Polyphenols as Immunomodulatory Compounds in the Tumor Microenvironment: Friends or Foes?

Downregulation of Pro-Inflammatory and Pro-Angiogenic Pathways in Prostate Cancer Cells by a Polyphenol-Rich Extract from Olive Mill Wastewater

(2019) Denisa Baci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin enhances anti-tumor immune response in tongue squamous cell carcinoma

(2018) Feng Liao et al.   ARCHIVES OF ORAL BIOLOGY

TriCurin, a synergistic formulation of curcumin, resveratrol, and epicatechin gallate, repolarizes tumor-associated macrophages and triggers an immune response to cause suppression of HPV+ tumors

(2018) Sumit Mukherjee et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CAR T-cell Therapy: A New Era in Cancer Immunotherapy

(2018) Miliotou N. Androulla et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

Cancer-Cell-Intrinsic Mechanisms Shaping the Tumor Immune Landscape

(2018) Max D. Wellenstein et al.   IMMUNITY

Therapeutic cancer vaccines: From initial findings to prospects

(2018) Qian Song et al.   IMMUNOLOGY LETTERS

Liposomal TriCurin, A Synergistic Combination of Curcumin, Epicatechin Gallate and Resveratrol, Repolarizes Tumor-Associated Microglia/Macrophages, and Eliminates Glioblastoma (GBM) and GBM Stem Cells

(2018) Sumit Mukherjee et al.   MOLECULES

Transforming Growth Factor-β and Interleukin-10 Synergistically Regulate Humoral Immunity via Modulating Metabolic Signals

(2018) Toshihiko Komai et al.   Frontiers in Immunology

Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

(2018) Judith A. Seidel et al.   Frontiers in Oncology

The Role of Tumor Microenvironment in Chemoresistance: 3D Extracellular Matrices as Accomplices

(2018) Dimakatso Senthebane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Upregulation of PD‑L1 expression by resveratrol and piceatannol in breast and colorectal cancer cells occurs via HDAC3/p300‑mediated NF‑κB signaling

(2018) Justin Lucas et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Green Tea Catechin Is an Alternative Immune Checkpoint Inhibitor that Inhibits PD-L1 Expression and Lung Tumor Growth

(2018) Anchalee Rawangkan et al.   MOLECULES

Prophylactic vs. Therapeutic Treatment With P2Et Polyphenol-Rich Extract Has Opposite Effects on Tumor Growth

(2018) Paola Lasso et al.   Frontiers in Oncology

New Strategies for Therapeutic Cancer Vaccines

(2018) Jiyao Sheng et al.   Anti-Cancer Agents in Medicinal Chemistry

Update on the current revolution in cancer immunotherapy

(2018) Ariana Nicole Renrick et al.   Immunotherapy

Progress in gene therapy using oncolytic vaccinia virus as vectors

(2018) Xue Yang et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Apigenin suppresses PD-L1 expression in melanoma and host dendritic cells to elicit synergistic therapeutic effects

(2018) Lu Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The Immunomodulatory and Anti-Inflammatory Role of Polyphenols

(2018) Nour Yahfoufi et al.   Nutrients

Immunomodulatory potential of hesperetin and chrysin through the cellular and humoral response

(2017) Aïcha Sassi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Modulation of cancer-specific immune responses by amino acid degrading enzymes

(2017) Elina Timosenko et al.   Immunotherapy

Curcumin converts Foxp3+ regulatory T cells to T helper 1 cells in patients with lung cancer

(2017) Jian Y. Zou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

Intratumor Heterogeneity: Novel Approaches for Resolving Genomic Architecture and Clonal Evolution

(2017) Ravi G. Gupta et al.   MOLECULAR CANCER RESEARCH

Olive Oil Phenolics Prevent Oxysterol-Induced Proinflammatory Cytokine Secretion and Reactive Oxygen Species Production in Human Peripheral Blood Mononuclear Cells, Through Modulation of p38 and JNK Pathways

(2017) Gessica Serra et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans

(2017) J. Luis Espinoza et al.   Oxidative Medicine and Cellular Longevity

The Dual Role of Treg in Cancer

(2017) M. Frydrychowicz et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment

(2017) Manoj K. Pandey et al.   SEMINARS IN CANCER BIOLOGY

Bisdemethoxycurcumin in combination with α-PD-L1 antibody boosts immune response against bladder cancer

(2017) Yiqun Shao et al.   OncoTargets and Therapy

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

(2017) Rosanna Mattera et al.   Nutrients

Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line

(2017) Laura Masuelli et al.   Oncotarget

Tolerogenic dendritic cell-based immunotherapy

(2017) Kiyuk Chang et al.   Oncotarget

Current Advances in γδ T Cell-Based Tumor Immunotherapy

(2017) Elena Lo Presti et al.   Frontiers in Immunology

PD-1 expression on tumor-specific T cells: Friend or foe for immunotherapy?

(2017) Sylvain Simon et al.   OncoImmunology

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

(2017) L. Masuelli et al.   OncoImmunology

Regulatory T-Cell Modulation by Green Tea in Chronic Lymphocytic Leukemia

(2017) G. D'arena et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Cancer Vaccines

(2016) Shamayel Mohammed et al.   ADVANCES IN ANATOMIC PATHOLOGY

Oxidative stress, polarization of macrophages and tumour angiogenesis: Efficacy of caffeic acid

(2016) Nada Oršolić et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The present status and future prospects of peptide-based cancer vaccines

(2016) Masatoshi Hirayama et al.   INTERNATIONAL IMMUNOLOGY

Inhibition of curcumin on myeloid-derived suppressor cells is requisite for controlling lung cancer

(2016) Dan Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Exosomes and tumor-mediated immune suppression

(2016) Theresa L. Whiteside   JOURNAL OF CLINICAL INVESTIGATION

Curcumin Micelles Remodel Tumor Microenvironment and Enhance Vaccine Activity in an Advanced Melanoma Model

(2016) Yao Lu et al.   MOLECULAR THERAPY

Resveratrol intake enhances indoleamine-2,3-dioxygenase activity in humans

(2016) Guido A. Gualdoni et al.   Pharmacological Reports

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment

(2016) Vinit Kumar et al.   TRENDS IN IMMUNOLOGY

Potential chemopreventive activities of a polyphenol rich purified extract from olive mill wastewater on colon cancer cells

(2016) Barbara Bassani et al.   Journal of Functional Foods

Immune-system-dependent anti-tumor activity of a plant-derived polyphenol rich fraction in a melanoma mouse model

(2016) A Gomez-Cadena et al.   Cell Death & Disease

Recommendations for myeloid-derived suppressor cell nomenclature and characterization standards

(2016) Vincenzo Bronte et al.   Nature Communications

The Potential Protective Effects of Polyphenols in Asbestos-Mediated Inflammation and Carcinogenesis of Mesothelium

(2016) Monica Benvenuto et al.   Nutrients

TAK1 deficiency in dendritic cells inhibits adaptive immunity in SRBC-immunized C57BL/6 mice

(2016) Yao Pan et al.   FEBS Open Bio

Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression

(2016) Jérémie D. Goldstein et al.   PLoS One

The Role of Stroma in Tumor Development

(2015) Zena Werb et al.   CANCER JOURNAL

Immune Checkpoint Targeting in Cancer Therapy: Toward Combination Strategies with Curative Potential

(2015) Padmanee Sharma et al.   CELL

Modification of Antitumor Immunity and Tumor Microenvironment by Resveratrol in Mouse Renal Tumor Model

(2015) Liang Chen et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Genetically modified T cells in cancer therapy: opportunities and challenges

(2015) M. Sharpe et al.   Disease Models & Mechanisms

In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment

(2015) Massimo Fantini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immune evasion in cancer: Mechanistic basis and therapeutic strategies

(2015) Dass S. Vinay et al.   SEMINARS IN CANCER BIOLOGY

Regulatory T cell identity: formation and maintenance

(2015) Xudong Li et al.   TRENDS IN IMMUNOLOGY

The exosomes in tumor immunity

(2015) Yanfang Liu et al.   OncoImmunology

Effects of 5-Fluorouracil on Morphology, Cell Cycle, Proliferation, Apoptosis, Autophagy and ROS Production in Endothelial Cells and Cardiomyocytes

(2015) Chiara Focaccetti et al.   PLoS One

Resveratrol potentiates the in vitro and in vivo anti-tumoral effects of curcumin in head and neck carcinomas

(2015) Laura Masuelli et al.   Oncotarget

Analysis of the effect of the active compound of green tea (EGCG) on the proliferation of peripheral blood mononuclear cells

