Endocannabinoid System in Hepatic Glucose Metabolism, Fatty Liver Disease, and Cirrhosis

Co-administration of APD668, a G protein-coupled receptor 119 agonist and linagliptin, a DPPIV inhibitor, prevents progression of steatohepatitis in mice fed on a high trans-fat diet

(2018) Umakant Ashok Bahirat et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Insights into the Role of PPARβ/δ in NAFLD

(2018) Jiapeng Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Insights into the role of hepatocyte PPARα activity in response to fasting

(2018) Marion Régnier et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues

(2018) Christopher Lipina et al.   FASEB JOURNAL

MECHANISMS IN ENDOCRINOLOGY: Endocannabinoids and metabolism: past, present and future

(2017) Vincent Simon et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

APD668, a G protein-coupled receptor 119 agonist improves fat tolerance and attenuates fatty liver in high-trans fat diet induced steatohepatitis model in C57BL/6 mice

(2017) Umakant Ashok Bahirat et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Left ventricular systolic function is associated with sympathetic nervous activity and markers of inflammation in cirrhosis

(2017) Raquel Yotti et al.   HEPATOLOGY

Daytime-Dependent Changes of Cannabinoid Receptor Type 1 and Type 2 Expression in Rat Liver

(2017) Ivonne Bazwinsky-Wutschke et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Liver inflammation and fibrosis

(2017) Yukinori Koyama et al.   JOURNAL OF CLINICAL INVESTIGATION

G protein-coupled receptors: signalling and regulation by lipid agonists for improved glucose homoeostasis

(2016) Brian M. Moran et al.   ACTA DIABETOLOGICA

CB1 receptor blockade counters age-induced insulin resistance and metabolic dysfunction

(2016) Christopher Lipina et al.   AGING CELL

Review article: emerging anti-fibrotic therapies in the treatment of non-alcoholic steatohepatitis

(2016) M. Noureddin et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

An update on PPAR activation by cannabinoids

(2016) Saoirse Elizabeth O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY

CREBH Couples Circadian Clock With Hepatic Lipid Metabolism

(2016) Ze Zheng et al.   DIABETES

Endocannabinoid regulation of β -cell functions: implications for glycaemic control and diabetes

(2016) T. Jourdan et al.   DIABETES OBESITY & METABOLISM

GPR119: a promising target for nonalcoholic fatty liver disease

(2016) Jin Won Yang et al.   FASEB JOURNAL

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

Hepatocyte-specific, PPARγ-regulated mechanisms to promote steatosis in adult mice

(2016) Abigail Wolf Greenstein et al.   JOURNAL OF ENDOCRINOLOGY

Sinusoidal communication in liver fibrosis and regeneration

(2016) Giusi Marrone et al.   JOURNAL OF HEPATOLOGY

Development and validation of a specific and sensitive HPLC-ESI-MS method for quantification of lysophosphatidylinositols and evaluation of their levels in mice tissues

(2016) Julien Masquelier et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Serum levels of endocannabinoids are independently associated with nonalcoholic fatty liver disease

(2016) Shira Zelber-Sagi et al.   Obesity

Human CB1 Receptor Isoforms, present in Hepatocytes and β-cells, are Involved in Regulating Metabolism

(2016) Isabel González-Mariscal et al.   Scientific Reports

PPARα gene expression correlates with severity and histological treatment response in patients with non-alcoholic steatohepatitis

(2015) Sven Francque et al.   JOURNAL OF HEPATOLOGY

Evolution in the understanding of the pathophysiological basis of portal hypertension: How changes in paradigm are leading to successful new treatments

(2015) Jaume Bosch et al.   JOURNAL OF HEPATOLOGY

Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease

(2015) Michal Pawlak et al.   JOURNAL OF HEPATOLOGY

Mechanisms of decompensation and organ failure in cirrhosis: From peripheral arterial vasodilation to systemic inflammation hypothesis

(2015) Mauro Bernardi et al.   JOURNAL OF HEPATOLOGY

Alteration of intrahepatic microcirculation in cirrhotic livers

(2015) Ying-Ying Yang et al.   Journal of the Chinese Medical Association

Endocannabinoid signaling at the periphery: 50 years after THC

(2015) Mauro Maccarrone et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Oleoylethanolamide, an endogenous PPAR-α ligand, attenuates liver fibrosis targeting hepatic stellate cells

(2015) Ling Chen et al.   Oncotarget

The therapeutic potential of orphan GPCRs, GPR35 and GPR55

(2015) Derek M. Shore et al.   Frontiers in Pharmacology

Hepatic PPARγ and LXRα independently regulate lipid accumulation in the livers of genetically obese mice

(2014) Kimihiko Matsusue et al.   FEBS LETTERS

Vascular pathobiology in chronic liver disease and cirrhosis – Current status and future directions

(2014) Yasuko Iwakiri et al.   JOURNAL OF HEPATOLOGY

Endocannabinoid Receptors Gene Expression in Morbidly Obese Women with Nonalcoholic Fatty Liver Disease

(2014) Teresa Auguet et al.   Biomed Research International

Peripherally restricted CB1 receptor blockers

(2013) Robert J. Chorvat   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Hepatic PPARs: Their Role in Liver Physiology, Fibrosis and Treatment

(2013) E. Zardi et al.   CURRENT MEDICINAL CHEMISTRY

The cannabinoid receptor 1 and its role in influencing peripheral metabolism

(2013) L. O'Keefe et al.   DIABETES OBESITY & METABOLISM

A potential role for GPR55 in the regulation of energy homeostasis

(2013) Anna C. Simcocks et al.   DRUG DISCOVERY TODAY

Cannabinoid receptor 2 counteracts interleukin-17-induced immune and fibrogenic responses in mouse liver

(2013) Adrien Guillot et al.   HEPATOLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasingde novosynthesis of long-chain ceramides

(2013) Resat Cinar et al.   HEPATOLOGY

Cannabinoid signaling and liver therapeutics

(2013) Ariane Mallat et al.   JOURNAL OF HEPATOLOGY

The endocannabinoid system in advanced liver cirrhosis: pathophysiological implication and future perspectives

(2013) Maurizio Baldassarre et al.   LIVER INTERNATIONAL

Monounsaturated fatty acids generated via stearoyl CoA desaturase-1 are endogenous inhibitors of fatty acid amide hydrolase

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of endocannabinoids system in fatty liver disease and therapeutic potentials

(2013) KhalidA Alswat   Saudi Journal of Gastroenterology

The endocannabinoid N-arachidonoyl dopamine (NADA) selectively induces oxidative stress-mediated cell death in hepatic stellate cells but not in hepatocytes

(2012) Alexandra Wojtalla et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance

(2012) Joseph Tam et al.   Cell Metabolism

Signal Transduction via Cannabinoid Receptors

(2012) George Dalton et al.   CNS & Neurological Disorders-Drug Targets

Hepatic Cannabinoid Receptor-1 Mediates Diet-Induced Insulin Resistance via Inhibition of Insulin Signaling and Clearance in Mice

(2012) Jie Liu et al.   GASTROENTEROLOGY

The Cannabinoid Receptor CB1 Modulates the Signaling Properties of the Lysophosphatidylinositol Receptor GPR55

(2012) Julia Kargl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Cannabinoid Receptor Type 1 (Cb1r) Disrupts Hepatic Insulin Receptor Signaling via Cyclic AMP-response Element-binding Protein H (Crebh)-mediated Induction ofLipin1Gene

(2012) Dipanjan Chanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid Receptor Type 2 Functional Variant Influences Liver Damage in Children with Non-Alcoholic Fatty Liver Disease

(2012) Francesca Rossi et al.   PLoS One

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PPARγ contributes to PKM2 and HK2 expression in fatty liver

(2012) Ganna Panasyuk et al.   Nature Communications

GW501516-activated PPARβ/δ promotes liver fibrosis via p38-JNK MAPK-induced hepatic stellate cell proliferation

(2012) Radina Kostadinova et al.   Cell and Bioscience

Roles of PPARs in NAFLD: Potential therapeutic targets

(2011) Anne Tailleux et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The endocannabinoid system as a key mediator during liver diseases: new insights and therapeutic openings

(2011) A Mallat et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils

(2011) Nariman A B Balenga et al.   CELL RESEARCH

The L- -Lysophosphatidylinositol/GPR55 System and Its Potential Role in Human Obesity

(2011) J. M. Moreno-Navarrete et al.   DIABETES

The atypical cannabinoid O-1602 stimulates food intake and adiposity in rats

(2011) A. Díaz-Arteaga et al.   DIABETES OBESITY & METABOLISM

Role for PPARγ in obesity-induced hepatic steatosis as determined by hepatocyte- and macrophage-specific conditional knockouts

(2011) Eva Morán-Salvador et al.   FASEB JOURNAL

Antagonism of peripheral hepatic cannabinoid receptor-1 improves liver lipid metabolism in mice: Evidence from cultured explants

(2011) Tony Jourdan et al.   HEPATOLOGY

Cannabinoid Receptor Type 1 (CB1R) Signaling Regulates Hepatic Gluconeogenesis via Induction of Endoplasmic Reticulum-bound Transcription Factor cAMP-responsive Element-binding Protein H (CREBH) in Primary Hepatocytes

(2011) Dipanjan Chanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Up-Regulation of PPAR-γ mRNA Expression in the Liver of Obese Patients: an Additional Reinforcing Lipogenic Mechanism to SREBP-1c Induction

(2011) Paulina Pettinelli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The cannabinoid type-1 receptor carboxyl-terminus, more than just a tail

(2011) Rebecca Stadel et al.   JOURNAL OF NEUROCHEMISTRY

PPARα Expression Protects Male Mice from High Fat–Induced Nonalcoholic Fatty Liver

(2011) Mohamed A. Abdelmegeed et al.   JOURNAL OF NUTRITION

Reversal of liver fibrosis by the antagonism of endocannabinoid CB1 receptor in a rat model of CCl4-induced advanced cirrhosis

(2011) Ferdinando A Giannone et al.   LABORATORY INVESTIGATION

Role of cannabinoid receptors in alcoholic hepatic injury: steatosis and fibrogenesis are increased in CB2 receptor-deficient mice and decreased in CB1 receptor knockouts

(2011) Jonel Trebicka et al.   LIVER INTERNATIONAL

Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver

(2011) B. Mukhopadhyay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR55: Current Knowledge and Future Perspectives of a Purported “Type-3” Cannabinoid Receptor

(2010) A. Moriconi et al.   CURRENT MEDICINAL CHEMISTRY

From Surface to Nuclear Receptors: The Endocannabinoid Family Extends its Assets

(2010) M. Pistis et al.   CURRENT MEDICINAL CHEMISTRY

CB1 Antagonism Exerts Specific Molecular Effects on Visceral and Subcutaneous Fat and Reverses Liver Steatosis in Diet-Induced Obese Mice

(2010) T. Jourdan et al.   DIABETES

Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age

(2010) J. Agudo et al.   DIABETOLOGIA

Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration

(2010) Fatima Teixeira-Clerc et al.   HEPATOLOGY

Endocannabinoids in liver disease

(2010) Joseph Tam et al.   HEPATOLOGY

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peripheral CB1 cannabinoid receptor blockade improves cardiometabolic risk in mouse models of obesity

(2010) Joseph Tam et al.   JOURNAL OF CLINICAL INVESTIGATION

Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes

(2010) Andrea De Gottardi et al.   LIVER INTERNATIONAL

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

Pharmacological characterization of GPR55, a putative cannabinoid receptor

(2010) Haleli Sharir et al.   PHARMACOLOGY & THERAPEUTICS

Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding

(2009) Angelo A Izzo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibitors of cannabinoid receptors and glucose metabolism

(2009) André J Scheen et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Cannabinoid Type 1 Receptor Antagonism Delays Ascites Formation in Rats With Cirrhosis

(2009) Marco Domenicali et al.   GASTROENTEROLOGY

PPAR-α and PPAR-γ agonists for type 2 diabetes

(2009) Bernard Charbonnel   LANCET

Circulating and hepatic endocannabinoids and endocannabinoid-related molecules in patients with cirrhosis

(2009) Paolo Caraceni et al.   LIVER INTERNATIONAL

Transcriptional profiling reveals divergent roles of PPARα and PPARβ/δ in regulation of gene expression in mouse liver

(2009) Linda M. Sanderson et al.   PHYSIOLOGICAL GENOMICS

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Cannabinoid CB2 Receptor Potentiates Obesity-Associated Inflammation, Insulin Resistance and Hepatic Steatosis

(2009) Vanessa Deveaux et al.   PLoS One

Time of feeding and the intrinsic circadian clock drive rhythms in hepatic gene expression

(2009) Christopher Vollmers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention of Hepatic Fibrosis in a Murine Model of Metabolic Syndrome with Nonalcoholic Steatohepatitis

(2008) Laurie D. DeLeve et al.   AMERICAN JOURNAL OF PATHOLOGY

The cannabinoid CB1 receptor is expressed in pancreatic δ-cells

(2008) William G. Tharp et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice

(2008) Elizabeth E. Girroir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on insulin secretion in MIN6c4 insulinoma cells

(2008) Y Ning et al.   BRITISH JOURNAL OF PHARMACOLOGY

Paracrine Activation of Hepatic CB1 Receptors by Stellate Cell-Derived Endocannabinoids Mediates Alcoholic Fatty Liver

(2008) Won-il Jeong et al.   Cell Metabolism

Peripheral, but Not Central, CB1 Antagonism Provides Food Intake-Independent Metabolic Benefits in Diet-Induced Obese Rats

(2008) R. Nogueiras et al.   DIABETES

CB1 receptor antagonism: biological basis for metabolic effects

(2008) Vincenzo Di Marzo   DRUG DISCOVERY TODAY

2-Arachidonoyl-sn-glycero-3-phosphoinositol: A Possible Natural Ligand for GPR55

(2008) S. Oka et al.   JOURNAL OF BIOCHEMISTRY

Hepatic CB1 receptor is required for development of diet-induced steatosis, dyslipidemia, and insulin and leptin resistance in mice

(2008) Douglas Osei-Hyiaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Overactive endocannabinoid signaling impairs apolipoprotein E-mediated clearance of triglyceride-rich lipoproteins

(2008) M. A. Ruby et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiological significance of a peripheral tissue circadian clock

(2008) K. A. Lamia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Should peripheral CB1 cannabinoid receptors be selectively targeted for therapeutic gain?

(2008) George Kunos et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Endocannabinoids and Liver Disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis

(2007) Sören V. Siegmund et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

GPR55: a new member of the cannabinoid receptor clan?

(2007) R G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

The orphan receptor GPR55 is a novel cannabinoid receptor

(2007) E Ryberg et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors

(2007) S E O'Sullivan   BRITISH JOURNAL OF PHARMACOLOGY