Melanocortin control of energy balance: evidence from rodent models

Melanocortin-4 Receptors Expressed by Cholinergic Neurons Regulate Energy Balance and Glucose Homeostasis

(2011) Jari Rossi et al.   Cell Metabolism

AGRP neurons are sufficient to orchestrate feeding behavior rapidly and without training

(2011) Yexica Aponte et al.   NATURE NEUROSCIENCE

TrkB Agonist Antibody Dose-Dependently Raises Blood Pressure in Mice With Diet-Induced Obesity

(2010) L. Xu et al.   AMERICAN JOURNAL OF HYPERTENSION

Food demand and meal size in mice with single or combined disruption of melanocortin type 3 and 4 receptors

(2010) Deniz Atalayer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist

(2010) Gina L. C. Yosten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

CNS leptin and insulin action in the control of energy homeostasis

(2010) Bengt F. Belgardt et al.   Annals of the New York Academy of Sciences

Functions for pro-opiomelanocortin-derived peptides in obesity and diabetes

(2010) Kathleen G. Mountjoy   BIOCHEMICAL JOURNAL

Brain-derived neurotrophic factor (BDNF) in the hypothalamic ventromedial nucleus increases energy expenditure

(2010) ChuanFeng Wang et al.   BRAIN RESEARCH

SIRT1 Deacetylase in POMC Neurons Is Required for Homeostatic Defenses against Diet-Induced Obesity

(2010) Giorgio Ramadori et al.   Cell Metabolism

Endogenous Leptin Signaling in the Caudal Nucleus Tractus Solitarius and Area Postrema Is Required for Energy Balance Regulation

(2010) Matthew R. Hayes et al.   Cell Metabolism

Direct Insulin and Leptin Action on Pro-opiomelanocortin Neurons Is Required for Normal Glucose Homeostasis and Fertility

(2010) Jennifer W. Hill et al.   Cell Metabolism

Increased Hypothalamic Signal Transducer and Activator of Transcription 3 Phosphorylation after Hindbrain Leptin Injection

(2010) Marieke Ruiter et al.   ENDOCRINOLOGY

Glut2-dependent glucose-sensing controls thermoregulation by enhancing the leptin sensitivity of NPY and POMC neurons

(2010) Lourdes Mounien et al.   FASEB JOURNAL

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

(2010) Ryoichi Banno et al.   JOURNAL OF CLINICAL INVESTIGATION

Genetic and pharmacologic blockade of central melanocortin signaling attenuates cardiac cachexia in rodent models of heart failure

(2010) Jarrad M Scarlett et al.   JOURNAL OF ENDOCRINOLOGY

Expanding roles of NUCB2/nesfatin-1 in neuroendocrine regulation

(2010) David García-Galiano et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Postnatal Sim1 Deficiency Causes Hyperphagic Obesity and Reduced Mc4r and Oxytocin Expression

(2010) K. P. Tolson et al.   JOURNAL OF NEUROSCIENCE

Pomc-expressing progenitors give rise to antagonistic neuronal populations in hypothalamic feeding circuits

(2010) Stephanie L Padilla et al.   NATURE MEDICINE

Pro-opiomelanocortin gene transfer to the nucleus of the solitary track but not arcuate nucleus ameliorates chronic diet-induced obesity

(2010) Y. Zhang et al.   NEUROSCIENCE

Enhanced anorexigenic signaling in lean obesity resistant syndecan-3 null mice

(2010) Q. Zheng et al.   NEUROSCIENCE

Effect of MTII on food intake and brain c-Fos in melanocortin-3, melanocortin-4, and double MC3 and MC4 receptor knockout mice

(2010) Neil E. Rowland et al.   PEPTIDES

The roles of leptin receptors on POMC neurons in the regulation of sex-specific energy homeostasis

(2010) Haifei Shi et al.   PHYSIOLOGY & BEHAVIOR

Neuropeptides in the pathophysiology and treatment of cachexia

(2010) Stephanie M Krasnow et al.   Current Opinion in Supportive and Palliative Care

Leptin at 14 y of age: an ongoing story

(2009) Jeffrey M Friedman   AMERICAN JOURNAL OF CLINICAL NUTRITION

Phenotype of neurons in the nucleus of the solitary tract that express CCK-induced activation of the ERK signaling pathway

(2009) Tanja Babic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Experimental rat models to study the metabolic syndrome

(2009) Amaya Aleixandre de Artiñano et al.   BRITISH JOURNAL OF NUTRITION

Loss of GABAergic Signaling by AgRP Neurons to the Parabrachial Nucleus Leads to Starvation

(2009) Qi Wu et al.   CELL

Critical Role for Hypothalamic mTOR Activity in Energy Balance

(2009) Hiroyuki Mori et al.   Cell Metabolism

Dominant Role of the p110β Isoform of PI3K over p110α in Energy Homeostasis Regulation by POMC and AgRP Neurons

(2009) Hind Al-Qassab et al.   Cell Metabolism

Leptin-Dependent Control of Glucose Balance and Locomotor Activity by POMC Neurons

(2009) Lihong Huo et al.   Cell Metabolism

Nesfatin-1-Regulated Oxytocinergic Signaling in the Paraventricular Nucleus Causes Anorexia through a Leptin-Independent Melanocortin Pathway

(2009) Yuko Maejima et al.   Cell Metabolism

Distinct Effects of Leptin and a Melanocortin Receptor Agonist Injected Into Medial Hypothalamic Nuclei on Glucose Uptake in Peripheral Tissues

(2009) Chitoku Toda et al.   DIABETES

Divergent Regulation of Energy Expenditure and Hepatic Glucose Production by Insulin Receptor in Agouti-Related Protein and POMC Neurons

(2009) H. V. Lin et al.   DIABETES

Brain-Derived Neurotrophic Factor/Tropomyosin-Related Kinase Receptor Type B Signaling Is a Downstream Effector of the Brainstem Melanocortin System in Food Intake Control

(2009) Bruno Bariohay et al.   ENDOCRINOLOGY

Phosphatidyl Inositol 3-Kinase Signaling in Hypothalamic Proopiomelanocortin Neurons Contributes to the Regulation of Glucose Homeostasis

(2009) Jennifer W. Hill et al.   ENDOCRINOLOGY

Peripheral Administration of Nesfatin-1 Reduces Food Intake in Mice: The Leptin-Independent Mechanism

(2009) H. Shimizu et al.   ENDOCRINOLOGY

Central Nesfatin-1 Reduces Dark-Phase Food Intake and Gastric Emptying in Rats: Differential Role of Corticotropin-Releasing Factor2Receptor

(2009) Andreas Stengel et al.   ENDOCRINOLOGY

Hypothalamic and Hindbrain Melanocortin Receptors Contribute to the Feeding, Thermogenic, and Cardiovascular Action of Melanocortins

(2009) Karolina P. Skibicka et al.   ENDOCRINOLOGY

Regulation of energy balance by leptin

(2009) A. Hamann et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Central nervous system melanocortin-3 receptors are required for synchronizing metabolism during entrainment to restricted feeding during the light cycle

(2009) Gregory M. Sutton et al.   FASEB JOURNAL

Leptin and the systems neuroscience of meal size control

(2009) Harvey J. Grill   FRONTIERS IN NEUROENDOCRINOLOGY

New ligands for melanocortin receptors

(2009) C B Kaelin et al.   INTERNATIONAL JOURNAL OF OBESITY

The nucleus tractus solitarius: a portal for visceral afferent signal processing, energy status assessment and integration of their combined effects on food intake

(2009) H J Grill et al.   INTERNATIONAL JOURNAL OF OBESITY

Enhanced Stat3 Activation in POMC Neurons Provokes Negative Feedback Inhibition of Leptin and InsulinSignaling in Obesity

(2009) M. B. Ernst et al.   JOURNAL OF NEUROSCIENCE

The obesity susceptibility gene Cpe links FoxO1 signaling in hypothalamic pro-opiomelanocortin neurons with regulation of food intake

(2009) Leona Plum et al.   NATURE MEDICINE

Energy-restricted pair-feeding normalizes low levels of brain-derived neurotrophic factor/tyrosine kinase B mRNA expression in the hippocampus, but not ventromedial hypothalamic nucleus, in diet-induced obese mice

(2009) Y. Yu et al.   NEUROSCIENCE

The role of melanocortin neuronal pathways in circadian biology: a new homeostatic output involving melanocortin-3 receptors?

(2009) K. Begriche et al.   Obesity Reviews

Overweight and obesity in infants and pre-school children in the European Union: a review of existing data

(2009) A. Cattaneo et al.   Obesity Reviews

The Medical Risks of Obesity

(2009) Xavier Pi-Sunyer   POSTGRADUATE MEDICINE

CCK-8S activates c-Fos in a dose-dependent manner in nesfatin-1 immunoreactive neurons in the paraventricular nucleus of the hypothalamus and in the nucleus of the solitary tract of the brainstem

(2009) Steffen Noetzel et al.   REGULATORY PEPTIDES

Role of central melanocortin pathways in energy homeostasis

(2009) Alastair S. Garfield et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Neural control of the anorexia-cachexia syndrome

(2008) Alessandro Laviano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Sexually different actions of leptin in proopiomelanocortin neurons to regulate glucose homeostasis

(2008) Haifei Shi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Melanocortin-4 receptor mRNA expressed in sympathetic outflow neurons to brown adipose tissue: neuroanatomical and functional evidence

(2008) C. Kay Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Forebrain melanocortin signaling enhances the hindbrain satiety response to CCK-8

(2008) James E. Blevins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Nesfatin-1 inhibits NPY neurons in the arcuate nucleus

(2008) Christopher J. Price et al.   BRAIN RESEARCH

Activation of Stat3 Signaling in AgRP Neurons Promotes Locomotor Activity

(2008) Andrea Mesaros et al.   Cell Metabolism

PDK1 Deficiency in POMC-Expressing Cells Reveals FOXO1-Dependent and -Independent Pathways in Control of Energy Homeostasis and Stress Response

(2008) Bengt F. Belgardt et al.   Cell Metabolism

Acute Effects of Glucagon-Like Peptide-1 on Hypothalamic Neuropeptide and AMP Activated Kinase Expression in Fasted Rats

(2008) Sanghee SEO et al.   ENDOCRINE JOURNAL

Energetic Responses Are Triggered by Caudal Brainstem Melanocortin Receptor Stimulation and Mediated by Local Sympathetic Effector Circuits

(2008) Karolina P. Skibicka et al.   ENDOCRINOLOGY

Hindbrain Leptin Stimulation Induces Anorexia and Hyperthermia Mediated by Hindbrain Melanocortin Receptors

(2008) Karolina P. Skibicka et al.   ENDOCRINOLOGY

Acute effects of leptin require PI3K signaling in hypothalamic proopiomelanocortin neurons in mice

(2008) Jennifer W. Hill et al.   JOURNAL OF CLINICAL INVESTIGATION

Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity

(2008) Jacob C Garza et al.   JOURNAL OF ENDOCRINOLOGY

The Tissue-Specific Processing of Pro-Opiomelanocortin

(2008) A. B. Bicknell   JOURNAL OF NEUROENDOCRINOLOGY

Presynaptic Melanocortin-4 Receptors on Vagal Afferent Fibers Modulate the Excitability of Rat Nucleus Tractus Solitarius Neurons

(2008) S. Wan et al.   JOURNAL OF NEUROSCIENCE

The Melanocortin-3 Receptor Is Required for Entrainment to Meal Intake

(2008) G. M. Sutton et al.   JOURNAL OF NEUROSCIENCE

Modulation of melanocortin signaling ameliorates uremic cachexia

(2008) Wai W. Cheung et al.   KIDNEY INTERNATIONAL

Characterization of mice deficient in Melanocortin 2 receptor on a B6/Balbc mix background

(2008) Dai Chida et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oxytocin Deficiency Mediates Hyperphagic Obesity ofSim1Haploinsufficient Mice

(2008) Bassil M. Kublaoui et al.   MOLECULAR ENDOCRINOLOGY

Hyperphagia and obesity produced by arcuate injection of NPY–saporin do not require upregulation of lateral hypothalamic orexigenic peptide genes

(2008) Ai-Jun Li et al.   PEPTIDES

Mechanisms of Leptin Action and Leptin Resistance

(2007) Martin G. Myers et al.   Annual Review of Physiology

TrkB Agonists Ameliorate Obesity and Associated Metabolic Conditions in Mice

(2007) David Tsao et al.   ENDOCRINOLOGY

Nesfatin-1 Neurons in Paraventricular and Supraoptic Nuclei of the Rat Hypothalamus Coexpress Oxytocin and Vasopressin and Are Activated by Refeeding

(2007) Daisuke Kohno et al.   ENDOCRINOLOGY

Collective and Individual Functions of Leptin Receptor Modulated Neurons Controlling Metabolism and Ingestion

(2007) Esther van de Wall et al.   ENDOCRINOLOGY

Divergent Leptin Signaling in Proglucagon Neurons of the Nucleus of the Solitary Tract in Mice and Rats

(2007) Lihong Huo et al.   ENDOCRINOLOGY