Review
Biochemistry & Molecular Biology
Keelan Jagaran, Moganavelli Singh
Summary: Parkinson's disease is a debilitating neurodegenerative disorder with limited treatment options. Nanomedicine, specifically lipid nanoparticles, shows promise as a therapeutic nanocarrier for PD due to their ability to target the brain and deliver drugs. The potential of lipid nanoparticles in PD treatment is evident in their formulations as vaccines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Lais Ribovski, Naomi M. Hamelmann, Jos M. J. Paulusse
Summary: Safe and reliable entry into the brain is crucial for successful treatment of central nervous system disorders, but remains challenging. Nano-sized systems as drug carriers show significant improvements in therapy delivery. Careful design of NP properties is essential for successful brain delivery, affecting the ability to overcome multiple barriers.
Review
Chemistry, Multidisciplinary
Jia Li, Meng Zheng, Olga Shimoni, William A. Banks, Ashley I. Bush, Jennifer R. Gamble, Bingyang Shi
Summary: The blood-brain barrier is a crucial neurovascular unit that prevents harmful substances from entering the brain and maintains normal neuronal function. Disruption of BBB in diseases can contribute to disease progression, while restoration of BBB integrity is a biomarker for better clinical outcomes. The BBB also plays a role in facilitating communication between neuronal and circulatory systems, showing promising results for brain-targeted drug delivery.
Review
Chemistry, Multidisciplinary
Miguel M. Lino, Susana Simoes, Francesca Tomatis, Ines Albino, Angela Barrera, Denis Vivien, Tomas Sobrino, Lino Ferreira
Summary: Extracellular vesicles (EVs) serve as communication channels between different cell types in the brain and between the brain and the periphery, showing potential as nano-carriers for treating brain pathologies. While EVs contain bioactive factors and can be engineered for enhanced biological activity, challenges remain in their accumulation and therapeutic efficacy in the brain.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Instruments & Instrumentation
Yuan Rui, Jordan J. Green
Summary: Glioblastoma remains one of the most deadly forms of primary adult tumors, with little improvement in prognosis over the past two decades. Cancer immunotherapy shows promise in treating glioblastoma, but faces unique challenges in drug delivery due to the blood-brain barrier and immune privileged status of the central nervous system. Recent advances in biomaterial-based strategies for cancer immunotherapy may offer potential solutions for effective treatment of glioblastoma.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2021)
Review
Cell Biology
Liqiang Hu, Yiran Tao, Yanjiao Jiang, Feng Qin
Summary: Alzheimer's disease is the most common cause of memory disruption in elderly individuals, and the lack of effective therapy is due to low drug potency and challenges in drug delivery. Recent advances in nanomedicine have shown promising developments in Alzheimer's disease treatment, using various nano-carriers to develop successful strategies. This review comprehensively summarizes the efficacy of different nanomedicine in pre-clinical studies and provides insights and future research directions. It can guide the design and evaluation of nanomedicine in Alzheimer's disease treatment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Pharmacology & Pharmacy
Waqas Ahmed, Muhammed Shibil Kuniyan, Aqil Mohammad Jawed, Lukui Chen
Summary: Extracellular vesicles (EVs) are a promising therapeutic modality for neurological conditions, facilitating intercellular communication among brain cells. Their potential to pass through the blood-brain barrier (BBB) makes them highly promising for stroke management. Compared to existing drug-delivery vehicles, EVs have several advantages including the ability to surpass natural barriers, target specific cells, and maintain stability within the circulatory system.
Review
Medicine, Research & Experimental
Suhel Parvez, Medha Kaushik, Mubashshir Ali, Mohammad Mumtaz Alam, Javed Ali, Heena Tabassum, Pooja Kaushik
Summary: Ischemic stroke is a major cause of death and disability worldwide, but the only approved treatment, tissue plasminogen activator, has limitations. There is a need for novel therapeutic perspectives, and nanomedicine offers new approaches to improve the understanding and treatment of ischemic stroke.
Article
Biotechnology & Applied Microbiology
Caroline R. Garcia, Armin T. Rad, Farnoosh Saeedinejad, Arvind Manojkumar, Deepa Roy, Hansapani Rodrigo, Sue Anne Chew, Ziyaur Rahman, Mu-Ping Nieh, Upal Roy
Summary: This study investigated the safety and extended release of a combination antiretroviral therapy drug (tenofovir)-loaded nanodiscs for HIV-1 treatment in the brain. The results showed that the nanodiscs entrapped the drug in their interior and released it in a controlled manner at the desired location.
Article
Chemistry, Multidisciplinary
Emile F. van Vliet, Maarten J. Knol, Raymond M. Schiffelers, Massimiliano Caiazzo, Marcel H. A. M. Fens
Summary: Parkinson's disease is characterized by degeneration of dopaminergic neurons, causing dopamine deficiency and motor symptoms. Current treatment using L-DOPA has limitations and side effects. Encapsulation of L-DOPA into nanoparticles can protect it and improve delivery to the brain, reducing required dosages and side effects. Alternative delivery methods, such as intravenous administration and transdermal delivery, enhance therapeutic effects. This review discusses recent advances and future perspectives on NP-mediated L-DOPA delivery to the brain.
JOURNAL OF CONTROLLED RELEASE
(2023)
Review
Neurosciences
Livia La Barbera, Emanuele Mauri, Marcello D'Amelio, Manuele Gori
Summary: Alzheimer's disease is a common form of dementia with unknown primary causes and no definitive cure. Developing novel therapeutic strategies is important for preventing, diagnosing, and treating Alzheimer's disease. Nanomedicine has shown potential in bypassing the blood-brain barrier and improving drug safety and efficacy in Alzheimer's disease management.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Pharmacology & Pharmacy
Tobeka Naki, Blessing A. Aderibigbe
Summary: Malignant brain tumor is a life-threatening disease with poor survival rate. Nanomedicines have shown promise in the treatment of brain cancer by overcoming the blood-brain barrier and reducing drug toxicity, leading to improved drug delivery and targeted drug release.
Review
Chemistry, Multidisciplinary
Vincent Lenders, Xanthippi Koutsoumpou, Philana Phan, Stefaan. J. J. Soenen, Karel Allegaert, Steven de Vleeschouwer, Jaan Toelen, Zongmin Zhao, Bella. B. B. Manshian
Summary: The use of nanoparticles in biomedicine has been extensively studied, with a focus on their role as carriers for drug delivery. Most studies have focused on tumor models, but recent research has also explored the challenges of delivering nanoparticles to other organs. This review discusses recent advancements in overcoming biological barriers such as lung mucus, gastrointestinal mucus, placental barrier, and blood-brain barrier.
CHEMICAL SOCIETY REVIEWS
(2023)
Review
Neurosciences
Yiming Liu, Yong Shen
Summary: Nanoparticles offer a promising solution to the challenges posed by the blood-brain barrier, facilitating drug delivery to the central nervous system with good targeting ability.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Computer Science, Interdisciplinary Applications
Apostolos A. Gkountas, Nickolas D. Polychronopoulos, George N. Sofiadis, Evangelos G. Karvelas, Leonidas A. Spyrou, Ioannis E. Sarris
Summary: This study numerically investigates the delivery of magnetic nanoparticles through the blood-brain barrier, showing that an external magnetic field can significantly enhance drug delivery to the central nervous system. Factors such as the size of MNPs, external magnetic field, and blood flow affect the permeability of the barrier.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Multidisciplinary Sciences
Song Ih Ahn, Yoshitaka J. Sei, Hyun-Ji Park, Jinhwan Kim, Yujung Ryu, Jeongmoon J. Choi, Hak-Joon Sung, Tobey J. MacDonald, Allan Levey, YongTae Kim
NATURE COMMUNICATIONS
(2020)
Article
Chemistry, Multidisciplinary
Jeong-Kee Yoon, Dae-Hyun Kim, Mi-Lan Kang, Hyeon-Ki Jang, Hyun-Ji Park, Jung Bok Lee, Se Won Yi, Hye-Seon Kim, Sewoom Baek, Dan Bi Park, Jin You, Seong-Deok Lee, Yoshitaka Sei, Song Ih Ahn, Young Min Shin, Chang Soo Kim, Sangsu Bae, YongTae Kim, Hak-Joon Sung
Article
Chemistry, Multidisciplinary
Yunki Lee, Jeongmoon J. Choi, Song Ih Ahn, Nan Hee Lee, Woojin M. Han, Mahir Mohiuddin, Eun Jung Shin, Levi Wood, Ki Dong Park, YongTae Kim, Young C. Jang
ADVANCED FUNCTIONAL MATERIALS
(2020)
Article
Multidisciplinary Sciences
Jinhwan Kim, Abhinav Dey, Anshu Malhotra, Jingbo Liu, Song Ih Ahn, Yoshitaka J. Sei, Anna M. Kenney, Tobey J. MacDonald, YongTae Kim
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Engineering, Biomedical
Sungjin Jung, Junseok Lee, Junha Lim, Jeeyeon Suh, Taeyoung Kim, Jungho Ahn, Won Jong Kim, YongTae Kim
ADVANCED HEALTHCARE MATERIALS
(2020)
Editorial Material
Biotechnology & Applied Microbiology
Song Ih Ahn, YongTae Kim
Summary: Advancements in stem cell engineering have facilitated the development of human BBB-on-a-chip technologies, enabling more accurate modeling of the human blood-brain barrier. The use of human brain cells is crucial for better modeling human brain pathophysiology.
TRENDS IN BIOTECHNOLOGY
(2021)
Article
Multidisciplinary Sciences
Yutong Guo, Hohyun Lee, Zhou Fang, Anastasia Velalopoulou, Jinhwan Kim, Midhun Ben Thomas, Jingbo Liu, Ryan G. Abramowitz, YongTae Kim, Ahmet F. Coskun, Daniel Pomeranz Krummel, Soma Sengupta, Tobey J. MacDonald, Costas Arvanitis
Summary: RNA-based therapies have unique advantages in treating brain tumors, but challenges exist in effective delivery due to size and charge issues of therapeutic RNA. Combining microbubble-enhanced focused ultrasound with 50-nm cationic lipid-polymer hybrid nanoparticles containing siRNA significantly improves siRNA delivery into brain tumor microenvironments. This approach not only reduces protein production in targeted cells but also increases cell death in brain tumors, showing potential for developing next-generation delivery systems for RNA-based therapy.
Review
Nanoscience & Nanotechnology
Jungeun Lim, Hanna Ching, Jeong-Kee Yoon, Noo Li Jeon, YongTae Kim
Summary: The recent advancements in organoids engineering and organ-on-a-chip microfluidic technologies have allowed for the recapitulation of the major functions and structures of microscale human tissue, including tumor pathophysiology. However, challenges still exist in replicating the complexity and heterogeneity of the tumor microenvironment. The integration of these engineering technologies may offer a potential strategy to overcome limitations in reconstituting the perfusable microvascular system of large-scale tumors while conserving their key functional features.
Article
Engineering, Biomedical
Jeong-Kee Yoon, Jaehoon Kim, Zachary Shah, Ashi Awasthi, Advay Mahajan, YongTae Kim
Summary: Chronic disruption of the blood-brain barrier may lead to neurodegenerative diseases, and animal models are not suitable for modeling Alzheimer's disease, highlighting the importance of establishing in vitro models of the human BBB with physiological relevance.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Engineering, Biomedical
Jaehoon Kim, Hyejin Park, Hyunho Kim, YongTae Kim, Hyun Jeong Oh, Seok Chung
Summary: Tumors create interstitial flow (IF), which allows soluble substances from cancer cells to be transported towards the tumor stroma. Researchers have designed a microfluidic device that mimics one-directional flow of IF to investigate how cancer cells activate and differentiate stromal cells.
ACTA BIOMATERIALIA
(2022)
Article
Multidisciplinary Sciences
Huanzhen Ni, Marine Z. C. Hatit, Kun Zhao, David Loughrey, Melissa P. Lokugamage, Hannah E. Peck, Ada Del Cid, Abinaya Muralidharan, YongTae Kim, Philip J. Santangelo, James E. Dahlman
Summary: This study reports the development of piperazine-containing lipid nanoparticles (Pi-Lipids) that can selectively deliver mRNA to immune cells without the need for targeting ligands. Using in vivo DNA barcoding, the researchers demonstrated that these nanoparticles efficiently delivered mRNA to non-hepatocytes, which has been a challenging task without the use of ligands. The findings highlight the potential of Pi-Lipids and support the hypothesis that lipids with bioactive small-molecule motifs can deliver mRNA in vivo.
NATURE COMMUNICATIONS
(2022)
Article
Biochemical Research Methods
Jaehoon Kim, Hyunho Kim, Jeong Suk Kang, Eun Soo Lee, Choon Hee Chung, Hyun Jeong Oh, YongTae Kim, Seok Chung, Eun Young Lee
Summary: We have developed a microfluidic model that replicates the physiology of the glomerular filtration barrier (GFB) through tunable glomerular basement membrane (gBM) deposition and 3D co-culture of podocytes with glomerular endothelial cells (gECs). By controlling the thickness of the gBM, our model successfully reproduces the biphasic response of the GFB and facilitates dynamic crosstalk between gECs and podocytes. The interaction of gECs and podocytes plays a significant role in drug-induced injury and regulation of barrier properties.
Article
Biochemical Research Methods
Jaehoon Kim, Taehee Yoon, Paul Kim, Mandakh Bekhbat, So Mang Kang, Hoon Suk Rho, Song Ih Ahn, YongTae Kim
Summary: Microphysiological system or organ-on-a-chip technologies have the potential to replicate the key structure and function of 3D human tissues with higher reproducibility than traditional models, making them promising alternatives to animal models for drug testing. However, standardized manufacturing of these organ chip models is necessary for reliable drug screening and mechanism research.
Article
Engineering, Biomedical
Melissa P. Lokugamage, Daryll Vanover, Jared Beyersdorf, Marine Z. C. Hatit, Laura Rotolo, Elisa Schrader Echeverri, Hannah E. Peck, Huanzhen Ni, Jeong-Kee Yoon, Yongtae Kim, Philip J. Santangelo, James E. Dahlman
Summary: This study optimized the design of lipid nanoparticles for the efficient delivery of therapeutic mRNA to the lungs via nebulization, resulting in protection of mice from a lethal challenge of H1N1 influenza A virus and more efficient delivery of mRNA compared to LNPs previously optimized for systemic delivery. The cluster approach to LNP design may facilitate the optimization of LNPs for other administration routes and therapeutics.
NATURE BIOMEDICAL ENGINEERING
(2021)
