Fishing in the Cell Powerhouse: Zebrafish as A Tool for Exploration of Mitochondrial Defects Affecting the Nervous System

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

(2019) Chunhui Huang et al.   Marine Drugs

Neurotoxin-Induced Animal Models of Parkinson Disease: Pathogenic Mechanism and Assessment

(2018) Xian-Si Zeng et al.   ASN Neuro

The idebenone metabolite QS10 restores electron transfer in complex I and coenzyme Q defects

(2018) Valentina Giorgio et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Human diseases associated with defects in assembly of OXPHOS complexes

(2018) Daniele Ghezzi et al.   Essays in Biochemistry

What’s new in pontocerebellar hypoplasia? An update on genes and subtypes

(2018) Tessa van Dijk et al.   Orphanet Journal of Rare Diseases

A beginner's guide to understanding and implementing the genetic modification of zebrafish

(2018) Sara A. Rafferty et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A mitochondria-targeted ratiometric two-photon fluorescent probe for detecting intracellular cysteine and homocysteine

(2018) Ping Yue et al.   TALANTA

Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo

(2018) Ann Kristin Frøyset et al.   Redox Biology

Elesclomol restores mitochondrial function in genetic models of copper deficiency

(2018) Shivatheja Soma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Properties of the Mitochondrial Carrier System

(2017) Eric B. Taylor   TRENDS IN CELL BIOLOGY

Regulation of mitochondria-dynactin interaction and mitochondrial retrograde transport in axons

(2017) Catherine M Drerup et al.   eLife

Neuronal Mitophagy in Neurodegenerative Diseases

(2017) Marta Martinez-Vicente   Frontiers in Molecular Neuroscience

The Treatment of Sleep Disorders in Parkinson’s Disease: From Research to Clinical Practice

(2017) Giuseppe Loddo et al.   Frontiers in Neurology

Oxidative Stress: Emerging Mitochondrial and Cellular Themes and Variations in Neuronal Injury

(2017) Gavin C. Higgins et al.   JOURNAL OF ALZHEIMERS DISEASE

Mitochondrial complex I-linked disease

(2016) Richard J. Rodenburg   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Zebrafish Tg(hb9:MTS-Kaede): a new in vivo tool for studying the axonal movement of mitochondria

(2016) Giorgia Bergamin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Loss of function of SLC25A46 causes lethal congenital pontocerebellar hypoplasia

(2016) Jijun Wan et al.   BRAIN

Mitochondrial Oxidative Phosphorylation System (OXPHOS) Deficits in Schizophrenia

(2016) Oded Bergman et al.   CANADIAN JOURNAL OF PSYCHIATRY-REVUE CANADIENNE DE PSYCHIATRIE

Inhibition of the mitochondrial calcium uniporter rescues dopaminergic neurons inpink1−/−zebrafish

(2016) Smijin Soman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial biogenesis and clearance: a balancing act

(2016) Christina Ploumi et al.   FEBS Journal

Mouse models for mitochondrial diseases

(2016) Benedetta Ruzzenente et al.   HUMAN MOLECULAR GENETICS

Melatonin rescues zebrafish embryos from the parkinsonian phenotype restoring the parkin/PINK1/DJ-1/MUL1 network

(2016) María E. Díaz-Casado et al.   JOURNAL OF PINEAL RESEARCH

Neuroprotective Effect of the Marine-Derived Compound 11-Dehydrosinulariolide through DJ-1-Related Pathway in In Vitro and In Vivo Models of Parkinson’s Disease

(2016) Chien-Wei Feng et al.   Marine Drugs

Live imaging of mitochondrial dynamics in CNS dopaminergic neurons in vivo demonstrates early reversal of mitochondrial transport following MPP+ exposure

(2016) April A. Dukes et al.   NEUROBIOLOGY OF DISEASE

ES1 is a mitochondrial enlarging factor contributing to form mega-mitochondria in zebrafish cones

(2016) Takamasa Masuda et al.   Scientific Reports

Paeonolum protects against MPP+-induced neurotoxicity in zebrafish and PC12 cells

(2015) Xi-Lin Lu et al.   BMC Complementary and Alternative Medicine

The cellular and molecular progression of mitochondrial dysfunction induced by 2,4-dinitrophenol in developing zebrafish embryos

(2015) Jennifer E. Bestman et al.   DIFFERENTIATION

Parkin structure and function

(2015) Marjan Seirafi et al.   FEBS Journal

Autophagosome dynamics in neurodegeneration at a glance

(2015) Y. C. Wong et al.   JOURNAL OF CELL SCIENCE

Erk2 Phosphorylation of Drp1 Promotes Mitochondrial Fission and MAPK-Driven Tumor Growth

(2015) Jennifer A. Kashatus et al.   MOLECULAR CELL

Mutations in SLC25A46, encoding a UGO1-like protein, cause an optic atrophy spectrum disorder

(2015) Alexander J Abrams et al.   NATURE GENETICS

Deletion of a kinesin I motor unmasks a mechanism of homeostatic branching control by neurotrophin-3

(2015) Thomas O Auer et al.   eLife

The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis.

(2015) Olga Catalina-Rodriguez et al.   Oncotarget

Axon degeneration and PGC-1 -mediated protection in a zebrafish model of  -synuclein toxicity

(2014) K. C. O'Donnell et al.   Disease Models & Mechanisms

Copper supplementation restores cytochrome c oxidase assembly defect in a mitochondrial disease model of COA6 deficiency

(2014) A. Ghosh et al.   HUMAN MOLECULAR GENETICS

The arginine methyltransferase NDUFAF7 is essential for complex I assembly and early vertebrate embryogenesis

(2014) Olga Zurita Rendón et al.   HUMAN MOLECULAR GENETICS

Modelling inborn errors of metabolism in zebrafish

(2014) Kim Wager et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Unique Function of Kinesin Kif5A in Localization of Mitochondria in Axons

(2014) P. D. Campbell et al.   JOURNAL OF NEUROSCIENCE

Quality matters: how does mitochondrial network dynamics and quality control impact on mtDNA integrity?

(2014) K. B. Busch et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Deficiency in SLC25A1, Encoding the Mitochondrial Citrate Carrier, Causes Combined D-2- and L-2-Hydroxyglutaric Aciduria

(2013) Benjamin Nota et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TigarBcauses mitochondrial dysfunction and neuronal loss in PINK1 deficiency

(2013) Laura J. Flinn et al.   ANNALS OF NEUROLOGY

Mutagenesis and phenotyping resources in zebrafish for studying development and human disease

(2013) G. K. Varshney et al.   Briefings in Functional Genomics

Temporal and tissue specific gene expression patterns of the zebrafish kinesin-1 heavy chain family, kif5s, during development

(2013) Philip D. Campbell et al.   GENE EXPRESSION PATTERNS

Agenesis of corpus callosum and optic nerve hypoplasia due to mutations inSLC25A1encoding the mitochondrial citrate transporter

(2013) Simon Edvardson et al.   JOURNAL OF MEDICAL GENETICS

WldS and PGC-1  Regulate Mitochondrial Transport and Oxidation State after Axonal Injury

(2013) K. C. O'Donnell et al.   JOURNAL OF NEUROSCIENCE

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

TALEN-mediated precise genome modification by homologous recombination in zebrafish

(2013) Yao Zu et al.   NATURE METHODS

The clinical maze of mitochondrial neurology

(2013) Salvatore DiMauro et al.   Nature Reviews Neurology

A zebrafish model of PINK1 deficiency reveals key pathway dysfunction including HIF signaling

(2013) M. Priyadarshini et al.   NEUROBIOLOGY OF DISEASE

α-Synuclein and Mitochondria: Partners in Crime?

(2013) Ken Nakamura   Neurotherapeutics

Regulation of Mitochondrial Morphogenesis by Annexin A6

(2013) Marcin Chlystun et al.   PLoS One

Opa1 Is Required for Proper Mitochondrial Metabolism in Early Development

(2013) Jennifer J. Rahn et al.   PLoS One

Axonal Transport Defects in a Mitofusin 2 Loss of Function Model of Charcot-Marie-Tooth Disease in Zebrafish

(2013) Anna L. Chapman et al.   PLoS One

Phenylbutyrate Therapy for Pyruvate Dehydrogenase Complex Deficiency and Lactic Acidosis

(2013) R. Ferriero et al.   Science Translational Medicine

Zebrafish as a model system for mitochondrial biology and diseases

(2013) Shelby L. Steele et al.   Translational Research

Mitochondrial disorders: aetiologies, models systems, and candidate therapies

(2013) G. Jane Farrar et al.   TRENDS IN GENETICS

The Role of Mitochondria in Cellular Iron-Sulfur Protein Biogenesis: Mechanisms, Connected Processes, and Diseases

(2013) O. Stehling et al.   Cold Spring Harbor Perspectives in Biology

Multi-organ Abnormalities and mTORC1 Activation in Zebrafish Model of Multiple Acyl-CoA Dehydrogenase Deficiency

(2013) Seok-Hyung Kim et al.   PLoS Genetics

Mitochondrial DNA metabolism in early development of zebrafish (Danio rerio)

(2012) Lucia Artuso et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Membrane transport metabolons

(2012) Trevor F. Moraes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The meaning of mitochondrial movement to a neuron's life

(2012) Jonathan R. Lovas et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Oxidative stress and successful antioxidant treatment in models of RYR1-related myopathy

(2012) James J. Dowling et al.   BRAIN

Lessons from the Past and Charting the Future of Marine Natural Products Drug Discovery and Chemical Biology

(2012) William H. Gerwick et al.   CHEMISTRY & BIOLOGY

OXPHOS mutations and neurodegeneration

(2012) Werner J H Koopman et al.   EMBO JOURNAL

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

Zebrafish: A model animal for analyzing the impact of environmental pollutants on muscle and brain mitochondrial bioenergetics

