Discovery of Novel Potential Reversible Peptidyl Arginine Deiminase Inhibitor

Conserved Citrullinating Exoenzymes in Porphyromonas Species

(2018) G. Gabarrini et al.   JOURNAL OF DENTAL RESEARCH

Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix

(2018) A. E. Yuzhalin et al.   Nature Communications

Autoantibodies against citrullinated histone H3 in rheumatoid arthritis and periodontitis patients

(2017) Koen M. J. Janssen et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

An emerging role for neutrophil extracellular traps in noninfectious disease

(2017) Selina K Jorch et al.   NATURE MEDICINE

The case for periodontitis in the pathogenesis of rheumatoid arthritis

(2017) Jan Potempa et al.   Nature Reviews Rheumatology

Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses

(2016) Joanna Kawalkowska et al.   Scientific Reports

Crystal structure ofPorphyromonas gingivalispeptidylarginine deiminase: implications for autoimmunity in rheumatoid arthritis

(2015) Anna B Montgomery et al.   ANNALS OF THE RHEUMATIC DISEASES

Single cell cloning and recombinant monoclonal antibodies generation from RA synovial B cells reveal frequent targeting of citrullinated histones of NETs

(2015) Elisa Corsiero et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation

(2015) Huw D Lewis et al.   Nature Chemical Biology

Biological relevance of citrullinations: diagnostic, prognostic and therapeutic options

(2014) Natasja S. Gudmann et al.   AUTOIMMUNITY

Peptidyl Arginine Deiminase fromPorphyromonas gingivalisAbolishes Anaphylatoxin C5a Activity

(2014) Ewa Bielecka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Porphyromonas gingivalis peptidylarginine deiminase substrate specificity

(2013) Syatirah-Najmi Abdullah et al.   ANAEROBE

Antibodies from patients with rheumatoid arthritis target citrullinated histone 4 contained in neutrophils extracellular traps

(2013) Federico Pratesi et al.   ANNALS OF THE RHEUMATIC DISEASES

Peptidylarginine deiminases in citrullination, gene regulation, health and pathogenesis

(2013) Shu Wang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Lessons to be learned from periodontitis

(2013) Koen M.J. Janssen et al.   CURRENT OPINION IN RHEUMATOLOGY

NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

(2013) R. Khandpur et al.   Science Translational Medicine

The protein arginine deiminases: Structure, function, inhibition, and disease

(2012) Kevin L. Bicker et al.   BIOPOLYMERS

Citrullination under physiological and pathological conditions

(2012) Zsuzsanna Baka et al.   JOINT BONE SPINE

Anticancer Peptidylarginine Deiminase (PAD) Inhibitors Regulate the Autophagy Flux and the Mammalian Target of Rapamycin Complex 1 Activity

(2012) Yuji Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Screening of a Haloacetamidine Containing Library To Identify PAD4 Selective Inhibitors

(2011) Justin E. Jones et al.   ACS Chemical Biology

Structural and biochemical analyses of the human PAD4 variant encoded by a functional haplotype gene

(2011) Naoki Horikoshi et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

(2011) Alexander A. Chumanevich et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Peptidylarginine deiminase 2, 3 and 4 have distinct specificities against cellular substrates: novel insights into autoantigen selection in rheumatoid arthritis

(2011) Erika Darrah et al.   ANNALS OF THE RHEUMATIC DISEASES

N-α-Benzoyl-N5-(2-Chloro-1-Iminoethyl)-l-Ornithine Amide, a Protein Arginine Deiminase Inhibitor, Reduces the Severity of Murine Collagen-Induced Arthritis

(2011) Van C. Willis et al.   JOURNAL OF IMMUNOLOGY

Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3

(2010) Bryan Knuckley et al.   BIOCHEMISTRY

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

(2010) Pingxin Li et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-CCP Antibody, a Marker for the Early Detection of Rheumatoid Arthritis

(2009) Walther J. van Venrooij et al.   Annals of the New York Academy of Sciences

Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors

(2007) Bryan Knuckley et al.   BIOORGANIC & MEDICINAL CHEMISTRY