(2014) Farid Saleh et al.   BMC Complementary and Alternative Medicine

CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models

(2014) Y. Zhu et al.   CANCER RESEARCH

Immune Escape Mechanisms as a Guide for Cancer Immunotherapy

(2014) G. L. Beatty et al.   CLINICAL CANCER RESEARCH

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Current advances in T-cell-based cancer immunotherapy

(2014) Mingjun Wang et al.   Immunotherapy

Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity

(2014) Mei-Yin Chang et al.   MOLECULES

Mechanism of Action of Immunotherapy

(2014) Mary L. Disis   SEMINARS IN ONCOLOGY

CSF-1 Receptor Signaling in Myeloid Cells

(2014) E. R. Stanley et al.   Cold Spring Harbor Perspectives in Biology

IL-10: Master Switch from Tumor-Promoting Inflammation to Antitumor Immunity

(2014) M. Oft   Cancer Immunology Research

Molecular Recognition of Gangliosides and Their Potential for Cancer Immunotherapies

(2014) Ute Krengel et al.   Frontiers in Immunology

Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy

(2013) Matthew D. Vesely et al.   Annals of the New York Academy of Sciences

Resveratrol suppresses tumor progression via the regulation of indoleamine 2,3-dioxygenase

(2013) Kyung Tae Noh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Galectin-9 in tumor biology: A jack of multiple trades

(2013) Roy Heusschen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Exosome derived from epigallocatechin gallate treated breast cancer cells suppresses tumor growth by inhibiting tumor-associated macrophage infiltration and M2 polarization

(2013) Ji-Young Jang et al.   BMC CANCER

Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer

(2013) Roberto Bei   Frontiers in Bioscience-Landmark

Nano-Curcumin Inhibits Proliferation of Esophageal Adenocarcinoma Cells and Enhances the T Cell Mediated Immune Response

(2013) Francesca Milano et al.   Frontiers in Oncology

Immunoediting and Antigen Loss: Overcoming the Achilles Heel of Immunotherapy with Antigen Non-Specific Therapies

(2013) Arta Monir Monjazeb et al.   Frontiers in Oncology

Resveratrol affects the cross talk between immune and colon cancer cells

(2012) Michael Bergman et al.   BIOMEDICINE & PHARMACOTHERAPY

The effects of dietary flavonoids on the regulation of redox inflammatory networks

(2012) Valerio Izzi   Frontiers in Bioscience-Landmark

Antitumor and immunomodulatory effects of Justicia spicigera Schltdl (Acanthaceae)

(2012) Angel Josabad Alonso-Castro et al.   JOURNAL OF ETHNOPHARMACOLOGY

Resveratrol Prevents Endothelial Cells Injury in High-Dose Interleukin-2 Therapy against Melanoma

(2012) Hongbing Guan et al.   PLoS One

Tumor associated regulatory dendritic cells

(2012) Yang Ma et al.   SEMINARS IN CANCER BIOLOGY

Comprehensive analysis of current approaches to inhibit regulatory T cells in cancer

(2012) Helene Pere et al.   OncoImmunology

Polyphenols and Human Health: A Prospectus

(2011) Francesco Visioli et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Variation of tumor-infiltrating lymphocytes in human cancers: controversy on clinical significance

(2011) Tetsuro Sasada et al.   Immunotherapy

Anti-tumor and immunomodulatory activity of resveratrol in vitro and its potential for combining with cancer immunotherapy

(2011) Brenda L. Soto et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Low-dose curcumin leads to the inhibition of tumor growth via enhancing CTL-mediated antitumor immunity

(2011) Feifei Luo et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Cytokines in Cancer Immunotherapy

(2011) Sylvia Lee et al.   Cancers

Resveratrol enhances cell-mediated immune response to DMBA through TLR4 and prevents DMBA induced cutaneous carcinogenesis

(2009) Nabiha Yusuf et al.   MOLECULAR CARCINOGENESIS

Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells

(2008) Yoolhee Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Rutin inhibits the proliferation of murine leukemia WEHI-3 cells in vivo and promotes immune response in vivo

(2008) Jing-Pin Lin et al.   LEUKEMIA RESEARCH

CTLA-4 trafficking and surface expression

(2008) Elke Valk et al.   TRENDS IN IMMUNOLOGY