The Role of Fibrosis and Liver-Associated Fibroblasts in the Pathogenesis of Hepatocellular Carcinoma

FOXQ1/NDRG1 axis exacerbates hepatocellular carcinoma initiation via enhancing crosstalk between fibroblasts and tumor cells

(2018) Qin Luo et al.   CANCER LETTERS

Proteomic Analysis of Cancer-Associated Fibroblasts Reveals a Paracrine Role for MFAP5 in Human Oral Tongue Squamous Cell Carcinoma

(2018) Simona Principe et al.   JOURNAL OF PROTEOME RESEARCH

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

NADPH Oxidase 1 in Liver Macrophages Promotes Inflammation and Tumor Development in Mice

(2018) Shuang Liang et al.   GASTROENTEROLOGY

Transforming Growth Factor-β Promotes Liver Tumorigenesis in Mice via Up-regulation of Snail

(2017) Hyuk Moon et al.   GASTROENTEROLOGY

Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy

(2017) Maryam Tahmasebi Birgani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mesothelin/mucin 16 signaling in activated portal fibroblasts regulates cholestatic liver fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors

(2017) Huipeng Li et al.   NATURE GENETICS

Can a fibrotic liver afford epithelial-mesenchymal transition?

(2017) Stefan Munker et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Hepatocellular Carcinomas Originate Predominantly from Hepatocytes and Benign Lesions from Hepatic Progenitor Cells

(2017) Krishna S. Tummala et al.   Cell Reports

Characterization of hepatic stellate cells, portal fibroblasts, and mesothelial cells in normal and fibrotic livers

(2016) Ingrid Lua et al.   JOURNAL OF HEPATOLOGY

Inflammation, fibrosis, and modulation of the process by mesenchymal stem/stromal cells

(2016) Darwin J. Prockop   MATRIX BIOLOGY

NAFLD causes selective CD4+ T lymphocyte loss and promotes hepatocarcinogenesis

(2016) Chi Ma et al.   NATURE

Activated hepatic stellate cells promote liver cancer by induction of myeloid-derived suppressor cells through cyclooxygenase-2

(2016) Yaping Xu et al.   Oncotarget

Cancer-Associated Fibroblasts Regulate Tumor-Initiating Cell Plasticity in Hepatocellular Carcinoma through c-Met/FRA1/HEY1 Signaling

(2016) Eunice Yuen Ting Lau et al.   Cell Reports

Reversible Human TGF-β Signal Shifting between Tumor Suppression and Fibro-Carcinogenesis: Implications of Smad Phospho-Isoforms for Hepatic Epithelial-Mesenchymal Transitions

(2016) Katsunori Yoshida et al.   Journal of Clinical Medicine

Myofibroblastic Conversion and Regeneration of Mesothelial Cells in Peritoneal and Liver Fibrosis

(2015) Ingrid Lua et al.   AMERICAN JOURNAL OF PATHOLOGY

The role of multipotent cancer associated fibroblasts in hepatocarcinogenesis

(2015) Caecilia Hapsari Ceriapuri Sukowati et al.   BMC CANCER

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

A hepatic stellate cell gene expression signature associated with outcomes in hepatitis C cirrhosis and hepatocellular carcinoma after curative resection

(2015) David Y Zhang et al.   GUT

Hepatic inflammation and fibrosis: Functional links and key pathways

(2015) Ekihiro Seki et al.   HEPATOLOGY

Hepatic stellate cell and monocyte interaction contributes to poor prognosis in hepatocellular carcinoma

(2015) Juling Ji et al.   HEPATOLOGY

Increased risk of hepatocellular carcinoma in chronic hepatitis B patients with transient elastography-defined subclinical cirrhosis

(2015) Mi Na Kim et al.   HEPATOLOGY

High liver fibrosis index FIB-4 is highly predictive of hepatocellular carcinoma in chronic hepatitis B carriers

(2015) Beomseok Suh et al.   HEPATOLOGY

DDR2 facilitates hepatocellular carcinoma invasion and metastasis via activating ERK signaling and stabilizing SNAIL1

(2015) Binhui Xie et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Clinical trial watch: Reports from the AASLD Liver Meeting®, Boston, November 2014

(2015) María-Carlota Londoño et al.   JOURNAL OF HEPATOLOGY

Matrix metalloproteinases in liver injury, repair and fibrosis

(2015) Sergio Duarte et al.   MATRIX BIOLOGY

NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma

(2015) C. L. Wilson et al.   Nature Communications

Tenascin-C and integrins in cancer

(2015) Toshimichi Yoshida et al.   Cell Adhesion & Migration

TIMP-1 activated carcinoma-associated fibroblasts inhibit tumor apoptosis by activating SDF1/CXCR4 signaling in hepatocellular carcinoma

(2015) Tao Song et al.   Oncotarget

Establishment and Characterization of Rat Portal Myofibroblast Cell Lines

(2015) Michel Fausther et al.   PLoS One

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Activated Human Hepatic Stellate Cells Promote Growth of Human Hepatocellular Carcinoma in a Subcutaneous Xenograft Nude Mouse Model

(2014) Zhi-min Geng et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Role of activated hepatic stellate cells in proliferation and metastasis of hepatocellular carcinoma

(2014) Nan Lin et al.   HEPATOLOGY RESEARCH

A mesenchymal-like phenotype and expression of CD44 predict lack of apoptotic response to sorafenib in liver tumor cells

(2014) Joan Fernando et al.   INTERNATIONAL JOURNAL OF CANCER

Hepatic stellate cells and extracellular matrix in hepatocellular carcinoma: more complicated than ever

(2014) Vinicio Carloni et al.   LIVER INTERNATIONAL

Rat hepatic stellate cells alter the gene expression profile and promote the growth, migration and invasion of hepatocellular carcinoma cells

(2014) ZHI-MING WANG et al.   Molecular Medicine Reports

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor microenvironment: Bone marrow-mesenchymal stem cells as key players

(2013) Pedro Barcellos-de-Souza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Impact of liver fibrosis on prognosis following liver resection for hepatitis B-associated hepatocellular carcinoma

(2013) Q Wang et al.   BRITISH JOURNAL OF CANCER

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling

(2013) Guobin He et al.   CELL

Bone marrow cells as precursors of the tumor stroma

(2013) Daniel L. Worthley et al.   EXPERIMENTAL CELL RESEARCH

Role of the Microenvironment in the Pathogenesis and Treatment of Hepatocellular Carcinoma

(2013) Virginia Hernandez–Gea et al.   GASTROENTEROLOGY

Depletion of stromal cells expressing fibroblast activation protein-α from skeletal muscle and bone marrow results in cachexia and anemia

(2013) Edward W. Roberts et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Activated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion

(2013) Bastian Höchst et al.   JOURNAL OF HEPATOLOGY

A TLR2/S100A9/CXCL-2 signaling network is necessary for neutrophil recruitment in acute and chronic liver injury in the mouse

(2013) Anna Moles et al.   JOURNAL OF HEPATOLOGY

Hepatic stellate cells promote tumor progression by enhancement of immunosuppressive cells in an orthotopic liver tumor mouse model

(2013) Wenxiu Zhao et al.   LABORATORY INVESTIGATION

Liver stiffness measurement as an alternative to fibrotic stage in risk assessment of hepatocellular carcinoma incidence for chronic hepatitis C patients

(2013) Hsin-Ming Wang et al.   LIVER INTERNATIONAL

Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts

(2013) Fernando Calvo et al.   NATURE CELL BIOLOGY

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Hepatic Stellate Cells Secreted Hepatocyte Growth Factor Contributes to the Chemoresistance of Hepatocellular Carcinoma

(2013) Guofeng Yu et al.   PLoS One

Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury

(2013) Y. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

Carcinoma-Associated Fibroblasts Are a Promising Therapeutic Target

(2013) Shinsaku Togo et al.   Cancers

PREFACE [Hot Topic: Novel Cancer-Targeting Agents/Application Strategies Developed from MMP Science]

(2012) Isao Okazaki   Anti-Cancer Agents in Medicinal Chemistry

Hepatocyte-Stellate Cell Cross-Talk in the Liver Engenders a Permissive Inflammatory Microenvironment That Drives Progression in Hepatocellular Carcinoma

(2012) C. Coulouarn et al.   CANCER RESEARCH

T-Regulatory Cells: Key Players in Tumor Immune Escape and Angiogenesis

(2012) A. Facciabene et al.   CANCER RESEARCH

TGF-� Signaling in Onset and Progression of Hepatocellular Carcinoma

(2012) Nadja M. Meindl-Beinker et al.   DIGESTIVE DISEASES

Hepatic transforming growth factor beta gives rise to tumor-initiating cells and promotes liver cancer development

(2012) Kun Wu et al.   HEPATOLOGY

A novel murine model to deplete hepatic stellate cells uncovers their role in amplifying liver damage in mice

(2012) Juan E. Puche et al.   HEPATOLOGY

The role of hepatic stellate cells in the regulation of T-cell function and the promotion of hepatocellular carcinoma

(2012) WENXIU ZHAO et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Bak deficiency inhibits liver carcinogenesis: A causal link between apoptosis and carcinogenesis

(2012) Hayato Hikita et al.   JOURNAL OF HEPATOLOGY

Identification and prospective isolation of a mesothelial precursor lineage giving rise to smooth muscle cells and fibroblasts for mammalian internal organs and their vasculature

(2012) Yuval Rinkevich et al.   NATURE CELL BIOLOGY

The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages

(2012) Daria Capece et al.   Biomed Research International

Myeloid-derived suppressor cells: mechanisms of action and recent advances in their role in transplant tolerance

(2012) Nahzli Dilek et al.   Frontiers in Immunology

Migration of Fibrocytes in Fibrogenic Liver Injury

(2011) David Scholten et al.   AMERICAN JOURNAL OF PATHOLOGY

Hepatic stellate cells require a stiff environment for myofibroblastic differentiation

(2011) Abby L. Olsen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Mechanisms of hepatic fibrogenesis

(2011) Ursula E. Lee et al.   BEST PRACTICE & RESEARCH IN CLINICAL GASTROENTEROLOGY

Bone Marrow-Derived Myofibroblasts Contribute to the Mesenchymal Stem Cell Niche and Promote Tumor Growth

(2011) Michael Quante et al.   CANCER CELL

Hepatic stellate cells stimulate HCC cell migration via laminin-5 production

(2011) Angela Santamato et al.   CLINICAL SCIENCE

Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma

(2011) Chuen–Fei Chen et al.   GASTROENTEROLOGY

Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis

(2011) Ya-Li Jia et al.   HEPATOLOGY

Questioning the challenging role of epithelial-to-mesenchymal transition in liver injury

(2011) David Scholten et al.   HEPATOLOGY

Lineage tracing demonstrates no evidence of cholangiocyte epithelial-to-mesenchymal transition in murine models of hepatic fibrosis

(2011) Andrew S. Chu et al.   HEPATOLOGY

Liver stiffness measured by transient elastography is a predictor of hepatocellular carcinoma development in viral hepatitis

(2011) Takashi Akima et al.   HEPATOLOGY RESEARCH

Activated hepatic stellate cells promote hepatocellular carcinoma development in immunocompetent mice

(2011) Wenxiu Zhao et al.   INTERNATIONAL JOURNAL OF CANCER

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Extracellular Matrix Dynamics in Hepatocarcinogenesis: a Comparative Proteomics Study of PDGFC Transgenic and Pten Null Mouse Models

(2011) Keane K. Y. Lai et al.   PLoS Genetics

Focal Adhesion Assembly in Myofibroblasts Fosters a Microenvironment that Promotes Tumor Growth

(2010) Ningling Kang et al.   AMERICAN JOURNAL OF PATHOLOGY

TAK1 Suppresses a NEMO-Dependent but NF-κB-Independent Pathway to Liver Cancer

(2010) Kira Bettermann et al.   CANCER CELL

Myeloid-derived suppressor cells: more mechanisms for inhibiting antitumor immunity

(2010) Suzanne Ostrand-Rosenberg   CANCER IMMUNOLOGY IMMUNOTHERAPY

Conditional β-catenin loss in mice promotes chemical hepatocarcinogenesis: Role of oxidative stress and platelet-derived growth factor receptor α/phosphoinositide 3-kinase signaling

