Potentiating α 2 subunit containing perisomatic GABA A receptors protects against seizures in a mouse model of Dravet syndrome

Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865

(2018) Sarah A Nickolls et al.   BRITISH JOURNAL OF PHARMACOLOGY

GABA A receptor: Positive and negative allosteric modulators

(2018) Richard W. Olsen   NEUROPHARMACOLOGY

Developmental seizures and mortality result from reducing GABAA receptor α2-subunit interaction with collybistin

(2018) Rochelle M. Hines et al.   Nature Communications

Cacna1g is a genetic modifier of epilepsy in a mouse model of Dravet syndrome

(2017) Jeffrey D. Calhoun et al.   EPILEPSIA

Dravet syndrome and its mimics: Beyond SCN1A

(2017) Dora Steel et al.   EPILEPSIA

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Recent advances in epilepsy

(2017) Mark Manford   JOURNAL OF NEUROLOGY

Optimizing the Diagnosis and Management of Dravet Syndrome: Recommendations From a North American Consensus Panel

(2017) Elaine C. Wirrell et al.   PEDIATRIC NEUROLOGY

Outcomes in newly diagnosed epilepsy in adolescents and adults: Insights across a generation in Scotland

(2017) Martin J. Brodie   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Screening of conventional anticonvulsants in a genetic mouse model of epilepsy

(2017) Nicole A. Hawkins et al.   Annals of Clinical and Translational Neurology

The abundance of cis-acting loci leading to differential allele expression in F1 mice and their relationship to loci harboring genes affecting complex traits

(2016) Seungeun Yeo et al.   BMC GENOMICS

Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations

(2016) Nicole A. Hawkins et al.   EPILEPSY RESEARCH

Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1

(2016) A Saito et al.   MOLECULAR PSYCHIATRY

Subchronic phencyclidine treatment in adult mice increases GABAergic transmission and LTP threshold in the hippocampus

(2016) Toshihiro Nomura et al.   NEUROPHARMACOLOGY

The clobazam metabolite N -desmethyl clobazam is an α2 preferring benzodiazepine with an improved therapeutic window for antihyperalgesia

(2016) William T. Ralvenius et al.   NEUROPHARMACOLOGY

Fine Mapping of a Dravet Syndrome Modifier Locus on Mouse Chromosome 5 and Candidate Gene Analysis by RNA-Seq

(2016) Nicole A. Hawkins et al.   PLoS Genetics

Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells

(2016) Katalin Kerti-Szigeti et al.   eLife

Selective Dysregulation of Hippocampal Inhibition in the Mouse Lacking Autism Candidate Gene CNTNAP2

(2015) S. Jurgensen et al.   JOURNAL OF NEUROSCIENCE

Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus

(2015) H. B. Fernandes et al.   JOURNAL OF NEUROSCIENCE

Genetic background modulates impaired excitability of inhibitory neurons in a mouse model of Dravet syndrome

(2015) Moran Rubinstein et al.   NEUROBIOLOGY OF DISEASE

Functional Characterization of the 1,5-Benzodiazepine Clobazam and Its Major Active Metabolite N-Desmethylclobazam at Human GABAA Receptors Expressed in Xenopus laevis Oocytes

(2015) Harriet Hammer et al.   PLoS One

Dravet syndrome-From epileptic encephalopathy to channelopathy

(2014) Andreas Brunklaus et al.   EPILEPSIA

Strain- and age-dependent hippocampal neuron sodium currents correlate with epilepsy severity in Dravet syndrome mice

(2014) Akshitkumar M. Mistry et al.   NEUROBIOLOGY OF DISEASE

Clobazam and Its Active Metabolite N-desmethylclobazam Display Significantly Greater Affinities for α2- versus α1-GABAA–Receptor Complexes

(2014) Henrik Sindal Jensen et al.   PLoS One

Mapping genetic modifiers of survival in a mouse model of Dravet syndrome

(2013) A. R. Miller et al.   GENES BRAIN AND BEHAVIOR

Molecular mechanisms of antiseizure drug activity at GABAA receptors

(2013) L. John Greenfield   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Complex Control of GABA(A) Receptor Subunit mRNA Expression: Variation, Covariation, and Genetic Regulation

(2012) Megan K. Mulligan et al.   PLoS One

Development and SAR of functionally selective allosteric modulators of GABAA receptors

(2011) Cristobal Alhambra et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A clinical study to assess CYP1A2 and CYP3A4 induction by AZD7325, a selective GABAA receptor modulator - an in vitro and in vivo comparison

(2011) Diansong Zhou et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Differential localization of GABAA receptor subunits in relation to rat striatopallidal and pallidopallidal synapses

(2011) A. Gross et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distinct mechanisms regulate GABAAreceptor and gephyrin clustering at perisomatic and axo-axonic synapses on CA1 pyramidal cells

(2011) Patrizia Panzanelli et al.   JOURNAL OF PHYSIOLOGY-LONDON

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Quantitative localisation of synaptic and extrasynaptic GABAA receptor subunits on hippocampal pyramidal cells by freeze-fracture replica immunolabelling

(2010) Yu Kasugai et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Translational Research in Epilepsy Genetics

(2009) Saul A. Mullen et al.   ARCHIVES OF NEUROLOGY

Identification of Anxiolytic/Nonsedative Agents among Indol-3-ylglyoxylamides Acting as Functionally Selective Agonists at the γ-Aminobutyric Acid-A (GABAA) α2Benzodiazepine Receptor

(2009) Sabrina Taliani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Adverse antiepileptic drug effects: Toward a clinically and neurobiologically relevant taxonomy

(2009) P. Perucca et al.   NEUROLOGY

Reversal of pathological pain through specific spinal GABAA receptor subtypes

(2008) Julia Knabl et al.   NATURE

Antiepileptic drug resistant rats differ from drug responsive rats in GABAA receptor subunit expression in a model of temporal lobe epilepsy

(2008) Kerstin Bethmann et al.   NEUROBIOLOGY OF DISEASE

International Union of Pharmacology. LXX. Subtypes of  -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

(2008) R. W. Olsen et al.   PHARMACOLOGICAL REVIEWS