TCR repertoire sequencing identifies synovial Treg cell clonotypes in the bloodstream during active inflammation in human arthritis

A circulating reservoir of pathogenic-like CD4+T cells shares a genetic and phenotypic signature with the inflamed synovial micro-environment

(2014) Roberto Spreafico et al.   ANNALS OF THE RHEUMATIC DISEASES

A sensitive protocol forFOXP3epigenetic analysis in scarce human samples

(2014) Roberto Spreafico et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Ex Vivo–Expanded but Not In Vitro–Induced Human Regulatory T Cells Are Candidates for Cell Therapy in Autoimmune Diseases Thanks to Stable Demethylation of the FOXP3 Regulatory T Cell–Specific Demethylated Region

(2014) Maura Rossetti et al.   JOURNAL OF IMMUNOLOGY

The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function

(2014) Kristin A Hogquist et al.   NATURE IMMUNOLOGY

T regulatory cells in childhood arthritis – novel insights

(2013) Anne M. Pesenacker et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Development and Maintenance of Regulatory T cells

(2013) Naganari Ohkura et al.   IMMUNITY

Multifunctional T cell reactivity with native and glycosylated type II collagen in rheumatoid arthritis

(2012) Omri Snir et al.   ARTHRITIS AND RHEUMATISM

T cells out of control—impaired immune regulation in the inflamed joint

(2012) Ellen J. Wehrens et al.   Nature Reviews Rheumatology

Impaired suppression of synovial fluid CD4+CD25− T cells from patients with juvenile idiopathic arthritis by CD4+CD25+ Treg cells

(2011) Susanne Haufe et al.   ARTHRITIS AND RHEUMATISM

Trial of early aggressive therapy in polyarticular juvenile idiopathic arthritis

(2011) Carol A. Wallace et al.   ARTHRITIS AND RHEUMATISM

Functional human regulatory T cells fail to control autoimmune inflammation due to PKB/c-akt hyperactivation in effector cells

(2011) E. J. Wehrens et al.   BLOOD

The inflammatory milieu in the rheumatic joint reduces regulatory T-cell function

(2011) Jessica Herrath et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

TRAIL Is Associated with Impaired Regulation of CD4+CD25− T Cells by Regulatory T Cells in Patients with Rheumatoid Arthritis

(2011) Hong Xiao et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Juvenile idiopathic arthritis

(2011) Berent Prakken et al.   LANCET

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

(2009) Makoto Miyara et al.   IMMUNITY

Regulatory T Cells: Mechanisms of Differentiation and Function

(2007) Steven Z. Josefowicz et al.   Annual Review of Immunology