(2010) Xu-Feng Zhang et al.   HEPATOLOGY

Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells

(2010) Jörg Schrader et al.   HEPATOLOGY

Septum transversum-derived mesothelium gives rise to hepatic stellate cells and perivascular mesenchymal cells in developing mouse liver

(2010) Kinji Asahina et al.   HEPATOLOGY

Hepatitis C Virus Seromarkers and Subsequent Risk of Hepatocellular Carcinoma: Long-Term Predictors From a Community-Based Cohort Study

(2010) Lee Mei-Hsuan et al.   JOURNAL OF CLINICAL ONCOLOGY

Mechanical stiffness of liver tissues in relation to integrin β1 expression may influence the development of hepatic cirrhosis and hepatocellular carcinoma

(2010) Gang Zhao et al.   JOURNAL OF SURGICAL ONCOLOGY

Integrins as therapeutic targets: lessons and opportunities

(2010) Dermot Cox et al.   NATURE REVIEWS DRUG DISCOVERY

Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver

(2010) C. H. Osterreicher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of Lymphoidlike Stroma and Immune Escape by Tumors That Express the Chemokine CCL21

(2010) J. D. Shields et al.   SCIENCE

Hypoxia: A Link between Fibrogenesis, Angiogenesis, and Carcinogenesis in Liver Disease

(2010) Olivier Rosmorduc et al.   SEMINARS IN LIVER DISEASE

TGF-β and immune cells: an important regulatory axis in the tumor microenvironment and progression

(2010) Li Yang et al.   TRENDS IN IMMUNOLOGY

Peritumoral Activated Hepatic Stellate Cells Predict Poor Clinical Outcome in Hepatocellular Carcinoma After Curative Resection

(2009) Min-Jie Ju et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma

(2009) Johannes Haybaeck et al.   CANCER CELL

Activated hepatic stellate cells promote tumorigenicity of hepatocellular carcinoma

(2009) Thomas Amann et al.   CANCER SCIENCE

Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography

(2009) Ryota Masuzaki et al.   HEPATOLOGY

Portal fibroblasts: Underappreciated mediators of biliary fibrosis

(2009) Jonathan A. Dranoff et al.   HEPATOLOGY

Epithelial-to-mesenchymal transitions in the liver

(2009) Steve S. Choi et al.   HEPATOLOGY

Hepatocyte-specific deletion of the antiapoptotic protein myeloid cell leukemia-1 triggers proliferation and hepatocarcinogenesis in mice

(2009) Achim Weber et al.   HEPATOLOGY

Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice

(2009) Kojiro Taura et al.   HEPATOLOGY

EMT: When epithelial cells decide to become mesenchymal-like cells

(2009) Raghu Kalluri   JOURNAL OF CLINICAL INVESTIGATION

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic tumor–stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge

(2009) F van Zijl et al.   ONCOGENE

Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis

(2009) S. Inokuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Podoplanin, a novel marker of tumor-initiating cells in human squamous cell carcinoma A431

(2008) Naho Atsumi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatocyte Necrosis Induced by Oxidative Stress and IL-1α Release Mediate Carcinogen-Induced Compensatory Proliferation and Liver Tumorigenesis

(2008) Toshiharu Sakurai et al.   CANCER CELL

Carcinoma-Associated Fibroblast-Like Differentiation of Human Mesenchymal Stem Cells

(2008) P. J. Mishra et al.   CANCER RESEARCH

Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells

(2008) W. Wirz et al.   DIFFERENTIATION

A New Population of Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Induces CD4+CD25+Foxp3+ T Cells

(2008) Bastian Hoechst et al.   GASTROENTEROLOGY

Hepatic Stellate Cells Secrete Angiopoietin 1 That Induces Angiogenesis in Liver Fibrosis

(2008) Kojiro Taura et al.   GASTROENTEROLOGY

Periostin Is Expressed in Pericryptal Fibroblasts and Cancer-associated Fibroblasts in the Colon

(2008) Yoshinao Kikuchi et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Immune-mediated dormancy: an equilibrium with cancer

(2008) Michele W. L. Teng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Hepatic Stellate Cells: Protean, Multifunctional, and Enigmatic Cells of the Liver

(2008) Scott L. Friedman   PHYSIOLOGICAL REVIEWS