Article
Cardiac & Cardiovascular Systems
Lin Wang, Fengmin Lu, Jing Xu
Summary: By analyzing miRNA and mRNA expression profiles from the GEO database, this study identified differentially expressed miRNAs (DEMs) and genes (DEGs) between HCM and normal samples. A miRNA-mRNA regulatory network was constructed to identify hub genes and miRNAs, leading to the establishment of a logistic regression model for predicting HCM.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Cristian Statescu, Stefana Enachi, Carina Ureche, Laura Tapoi, Larisa Anghel, Delia Salaru, Carmen Plesoianu, Madalina Bostan, Dragos Marcu, Mircea Ovanez Balasanian, Radu Andy Sascau
Summary: Hypertrophic cardiomyopathy (HCM) is a common monogenic heart disease with variable phenotypic expression, treated primarily with pharmacological therapy. While septal reduction therapy (SRT) is the gold standard for drug refractory HCM, it is invasive and limiting in accessibility. Researchers are seeking pharmacological alternatives for better outcomes in HCM treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Marilena Melas, Eleftherios T. Beltsios, Antonis Adamou, Konstantinos Koumarelas, Kim L. McBride
Summary: Hypertrophic cardiomyopathy (HCM) is a genetic myocardial disease characterized by left ventricular hypertrophy (LVH). The disease exhibits high heterogeneity in terms of genetic loci, alleles, and phenotypes, even within the same family. Recent genetic discoveries have expanded our understanding of the molecular pathogenic mechanisms of HCM, leading to significant advancements in disease diagnosis. Genetic testing using next-generation sequencing (NGS) technologies and early detection among family members before clinical manifestation have demonstrated important improvements in this field.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Katarzyna Kazmierczak, Jingsheng Liang, Michelle Gomez-Guevara, Danuta Szczesna-Cordary
Summary: In this study, phosphomimetic mutants of the myosin regulatory light chain (RLC) were investigated for their potential in rescuing hypertrophic cardiomyopathy (HCM) symptoms. The S15D-RLC mutant showed significant enhancement in myosin ATPase activity and rescue of the V-max of Tg-R58Q myosin. Moreover, S15D-RLC was able to shift the super-relaxed state to the disordered relaxed state, increasing the availability of heads to interact with actin and produce force.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Chemistry, Medicinal
Huan Zhang, Cheng Yu, Yuanling Cheng, Zhi Chen, Min Chen, Wangan He, Zhigang Jin, Shaoqian Cai, Lijuan Yu
Summary: The number of clinical trials investigating therapeutic interventions for HCM has increased in recent years. These trials generally did not incorporate randomized controlled trials or masking and were small studies recruiting fewer than 50 participants. Targeting myosin-7 has been the focus of recent research, but the molecular signaling mechanisms involved in the pathogenesis of HCM have the potential to elucidate novel target pathways.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Milind Y. Desai, Anjali Owens, Kathy Wolski, Jeffrey B. Geske, Sara Saberi, Andrew Wang, Mark Sherrid, Paul C. Cremer, Neal K. Lakdawala, Albree Tower-Rader, David Fermin, Srihari S. Naidu, Nicholas G. Smedira, Hartzell Schaff, Ellen McErlean, Christina Sewell, Lana Mudarris, Zhiqun Gong, Kathy Lampl, Amy J. Sehnert, Steven E. Nissen
Summary: This study demonstrates the long-term efficacy of mavacamten in reducing the need for septal reduction therapy in patients with obstructive hypertrophic cardiomyopathy. It shows that mavacamten provides sustained improvement in symptoms and left ventricular outflow tract gradients, making it a useful therapeutic option for these patients.
Article
Cardiac & Cardiovascular Systems
Jose Manuel Pioner, Giulia Vitale, Sonette Steczina, Marianna Langione, Francesca Margara, Lorenzo Santini, Francesco Giardini, Erica Lazzeri, Nicoletta Piroddi, Beatrice Scellini, Chiara Palandri, Maike Schuldt, Valentina Spinelli, Francesca Girolami, Francesco Mazzarotto, Jolanda van der Velden, Elisabetta Cerbai, Chiara Tesi, Iacopo Olivotto, Alfonso Bueno-Orovio, Leonardo Sacconi, Raffaele Coppini, Cecilia Ferrantini, Michael Regnier, Corrado Poggesi
Summary: This study investigates the pathogenesis of MYBPC3-associated hypertrophic cardiomyopathy (HCM) and finds that the MYBPC3:c772G>A mutation impairs sarcomere energetics and cross-bridge cycling, while causing compensatory electrophysiological changes. correcting the primary sarcomeric defects may prevent secondary cardiomyocyte remodeling.
CIRCULATION RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Peter O. Awinda, Marissa Watanabe, Yemeserach Bishaw, Anna M. Huckabee, Keinan B. Agonias, Katarzyna Kazmierczak, Danuta Szczesna-Cordary, Bertrand C. W. Tanner
Summary: Mavacamten, a pharmaceutical that binds to myosin, reduces isometric tension and Ca2+ sensitivity of contraction in a mouse model of hypertrophic cardiomyopathy expressing the N47K mutation, potentially making it a useful therapy for certain forms of heart disease.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Ashley Schenk, Nathan Fields
Summary: The pathophysiology of hypertrophic cardiomyopathy involves left ventricular outflow tract obstruction, mitral regurgitation, and diastolic dysfunction. Symptom relief is achieved through optimizing left ventricular preload and reducing inotropy using various medications. Mavacamten, a novel cardiac myosin inhibitor, has shown promising results in phase 2 and 3 clinical trials and has been approved for the treatment of obstructive hypertrophic cardiomyopathy.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Rui Zhang, Fan Zhao, Jing Wang, Yahong Qin, Tingting Wang, Ai-Ai Chu
Summary: Hypertrophic cardiomyopathy is a genetic heart disease, and left ventricular apical aneurysm is a rare subtype. Echocardiography-guided percutaneous intra-myocardial septal radiofrequency ablation can be an effective treatment for obstructive hypertrophic cardiomyopathy with left ventricular apical aneurysm.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Shinichi Goto, Divyarajsinhji Solanki, Jenine E. John, Ryuichiro Yagi, Max Homilius, Genki Ichihara, Yoshinori Katsumata, Hanna K. Gaggin, Yuji Itabashi, Calum A. MacRae, Rahul C. Deo
Summary: This study developed machine learning models using ECGs and echocardiograms to detect and differentiate hypertrophic cardiomyopathy (HCM) from other cardiac conditions. The models showed good generalizability across multiple institutions when trained in a federated manner, improving the accuracy of HCM detection.
Article
Medicine, Research & Experimental
Haisong Bu, Yonghe Ding, Jiarong Li, Ping Zhu, Yu-Huan Shih, Mingmin Wang, Yuji Zhang, Xueying Lin, Xiaolei Xu
Summary: Research identified vmhcl as a zebrafish homolog of human MYH7, with therapeutic benefits of mTOR or MAPK inhibition on VEC model. These findings were later validated in VAC model, offering a rapid in vivo platform for discovering candidate signaling pathways of MYH7 cardiomyopathy.
Article
Cardiac & Cardiovascular Systems
Mirae Lee, Alon Shechter, Donghee Han, Long-Co Nguyen, Min Sun Kim, Daniel S. Berman, Florian Rader, Robert J. Siegel
Summary: This study evaluated the morphologic progression of the left ventricle (LV) in apical hypertrophic cardiomyopathy (AHC) patients using serial echocardiograms. The results showed that about half of the patients had changes in LV morphology, with some patients experiencing further hypertrophic involvement and the development of apical pouches or aneurysms. The study also found that patients with more severe LV hypertrophy and apical involvement had higher rates of adverse clinical events.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daniele Massera, Yuhe Xia, Boyangzi Li, Katherine Riedy, Daniel G. Swistel, Mark V. Sherrid
Summary: This study found that mitral annular calcification (MAC) is associated with anterior displacement of the mitral valve and left ventricular outflow tract obstruction (LVOTO) in hypertrophic cardiomyopathy (HCM) patients. The mitral valve position and septal-mitral valve distance were shorter in patients with MAC, especially in those with LVOTO. These findings suggest that surgical relief of LVOTO in the presence of MAC is safe when performed by an experienced surgeon.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Biology
Makenna M. Morck, Debanjan Bhowmik, Divya Pathak, Aminah Dawood, James Spudich, Kathleen M. Ruppel
Summary: Mutations in the lever arm of beta-cardiac myosin have divergent allosteric effects on myosin function, depending on whether they are in the pliant or light chain-binding regions.
