Regulation of Autophagy by Nuclear GAPDH and Its Aggregates in Cancer and Neurodegenerative Disorders

Biological Functions of Autophagy Genes: A Disease Perspective

(2019) Beth Levine et al.   CELL

Evolution of GAPDH as a druggable target of tumor glycolysis?

(2018) Shanmugasundaram Ganapathy-Kanniappan   EXPERT OPINION ON THERAPEUTIC TARGETS

Glyceraldehyde 3-phosphate dehydrogenase is a chaperone that allocates labile heme in cells

(2018) Elizabeth A. Sweeny et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oxidatively modified glyceraldehyde-3-phosphate dehydrogenase in neurodegenerative processes and the role of low molecular weights compounds in counteracting its aggregation and nuclear translocation

(2018) Joanna Gerszon et al.   AGEING RESEARCH REVIEWS

Pleiotropic effects of moonlighting glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in cancer progression, invasiveness, and metastases

(2018) Michael A. Sirover   CANCER AND METASTASIS REVIEWS

Mutant p53 prevents GAPDH nuclear translocation in pancreatic cancer cells favoring glycolysis and 2-deoxyglucose sensitivity

(2018) Giovanna Butera et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mutant p53 blocks SESN1/AMPK/PGC-1α/UCP2 axis increasing mitochondrial O2ˉ· production in cancer cells

(2018) Marco Cordani et al.   BRITISH JOURNAL OF CANCER

Autophagy and the cell biology of age-related disease

(2018) Andrew M. Leidal et al.   NATURE CELL BIOLOGY

UCP2 inhibition induces ROS/Akt/mTOR axis: Role of GAPDH nuclear translocation in genipin/everolimus anticancer synergism

(2017) Ilaria Dando et al.   FREE RADICAL BIOLOGY AND MEDICINE

Glyceraldehyde-3-phosphate dehydrogenase: Aggregation mechanisms and impact on amyloid neurodegenerative diseases

(2017) Vladimir I. Muronetz et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Aggregation Causes Mitochondrial Dysfunction during Oxidative Stress-induced Cell Death

(2017) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-induced tumor cell resistance is overcome by synergistic GAPDH-siRNA and chemotherapy co-delivered by long-circulating and cationic-interior liposomes

(2017) Jibin Guan et al.   Nanoscale

Oxidatively Modified Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) and Alzheimer's Disease: Many Pathways to Neurodegeneration

(2017) D. Allan Butterfield et al.   JOURNAL OF ALZHEIMERS DISEASE

Cross-Talk Between NO Synthase Isoforms in Neuro-Inflammation: Possible Implications in HIV-Associated Neurocognitive Disorders

(2016) Tiziana Persichini et al.   CURRENT MEDICINAL CHEMISTRY

GAPDH binds Akt to facilitate cargo transport in the early secretory pathway

(2016) Ellen J. Tisdale et al.   EXPERIMENTAL CELL RESEARCH

Small molecules preventing GAPDH aggregation are therapeutically applicable in cell and rat models of oxidative stress

(2016) Vladimir F. Lazarev et al.   FREE RADICAL BIOLOGY AND MEDICINE

Therapy-induced microenvironmental changes in cancer

(2016) Yuting Ma et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Mutant p53 proteins counteract autophagic mechanism sensitizing cancer cells to mTOR inhibition

(2016) Marco Cordani et al.   Molecular Oncology

Active site cysteine-null glyceraldehyde-3-phosphate dehydrogenase (GAPDH) rescues nitric oxide-induced cell death

(2016) Takeya Kubo et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Cocaine elicits autophagic cytotoxicity via a nitric oxide-GAPDH signaling cascade

(2016) Prasun Guha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cross-cancer profiling of molecular alterations within the human autophagy interaction network

(2015) Chandra B Lebovitz et al.   Autophagy

Autophagy, Metabolism, and Cancer

(2015) E. White et al.   CLINICAL CANCER RESEARCH

Impaired GAPDH-induced mitophagy contributes to the pathology of Huntington's disease

(2015) S. Hwang et al.   EMBO Molecular Medicine

AMPK-Dependent Phosphorylation of GAPDH Triggers Sirt1 Activation and Is Necessary for Autophagy upon Glucose Starvation

(2015) Chunmei Chang et al.   MOLECULAR CELL

Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation

(2015) Rui Huang et al.   MOLECULAR CELL

Secreted multifunctional Glyceraldehyde-3-phosphate dehydrogenase sequesters lactoferrin and iron into cells via a non-canonical pathway

(2015) Anoop S. Chauhan et al.   Scientific Reports

Beyond Glycolysis: GAPDHs Are Multi-functional Enzymes Involved in Regulation of ROS, Autophagy, and Plant Immune Responses

