatment modalities affecting survival in dogs with presumptive aspiration pneumonia: 125 cases (2005-2008)

(2010) Kelly M. Tart et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Population Pharmacokinetics of High-Dose, Prolonged-Infusion Cefepime in Adult Critically Ill Patients with Ventilator-Associated Pneumonia

(2009) A. M. Nicasio et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Initiation of Inappropriate Antimicrobial Therapy Results in a Fivefold Reduction of Survival in Human Septic Shock

(2009) Anand Kumar et al.   CHEST

Randomized trial of combination versus monotherapy for the empiric treatment of suspected ventilator-associated pneumonia*

(2009) Daren K. Heyland et al.   CRITICAL CARE MEDICINE

Pharmacokinetic issues for antibiotics in the critically ill patient

(2009) Jason A. Roberts et al.   CRITICAL CARE MEDICINE

A systematic review on clinical benefits of continuous administration of β-lactam antibiotics*

(2009) Jason A. Roberts et al.   CRITICAL CARE MEDICINE

Feedback dose alteration significantly affects probability of pathogen eradication in nosocomial pneumonia

(2009) F. Scaglione et al.   EUROPEAN RESPIRATORY JOURNAL

First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis

(2009) Jason A. Roberts et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antimicrobial therapy and aerobic bacteriologic culture patterns in canine intensive care unit patients: 74 dogs (January-June 2006)

(2009) Dorothy M. Black et al.   JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

(2008) Peggy S. McKinnon et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Etiology and clinical outcome in dogs with aspiration pneumonia: 88 cases (2004–2006)

(2008) David A. Kogan et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Trends in antimicrobial susceptibility of Gram-negative isolates from a paediatric intensive care unit in Warsaw: results from the MYSTIC programme (1997-2007)

(2008) J. A. Patzer et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY