Scorpion toxins targeting Kv1.3 channels: insights into immunosuppression

Ion channelopathies of the immune system

(2018) Martin Vaeth et al.   CURRENT OPINION IN IMMUNOLOGY

Elevated Anxiety and Impaired Attention in Super-Smeller, Kv1.3 Knockout Mice

(2018) Zhenbo Huang et al.   Frontiers in Behavioral Neuroscience

Sea Anemones: Quiet Achievers in the Field of Peptide Toxins

(2018) Peter J. Prentis et al.   Toxins

Animal Toxins as Therapeutic Tools to Treat Neurodegenerative Diseases

(2018) Jessica M. de Souza et al.   Frontiers in Pharmacology

Kv1.3: a multifunctional channel with many pathological implications

(2017) Antonio Serrano-Albarrás et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Venom-derived peptide inhibitors of voltage-gated potassium channels

(2017) Raymond S. Norton et al.   NEUROPHARMACOLOGY

Arthropod toxins acting on neuronal potassium channels

(2017) Juana María Jiménez-Vargas et al.   NEUROPHARMACOLOGY

Discovery of three toxin peptides with Kv1.3 channel and IL-2 cytokine-inhibiting activities from Non-Buthidae scorpions, Chaerilus tricostatus and Chaerilus tryznai

(2017) Li Ding et al.   PEPTIDES

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

(2017) Eugene Y. Chiang et al.   Nature Communications

Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis

(2017) Jie Huang et al.   Cell and Bioscience

Systemic lupus erythematosus and atherosclerosis: Review of the literature

(2016) Marianne Frieri et al.   AUTOIMMUNITY REVIEWS

Immunosuppressive evidence ofTityus serrulatustoxins Ts6 and Ts15: insights of a novel K+channel pattern in T cells

(2016) Manuela B. Pucca et al.   IMMUNOLOGY

Kalium: a database of potassium channel toxins from scorpion venom

(2016) Alexey I. Kuzmenkov et al.   Database-The Journal of Biological Databases and Curation

Structural and Functional Elucidation of Peptide Ts11 Shows Evidence of a Novel Subfamily of Scorpion Venom Toxins

(2016) Caroline Cremonez et al.   Toxins

Chronic lymphocytic leukemia: 2015 Update on diagnosis, risk stratification, and treatment

(2015) Michael Hallek   AMERICAN JOURNAL OF HEMATOLOGY

Ion Channels in Innate and Adaptive Immunity

(2015) Stefan Feske et al.   Annual Review of Immunology

Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3-Independent T Cells with Suppressive Properties

(2015) Inna V. Grishkan et al.   JOURNAL OF IMMUNOLOGY

Immunomodulatory activity of Tityus serrulatus scorpion venom on human T lymphocytes

(2015) Andrea Casella-Martins et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Tityus serrulatus venom – A lethal cocktail

(2015) Manuela Berto Pucca et al.   TOXICON

Voltage-Gated Ptassium Channels Kv1.3 - Potentially New Molecular Target in Cancer Diagnostics and Therapy

(2015) Andrzej Teisseyre et al.   Advances in Clinical and Experimental Medicine

Toxins Targeting the KV1.3 Channel: Potential Immunomodulators for Autoimmune Diseases

(2015) Yipeng Zhao et al.   Toxins

Unusual binding mode of scorpion toxin BmKTX onto potassium channels relies on its distribution of acidic residues

(2014) Zongyun Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Electrophysiological Characterization of Ts6 and Ts7, K+ Channel Toxins Isolated through an Improved Tityus serrulatus Venom Purification Procedure

(2014) Felipe Cerni et al.   Toxins

Immunosuppressive peptides and their therapeutic applications

(2013) Kathrin Thell et al.   DRUG DISCOVERY TODAY

OcyKTx2, a new K+-channel toxin characterized from the venom of the scorpion Opisthacanthus cayaporum

(2013) Elisabeth F. Schwartz et al.   PEPTIDES

Vietnamese Heterometrus laoticus scorpion venom: Evidence for analgesic and anti-inflammatory activity and isolation of new polypeptide toxin acting on Kv1.3 potassium channel

(2013) Anh N. Hoang et al.   TOXICON

Structure, Function, and Chemical Synthesis of Vaejovis mexicanus Peptide 24: A Novel Potent Blocker of Kv1.3 Potassium Channels of Human T Lymphocytes

(2012) Georgina B. Gurrola et al.   BIOCHEMISTRY

Differential Expression of Kv1.3 and Kv1.5 Voltage-Dependent K+Channels in Human Skeletal Muscle Sarcomas

(2012) Joanna Bielanska et al.   CANCER INVESTIGATION

Hg1, Novel Peptide Inhibitor Specific for Kv1.3 Channels from First Scorpion Kunitz-type Potassium Channel Toxin Family

(2012) Zong-Yun Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kv1.3 Deletion Biases T Cells toward an Immunoregulatory Phenotype and Renders Mice Resistant to Autoimmune Encephalomyelitis

(2012) A. R. Gocke et al.   JOURNAL OF IMMUNOLOGY

Diet-Induced Obesity Resistance of Kv1.3−/− Mice is Olfactory Bulb Dependent

(2012) K. Tucker et al.   JOURNAL OF NEUROENDOCRINOLOGY

Identification of a new specific Kv1.3 channel blocker, Ctri9577, from the scorpion Chaerilus tricostatus

(2012) Shujun Xie et al.   PEPTIDES

Recombinant Expression of Margatoxin and Agitoxin-2 in Pichia pastoris: An Efficient Method for Production of KV1.3 Channel Blockers

(2012) Raveendra Anangi et al.   PLoS One

Two dyad-free Shaker-type K+ channel blockers from scorpion venom

(2012) Limei Zhu et al.   TOXICON

Novel potassium channel blocker venom peptides from Mesobuthus gibbosus (Scorpiones: Buthidae)

(2012) Elia Diego-García et al.   TOXICON

Complex cocktails: the evolutionary novelty of venoms

(2012) Nicholas R. Casewell et al.   TRENDS IN ECOLOGY & EVOLUTION

Ion channels and transporters in cancer. 1. Ion channels and cell proliferation in cancer

(2011) Andrea Becchetti   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Modeling the Binding of Three Toxins to the Voltage-Gated Potassium Channel (Kv1.3)

(2011) Rong Chen et al.   BIOPHYSICAL JOURNAL

The lymphocyte potassium channels Kv1.3 and KCa3.1 as targets for immunosuppression

(2011) Jenny Lam et al.   DRUG DEVELOPMENT RESEARCH

ImKTx1, a new Kv1.3 channel blocker with a unique primary structure

(2011) Zongyun Chen et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Functional Blockade of the Voltage-gated Potassium Channel Kv1.3 Mediates Reversion of T Effector to Central Memory Lymphocytes through SMAD3/p21cip1Signaling

(2011) Lina Hu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SdPI, The First Functionally Characterized Kunitz-Type Trypsin Inhibitor from Scorpion Venom

(2011) Ruiming Zhao et al.   PLoS One

Purification and characterization of Ts15, the first member of a new α-KTX subfamily from the venom of the Brazilian scorpion Tityus serrulatus

(2011) C.T. Cologna et al.   TOXICON

A potent potassium channel blocker from Mesobuthus eupeus scorpion venom

(2010) Bin Gao et al.   BIOCHIMIE

Anti-proliferative effect of Kv1.3 blockers in A549 human lung adenocarcinoma in vitro and in vivo

(2010) Soo Hwa Jang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genome-wide association study in alopecia areata implicates both innate and adaptive immunity

(2010) Lynn Petukhova et al.   NATURE

ImKTx88, a novel selective Kv1.3 channel blocker derived from the scorpion Isometrus maculates

(2010) Song Han et al.   TOXICON

The functional network of ion channels in T lymphocytes

(2009) Michael D. Cahalan et al.   IMMUNOLOGICAL REVIEWS

Localization of Kv1.3 Channels in the Immunological Synapse Modulates the Calcium Response to Antigen Stimulation in T Lymphocytes

(2009) S. A. Nicolaou et al.   JOURNAL OF IMMUNOLOGY

Animal toxins: state of the art - perspectives in health and biotechnology

(2009) Maria Elena de Lima et al.   JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES

Voltage-gated potassium channels as therapeutic targets

(2009) Heike Wulff et al.   NATURE REVIEWS DRUG DISCOVERY

Tst26, a novel peptide blocker of Kv1.2 and Kv1.3 channels from the venom of Tityus stigmurus

(2009) Ferenc Papp et al.   TOXICON

A new Kaliotoxin selective towards Kv1.3 and Kv1.2 but not Kv1.1 channels expressed in oocytes

(2008) Najwa Abbas et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A selective blocker of Kv1.2 and Kv1.3 potassium channels from the venom of the scorpion Centruroides suffusus suffusus

(2008) Gerardo Corzo et al.   BIOCHEMICAL PHARMACOLOGY

Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus

(2008) Najet Srairi-Abid et al.   FEBS Journal

Structural Basis of a Potent Peptide Inhibitor Designed for Kv1.3 Channel, a Therapeutic Target of Autoimmune Disease

(2008) Song Han et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of a new Kv1.3 channel-specific blocker, J123, from the scorpion Buthus martensii Karsch

(2008) Yin Shijin et al.   PEPTIDES

Molecular cloning and functional identification of a new K+ channel blocker, LmKTx10, from the scorpion Lychas mucronatus

(2008) Jun Liu et al.   PEPTIDES

OdK2, a Kv1.3 channel-selective toxin from the venom of the Iranian scorpion Odonthobuthus doriae

(2008) Yousra Abdel-Mottaleb et al.   TOXICON