Pharmacology in translation: the preclinical and early clinical profile of the novel α2/3 functionally selective GABAA receptor positive allosteric modulator PF-06372865

Experimental design and analysis and their reporting: new guidance for publication in BJP

(2015) Michael J Curtis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP

(2015) John C McGrath et al.   BRITISH JOURNAL OF PHARMACOLOGY

EEG-β/γ spectral power elevation in rat: a translatable biomarker elicited by GABAAα2/3-positive allosteric modulators at nonsedating anxiolytic doses

(2015) Edward P. Christian et al.   JOURNAL OF NEUROPHYSIOLOGY

NS11821, a partial subtype-selective GABAA agonist, elicits selective effects on the central nervous system in randomized controlled trial with healthy subjects

(2015) Rob GJA Zuiker et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands

(2015) Christopher Southan et al.   NUCLEIC ACIDS RESEARCH

The central nervous system effects of the partial GABA-Aα2,3-selective receptor modulator AZD7325 in comparison with lorazepam in healthy males

(2014) Xia Chen et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

A Preclinical Physiological Assay to Test Modulation of Knee Joint Pain in the Spinal Cord: Effects of Oxycodone and Naproxen

(2014) Jason A. Miranda et al.   PLoS One

α2-containing GABAA receptors: A target for the development of novel treatment strategies for CNS disorders

(2012) Elif Engin et al.   PHARMACOLOGY & THERAPEUTICS

Can the flow of medicines be improved? Fundamental pharmacokinetic and pharmacological principles toward improving Phase II survival

(2011) Paul Morgan et al.   DRUG DISCOVERY TODAY

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Animal research: Reporting in vivo experiments: The ARRIVE guidelines

(2010) Carol Kilkenny et al.   BRITISH JOURNAL OF PHARMACOLOGY

Preclinical and clinical pharmacology of TPA023B, a GABAA receptor α2/α3 subtype-selective partial agonist

(2010) JR Atack et al.   JOURNAL OF PSYCHOPHARMACOLOGY

MRK-409 (MK-0343), a GABAA receptor subtype-selective partial agonist, is a non-sedating anxiolytic in preclinical species but causes sedation in humans

(2010) JR Atack et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The use of baseline covariates in crossover studies

(2009) Michael G. Kenward et al.   BIOSTATISTICS

The plasma-occupancy relationship of the novel GABAAreceptor benzodiazepine site ligand, α5IA, is similar in rats and primates

(2009) John R Atack et al.   BRITISH JOURNAL OF PHARMACOLOGY

Benzodiazepine Binding Site Occupancy by the Novel GABAA Receptor Subtype-Selective Drug 7-(1,1-Dimethylethyl)-6-(2-ethyl-2H-1,2,4-triazol-3-ylmethoxy)-3-(2-fluorophenyl)-1,2,4-triazolo[4,3-b]pyridazine (TPA023) in Rats, Primates, and Humans

(2009) J. R. Atack et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Pharmacokinetics, pharmacodynamics and the pharmacokinetic/ pharmacodynamic relationship of zolpidem in healthy subjects

(2009) SL de Haas et al.   JOURNAL OF PSYCHOPHARMACOLOGY

In Vivo Characterization and Dynamic Receptor Occupancy Imaging of TPA023B, an α2/α3/α5 Subtype Selective γ-Aminobutyric Acid–A Partial Agonist

(2008) Koen Van Laere et al.   BIOLOGICAL PSYCHIATRY

The pharmacokinetic and pharmacodynamic effects of SL65.1498, a GABA-A 2,3 selective agonist, in comparison with lorazepam in healthy volunteers

(2008) SL de Haas et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Reversal of pathological pain through specific spinal GABAA receptor subtypes

(2008) Julia Knabl et al.   NATURE

Contribution of α1 subunit-containing γ-aminobutyric acidA (GABAA) receptors to motor-impairing effects of benzodiazepines in squirrel monkeys

(2008) Stephanie C. Licata et al.   PSYCHOPHARMACOLOGY