Continuous beta-lactam infusion in critically ill patients: the clinical evidence

β-Lactam pharmacokinetics and pharmacodynamics in critically ill patients and strategies for dose optimization: A structured review

(2012) Mahipal G Sinnollareddy et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

What's behind the failure of emerging antibiotics in the critically ill? Understanding the impact of altered pharmacokinetics and augmented renal clearance

(2012) Andrew A. Udy et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Fourteen years in resistance

(2012) David M. Livermore   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Drotrecogin Alfa (Activated) in Adults with Septic Shock

(2012) V. Marco Ranieri et al.   NEW ENGLAND JOURNAL OF MEDICINE

Does prolonged β-lactam infusions improve clinical outcomes compared to intermittent infusions? A meta-analysis and systematic review of randomized, controlled trials

(2011) Pranita D Tamma et al.   BMC INFECTIOUS DISEASES

Continuous infusion of piperacillin/tazobactam in ventilator-associated pneumonia: a pilot study on efficacy and costs

(2011) Wieslawa Duszynska et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Doripenem: A new carbapenem antibiotic

(2010) E. B. Chahine et al.   AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY

Comparison of tigecycline with imipenem/cilastatin for the treatment of hospital-acquired pneumonia

(2010) Antonio T. Freire et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Continuous versus Intermittent Infusions of Ceftazidime for Treating Exacerbation of Cystic Fibrosis

(2009) D. Hubert et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Alveolar concentrations of piperacillin/tazobactam administered in continuous infusion to patients with ventilator-associated pneumonia*

(2009) Emmanuel Boselli et al.   CRITICAL CARE MEDICINE

Antibiotic resistance—What’s dosing got to do with it?

(2009) Jason A. Roberts et al.   CRITICAL CARE MEDICINE

Efficacy and safety of intravenous infusion of doripenem versus imipenem in ventilator-associated pneumonia: A multicenter, randomized study*

(2009) Jean Chastre et al.   CRITICAL CARE MEDICINE

Pharmacokinetic issues for antibiotics in the critically ill patient

(2009) Jason A. Roberts et al.   CRITICAL CARE MEDICINE

Piperacillin penetration into tissue of critically ill patients with sepsis—Bolus versus continuous administration?

(2009) Jason A. Roberts et al.   CRITICAL CARE MEDICINE

A systematic review on clinical benefits of continuous administration of β-lactam antibiotics*

(2009) Jason A. Roberts et al.   CRITICAL CARE MEDICINE

Clinical cure of ventilator-associated pneumonia treated with piperacillin/tazobactam administered by continuous or intermittent infusion

(2009) Leonardo Lorente et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution

(2009) Jason A. Roberts et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Acute kidney injury

(2008) John A. Kellum   CRITICAL CARE MEDICINE

Animal models of sepsis: Why does preclinical efficacy fail to translate to the clinical setting?

(2008) Alex Dyson et al.   CRITICAL CARE MEDICINE

Pharmacokinetics of meropenem during intermittent and continuous intravenous application in patients treated by continuous renal replacement therapy

(2008) Julia Langgartner et al.   INTENSIVE CARE MEDICINE

Pharmacokinetics/pharmacodynamics of antibacterials in the Intensive Care Unit: setting appropriate dosing regimens

(2008) Francesco Scaglione et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Evaluation of area under the inhibitory curve (AUIC) and time above the minimum inhibitory concentration (T>MIC) as predictors of outcome for cefepime and ceftazidime in serious bacterial infections

(2008) Peggy S. McKinnon et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS