Deletion of Biliverdin Reductase A in Myeloid Cells Promotes Chemokine Expression and Chemotaxis in Part via a Complement C5a­–C5aR1 Pathway

Biliverdin reductase and bilirubin in hepatic disease

(2018) Lauren Weaver et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Complement 5a stimulates macrophage polarization and contributes to tumor metastases of colon cancer

(2018) Chunmei Piao et al.   EXPERIMENTAL CELL RESEARCH

Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress

(2018) Weiyu Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Complement C5a Receptor 1 Exacerbates the Pathophysiology of N. meningitidis Sepsis and Is a Potential Target for Disease Treatment

(2018) Johannes B. Herrmann et al.   mBio

Transcriptional profiling identifies novel regulators of macrophage polarization

(2018) Kimberline Y. Gerrick et al.   PLoS One

New concepts on the therapeutic control of complement anaphylatoxin receptors

(2017) Owen A. Hawksworth et al.   MOLECULAR IMMUNOLOGY

The complement system as a potential therapeutic target in rheumatic disease

(2017) Leendert A. Trouw et al.   Nature Reviews Rheumatology

Differential regulation of C5a receptor 1 in innate immune cells during the allergic asthma effector phase

(2017) Fanny Ender et al.   PLoS One

Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis

(2016) Hongmei Gu et al.   FASEB JOURNAL

Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation

(2016) Tihomir Miralem et al.   FASEB JOURNAL

C5a induces caspase-dependent apoptosis in brain vascular endothelial cells in experimental lupus

(2016) Supriya D. Mahajan et al.   IMMUNOLOGY

Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Terry D. Hinds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phenotypic, Functional, and Plasticity Features of Classical and Alternatively Activated Human Macrophages

(2015) Abdullah A. Tarique et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

C5a alters blood-brain barrier integrity in a humanin vitromodel of systemic lupus erythematosus

(2015) Supriya D. Mahajan et al.   IMMUNOLOGY

Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney

(2015) Zhizhi Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulators of Macrophage Polarization Influence Healing of the Infarcted Myocardium

(2015) Ellis ter Horst et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Is the Complement Activation Product C3a a Proinflammatory Molecule? Re-evaluating the Evidence and the Myth

(2015) Liam G. Coulthard et al.   JOURNAL OF IMMUNOLOGY

Biliverdin modulates the expression of C5aR in response to endotoxin in part via mTOR signaling

(2014) Kavita Bisht et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Treatment with the C5a receptor/CD88 antagonist PMX205 reduces inflammation in a murine model of allergic asthma

(2014) Elizabeth B. Staab et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cutting Edge: Critical Role for C5aRs in the Development of Septic Lymphopenia in Mice

(2014) Jamison J. Grailer et al.   JOURNAL OF IMMUNOLOGY

C5L2: a controversial receptor of complement anaphylatoxin, C5a

(2012) Rui Li et al.   FASEB JOURNAL

Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase

(2012) Barbara Wegiel et al.   Frontiers in Pharmacology

Complement in health and disease

(2011) Maria V. Carroll et al.   ADVANCED DRUG DELIVERY REVIEWS

Complement C5a inhibition reduces atherosclerosis in ApoE−/− mice

(2011) Helga D. Manthey et al.   FASEB JOURNAL

Complement and non-complement activating functions of C1q: A prototypical innate immune molecule

(2011) Annapurna Nayak et al.   Innate Immunity

Formation of Ternary Complex of Human Biliverdin Reductase-Protein Kinase Cδ-ERK2 Protein Is Essential for ERK2-mediated Activation of Elk1 Protein, Nuclear Factor-κB, and Inducible Nitric-oxidase Synthase (iNOS)

(2011) Peter E. M. Gibbs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibiting the C5–C5a receptor axis

(2011) Trent M. Woodruff et al.   MOLECULAR IMMUNOLOGY

Heme oxygenase-1 and carbon monoxide modulate DNA repair through ataxia-telangiectasia mutated (ATM) protein

(2011) L. E. Otterbein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase

(2011) B. Wegiel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of C5 Activation Products in Sepsis

(2011) Peter A. Ward   TheScientificWorldJOURNAL

Inhibition of C5a receptor alleviates experimental CNS lupus

(2010) Alexander Jacob et al.   JOURNAL OF NEUROIMMUNOLOGY

Cell Surface Biliverdin Reductase Mediates Biliverdin-induced Anti-inflammatory Effects via Phosphatidylinositol 3-Kinase and Akt

(2009) Barbara Wegiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functions of C5a receptors

(2009) Peter A. Ward   JOURNAL OF MOLECULAR MEDICINE-JMM

Bilirubin and glutathione have complementary antioxidant and cytoprotective roles

(2009) T. W. Sedlak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mast cell activation is characterized by upregulation of a functional anaphylatoxin C5a receptor

(2008) Afsaneh Soruri et al.   BMC IMMUNOLOGY