Senescence Phenomena and Metabolic Alteration in Mesenchymal Stromal Cells from a Mouse Model of Rett Syndrome

Antiaging effects of bioactive molecules isolated from plants and fungi

(2019) Jan Martel et al.   MEDICINAL RESEARCH REVIEWS

Nano-delivery systems for encapsulation of dietary polyphenols: An experimental approach for neurodegenerative diseases and brain tumors

(2018) T. Squillaro et al.   BIOCHEMICAL PHARMACOLOGY

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Rett syndrome: insights into genetic, molecular and circuit mechanisms

(2018) Jacque P. K. Ip et al.   NATURE REVIEWS NEUROSCIENCE

Stress and stem cells: adult Muse cells tolerate extensive genotoxic stimuli better than mesenchymal stromal cells

(2018) Nicola Alessio et al.   Oncotarget

Loss of MECP2 Leads to Activation of P53 and Neuronal Senescence

(2018) Minori Ohashi et al.   Stem Cell Reports

Metabolic syndrome, Mediterranean diet, and polyphenols: Evidence and perspectives

(2018) Mauro Finicelli et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Protective Role of Polyphenols against Vascular Inflammation, Aging and Cardiovascular Disease

(2018) Alexa Serino et al.   Nutrients

The metabolic programming of stem cells

(2017) Ng Shyh-Chang et al.   GENES & DEVELOPMENT

mTOR as Regulator of Lifespan, Aging, and Cellular Senescence: A Mini-Review

(2017) Thomas Weichhart   GERONTOLOGY

The Role of p16INK4a Pathway in Human Epidermal Stem Cell Self-Renewal, Aging and Cancer

(2017) Daniela D’Arcangelo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Impact of lysosomal storage disorders on biology of mesenchymal stem cells: Evidences from in vitro silencing of glucocerebrosidase (GBA) and alpha-galactosidase A (GLA) enzymes

(2017) Tiziana Squillaro et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Adult-onset brain tumors and neurodegeneration: Are polyphenols protective?

(2017) Tiziana Squillaro et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Targeting metabolism in cellular senescence, a role for intervention

(2017) Timothy Nacarelli et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial Dysfunction in the Pathogenesis of Rett Syndrome: Implications for Mitochondria-Targeted Therapies

(2017) Natalya Shulyakova et al.   Frontiers in Cellular Neuroscience

Alterations in the carnitine cycle in a mouse model of Rett syndrome

(2017) Sabrina Mucerino et al.   Scientific Reports

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

(2016) Hannah E. Walters et al.   Aging-US

MECP2, a multi-talented modulator of chromatin architecture

(2016) Floriana Della Ragione et al.   Briefings in Functional Genomics

The Incidence and Evolution of Parkinsonian Rigidity in Rett Syndrome: A Pilot Study

(2016) Peter Humphreys et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Rett Syndrome and the Ongoing Legacy of Close Clinical Observation

(2016) Huda Y. Zoghbi   CELL

Mesenchymal stromal cells having inactivated RB1 survive following low irradiation and accumulate damaged DNA: Hints for side effects following radiotherapy

(2016) Nicola Alessio et al.   CELL CYCLE

Clinical Trials with Mesenchymal Stem Cells: An Update

(2016) Tiziana Squillaro et al.   CELL TRANSPLANTATION

The Impact of Epigenetics on Mesenchymal Stem Cell Biology

(2016) Yusuf Ozkul et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Patching Broken DNA: Nucleosome Dynamics and the Repair of DNA Breaks

(2016) Ozge Gursoy-Yuzugullu et al.   JOURNAL OF MOLECULAR BIOLOGY

Clinical Guidelines for Management of Bone Health in Rett Syndrome Based on Expert Consensus and Available Evidence

(2016) Amanda Jefferson et al.   PLoS One

De-regulated expression of the BRG1 chromatin remodeling factor in bone marrow mesenchymal stromal cells induces senescence associated with the silencing of NANOG and changes in the levels of chromatin proteins

(2015) Tiziana Squillaro et al.   CELL CYCLE

Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells

(2015) Stefania Capasso et al.   Oncotarget

DNA damage response (DDR) and senescence: shuttled inflamma-miRNAs on the stage of inflamm-aging

(2015) Fabiola Olivieri et al.   Oncotarget

Low dose radiation induced senescence of human mesenchymal stromal cells and impaired the autophagy process

(2015) Nicola Alessio et al.   Oncotarget

High grade glioblastoma is associated with aberrant expression of ZFP57, a protein involved in gene imprinting, and of CPT1A and CPT1C that regulate fatty acid metabolism

(2014) Alessandra Cirillo et al.   CANCER BIOLOGY & THERAPY

Metabolic Inflexibility: When Mitochondrial Indecision Leads to Metabolic Gridlock

(2014) Deborah M. Muoio   CELL

Silencing of RB1 and RB2/P130 during adipogenesis of bone marrow stromal cells results in dysregulated differentiation

(2014) Stefania Capasso et al.   CELL CYCLE

Chromatin Repressive Complexes in Stem Cells, Development, and Cancer

(2014) Anne Laugesen et al.   Cell Stem Cell

The Mechanistic Links Between Proteasome Activity, Aging and Agerelated Diseases

(2014) Isabel Saez et al.   CURRENT GENOMICS

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach

(2014) Dulce Calçada et al.   MECHANISMS OF AGEING AND DEVELOPMENT

The Gap Between the Physiological and Therapeutic Roles of Mesenchymal Stem Cells

(2014) Umberto Galderisi et al.   MEDICINAL RESEARCH REVIEWS

Mitochondrial dysfunction in the skeletal muscle of a mouse model of Rett syndrome (RTT): Implications for the disease phenotype

(2014) W.A. Gold et al.   MITOCHONDRION

Anaplerotic Triheptanoin Diet Enhances Mitochondrial Substrate Use to Remodel the Metabolome and Improve Lifespan, Motor Function, and Sociability in MeCP2-Null Mice

(2014) Min Jung Park et al.   PLoS One

Stable Cellular Senescence Is Associated with Persistent DDR Activation

(2014) Marzia Fumagalli et al.   PLoS One

Autophagy and senescence

(2013) David A. Gewirtz   Autophagy

Chromatin Remodeling at DNA Double-Strand Breaks

(2013) Brendan D. Price et al.   CELL

Adolescent onset cognitive regression and neuropsychiatric symptoms associated with the A140V MECP2 mutation

(2013) Sunita Venkateswaran et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Rapalogs and mTOR inhibitors as anti-aging therapeutics

(2013) Dudley W. Lamming et al.   JOURNAL OF CLINICAL INVESTIGATION

Chromatin modifiers and remodellers: regulators of cellular differentiation

(2013) Taiping Chen et al.   NATURE REVIEWS GENETICS

Metabolic Plasticity in Stem Cell Homeostasis and Differentiation

(2012) Clifford D.L. Folmes et al.   Cell Stem Cell

Chromatin Modification and Senescence

(2012) Giovanni Di Bernardo et al.   CURRENT PHARMACEUTICAL DESIGN

Partial rescue of Rett syndrome by ω-3 polyunsaturated fatty acids (PUFAs) oil

(2012) Claudio De Felice et al.   Genes and Nutrition

Female Mecp2+/− mice display robust behavioral deficits on two different genetic backgrounds providing a framework for pre-clinical studies

(2012) Rodney C. Samaco et al.   HUMAN MOLECULAR GENETICS

Reduced expression of MECP2 affects cell commitment and maintenance in neurons by triggering senescence: new perspective for Rett syndrome

(2012) Tiziana Squillaro et al.   MOLECULAR BIOLOGY OF THE CELL

Histone H2A.Z Controls a Critical Chromatin Remodeling Step Required for DNA Double-Strand Break Repair

(2012) Ye Xu et al.   MOLECULAR CELL

Correction: γ-H2AX Kinetics as a Novel Approach to High Content Screening for Small Molecule Radiosensitizers

(2012) Shibo Fu et al.   PLoS One

Chromatin dynamics and the repair of DNA double strand breaks

(2011) Ye Xu et al.   CELL CYCLE

Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications

(2011) S. E. Polo et al.   GENES & DEVELOPMENT

Cellular senescence and tumor suppressor gene p16

(2011) Hani Rayess et al.   INTERNATIONAL JOURNAL OF CANCER

The switch from pRb/p105 to Rb2/p130 in DNA damage and cellular senescence

(2011) Heike Helmbold et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Genes involved in regulation of stem cell properties: studies on their expression in a small cohort of neuroblastoma patients

(2010) Mariarosa A.B. Melone et al.   CANCER BIOLOGY & THERAPY

Phosphatases in the cellular response to DNA damage

(2010) Alyson K Freeman et al.   Cell Communication and Signaling

Partial silencing of methyl cytosine protein binding 2 (MECP2) in mesenchymal stem cells induces senescence with an increase in damaged DNA

(2010) Tiziana Squillaro et al.   FASEB JOURNAL

Eating to exit: autophagy-enabled senescence revealed

(2009) E. White et al.   GENES & DEVELOPMENT

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

(2008) Ralph J. DeBerardinis et al.   Cell Metabolism

Histone Deacetylase Inhibitors Promote Apoptosis and Senescence in Human Mesenchymal Stem Cells

(2008) Giovanni Di Bernardo et al.   STEM CELLS AND DEVELOPMENT

In Vitro Senescence of Rat Mesenchymal Stem Cells is Accompanied by Downregulation of Stemness-Related and DNA Damage Repair Genes

(2008) Umberto Galderisi et al.   STEM CELLS AND DEVELOPMENT

A case report: Bone marrow mesenchymal stem cells from a rett syndrome patient are prone to senescence and show a lower degree of apoptosis

(2007) Tiziana Squillaro et al.   JOURNAL OF CELLULAR BIOCHEMISTRY