Article
Multidisciplinary Sciences
Wenrui Huang, Anne Marie Bartosch, Harrison Xiao, Suvrajit Maji, Elliot H. H. Youth, Xena Flowers, Sandra Leskinen, Zeljko Tomljanovic, Gail Iodice, Deborah Boyett, Eleonora Spinazzi, Vilas Menon, Robert A. McGovern, Guy M. McKhann, Andrew F. Teich
Summary: Specific genes, particularly those related to microglial cells and non-microglial cells, correlate with early Alzheimer's disease pathology in cortical biopsies taken during shunt placement for Normal Pressure Hydrocephalus patients. Additionally, transcriptional analysis of human hydrocephalus biopsies identifies changes in immune response genes associated with early AD pathology, including cognitive decline.
NATURE COMMUNICATIONS
(2021)
Article
Computer Science, Information Systems
Mahyar Ghorbanzadeh, Linoj Vijayan, Jieya Yang, Eren Erman Ozguven, Wenrui Huang, Mengdi Ma
Summary: Hurricane Irma in 2017 posed challenges to the evacuation process in South Florida due to its unpredictability. This study developed a methodology integrating evacuation and storm surge modeling, showing that approximately three days are needed to safely evacuate the population in the study area. Integrated simulations before the hurricane hit the state could provide crucial information for decision-making on evacuation in hurricane-prone areas.
ISPRS INTERNATIONAL JOURNAL OF GEO-INFORMATION
(2021)
Article
Engineering, Civil
Wenrui Huang, Kai Yin, Mahyar Ghorbanzadeh, Eren Ozguven, Sudong Xu, Linoj Vijayan
Summary: Through a case study of Hurricane Irma, this study conducted an integrated storm surge modeling and traffic analysis. Results showed that storm surges and strong winds mainly affected coastal counties in southwest Florida, and over-evacuation was found to be due to the uncertainty of the hurricane path.
FRONTIERS OF STRUCTURAL AND CIVIL ENGINEERING
(2021)
Article
Agricultural Engineering
Liangyun Sun, Juan Han, Jiacong Wu, Wenrui Huang, Yuanyuan Li, Yanli Mao, Lei Wang, Yun Wang
Summary: This study investigated the pretreatment of microcrystalline cellulose (MCC) using two kinds of common inorganic salt hydrates. It was found that the water content of the inorganic salt hydrates affected the dissolution time of MCC and the reactivity of regenerated cellulose (RC). The pretreatment process led to changes in the structure, surface morphology, and thermal stability of MCC. ZnBr2·4H2O and FeCl3·6H2O showed better pretreatment effects. RC-ZnBr2·4H2O exhibited a higher adsorption rate of cellulase, accelerating the hydrolysis rate of cellulose. Furthermore, ZnBr2·4H2O was found to be a reusable pretreatment solvent.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Marine & Freshwater Biology
Shuo Huang, Wenrui Huang, Guihui Zhong
Summary: This study investigates the effects of groins on density-induced flow in an estuarine navigation channel through PIV based laboratory experiments. The results indicate that groins modify the velocity field in the channel, restrict the spread of density currents, and reduce the velocity of density-induced flow. Groins can effectively reduce sediment transport in estuarine navigation channels.
ESTUARINE COASTAL AND SHELF SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Xinnan Ma, Wenrui Huang, Yongqing Song, Juan Han, Jiacong Wu, Lei Wang, Yun Wang
Summary: This study developed a novel recyclable mVBA-b-P(AAm-co-AN)pglucose isomerase biocatalyst with improved substrate affinity and catalytic efficiency. Compared to the free enzyme, this biocatalyst showed superior stability and recyclability, making it a potential candidate for industrial production of high-fructose syrup.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Xueqiao Xie, Wenrui Huang, Tong Chen, Xingcheng He, Juan Han, Yun Wang, Yuxi Zhou
Summary: The deep eutectic solvents (DESs) + K2HPO4 aqueous two-phase systems were prepared, and the phase separation capacity of different systems under different temperatures was studied. A recombinant beta-glucosidase (GLytA) with enhanced purification effect was successfully constructed and expressed. The purified enzyme showed high stability and could be used for subsequent catalysis or preservation, indicating its potential for industrial applications.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2023)
Article
Transportation Science & Technology
Jieya Yang, Linoj Vijayan, Mahyar Ghorbanzadeh, Onur Alisan, Eren Erman Ozguven, Wenrui Huang, Simone Burns
Summary: This study investigated the transportation accessibility of special needs populations to Special Needs Shelters (SpNS) by incorporating storm surge modeling into hurricane shelter planning. The research focused on Panama City, which is close to the landfall location of Hurricane Michael. By using a validated storm surge model, the coastal inundation was predicted and an optimization methodology based on Geographical Information Systems (GIS) was developed. The proposed approach significantly reduced the travel time per person-trip by repurposing regular shelters and converting them to SpNS. The methodology improves emergency plans by estimating inundation zones, analyzing accessibility, and modeling shelter allocation.
TRANSPORTATION PLANNING AND TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Sihan Fang, Wenrui Huang, Jiacong Wu, Juan Han, Lei Wang, Yun Wang
Summary: The aim of this study was to separate and purify recombinant beta-glucosidase (GLEGB) with elastin-like polypeptide (ELP) and graphene-binding peptide (GB) from cell lysis solution by foam separation and further purification. The study found that the GLEGB cell lysis solution had excellent foaming property and foam stability, which was suitable for foam separation. The GB tag with hydrophobicity enabled the preferential adsorption of recombinant beta-glucosidase with GB on the surface of bubbles, resulting in a high enzyme activity recovery of GLEGB during foam separation. The foam solution of GLEGB was further purified based on the thermally responsive property of the ELP tag, achieving a significant purification effect.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Engineering, Marine
Linoj Vijayan, Wenrui Huang, Mengdi Ma, Eren Ozguven, Mahyar Ghorbanzadeh, Jieya Yang, Zhaoqing Yang
Summary: Dynamically-coupled SWAN and ADCIRC models have been used to improve the prediction of extreme waves and storm surges in the Gulf of Mexico caused by hurricanes and sea level rise. The performance of the models was evaluated using Hurricane Michael as a case study, and the results showed that the dynamically-coupled models significantly increased the accuracy of the simulations compared to the stand-alone SWAN model.
Article
Materials Science, Paper & Wood
Tao Wang, Cailiang Zhang, Hui Feng, Qingjun Zou, Wenrui Huang, Jiacong Wu, Juan Han, Yun Wang
Summary: A green and effective stepwise catalytic system for cellulose conversion to 5-hydroxymethylfurfural (HMF) was developed. The system involved fast dissolution of cellulose using ZnBr2 center dot 4H(2)O as the solvent, preparation of enzyme-inorganic hybrid nanoflowers as biocatalysts, and dehydration of fructose to 5-HMF using HCl as the catalyst. Under optimal conditions, the yield of 5-HMF from cellulose was about 21.6%.
Article
Agricultural Engineering
Wenrui Huang, Xingchen He, Jiacong Wu, Xinnan Ma, Juan Han, Lei Wang, Yun Wang
Summary: In this study, the effects of ILs, DESs, and their components on cellulase were evaluated. The cellulase activity was preserved in ILs/DESs below 60 degrees C. Adding DES composed of betaine and ethylene glycol promoted cellulose dissolution and improved enzyme accessibility. DESs were found to be compatible with cellulase and have the potential to improve cellulase properties for the conversion of cellulose to fermentable sugars.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Green & Sustainable Science & Technology
Jieya Yang, Onur Alisan, Mengdi Ma, Eren Erman Ozguven, Wenrui Huang, Linoj Vijayan
Summary: Hurricane-induced storm surge and sea level rise can lead to the disruption of evacuation routes and reduce accessibility to hurricane shelters. In this study, a methodology combining storm surge simulations and floating catchment area models was proposed to assess shelter accessibility. The results showed that rural areas lost accessibility faster than urban areas, and as inundation levels increased, urban census block groups closer to the shelters had higher accessibility scores. The findings from this study could inform emergency response plans and resilience action policies.
Article
Engineering, Environmental
Zhaohui Chen, Jiacong Wu, Wenrui Huang, Yuanyuan Li, Yanli Mao, Juan Han, Yun Wang, Liang Ni
Summary: In this study, UCST-type temperature-responsive polymer was combined with horseradish peroxidase (HRP) to produce a smart polymerase with enhanced stability. The smart polymerase exhibited strong temperature stability, pH stability, and storage stability compared to free enzymes. It was capable of degrading 91% of phenol in a 100 mg/L phenol solution within 1 hour and removing a significant amount of phenol from real water samples.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2023)
Article
Peripheral Vascular Disease
Dai-Yin Lu, Ioannis Ventoulis, Hongyun Liu, Bereketeab Haileselassie, Iraklis Pozios, Hsin-Yueh Liang, Lars L. Sorensen, Marco Canepa, Nicole Bavaro, Susan Phillip, M. Roselle Abraham, Theodore P. Abraham
Summary: In this study, HRE was observed in normotensive HCM patients during exercise, but its prevalence and prognostic implications remain unclear. After follow-up, there was no significant difference in the risk of developing hypertension, AF, HF, sustained VT/VF or death between patients with and without HRE.
INTERNATIONAL JOURNAL OF CARDIOLOGY CARDIOVASCULAR RISK AND PREVENTION
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew B. Harvey, Renelyn A. Woltes, Raymond N. Deepe, Hannah G. Tarolli, Jenna R. Drummond, Allison Trouten, Auva Zandi, Jeremy L. Barth, Rupak Mukherjee, Martin J. Romeo, Silvia G. Vaena, Ge Tao, Robin Muise-Helmericks, Paula S. Ramos, Russell A. Norris, Andy Wessels
Summary: This study highlights the importance of SOX9 in the regulation of epicardial cell invasion and emphasizes the role of EPDCs in regulating atrioventricular valve development and homeostasis. It also reports a novel expression profile of Cd109, a gene with previously unknown relevance in heart development.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Review
Cardiac & Cardiovascular Systems
MariaSanta C. Mangione, Jinhua Wen, Dian J. Cao
Summary: mTOR, a mechanistic target of rapamycin, is an evolutionarily conserved pathway that plays a fundamental role in nutrient sensing, growth, metabolism, lifespan, and aging. Recent studies have highlighted the regulatory role of mTOR in innate immune responses and its involvement in the pathogenesis of cardiovascular diseases, especially in acute inflammation and atherosclerotic cardiovascular disease. This review also discusses mTOR's role in trained immunity, immune senescence, and clonal hematopoiesis, as well as its architecture and regulatory complexes.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Junlin Li, Yajun Gong, Yiren Wang, Huihui Huang, Huan Du, Lianying Cheng, Cui Ma, Yongxiang Cai, Hukui Han, Jianhong Tao, Gang Li, Panke Cheng
Summary: Myocardial ischemia-reperfusion injury is closely related to the final infarct size in acute myocardial infarction. Regulatory T cells play an important role in the inflammatory response after AMI, but different subtypes of Tregs have different effects on the injury.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)
Article
Cardiac & Cardiovascular Systems
Yuxin Chu, Yutao Hua, Lihao He, Jin He, Yunxi Chen, Jing Yang, Ismail Mahmoud, Fanfang Zeng, Xiaochang Zeng, Gloria A. Benavides, Victor M. Darley-Usmar, Martin E. Young, Scott W. Ballinger, Sumanth D. Prabhu, Cheng Zhang, Min Xie
Summary: This study demonstrates that administering beta-hydroxybutyrate (beta-OHB) at the time of reperfusion can reduce infarct size and preserve cardiac function by activating autophagy and preserving mitochondrial homeostasis, potentially through mTOR inhibition.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2024)