(2015) Elizabeth Henry et al.   PLoS Genetics

The cytoplasmic side of p53's oncosuppressive activities

(2014) Anna Comel et al.   FEBS LETTERS

Mutational Landscape of the Essential Autophagy Gene BECN1 in Human Cancers

(2014) Saurabh V. Laddha et al.   MOLECULAR CANCER RESEARCH

Glyceraldehyde-3-Phosphate Dehydrogenase Acts as a Mitochondrial Trans-S-Nitrosylase in the Heart

(2014) Mark J. Kohr et al.   PLoS One

Overexpression of FOXO3, MYD88, and GAPDH Identified by Suppression Subtractive Hybridization in Esophageal Cancer Is Associated with Autophagy

(2014) Mohammad Soltany-Rezaee-Rad et al.   Gastroenterology Research and Practice

Autophagy Is Critical for Pancreatic Tumor Growth and Progression in Tumors with p53 Alterations

(2014) A. Yang et al.   Cancer Discovery

Inhibition of glycolysis attenuates 4-hydroxynonenal-dependent autophagy and exacerbates apoptosis in differentiated SH-SY5Y neuroblastoma cells

(2013) Matthew Dodson et al.   Autophagy

GAPDH binds to active Akt, leading to Bcl-xL increase and escape from caspase-independent cell death

(2013) M A Jacquin et al.   CELL DEATH AND DIFFERENTIATION

Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH) Phosphorylation by Protein Kinase Cδ (PKCδ) Inhibits Mitochondria Elimination by Lysosomal-like Structures following Ischemia and Reoxygenation-induced Injury

(2013) Gouri Yogalingam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 status determines the role of autophagy in pancreatic tumour development

(2013) Mathias T. Rosenfeldt et al.   NATURE

Glyceraldehyde-3-phosphate dehydrogenase regulates cyclooxygenase-2 expression by targeting mRNA stability

(2012) Yuki Ikeda et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Chronic Autophagy Is a Cellular Adaptation to Tumor Acidic pH Microenvironments

(2012) Jonathan W. Wojtkowiak et al.   CANCER RESEARCH

Over-expression of GAPDH in human colorectal carcinoma as a preferred target of 3-Bromopyruvate Propyl Ester

(2012) Zhenjie Tang et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Subcellular dynamics of multifunctional protein regulation: Mechanisms of GAPDH intracellular translocation

(2012) Michael A. Sirover   JOURNAL OF CELLULAR BIOCHEMISTRY

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

On the functional diversity of glyceraldehyde-3-phosphate dehydrogenase: Biochemical mechanisms and regulatory control

(2011) Michael A. Sirover   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Akt2 Kinase Suppresses Glyceraldehyde-3-phosphate Dehydrogenase (GAPDH)-mediated Apoptosis in Ovarian Cancer Cells via Phosphorylating GAPDH at Threonine 237 and Decreasing Its Nuclear Translocation

(2011) Qiaojia Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The diverse functions of GAPDH: Views from different subcellular compartments

(2010) Carlos Tristan et al.   CELLULAR SIGNALLING

Activation of AMP-activated protein kinase stimulates the nuclear localization of glyceraldehyde 3-phosphate dehydrogenase in human diploid fibroblasts

(2010) Hyun Jin Kwon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

mTOR regulation of autophagy

(2010) Chang Hwa Jung et al.   FEBS LETTERS

Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase is regulated by acetylation

(2010) Mireia Ventura et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Free cholesterol overloading induced smooth muscle cells death and activated both ER- and mitochondrial-dependent death pathway

(2009) Xu Kedi et al.   ATHEROSCLEROSIS

Novel roles for GAPDH in cell death and carcinogenesis

(2009) A Colell et al.   CELL DEATH AND DIFFERENTIATION

Glyceraldehyde-3-phosphate Dehydrogenase Aggregate Formation Participates in Oxidative Stress-induced Cell Death

(2009) Hidemitsu Nakajima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glycolytic Flux Signals to mTOR through Glyceraldehyde-3-Phosphate Dehydrogenase-Mediated Regulation of Rheb

(2009) M. N. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

GOSPEL: A Neuroprotective Protein that Binds to GAPDH upon S-Nitrosylation

(2009) Nilkantha Sen et al.   NEURON

Human Glyceraldehyde-3-phosphate Dehydrogenase Plays a Direct Role in Reactivating Oxidized Forms of the DNA Repair Enzyme APE1

(2008) Sonish Azam et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab2 Utilizes Glyceraldehyde-3-phosphate Dehydrogenase and Protein Kinase Cι to Associate with Microtubules and to Recruit Dynein

(2008) Ellen J. Tisdale et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of the interaction between Aβ 1–42 and glyceraldehyde phosphodehydrogenase

(2008) Yann Verdier et al.   JOURNAL OF PEPTIDE SCIENCE

Comparative Proteomics Study Reveals That Bacterial CpG Motifs Induce Tumor Cell Autophagyin Vitroandin Vivo

(2008) Samuel Bertin et al.   MOLECULAR & CELLULAR PROTEOMICS

The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

(2008) U. Bandyopadhyay et al.   MOLECULAR AND CELLULAR BIOLOGY

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

(2008) I. H. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA