Biliverdin reductase and bilirubin in hepatic disease

Absence of the biliverdin reductase-a gene is associated with increased endogenous oxidative stress

(2018) Weiyu Chen et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Functions of Heme Oxygenase-1 and Biliverdin Reductase in Diabetes

(2018) Luc Rochette et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Bilirubin in the Liver–Gut Signaling Axis

(2018) Abdul-Rizaq Hamoud et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Depletion of stercobilin in fecal matter from a mouse model of autism spectrum disorders

(2017) Emily R. Sekera et al.   Metabolomics

Unconjugated bilirubin ameliorates the inflammation and digestive protease increase in TNBS-induced colitis

(2017) Jin-An Zhou et al.   Molecular Medicine Reports

Low concentrations of bilirubin inhibit activation of hepatic stellate cells in vitro

(2017) Yinhe Tang et al.   Molecular Medicine Reports

Obesity and fatty liver are prevented by inhibition of the aryl hydrocarbon receptor in both female and male mice

(2017) Benjamin J. Moyer et al.   NUTRITION RESEARCH

Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis

(2017) Xue Chen et al.   TOXICOLOGY

Inhibitory effect of the low‑toxic exogenous aryl hydrocarbon receptor modulator 3'3‑diindolylmethane on gastric cancer in mice

(2017) Mingli Su et al.   Oncology Letters

Bilirubin Prevents Atherosclerotic Lesion Formation in Low‐Density Lipoprotein Receptor‐Deficient Mice by Inhibiting Endothelial VCAM‐1 and ICAM‐1 Signaling

(2017) Megan E. Vogel et al.   Journal of the American Heart Association

Inverse Relationship Between Serum Bilirubin Levels and Diabetic Foot in Chinese Patients with Type 2 Diabetes Mellitus

(2017) Jifan Chen et al.   MEDICAL SCIENCE MONITOR

Relationship between Serum Bilirubin Levels and Metabolic Syndrome in Patients with Schizophrenia Spectrum Disorders

(2017) Filiz Karadag et al.   Clinical Psychopharmacology and Neuroscience

Prevalence of non-alcoholic fatty liver disease and risk factors for advanced fibrosis and mortality in the United States

(2017) Michael H. Le et al.   PLoS One

Pathogenesis of alcoholic liver disease: Role of oxidative metabolism

(2017) Elisabetta Ceni et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Effect of bilirubin concentration on the risk of diabetic complications: A meta-analysis of epidemiologic studies

(2017) Bo Zhu et al.   Scientific Reports

Bilirubin Nanoparticles as a Nanomedicine for Anti-inflammation Therapy

(2016) Yonghyun Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Interaction of human biliverdin reductase with Akt/protein kinase B and phosphatidylinositol-dependent kinase 1 regulates glycogen synthase kinase 3 activity: a novel mechanism of Akt activation

(2016) Tihomir Miralem et al.   FASEB JOURNAL

Protective role of biliverdin against bile acid-induced oxidative stress in liver cells

(2016) Ester Gonzalez-Sanchez et al.   FREE RADICAL BIOLOGY AND MEDICINE

Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Terry D. Hinds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucocorticoid Receptor β Induces Hepatic Steatosis by Augmenting Inflammation and Inhibition of the Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Joseph S. Marino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Relationship Between the Serum Total Bilirubin and Inflammation in Patients With Psoriasis Vulgaris

(2016) Zhen-Xing Zhou et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Higher Bilirubin Levels of Healthy Living Liver Donors Are Associated With Lower Posttransplant Hepatocellular Carcinoma Recurrence

(2016) Sangbin Han et al.   TRANSPLANTATION

The Ras/Raf/MEK/ERK signaling pathway and its role in the occurrence and development of HCC

(2016) Lei Li et al.   Oncology Letters

Glucuronidation and UGT isozymes in bladder: new targets for the treatment of uroepithelial carcinomas?

(2016) Vikram L. Sundararaghavan et al.   Oncotarget

Nanoparticle Delivered Human Biliverdin Reductase-Based Peptide Increases Glucose Uptake by Activating IRK/Akt/GSK3 Axis: The Peptide Is Effective in the Cell and Wild-Type and Diabetic Ob/Ob Mice

(2016) Peter E. M. Gibbs et al.   Journal of Diabetes Research

Bilirubin Binding to PPARα Inhibits Lipid Accumulation

(2016) David E. Stec et al.   PLoS One

Features of an altered AMPK metabolic pathway in Gilbert’s Syndrome, and its role in metabolic health

(2016) Christine Mölzer et al.   Scientific Reports

Bilirubin is an Endogenous Antioxidant in Human Vascular Endothelial Cells

(2016) Lovro Ziberna et al.   Scientific Reports

Microbiota-Dependent Hepatic Lipogenesis Mediated by Stearoyl CoA Desaturase 1 (SCD1) Promotes Metabolic Syndrome in TLR5-Deficient Mice

(2015) Vishal Singh et al.   Cell Metabolism

Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney

(2015) Zhizhi Hu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatic insulin resistance and increased hepatic glucose production in mice lackingFgf21

(2015) João Paulo G Camporez et al.   JOURNAL OF ENDOCRINOLOGY

Tat-biliverdin reductase A inhibits inflammatory response by regulation of MAPK and NF-κB pathways in Raw 264.7 cells and edema mouse model

(2015) Hye Ri Kim et al.   MOLECULAR IMMUNOLOGY

Biliverdin reductase isozymes in metabolism

(2015) Luke O’Brien et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Biliverdin reductase: a target for cancer therapy?

(2015) Peter E. M. Gibbs et al.   Frontiers in Pharmacology

Effect of Low Serum Total Bilirubin Levels (≤0.32 mg/dl) on Risk of Coronary Artery Disease in Patients With Metabolic Syndrome

(2014) Young Shin Song et al.   AMERICAN JOURNAL OF CARDIOLOGY

Bilirubin as a Potential Causal Factor in Type 2 Diabetes Risk: A Mendelian Randomization Study

(2014) Ali Abbasi et al.   DIABETES

Human biliverdin reductase-based peptides activate and inhibit glucose uptake through direct interaction with the kinase domain of insulin receptor

(2014) Peter E. M. Gibbs et al.   FASEB JOURNAL

Glucocorticoid Receptor β Stimulates Akt1 Growth Pathway by Attenuation of PTEN

(2014) Lance A. Stechschulte et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Body Fat Percentage Is a Major Determinant of Total Bilirubin Independently of UGT1A1*28 Polymorphism in Young Obese

(2014) Luís Belo et al.   PLoS One

Nonalcoholic fatty liver disease: A comprehensive review of a growing epidemic

(2014) Kareem Hassan   WORLD JOURNAL OF GASTROENTEROLOGY

Clinical differences between alcoholic liver disease and nonalcoholic fatty liver disease

(2014) Nobuyuki Toshikuni   WORLD JOURNAL OF GASTROENTEROLOGY

Elevated serum bilirubin levels are inversely associated with coronary artery atherosclerosis

(2013) Seung Joo Kang et al.   ATHEROSCLEROSIS

Protection from age-related increase in lipid biomarkers and inflammation contributes to cardiovascular protection in Gilbert's syndrome

(2013) Marlies Wallner et al.   CLINICAL SCIENCE

Unconjugated bilirubin, a potent endogenous antioxidant, is decreased in patients with non-alcoholic steatohepatitis and advanced fibrosis

(2013) Federico Salomone et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

FGF21 mediates the lipid metabolism response to amino acid starvation

(2013) Ana Luísa De Sousa-Coelho et al.   JOURNAL OF LIPID RESEARCH

Serum Bilirubin Level Is Inversely Associated With Nonalcoholic Steatohepatitis in Children

(2013) Kanika Puri et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Serum bilirubin levels are lower in overweight asymptomatic middle-aged adults: An early indicator of metabolic syndrome?

(2013) Zala Jenko-Pražnikar et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Increased HO-1 levels ameliorate fatty liver development through a reduction of heme and recruitment of FGF21

(2013) Terry D. Hinds et al.   Obesity

Unconjugated hyperbilirubinemia is inversely associated with non-alcoholic steatohepatitis (NASH)

(2012) M. Hjelkrem et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

The Human Biliverdin Reductase-based Peptide Fragments and Biliverdin Regulate Protein Kinase Cδ Activity

(2012) Tihomir Miralem et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A selective aryl hydrocarbon receptor modulator 3,3'-Diindolylmethane inhibits gastric cancer cell growth

(2012) Xiao-Fei Yin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

α-SMA Overexpression Associated With Increased Liver Fibrosis in Infants With Biliary Atresia

(2012) Rui Dong et al.   JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION

Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?

(2012) Thomas Jansen et al.   Frontiers in Pharmacology

The Role of Bilirubin in Diabetes, Metabolic Syndrome, and Cardiovascular Diseases

(2012) Libor Vítek   Frontiers in Pharmacology

PPARs are a unique set of fatty acid regulated transcription factors controlling both lipid metabolism and inflammation

(2011) Tamas Varga et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Unconjugated hyperbilirubinemia in patients with non-alcoholic fatty liver disease: A favorable endogenous response

(2011) Ramesh Kumar et al.   CLINICAL BIOCHEMISTRY

Eponym

(2011) Andrew Fretzayas et al.   EUROPEAN JOURNAL OF PEDIATRICS

Reactive oxygen species in the normal and acutely injured liver

(2011) Hartmut Jaeschke et al.   JOURNAL OF HEPATOLOGY

Inverse Association Between Total Bilirubin and Metabolic Syndrome in Rural Korean Women

(2011) Kyung-Min Kwon et al.   JOURNAL OF WOMENS HEALTH

Biliverdin inhibits Toll-like receptor-4 (TLR4) expression through nitric oxide-dependent nuclear translocation of biliverdin reductase

(2011) B. Wegiel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Bilirubin-Increasing Drug Atazanavir Improves Endothelial Function in Patients With Type 2 Diabetes Mellitus

(2010) Douwe Dekker et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hepatic FGF21 Expression Is Induced at Birth via PPARα in Response to Milk Intake and Contributes to Thermogenic Activation of Neonatal Brown Fat

(2010) Elayne Hondares et al.   Cell Metabolism

Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation

(2010) Huaqiang Zhu et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Unconjugated Bilirubin Contributes to Early Inflammation and Edema after Intracerebral Hemorrhage

(2010) Matthew C Loftspring et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inhibition of bilirubin metabolism induces moderate hyperbilirubinemia and attenuates ANG II-dependent hypertension in mice

(2009) Trinity Vera et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

The selective aryl hydrocarbon receptor modulator 6-methyl-1,3,8-trichlorodibenzofuran inhibits prostate tumor metastasis in TRAMP mice

(2009) Wayne A. Fritz et al.   BIOCHEMICAL PHARMACOLOGY

Limited Role for the Bilirubin-Biliverdin Redox Amplification Cycle in the Cellular Antioxidant Protection by Biliverdin Reductase

(2009) Ghassan J. Maghzal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Surface Biliverdin Reductase Mediates Biliverdin-induced Anti-inflammatory Effects via Phosphatidylinositol 3-Kinase and Akt

(2009) Barbara Wegiel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variants in the UGT1A1 Gene and the Risk of Pediatric Nonalcoholic Fatty Liver Disease

(2009) Y.-C. Lin et al.   PEDIATRICS

Bilirubin and glutathione have complementary antioxidant and cytoprotective roles

(2009) T. W. Sedlak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathogenesis of non-alcoholic fatty liver disease

(2009) J. K. Dowman et al.   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Gilbert syndrome, UGT1A1*28 allele, and cardiovascular disease risk: Possible protective effects and therapeutic applications of bilirubin

(2008) Harvey A. Schwertner et al.   ATHEROSCLEROSIS

Comparative redox status in alcoholic liver disease and nonalcoholic fatty liver disease

(2008) Payal Bhardwaj et al.   Hepatology International

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS