Sphingosine kinase 1 in viral infections

The Role of Sphingosine Kinase in a Murine Model of Allergic Asthma

(2014) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

Anti-Inflammatory Effects of Sphingosine Kinase Modulation in Inflammatory Arthritis

(2014) W.-Q. Lai et al.   JOURNAL OF IMMUNOLOGY

SAR analysis of innovative selective small molecule antagonists of sphingosine-1-phosphate 4 (S1P4) receptor

(2011) Mariangela Urbano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Sequential desensitization of CXCR4 and S1P5 controls natural killer cell trafficking

(2011) K. Mayol et al.   BLOOD

Sphingosine Kinase Inhibitors and Cancer: Seeking the Golden Sword of Hercules

(2011) S. Pyne et al.   CANCER RESEARCH

Endothelial Cells Are Central Orchestrators of Cytokine Amplification during Influenza Virus Infection

(2011) John R. Teijaro et al.   CELL

The compartmentalization and translocation of the sphingosine kinases: Mechanisms and functions in cell signaling and sphingolipid metabolism

(2011) Deanna Siow et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Applications of Animal Models of Infectious Arthritis in Drug Discovery:A focus on Alphaviral Disease

(2011) Lara Herrero et al.   CURRENT DRUG TARGETS

Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?

(2011) Young-Jin Seo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Quelling the storm: utilization of sphingosine-1-phosphate receptor signaling to ameliorate influenza virus-induced cytokine storm

(2011) Kevin B. Walsh et al.   IMMUNOLOGIC RESEARCH

Protection From Arthritis and Myositis in a Mouse Model of Acute Chikungunya Virus Disease by Bindarit, an Inhibitor of Monocyte Chemotactic Protein-1 Synthesis

(2011) Nestor E. Rulli et al.   JOURNAL OF INFECTIOUS DISEASES

Role of sphingosine-1-phosphate (S1P) and S1P receptor 2 in the phagocytosis of Cryptococcus neoformans by alveolar macrophages

(2011) T. McQuiston et al.   MICROBIOLOGY-SGM

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus

(2011) K. B. Walsh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis

(2011) L. J. Herrero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inflammatory Cytokine Expression Is Associated with Chikungunya Virus Resolution and Symptom Severity

(2011) Alyson A. Kelvin et al.   PLoS Neglected Tropical Diseases

Tumor Necrosis Factor-Induced Neutrophil Adhesion Occurs Via Sphingosine Kinase-1-Dependent Activation of Endothelial α5β1 Integrin

(2010) Wai Y. Sun et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine and FTY720 directly bind pro-survival 14-3-3 proteins to regulate their function

(2010) Joanna M. Woodcock et al.   CELLULAR SIGNALLING

Inhibitors of the Sphingosine Kinase Pathway as Potential Therapeutics

(2010) M.R. Pitman et al.   CURRENT CANCER DRUG TARGETS

Sphingosine 1-phosphate, a key mediator of the cytokine network: Juxtacrine signaling

(2010) Pu Xia et al.   CYTOKINE & GROWTH FACTOR REVIEWS

The involvement of sphingosine kinase 1 in LPS-induced Toll-like receptor 4-mediated accumulation of HIF-1α protein, activation of ASK1 and production of the pro-inflammatory cytokine IL-6

(2010) Dmitri Pchejetski et al.   IMMUNOLOGY AND CELL BIOLOGY

Role of Host Sphingosine Kinase 1 in the Lung Response against Cryptococcosis

(2010) T. McQuiston et al.   INFECTION AND IMMUNITY

A critical role for the protein phosphatase 2A B′α regulatory subunit in dephosphorylation of sphingosine kinase 1

(2010) Melissa R. Pitman et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Tumour necrosis factor alpha (TNF- ) stimulation of cells with established dengue virus type 2 infection induces cell death that is accompanied by a reduced ability of TNF-  to activate nuclear factor  B and reduced sphingosine kinase-1 activity

(2010) S. Wati et al.   JOURNAL OF GENERAL VIROLOGY

Genetic Sphingosine Kinase 1 Deficiency Significantly Decreases Synovial Inflammation and Joint Erosions in Murine TNF- -Induced Arthritis

(2010) D. A. Baker et al.   JOURNAL OF IMMUNOLOGY

Ceramide and Ceramide 1-Phosphate Are Negative Regulators of TNF-  Production Induced by Lipopolysaccharide

(2010) S. Jozefowski et al.   JOURNAL OF IMMUNOLOGY

Intracellular localization of sphingosine kinase 1 alters access to substrate pools but does not affect the degradative fate of sphingosine-1-phosphate

(2010) Deanna L. Siow et al.   JOURNAL OF LIPID RESEARCH

Inhibition of Sphingosine 1-Phosphate Lyase for the Treatment of Rheumatoid Arthritis: Discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone Oxime (LX2931) and (1R,2S,3R)-1-(2-(Isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932)

(2010) Jeffrey T. Bagdanoff et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological Manipulation of the Akt Signaling Pathway Regulates Myxoma Virus Replication and Tropism in Human Cancer Cells

(2010) S. J. Werden et al.   JOURNAL OF VIROLOGY

Sphingosine 1-Phosphate-Metabolizing Enzymes Control Influenza Virus Propagation and Viral Cytopathogenicity

(2010) Y.-J. Seo et al.   JOURNAL OF VIROLOGY

Virus-Induced Ca2+ Influx Extends Survival of West Nile Virus-Infected Cells

(2010) S. V. Scherbik et al.   JOURNAL OF VIROLOGY

Intrinsic antibody-dependent enhancement of microbial infection in macrophages: disease regulation by immune complexes

(2010) Scott B Halstead et al.   LANCET INFECTIOUS DISEASES

Japanese encephalitis virus down-regulates thioredoxin and induces ROS-mediated ASK1-ERK/p38 MAPK activation in human promonocyte cells

(2010) Tsuey-Ching Yang et al.   MICROBES AND INFECTION

Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2

(2010) Sergio E. Alvarez et al.   NATURE

Fingolimod (FTY720): discovery and development of an oral drug to treat multiple sclerosis

(2010) Volker Brinkmann et al.   NATURE REVIEWS DRUG DISCOVERY

Guanine nucleotides regulate sphingosine kinase 1 activation by eukaryotic elongation factor 1A and provide a mechanism for eEF1A-associated oncogenesis

(2010) T M Leclercq et al.   ONCOGENE

Sphingosine Kinase-1 (SphK-1) Regulates Mycobacterium smegmatis Infection in Macrophages

(2010) Hridayesh Prakash et al.   PLoS One

Regulation of sphingosine kinase and sphingolipid signaling

(2010) Stuart M. Pitson   TRENDS IN BIOCHEMICAL SCIENCES

Sphingosine-1-phosphate and immune regulation: trafficking and beyond

(2010) Hongbo Chi   TRENDS IN PHARMACOLOGICAL SCIENCES

Sphingosine Kinase-1 Associates with Integrin α V β 3 to Mediate Endothelial Cell Survival

(2009) Jennifer R. Gamble et al.   AMERICAN JOURNAL OF PATHOLOGY

Sphingosine 1-Phosphate Receptor Signaling

(2009) Hugh Rosen et al.   Annual Review of Biochemistry

Amelioration of alphavirus-induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins

(2009) Nestor E. Rulli et al.   ARTHRITIS AND RHEUMATISM

Bone Marrow Progenitor Cells Induce Endothelial Adherens Junction Integrity by Sphingosine-1-Phosphate–Mediated Rac1 and Cdc42 Signaling

(2009) Yidan D. Zhao et al.   CIRCULATION RESEARCH

Dengue Virus Pathogenesis: an Integrated View

(2009) B. E. E. Martina et al.   CLINICAL MICROBIOLOGY REVIEWS

S1P3 confers differential S1P-induced migration by autoreactive and non-autoreactive immature B cells and is required for normal B-cell development

(2009) Erin E. Donovan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulation of macrophage function by sphingosine-1-phosphate

(2009) Andreas Weigert et al.   IMMUNOBIOLOGY

Evaluation of the lymphocyte trafficking drug FTY720 in SHIVSF162P3-infected rhesus macaques

(2009) E. N. Kersh et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Translocation of Sphingosine Kinase 1 to the Plasma Membrane Is Mediated by Calcium- and Integrin-binding Protein 1

(2009) Kate E. Jarman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Sphingosine Kinase by Bovine Viral Diarrhea Virus NS3 Is Crucial for Efficient Viral Replication and Cytopathogenesis

(2009) Daisuke Yamane et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sphingosine Kinase1 Is Pivotal for Fc RI-Mediated Mast Cell Signaling and Functional Responses In Vitro and In Vivo

(2009) P. N. Pushparaj et al.   JOURNAL OF IMMUNOLOGY

Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection

(2009) Maria T. Arévalo et al.   JOURNAL OF MEDICAL VIROLOGY

Expression of sphingosine kinase 2 in synovial fibroblasts of rheumatoid arthritis contributing to apoptosis by a sphingosine analogue, FTY720

(2009) Kazuo Kamada et al.   PATHOLOGY INTERNATIONAL

Essential role of platelet-activating factor receptor in the pathogenesis of Dengue virus infection

(2009) D. G. Souza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A critical role for the sphingosine analog AAL-R in dampening the cytokine response during influenza virus infection

(2009) D. Marsolais et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of Histone Acetylation in the Nucleus by Sphingosine-1-Phosphate

(2009) N. C. Hait et al.   SCIENCE

Treatment with a sphingosine analog does not alter the outcome of a persistent virus infection

(2009) Kevin B. Walsh et al.   VIROLOGY

Sphingosine kinase regulates the rate of endothelial progenitor cell differentiation

(2008) C. S. Bonder et al.   BLOOD

Distinct roles of sphingosine kinases 1 and 2 in human mast-cell functions

(2008) C. A. Oskeritzian et al.   BLOOD

Basal and angiopoietin-1-mediated endothelial permeability is regulated by sphingosine kinase-1

(2008) X. Li et al.   BLOOD

Vascular Endothelium As a Contributor of Plasma Sphingosine 1-Phosphate

(2008) Krishnan Venkataraman et al.   CIRCULATION RESEARCH

The Role of TRAF2 Binding to the Type I Interferon Receptor in Alternative NFκB Activation and Antiviral Response

(2008) Chuan He Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deactivation of Sphingosine Kinase 1 by Protein Phosphatase 2A

(2008) Renae K. Barr et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Cytomegalovirus Regulates Bioactive Sphingolipids

(2008) Nicholas J. Machesky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophage‐Derived Proinflammatory Factors Contribute to the Development of Arthritis and Myositis after Infection with an Arthrogenic Alphavirus

(2008) Brett A. Lidbury et al.   JOURNAL OF INFECTIOUS DISEASES

Sphingosine-1-phosphate: the Swiss army knife of sphingolipid signaling

(2008) Michael Maceyka et al.   JOURNAL OF LIPID RESEARCH

Hantaviruses Direct Endothelial Cell Permeability by Sensitizing Cells to the Vascular Permeability Factor VEGF, while Angiopoietin 1 and Sphingosine 1-Phosphate Inhibit Hantavirus-Directed Permeability

(2008) I. N. Gavrilovskaya et al.   JOURNAL OF VIROLOGY

Principles of bioactive lipid signalling: lessons from sphingolipids

(2008) Yusuf A. Hannun et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

"Inside-Out" Signaling of Sphingosine-1-Phosphate: Therapeutic Targets

(2008) K. Takabe et al.   PHARMACOLOGICAL REVIEWS