(2012) Jean-Paul Bourdineaud et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Zebrafish Parla- and Parlb-deficiency affects dopaminergic neuron patterning and embryonic survival

(2012) Sandra Noble et al.   JOURNAL OF NEUROCHEMISTRY

In Vivo Imaging of Disease-Related Mitochondrial Dynamics in a Vertebrate Model System

(2012) G. Plucinska et al.   JOURNAL OF NEUROSCIENCE

Mitochondria, oxidative stress and neurodegeneration

(2012) Antonio Federico et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mitochondrial disorders as windows into an ancient organelle

(2012) Scott B. Vafai et al.   NATURE

Fusion and Fission: Interlinked Processes Critical for Mitochondrial Health

(2011) David C. Chan   Annual Review of Genetics

A randomized placebo-controlled trial of idebenone in Leber’s hereditary optic neuropathy

(2011) Thomas Klopstock et al.   BRAIN

Modeling Neurodegeneration in Zebrafish

(2011) Yanwei Xi et al.   Current Neurology and Neuroscience Reports

Impairment of the tRNA-splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of pontocerebellar hypoplasia

(2011) Paul R. Kasher et al.   HUMAN MOLECULAR GENETICS

Functional alteration of PARL contributes to mitochondrial dysregulation in Parkinson's disease

(2011) Guang Shi et al.   HUMAN MOLECULAR GENETICS

Mutations inLRRK2increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

(2011) Dario C. Angeles et al.   HUMAN MUTATION

Hypokinesia and Reduced Dopamine Levels in Zebrafish Lacking β- and γ1-Synucleins

(2011) Chiara Milanese et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondria: The Next (Neurode)Generation

(2011) Eric A. Schon et al.   NEURON

Neurotoxin-based models of Parkinson's disease

(2011) J. Bové et al.   NEUROSCIENCE

Bioenergetic Profiling of Zebrafish Embryonic Development

(2011) Krista D. Stackley et al.   PLoS One

Therapeutic potential of melatonin and its analogs in Parkinson’s disease: focus on sleep and neuroprotection

(2011) Venkatramanujam Srinivasan et al.   Therapeutic Advances in Neurological Disorders

Pontocerebellar hypoplasia type 6: A British case with PEHO-like features

(2010) Julia Rankin et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Zebrafish models for the functional genomics of neurogenetic disorders

(2010) Edor Kabashi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3

(2010) W. Pei et al.   DEVELOPMENT

Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development

(2010) Sebastian S. Gerety et al.   DEVELOPMENTAL BIOLOGY

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

Distinct Retinal Deficits in a Zebrafish Pyruvate Dehydrogenase-Deficient Mutant

(2010) C. M. Maurer et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial dysfunction occurs early in PD

(2010) Nick Jones   Nature Reviews Neurology

Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafish

(2010) Ville Sallinen et al.   NEUROBIOLOGY OF DISEASE

Developmental defects and neuromuscular alterations due to mitofusin 2 gene (MFN2) silencing in zebrafish: a new model for Charcot-Marie-Tooth type 2A neuropathy

(2010) Andrea Vettori et al.   NEUROMUSCULAR DISORDERS

Deletion of the WD40 Domain of LRRK2 in Zebrafish Causes Parkinsonism-Like Loss of Neurons and Locomotive Defect

(2010) Donglai Sheng et al.   PLoS Genetics

Complex I deficiency and dopaminergic neuronal cell loss in parkin-deficient zebrafish (Danio rerio)

(2009) L. Flinn et al.   BRAIN

A conserved role for the mitochondrial citrate transporter Sea/SLC25A1 in the maintenance of chromosome integrity

(2009) Patrizia Morciano et al.   HUMAN MOLECULAR GENETICS

Mechanisms Underlying Metabolic and Neural Defects in Zebrafish and Human Multiple Acyl-CoA Dehydrogenase Deficiency (MADD)

(2009) Yuanquan Song et al.   PLoS One

Characterization and Classification of Zebrafish Brain Morphology Mutants

(2008) Laura Anne Lowery et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Real-time imaging of mitochondria in transgenic zebrafish expressing mitochondrially targeted GFP

(2008) Min Jung Kim et al.   BIOTECHNIQUES

A Mitochondrial Protein Compendium Elucidates Complex I Disease Biology

(2008) David J. Pagliarini et al.   CELL

KBP is essential for axonal structure, outgrowth and maintenance in zebrafish, providing insight into the cellular basis of Goldberg-Shprintzen syndrome

(2008) D. A. Lyons et al.   DEVELOPMENT

Discovery and characterization of three novel synuclein genes in zebrafish

(2008) Zhihui Sun et al.   DEVELOPMENTAL DYNAMICS

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

(2008) Yannick Doyon et al.   NATURE BIOTECHNOLOGY

Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

(2008) Xiangdong Meng et al.   NATURE BIOTECHNOLOGY

Gal4/UAS Transgenic Tools and Their Application to Zebrafish

(2008) Marnie E. Halpern et al.   Zebrafish

Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish

(2007) Lu Wen et al.   DEVELOPMENTAL BIOLOGY