Systems biology of the secretory pathway: What have we learned so far?

Cellular and metabolic functions for autophagy in cancer cells

(2015) Candia M. Kenific et al.   TRENDS IN CELL BIOLOGY

A minimum-labeling approach for reconstructing protein networks across multiple conditions

(2014) Arnon Mazza et al.   Algorithms for Molecular Biology

A requirement for ER-derived COPII vesicles in phagophore initiation

(2014) Juan Wang et al.   Autophagy

Comparative Analysis of RNAi Screening Technologies at Genome-Scale Reveals an Inherent Processing Inefficiency of the Plasmid-Based shRNA Hairpin

(2014) Bhavneet Bhinder et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Scyl1 scaffolds class II Arfs to specific subcomplexes of coatomer through the  -COP appendage domain

(2014) J. N. R. Hamlin et al.   JOURNAL OF CELL SCIENCE

Regulation of Sec16 levels and dynamics links proliferation and secretion

(2014) K. D. Tillmann et al.   JOURNAL OF CELL SCIENCE

Genome-wide RNAi screen identifies the Parkinson disease GWAS risk locus SREBF1 as a regulator of mitophagy

(2014) R. M. Ivatt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

O-Glycosylation regulates polarized secretion by modulating Tango1 stability

(2014) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial control of Cdc42 signalling by a GM130–RasGRF complex regulates polarity and tumorigenesis

(2014) Francesco Baschieri et al.   Nature Communications

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Chlamydia trachomatisinfection prevents front-rear polarity of migrating HeLa cells

(2013) Julia Heymann et al.   CELLULAR MICROBIOLOGY

Systematic Analysis of RNAi Reports Identifies Dismal Commonality at Gene-Level and Reveals an Unprecedented Enrichment in Pooled shRNA Screens

(2013) Bhavneet Bhinder et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Tango7 directs cellular remodeling by the Drosophila apoptosome

(2013) A. D'Brot et al.   GENES & DEVELOPMENT

ER exit sites are physical and functional core autophagosome biogenesis components

(2013) Martin Graef et al.   MOLECULAR BIOLOGY OF THE CELL

Location and membrane sources for autophagosome formation – from ER-mitochondria contact sites to Golgi-endosome-derived carriers

(2013) Shu Ning Chan et al.   MOLECULAR MEMBRANE BIOLOGY

Autophagosomes form at ER–mitochondria contact sites

(2013) Maho Hamasaki et al.   NATURE

The autophagosome: origins unknown, biogenesis complex

(2013) Christopher A. Lamb et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Pseudophosphatase STYX modulates cell-fate decisions and cell migration by spatiotemporal regulation of ERK1/2

(2013) V. Reiterer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

(2013) Tim Wang et al.   SCIENCE

TRPM5-mediated calcium uptake regulates mucin secretion from human colon goblet cells

(2013) Sandra Mitrovic et al.   eLife

The ER–Golgi intermediate compartment is a key membrane source for the LC3 lipidation step of autophagosome biogenesis

(2013) Liang Ge et al.   eLife

Mechanisms of Autophagosome Biogenesis

(2012) David C. Rubinsztein et al.   CURRENT BIOLOGY

Genome-wide siRNA screen reveals amino acid starvation-induced autophagy requires SCOC and WAC

(2012) Nicole C McKnight et al.   EMBO JOURNAL

RNAi screening reveals a large signaling network controlling the Golgi apparatus in human cells

(2012) Joanne Chia et al.   Molecular Systems Biology

Genome-wide RNAi screening identifies human proteins with a regulatory function in the early secretory pathway

(2012) Jeremy C. Simpson et al.   NATURE CELL BIOLOGY

Strategies for the discovery and development of therapies for metastatic breast cancer

(2012) Bedrich L. Eckhardt et al.   NATURE REVIEWS DRUG DISCOVERY

Use and Abuse of RNAi to Study Mammalian Gene Function

(2012) W. G. Kaelin   SCIENCE

A comprehensive siRNA screen for kinases that suppress macroautophagy in optimal growth conditions

(2011) Piotr Szyniarowski et al.   Autophagy

Systems Biology: Evolving into the Mainstream

(2011) Colin Macilwain   CELL

ERK7 is a negative regulator of protein secretion in response to amino-acid starvation by modulating Sec16 membrane association

(2011) Margarita Zacharogianni et al.   EMBO JOURNAL

Disconnecting the Golgi ribbon from the centrosome prevents directional cell migration and ciliogenesis

(2011) Lidia Hurtado et al.   JOURNAL OF CELL BIOLOGY

Image-based genome-wide siRNA screen identifies selective autophagy factors

(2011) Anthony Orvedahl et al.   NATURE

An siRNA screen identifies RSK1 as a key modulator of lung cancer metastasis

(2011) R Lara et al.   ONCOGENE

Identification of ER Proteins Involved in the Functional Organisation of the Early Secretory Pathway in Drosophila Cells by a Targeted RNAi Screen

(2011) Vangelis Kondylis et al.   PLoS One

A Genome-Wide siRNA Screen Reveals Multiple mTORC1 Independent Signaling Pathways Regulating Autophagy under Normal Nutritional Conditions

(2010) Marta M. Lipinski et al.   DEVELOPMENTAL CELL

MAPK signaling to the early secretory pathway revealed by kinase/phosphatase functional screening

(2010) Hesso Farhan et al.   JOURNAL OF CELL BIOLOGY

Sec16A defines the site for vesicle budding from the endoplasmic reticulum on exit from mitosis

(2010) Helen Hughes et al.   JOURNAL OF CELL SCIENCE

Signalling to and from the secretory pathway

(2010) H. Farhan et al.   JOURNAL OF CELL SCIENCE

Systems survey of endocytosis by multiparametric image analysis

(2010) Claudio Collinet et al.   NATURE

Scyl1 Regulates Golgi Morphology

(2010) Jonathon L. Burman et al.   PLoS One

Loss of high-frequency glucose-induced Ca2+ oscillations in pancreatic islets correlates with impaired glucose tolerance in Trpm5-/- mice

(2010) B. Colsoul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagosome Formation Depends on the Small GTPase Rab1 and Functional ER Exit Sites

(2010) Felipe Carlos Martín Zoppino et al.   TRAFFIC

TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites

(2009) Kota Saito et al.   CELL

Microtubule nucleation at the cis-side of the Golgi apparatus requires AKAP450 and GM130

(2009) Sabrina Rivero et al.   EMBO JOURNAL

A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway

(2009) Franz Wendler et al.   EMBO JOURNAL

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER

(2009) H. Hughes et al.   JOURNAL OF CELL SCIENCE

Biogenesis of secretory organelles during B cell differentiation

(2009) Semra J. Kirk et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A Primary Role for Golgi Positioning in Directed Secretion, Cell Polarity, and Wound Healing

(2009) Smita Yadav et al.   MOLECULAR BIOLOGY OF THE CELL

Golgi-derived CLASP-dependent microtubules control Golgi organization and polarized trafficking in motile cells

(2009) Paul M. Miller et al.   NATURE CELL BIOLOGY

NMDA Receptor Stimulation Induces Reversible Fission of the Neuronal Endoplasmic Reticulum

(2009) Krzysztof Kucharz et al.   PLoS One

p28, A Novel ERGIC/cis Golgi Protein, Required for Golgi Ribbon Formation

(2009) Eva Koegler et al.   TRAFFIC

Depletion of β-COP reveals a role for COP-I in compartmentalization of secretory compartments and in biosynthetic transport of caveolin-1

(2008) Melanie L. Styers et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Adaptation of endoplasmic reticulum exit sites to acute and chronic increases in cargo load

(2008) Hesso Farhan et al.   EMBO JOURNAL

Scyl1, Mutated in a Recessive Form of Spinocerebellar Neurodegeneration, Regulates COPI-mediated Retrograde Traffic

(2008) Jonathon L. Burman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ERK regulates Golgi and centrosome orientation towards the leading edge through GRASP65

(2008) Blaine Bisel et al.   JOURNAL OF CELL BIOLOGY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

Drosophila Sec16 Mediates the Biogenesis of tER Sites Upstream of Sar1 through an Arginine-Rich Motif

(2008) Viorica Ivan et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of genes that regulate epithelial cell migration using an siRNA screening approach

(2008) Kaylene J. Simpson et al.   NATURE CELL BIOLOGY

Early postnatal pulmonary failure and primary hypothyroidism in mice with combined TPST-1 and TPST-2 deficiency

(2007) Andrew D. Westmuckett et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY