Therapeutic potential of AAV9-S15D-RLC gene delivery in humanized MYL2 mouse model of HCM

Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modifiedMYL2mice

(2018) Chen-Ching Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac myosin light chain is phosphorylated by Ca2+/calmodulin-dependent and -independent kinase activities

(2016) Audrey N. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Results of clinical genetic testing of 2,912 probands with hypertrophic cardiomyopathy: expanded panels offer limited additional sensitivity

(2015) Ahmed A. Alfares et al.   GENETICS IN MEDICINE

Constitutive Phosphorylation of Cardiac Myosin Regulatory Light Chainin Vivo

(2015) Audrey N. Chang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myosin light chain phosphorylation to the rescue: Fig. 1.

(2015) Henk L. Granzier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice

(2015) Chen-Ching Yuan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypertrophic cardiomyopathy associated Lys104Glu mutation in the myosin regulatory light chain causes diastolic disturbance in mice

(2014) Wenrui Huang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

In vitro rescue study of a malignant familial hypertrophic cardiomyopathy phenotype by pseudo-phosphorylation of myosin regulatory light chain

(2013) Priya Muthu et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Myosin Light Chain Phosphorylation Is Critical for Adaptation to Cardiac Stress

(2012) Sonisha A. Warren et al.   CIRCULATION

Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease

(2012) Farah Sheikh et al.   JOURNAL OF CLINICAL INVESTIGATION

Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling

(2012) Prasad R. Konkalmatt et al.   JOURNAL OF GENE MEDICINE

The effect of myosin RLC phosphorylation in normal and cardiomyopathic mouse hearts

(2011) Priya Muthu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Robust cardiomyocyte-specific gene expression following systemic injection of AAV: in vivo gene delivery follows a Poisson distribution

(2010) K-M R Prasad et al.   GENE THERAPY

Hypertrophic Cardiomyopathy

(2010) Carolyn Y. Ho   Heart Failure Clinics

Diastolic dysfunction in familial hypertrophic cardiomyopathy transgenic model mice

(2009) Theodore P. Abraham et al.   CARDIOVASCULAR RESEARCH

Malignant familial hypertrophic cardiomyopathy D166V mutation in the ventricular myosin regulatory light chain causes profound effects in skinned and intact papillary muscle fibers from transgenic mice

(2008) W. Glenn L. Kerrick et al.   FASEB JOURNAL

Adeno-Associated Virus (AAV) Serotype 9 Provides Global Cardiac Gene Transfer Superior to AAV1, AAV6, AAV7, and AAV8 in the Mouse and Rat

(2008) Lawrence T. Bish et al.   HUMAN GENE THERAPY

Myosin Regulatory Light Chain Phosphorylation Attenuates Cardiac Hypertrophy

(2008) Jian Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ablation of Ventricular Myosin Regulatory Light Chain Phosphorylation in Mice Causes Cardiac Dysfunctionin Situand Affects Neighboring Myofilament Protein Phosphorylation

(2008) Sarah B. Scruggs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY