Editorial Material
Oncology
Chonji Fukumoto, Daisuke Uchida, Hitoshi Kawamata
Summary: This review article discusses the diversity of the origin of oral squamous cell carcinoma (OSCC) and the role of cancer stem cells (CSCs). CSCs, a subset of cancer cells with stem cell characteristics, play a key role in the malignancy of OSCC. The article explains that when gene abnormalities occur in somatic stem cells, they transform into CSCs, which then autonomously grow and develop into cancer. The histopathological phenotype of cancer cells is influenced by the original characteristics of the somatic stem cells and/or surrounding environment. OSCC can be categorized into three different malignancies based on the origin of CSCs.
Review
Pathology
Guorui Sun, Yanru Yang, Jin Liu, Zizhao Gao, Tianqi Xu, Jia Chai, Junpeng Xu, Zhenge Fan, Tian Xiao, Qingge Jia, Mingyang Li
Summary: This review discusses the importance of cancer stem cells (CSCs) in the diagnosis and treatment of esophageal squamous cell carcinoma (ESCC). It outlines the known methods for isolation and verification of CSCs, as well as the significance of CSCs' biomarkers and signaling pathways.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Review
Oncology
Ying Yang, Wen-Jian Meng, Zi-Qiang Wang
Summary: Gastric cancer is a common malignancy with poor prognosis. Gastric cancer stem cells (GCSCs) are closely associated with drug resistance, recurrence, and metastasis, indicating their potential as therapeutic targets for gastric cancer. However, the relationship and mechanism between GCSCs and gastric cancer still require further exploration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Xing Jin, Lei Liu, Jia Wu, Xiaoxia Jin, Guanzhen Yu, Lijun Jia, Fengying Wang, Minxin Shi, Haimin Lu, Jibin Liu, Dan Liu, Jing Yang, Hua Li, Yan Ni, Qin Luo, Wei Jia, Wei Wang, Wen-Lian Chen
Summary: This study utilized multi-omics technologies to analyze ESCC patient samples and identified new molecular features associated with ESCC pathobiology, including epigenetic, posttranscriptional, posttranslational, and metabolic characteristics, uncovering molecular vulnerabilities and potential therapeutic targets for ESCC.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Sally C. M. Lau, Yuanwang Pan, Vamsidhar Velcheti, Kwok Kin Wong
Summary: Squamous cell lung cancers have high mortality and a lack of specific therapies. Current treatment strategies focus on epigenetic therapies and exploiting unique metabolic vulnerabilities. These novel therapies may synergize with immune checkpoint inhibitors, providing a potential treatment option.
Article
Biochemistry & Molecular Biology
Anna Cazzola, David Calzon Lozano, Dennis Hirsch Menne, Raquel Davila Pedrera, Jingcheng Liu, Daniel Pena-Jimenez, Silvia Fontenete, Cornelia Halin, Mirna Perez-Moreno
Summary: Lymph vessels and lymph node involvement are crucial in the staging of various cancers. In skin squamous cell carcinoma, lymph vessels have a significant role in cancer development and metastasis. However, their interaction with the cancer stem cell niche during early tumor stages has not been well understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Xuejie Yang, Chunrong Wang, Hui Nie, Jianhua Zhou, Xiaoyun He, Chunlin Ou
Summary: In this study, the roles of MCM genes in lung squamous cell carcinoma (LUSC) were investigated. The results showed aberrant expression of MCM family members in LUSC, and their expression correlated with patient prognosis and infiltrating immune cells.
Review
Immunology
Qihang Hou, Jingxi Huang, Hammed Ayansola, Hori Masatoshi, Bingkun Zhang
Summary: The mammalian intestine is the largest immune organ, containing intestinal stem cells (ISC), differentiated epithelial cells, and gut resident-immune cells. Inflammatory bowel disease (IBD) threatens intestinal integrity and the continuous renewal of intestinal mucosal epithelium relies on ISC. Targeting inflamed mucosa healing may improve clinical symptoms and disease recurrence in IBD patients. Recent findings suggest that immune cells and cytokines play critical roles in ISC and intestinal epithelium regeneration, paving the way for new therapeutic approaches such as ISC transplantation. Integration of biological agents and ISC transplantation could revolutionize future therapy for IBD patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Xuanyu Liu, Meng Yuan, Qinqin Xiang, Zhujun Li, Fen Xu, Wen Chen, Jie Chen, Jiuzuo Huang, Nanze Yu, Zhou Zhou, Xiao Long
Summary: This study investigates the cellular alterations in adipose tissues of lymphedema patients and identifies CLEC3B and TREM1 as potential targets for treating lymphedema. It also uncovers the cell-cell communication among ASCs, macrophages, and vascular endothelial cells.
Article
Multidisciplinary Sciences
Shaoqiu Zheng, Jing Luo, Shoucheng Xie, Shanming Lu, Qinghua Liu, Huanqin Xiao, Wenjuan Luo, Yanfang Huang, Kun Liu
Summary: Recent evidence suggests that cancer stem cells (CSCs) are the origin of cancers. This study investigated the relationship between tumor buds, which are hypothesized to represent epithelial-mesenchymal transition (EMT)-like CSCs, and EMT and CSC markers in cervical squamous cell carcinoma (CxSCC). The findings indicate that tumor buds in CxSCC may represent EMT-like CSCs in vivo.
Article
Endocrinology & Metabolism
Jee-Eun Choi, Carlos Sebastian, Christina M. Ferrer, Caroline A. Lewis, Moshe Sade-Feldman, Thomas LaSalle, Anna Gonye, Begona G. C. Lopez, Walid M. Abdelmoula, Michael S. Regan, Murat Cetinbas, Gloria Pascual, Gregory R. Wojtkiewicz, Giorgia G. Silveira, Ruben Boon, Kenneth N. Ross, Itay Tirosh, Srinivas V. Saladi, Leif W. Ellisen, Ruslan I. Sadreyev, Salvador Aznar Benitah, Nathalie Y. R. Agar, Nir Hacohen, Raul Mostoslavsky
Summary: The study highlights the important tumor suppressor role of NAD(+)-dependent histone deacetylase sirtuin 6 in squamous cell carcinoma, as well as the existence of a subset of highly glycolytic tumor-propagating cells with elevated antioxidant capacity. These findings emphasize the key role of metabolism in intra-tumor heterogeneity.
Article
Immunology
Mintao Xiao, Xinyi Zhang, Duoli Zhang, Shuai Deng, Anfu Zheng, Fukuan Du, Jing Shen, Lin Yue, Tao Yi, Zhangang Xiao, Yueshui Zhao
Summary: This study reveals the heterogeneity of cancer stem cells (CSCs) in head and neck squamous cell carcinoma (HNSCC) and their underlying mechanisms in the formation of the tumor microenvironment (TME). The functional diversity and signal transduction of CSCs are found to play a crucial role in the progression of HNSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Analytical
Zhongjian Chen, Yun Gao, Xiancong Huang, Yao Yao, Keke Chen, Su Zeng, Weimin Mao
Summary: This study explored metabolic biomarkers and potential therapeutic targets for ESCC, identifying several metabolites with diagnostic and prognostic value, and providing accurate metabolite-based prediction models. Additionally, three up-regulated amino acid transporters were identified as potential therapeutic targets for ESCC.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2021)
Review
Biochemistry & Molecular Biology
Tsukuru Amano, Atsushi Murakami, Takashi Murakami, Tokuhiro Chano
Summary: Ovarian clear cell carcinomas (OCCCs) are resistant to conventional anti-cancer drugs and often arise from endometriosis associated with strong oxidative stress. The oxidative stress tolerance properties are involved in the survival and cancer stemness of OCCC cells. Therapeutic approaches need improvement, with multi-combinatorial treatments expected to improve patient outcomes.
Review
Biochemistry & Molecular Biology
Bo Wu, Xiang Shi, Meixi Jiang, Hongxu Liu
Summary: Ongoing research has revealed that the existence of cancer stem cells (CSCs) is a major obstacle in current cancer therapy. CSCs play a significant role in tumor progression, recurrence, and chemoresistance due to their stemness characteristics. CSCs interact with the tumor microenvironment through complex mechanisms, and also engage in interactions with immune cells and molecules to protect themselves against immune clearance. Understanding these interactions may provide novel therapeutic approaches to cancer.
Article
Dermatology
Michael Cangkrama, Charbel Darido, Smitha R. Georgy, Darren Partridge, Alana Auden, Seema Srivastava, Tomasz Wilanowski, Stephen M. Jane
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2016)
Review
Biochemistry & Molecular Biology
Marina Youssef, Andrew Cuddihy, Charbel Darido
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Multidisciplinary Sciences
Lee B. Miles, Charbel Darido, Jan Kaslin, Joan K. Heath, Stephen M. Jane, Sebastian Dworkin
SCIENTIFIC REPORTS
(2017)
Article
Cell Biology
Stephen J. Goldie, Denny L. Cottle, Fiona H. Tan, Suraya Roslan, Seema Srivastava, Rhys Brady, Darren D. Partridge, Alana Auden, Ian M. Smyth, Stephen M. Jane, Sebastian Dworkin, Charbel Darido
CELL DEATH & DISEASE
(2018)
Review
Cell Biology
Fiona H. Tan, Yuchen Bai, Pierre Saintigny, Charbel Darido
Article
Biochemistry & Molecular Biology
Rajdeep Chakraborty, Karen Vickery, Charbel Darido, Shoba Ranganathan, Honghua Hu
Summary: Oral cancer is a global health issue with low survival rates, and bacterial antigens may interfere with the effectiveness of capsaicin in treating oral cancer cells. Capsaicin's anti-cancer effects on oral cancer cells are significantly reduced by bacterial antigens, suggesting a need for clinical consideration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rajdeep Chakraborty, Honghua Hu, Charbel Darido, Karen Vickery, Shoba Ranganathan
Summary: The study investigated the effect of the calcium channel blocker ML218 HCl on oral cancer cell proliferation, finding that it effectively reduced LPS-induced proliferation and increased apoptosis and cell death. However, the efficacy of ML218 HCl was significantly reduced in the presence of bacterial antigens.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Yuchen Bai, Jarryd Boath, Gabrielle R. White, Uluvitike G. I. U. Kariyawasam, Camile S. Farah, Charbel Darido
Summary: Oral cancer is a multi-step disease with limited treatment options. The processes of oral cell proliferation, differentiation, and terminal differentiation play crucial roles in maintaining the homeostasis of oral epithelial tissue.
Article
Biochemistry & Molecular Biology
Jemma G. Gasperoni, Jarrad N. Fuller, Charbel Darido, Tomasz Wilanowski, Sebastian Dworkin
Summary: Grainyhead-like (GRHL) factors are critical transcription factors that regulate cellular behaviors during development and in cancer. Identifying and studying the target genes of these factors are essential for discovering potential targets for disease diagnosis, drug discovery, and therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Oncology
Imran Khan, Charbel Darido
Review
Oncology
Rajdeep Chakraborty, Charbel Darido, Fei Liu, Maciej Maselko, Shoba Ranganathan
Summary: Immune therapies have shown promising results in the treatment of head and neck cancer by boosting the patient's immune system to fight tumor spread. This review highlights recent clinical success in the field of head and neck cancer immunotherapy, including the development of immune checkpoint inhibitors and a human papilloma virus vaccine. The review also emphasizes the importance of understanding basic biology and implementing personalized immunotherapy for better treatment outcomes.
Article
Biochemistry & Molecular Biology
Charbel Darido, Smitha R. Georgy, Carleen Cullinane, Darren D. Partridge, Rachael Walker, Seema Srivastava, Suraya Roslan, Marina R. Carpinelli, Sebastian Dworkin, Richard B. Pearson, Stephen M. Jane
CELL DEATH AND DIFFERENTIATION
(2018)
Review
Developmental Biology
Lee B. Miles, Sebastian Dworkin, Charbel Darido
DEVELOPMENTAL BIOLOGY
(2017)
Article
Developmental Biology
Sebastian Dworkin, Alana Auden, Darren D. Partridge, Maria Daglas, Robert L. Medcalf, Theo Mantamadiotis, Smitha R. Georgy, Charbel Darido, Stephen M. Jane, Stephen B. Ting
DEVELOPMENTAL NEUROBIOLOGY
(2017)