Are innovation and new technologies in precision medicine paving a new era in patients centric care?

A multifactorial model of T cell expansion and durable clinical benefit in response to a PD-L1 inhibitor

(2019) Mark D. M. Leiserson et al.   PLoS One

Towards a consensus around standards for smartphone apps and digital mental health

(2019) John Torous et al.   World Psychiatry

Pancreatic Cancer Diagnosis and Management: Has the Time Come to Prick the Bubble?

(2019) Pedro Moutinho-Ribeiro et al.   Frontiers in Endocrinology

DNA methylation-based classification of central nervous system tumours

(2018) David Capper et al.   NATURE

Elevated and Correlated Expressions of miR-24, miR-30d, miR-146a, and SFRP-4 in Human Abdominal Adipose Tissue Play a Role in Adiposity and Insulin Resistance

(2018) Yury O. Nunez Lopez et al.   International Journal of Endocrinology

Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning

(2018) Nicolas Coudray et al.   NATURE MEDICINE

Precision immunoprofiling by image analysis and artificial intelligence

(2018) Viktor H. Koelzer et al.   VIRCHOWS ARCHIV

Predicting and understanding the response to short-term intensive insulin therapy in people with early type 2 diabetes

(2018) Yury O. Nunez Lopez et al.   Molecular Metabolism

Gastric bypass surgery with exercise alters plasma microRNAs that predict improvements in cardiometabolic risk

(2017) Y O Nunez Lopez et al.   INTERNATIONAL JOURNAL OF OBESITY

Circulating levels of miR-7, miR-152 and miR-192 respond to vitamin D supplementation in adults with prediabetes and correlate with improvements in glycemic control

(2017) Yury O. Nunez Lopez et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Altered levels of circulating cytokines and microRNAs in lean and obese individuals with prediabetes and type 2 diabetes

(2017) Yury O. Nunez Lopez et al.   Molecular BioSystems

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Reduced skeletal muscle secreted frizzled-related protein 3 is associated with inflammation and insulin resistance

(2017) Alok S. Pachori et al.   Obesity

Contribution of systemic and somatic factors to clinical response and resistance to PD-L1 blockade in urothelial cancer: An exploratory multi-omic analysis

(2017) Alexandra Snyder et al.   PLOS MEDICINE

Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis

(2016) Sebastian Moran et al.   LANCET ONCOLOGY

The "cancer immunogram"

(2016) C. U. Blank et al.   SCIENCE

Pancreas-enriched miRNAs are altered in the circulation of subjects with diabetes: a pilot cross-sectional study

(2016) Attila A. Seyhan et al.   Scientific Reports

microRNAs with different functions and roles in disease development and as potential biomarkers of diabetes: progress and challenges

(2015) Attila A. Seyhan   Molecular BioSystems

Prognostic and predictive values of EGFR overexpression and EGFR copy number alteration in HER2-positive breast cancer

(2014) H J Lee et al.   BRITISH JOURNAL OF CANCER

Identification of novel markers in rheumatoid arthritis through integrated analysis of DNA methylation and microRNA expression

(2013) Lorenzo de la Rica et al.   JOURNAL OF AUTOIMMUNITY

Knowledge engineering for health: A new discipline required to bridge the “ICT gap” between research and healthcare

(2012) Tim Beck et al.   HUMAN MUTATION

Deep phenotyping for precision medicine

(2012) Peter N. Robinson   HUMAN MUTATION

A genome-wide RNAi screen identifies novel targets of neratinib resistance leading to identification of potential drug resistant genetic markers

(2012) Attila A. Seyhan et al.   Molecular BioSystems

Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients

(2012) Kaleb M Pauley et al.   ARTHRITIS RESEARCH & THERAPY

miRNAs and related polymorphisms in rheumatoid arthritis susceptibility

(2011) Anthoula Chatzikyriakidou et al.   AUTOIMMUNITY REVIEWS

A genome-wide RNAi screen identifies novel targets of neratinib sensitivity leading to neratinib and paclitaxel combination drug treatments

(2011) Attila A. Seyhan et al.   Molecular BioSystems

Bring on the biomarkers

(2011) George Poste   NATURE

MicroRNAs in Sjögren's syndrome as a prototypic autoimmune disease

(2010) Ilias Alevizos et al.   AUTOIMMUNITY REVIEWS

Altered expression of miR-17-5p in CD4+lymphocytes of relapsing-remitting multiple sclerosis patients

(2010) Raija L. P. Lindberg et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

MicroRNAs as biomarkers in rheumatic diseases

(2010) Ilias Alevizos et al.   Nature Reviews Rheumatology

MicroRNA-124a is a key regulator of proliferation and monocyte chemoattractant protein 1 secretion in fibroblast-like synoviocytes from patients with rheumatoid arthritis

(2009) Yuji Nakamachi et al.   ARTHRITIS AND RHEUMATISM

MicroRNA-146a contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins

(2009) Yuanjia Tang et al.   ARTHRITIS AND RHEUMATISM

Computational biology for cardiovascular biomarker discovery

(2009) F. Azuaje et al.   BRIEFINGS IN BIOINFORMATICS

microRNA-342, microRNA-191 and microRNA-510 are differentially expressed in T regulatory cells of type 1 diabetic patients

(2009) Renata Hezova et al.   CELLULAR IMMUNOLOGY

Primary biliary cirrhosis is associated with altered hepatic microRNA expression

(2009) Kerstien A. Padgett et al.   JOURNAL OF AUTOIMMUNITY

Bruton's Tyrosine Kinase Is Involved in miR-346-Related Regulation of IL-18 Release by Lipopolysaccharide-Activated Rheumatoid Fibroblast-Like Synoviocytes

(2009) G. Alsaleh et al.   JOURNAL OF IMMUNOLOGY

Molecular networks as sensors and drivers of common human diseases

(2009) Eric E. Schadt   NATURE

MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis

(2009) Changsheng Du et al.   NATURE IMMUNOLOGY

Walking the Interactome for Prioritization of Candidate Disease Genes

(2008) Sebastian Köhler et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Human Phenotype Ontology: A Tool for Annotating and Analyzing Human Hereditary Disease

(2008) Peter N. Robinson et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Expression of microRNA-146 in rheumatoid arthritis synovial tissue

(2008) Tomoyuki Nakasa et al.   ARTHRITIS AND RHEUMATISM

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

Identification of dilated cardiomyopathy signature genes through gene expression and network data integration

(2008) Anyela Camargo et al.   GENOMICS

A systematic approach to biomarker discovery; Preamble to "the iSBTc-FDA taskforce on immunotherapy biomarkers"

(2008) Lisa H Butterfield et al.   Journal of Translational Medicine

Network properties of genes harboring inherited disease mutations

(2008) I. Feldman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients

(2008) Yong Dai et al.   RHEUMATOLOGY INTERNATIONAL

Do CSF total tau, phosphorylated tau, and β-amyloid 42 help to predict progression of mild cognitive impairment to Alzheimer's disease? A systematic review and meta-analysis of the literature

(2008) Breno S. O. Diniz et al.   WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY