Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1

GABAAreceptors and plasticity of inhibitory neurotransmission in the central nervous system

(2014) Jean-Marc Fritschy et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Enhancement of Inhibitory Neurotransmission by GABA A Receptors Having α 2,3 -Subunits Ameliorates Behavioral Deficits in a Mouse Model of Autism

(2014) Sung Han et al.   NEURON

Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring

(2014) R. Tyzio et al.   SCIENCE

GABAergic Signaling as Therapeutic Target for Autism Spectrum Disorders

(2014) Giada Cellot et al.   Frontiers in Pediatrics

GABAergic Interneurons Shape the Functional Maturation of the Cortex

(2013) Corentin Le Magueresse et al.   NEURON

Functional role of ambient GABA in refining neuronal circuits early in postnatal development

(2013) Giada Cellot et al.   Frontiers in Neural Circuits

Interplay between DISC1 and GABA Signaling Regulates Neurogenesis in Mice and Risk for Schizophrenia

(2012) Ju Young Kim et al.   CELL

Disrupted-in-Schizophrenia (DISC1) Functions Presynaptically at Glutamatergic Synapses

(2012) Brady J. Maher et al.   PLoS One

DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders

(2012) Atsushi Kamiya et al.   Frontiers in Psychiatry

Development and SAR of functionally selective allosteric modulators of GABAA receptors

(2011) Cristobal Alhambra et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Positive Feedback Regulation between γ-Aminobutyric Acid Type A (GABAA) Receptor Signaling and Brain-derived Neurotrophic Factor (BDNF) Release in Developing Neurons

(2011) Christophe Porcher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disc1 Point Mutations in Mice Affect Development of the Cerebral Cortex

(2011) F. H. F. Lee et al.   JOURNAL OF NEUROSCIENCE

DISC1-dependent switch from progenitor proliferation to migration in the developing cortex

(2011) Koko Ishizuka et al.   NATURE

Beyond classical benzodiazepines: novel therapeutic potential of GABAA receptor subtypes

(2011) Uwe Rudolph et al.   NATURE REVIEWS DRUG DISCOVERY

Linking neurodevelopmental and synaptic theories of mental illness through DISC1

(2011) Nicholas J. Brandon et al.   NATURE REVIEWS NEUROSCIENCE

In Utero Electroporation as a Tool For Genetic Manipulation In Vivo to Study Psychiatric Disorders

(2011) Yu Taniguchi et al.   NEUROSCIENTIST

Postnatal Developmental Trajectories of Neural Circuits in the Primate Prefrontal Cortex: Identifying Sensitive Periods for Vulnerability to Schizophrenia

(2011) G. D. Hoftman et al.   SCHIZOPHRENIA BULLETIN

DISC1 at 10: connecting psychiatric genetics and neuroscience

(2011) David J. Porteous et al.   TRENDS IN MOLECULAR MEDICINE

Migration defects by DISC1 knockdown in C57BL/6, 129X1/SvJ, and ICR strains via in utero gene transfer and virus-mediated RNAi

(2010) Ken-ichiro Kubo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A Randomized Clinical Trial of MK-0777 for the Treatment of Cognitive Impairments in People with Schizophrenia

(2010) Robert W. Buchanan et al.   BIOLOGICAL PSYCHIATRY

Blocking Early GABA Depolarization with Bumetanide Results in Permanent Alterations in Cortical Circuits and Sensorimotor Gating Deficits

(2010) Doris D. Wang et al.   CEREBRAL CORTEX

Biochemical and Functional Interaction of Disrupted-in-Schizophrenia 1 and Amyloid Precursor Protein Regulates Neuronal Migration during Mammalian Cortical Development

(2010) T. L. Young-Pearse et al.   JOURNAL OF NEUROSCIENCE

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

Knockdown of DISC1 by In Utero Gene Transfer Disturbs Postnatal Dopaminergic Maturation in the Frontal Cortex and Leads to Adult Behavioral Deficits

(2010) Minae Niwa et al.   NEURON

Delivery of GABAARs to Synapses Is Mediated by HAP1-KIF5 and Disrupted by Mutant Huntingtin

(2010) Alison E. Twelvetrees et al.   NEURON

Disrupted-in-Schizophrenia-1 expression is regulated by  -site amyloid precursor protein cleaving enzyme-1-neuregulin cascade

(2010) S. Seshadri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupted in Schizophrenia 1 Regulates Neuronal Progenitor Proliferation via Modulation of GSK3β/β-Catenin Signaling

(2009) Yingwei Mao et al.   CELL

New and Improved Tools for In Utero Electroporation Studies of Developing Cerebral Cortex

(2009) J. LoTurco et al.   CEREBRAL CORTEX

GABAA receptors and their associated proteins: Implications in the etiology and treatment of schizophrenia and related disorders

(2009) Erik I. Charych et al.   NEUROPHARMACOLOGY

Subunit-Selective Modulation of GABA Type A Receptor Neurotransmission and Cognition in Schizophrenia

(2008) David A. Lewis et al.   AMERICAN JOURNAL OF PSYCHIATRY

Schizophrenia-Related Neural and Behavioral Phenotypes in Transgenic Mice Expressing Truncated Disc1

(2008) S. Shen et al.   JOURNAL OF NEUROSCIENCE

Dcx reexpression reduces subcortical band heterotopia and seizure threshold in an animal model of neuronal migration disorder

(2008) Jean-Bernard Manent et al.   NATURE MEDICINE

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

(2008) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA