Transmission-Blocking Vaccines: Old Friends and New Prospects

Regulation of Sexual Commitment and Gametocytogenesis in Malaria Parasites

(2018) Gabrielle A. Josling et al.   Annual Review of Microbiology

Malaria Derived Glycosylphosphatidylinositol Anchor Enhances Anti-Pfs25 Functional Antibodies That Block Malaria Transmission

(2018) Neeraj Kapoor et al.   BIOCHEMISTRY

Whole blood transcriptome changes following controlled human malaria infection in malaria pre-exposed volunteers correlate with parasite prepatent period

(2018) Julian Rothen et al.   PLoS One

Unravelling the immune signature of Plasmodium falciparum transmission-reducing immunity

(2018) Will J. R. Stone et al.   Nature Communications

Immune Response and Evasion Mechanisms of Plasmodium falciparum Parasites

(2018) Esmael Besufikad Belachew   Journal of Immunology Research

Antibody targeting of a specific region of Pfs47 blocks Plasmodium falciparum malaria transmission

(2018) Gaspar E. Canepa et al.   npj Vaccines

Safety and immunogenicity of Pfs25H-EPA/Alhydrogel, a transmission-blocking vaccine against Plasmodium falciparum: a randomised, double-blind, comparator-controlled, dose-escalation study in healthy Malian adults

(2018) Issaka Sagara et al.   LANCET INFECTIOUS DISEASES

Safety and immunogenicity of a plant-produced Pfs25 virus-like particle as a transmission blocking vaccine against malaria: A Phase 1 dose-escalation study in healthy adults

(2018) Jessica A. Chichester et al.   VACCINE

Structural basis for recognition of the malaria vaccine candidate Pfs48/45 by a transmission blocking antibody

(2018) Frank Lennartz et al.   Nature Communications

The s48/45 six-cysteine proteins: mediators of interaction throughout the Plasmodium life cycle

(2017) Silvia A. Arredondo et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Detecting Gametocytes: How Sensitive Is Sensible?

(2017) Lisette Meerstein-Kessel et al.   JOURNAL OF INFECTIOUS DISEASES

New adenovirus-based vaccine vectors targeting Pfs25 elicit antibodies that inhibit Plasmodium falciparum transmission

(2017) Kathleen A. McGuire et al.   MALARIA JOURNAL

Antibody responses to two new Lactococcus lactis-produced recombinant Pfs48/45 and Pfs230 proteins increase with age in malaria patients living in the Central Region of Ghana

(2017) Festus K. Acquah et al.   MALARIA JOURNAL

Quantitative Proteomic Profiling Reveals NovelPlasmodium falciparumSurface Antigens and Possible Vaccine Candidates

(2017) Sandra K. Nilsson Bark et al.   MOLECULAR & CELLULAR PROTEOMICS

Variant surface antigens of Plasmodium falciparum and their roles in severe malaria

(2017) Mats Wahlgren et al.   NATURE REVIEWS MICROBIOLOGY

Genetic diversity and antibody responses against Plasmodium falciparum vaccine candidate genes from Chhattisgarh, Central India: Implication for vaccine development

(2017) Priyanka Patel et al.   PLoS One

Comparative functional potency of DNA vaccines encoding Plasmodium falciparum transmission blocking target antigens Pfs48/45 and Pfs25 administered alone or in combination by in vivo electroporation in rhesus macaques

(2017) Dibyadyuti Datta et al.   VACCINE

Targeting the Conserved Fusion Loop of HAP2 Inhibits the Transmission of Plasmodium berghei and falciparum

(2017) Fiona Angrisano et al.   Cell Reports

Advances in malaria vaccine development: report from the 2017 malaria vaccine symposium

(2017) Camila Henriques Coelho et al.   npj Vaccines

Pooled Amplicon Deep Sequencing of Candidate Plasmodium falciparum Transmission-Blocking Vaccine Antigens

(2016) Jonathan J. Juliano et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of thePlasmodium falciparumSexual Stage Protein Pfs230

(2016) Nicholas J. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Whole-Killed Blood-Stage Vaccine-Induced Immunity Suppresses the Development of Malaria Parasites in Mosquitoes

(2016) Feng Zhu et al.   JOURNAL OF IMMUNOLOGY

Assessment of Pfs25 expressed from multiple soluble expression platforms for use as transmission-blocking vaccine candidates

(2016) Shwu-Maan Lee et al.   MALARIA JOURNAL

An inter-laboratory comparison of standard membrane-feeding assays for evaluation of malaria transmission-blocking vaccines

(2016) Kazutoyo Miura et al.   MALARIA JOURNAL

Antibody responses to surface antigens ofPlasmodium falciparumgametocyte-infected erythrocytes and their relation to gametocytaemia

(2016) B. Dinko et al.   PARASITE IMMUNOLOGY

Transmission-blocking activity is determined by transmission-reducing activity and number of control oocysts in Plasmodium falciparum standard membrane-feeding assay

(2016) Kazutoyo Miura et al.   VACCINE

Safety and Immunogenicity of Pfs25-EPA/Alhydrogel®, a Transmission Blocking Vaccine against Plasmodium falciparum: An Open Label Study in Malaria Naïve Adults

(2016) Kawsar R. Talaat et al.   PLoS One

Enhancing immunogenicity and transmission-blocking activity of malaria vaccines by fusing Pfs25 to IMX313 multimerization technology

(2016) Yuanyuan Li et al.   Scientific Reports

A humanized mouse model for sequestration of Plasmodium falciparum sexual stages and in vivo evaluation of gametocytidal drugs

(2016) Yoann Duffier et al.   Scientific Reports

The March Toward Malaria Vaccines

(2015) Stephen L. Hoffman et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

The cell biology of malaria infection of mosquito: advances and opportunities

(2015) R. E. Sinden   CELLULAR MICROBIOLOGY

Plasmodium falciparum Gametocyte-Specific Antibody Profiling Reveals Boosting through Natural Infection and Identifies Potential Markers of Gametocyte Exposure

(2015) Jeff Skinner et al.   INFECTION AND IMMUNITY

Alga-Produced Malaria Transmission-Blocking Vaccine Candidate Pfs25 Formulated with a Human Use-Compatible Potent Adjuvant Induces High-Affinity Antibodies That Block Plasmodium falciparum Infection of Mosquitoes

(2015) Kailash P. Patra et al.   INFECTION AND IMMUNITY

Naturally acquired antibody responses to recombinant Pfs230 and Pfs48/45 transmission blocking vaccine candidates

(2015) Sophie Jones et al.   JOURNAL OF INFECTION

Dynamics of the Human Infectious Reservoir for Malaria Determined by Mosquito Feeding Assays and Ultrasensitive Malaria Diagnosis in Burkina Faso

(2015) André Lin Ouédraogo et al.   JOURNAL OF INFECTIOUS DISEASES

A comparative study of the localization and membrane topology of members of the RIFIN, STEVOR and PfMC-2TM protein families in Plasmodium falciparum-infected erythrocytes

(2015) Anna Bachmann et al.   MALARIA JOURNAL

RIFINs are adhesins implicated in severe Plasmodium falciparum malaria

(2015) Suchi Goel et al.   NATURE MEDICINE

The Anopheles-midgut APN1 structure reveals a new malaria transmission–blocking vaccine epitope

(2015) Sarah C Atkinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Malaria parasite Pfs47 disrupts JNK signaling to escape mosquito immunity

(2015) Ryan C. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodiumevasion of mosquito immunity and global malaria transmission: The lock-and-key theory

(2015) Alvaro Molina-Cruz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Plasmodium falciparum 48/45 single epitope R0.6C subunit protein elicits high levels of transmission blocking antibodies

(2015) Susheel K. Singh et al.   VACCINE

Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization

(2015) Mayumi Tachibana et al.   VACCINE

Development of vaccines for Plasmodium vivax malaria

(2015) Ivo Mueller et al.   VACCINE

The Anopheles-midgut APN1 structure reveals a new malaria transmission–blocking vaccine epitope

(2015) Sarah C Atkinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Plasmodium falciparumevades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cells

(2015) Urvashi N. Ramphul et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative Assessment of Transmission-Blocking Vaccine Candidates against Plasmodium falciparum

(2015) M. C. Kapulu et al.   Scientific Reports

Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates

(2014) Jo-Anne Chan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Potent Malaria Transmission-Blocking Antibody Responses Elicited by Plasmodium falciparum Pfs25 Expressed in Escherichia coli after Successful Protein Refolding

(2014) Rajesh Kumar et al.   INFECTION AND IMMUNITY

The Plasmodium bottleneck: malaria parasite losses in the mosquito vector

(2014) Ryan C Smith et al.   MEMORIAS DO INSTITUTO OSWALDO CRUZ

Development of a Single-Replicon miniBYV Vector for Co-expression of Heterologous Proteins

(2014) Alex Prokhnevsky et al.   MOLECULAR BIOTECHNOLOGY

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Plasmodium falciparum transmission stages accumulate in the human bone marrow

(2014) R. Joice et al.   Science Translational Medicine

A multi-stage malaria vaccine candidate targeting both transmission and asexual parasite life-cycle stages

(2014) Michael Theisen et al.   VACCINE

Identification of MMV Malaria Box Inhibitors of Plasmodium falciparum Early-Stage Gametocytes Using a Luciferase-Based High-Throughput Assay

(2013) Leonardo Lucantoni et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow

(2013) R. Aguilar et al.   BLOOD

Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria

(2013) Jennifer S. Armistead et al.   INFECTION AND IMMUNITY

Functional Comparison of Plasmodium falciparum Transmission-Blocking Vaccine Candidates by the Standard Membrane-Feeding Assay

(2013) Kazutoyo Miura et al.   INFECTION AND IMMUNITY

Plasmodium falciparum gametocytes: with a view to a kill

(2013) ALICE S. BUTTERWORTH et al.   PARASITOLOGY

The N-terminal segment of Plasmodium falciparum SURFIN4.1 is required for its trafficking to the red blood cell cytosol through the endoplasmic reticulum

(2013) Xiaotong Zhu et al.   PARASITOLOGY INTERNATIONAL

Qualification of Standard Membrane-Feeding Assay with Plasmodium falciparum Malaria and Potential Improvements for Future Assays

(2013) Kazutoyo Miura et al.   PLoS One

The Human Malaria Parasite Pfs47 Gene Mediates Evasion of the Mosquito Immune System

(2013) A. Molina-Cruz et al.   SCIENCE

Heterologous expression of the C-terminal antigenic domain of the malaria vaccine candidate Pfs48/45 in the green algae Chlamydomonas reinhardtii

(2012) Carla S. Jones et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

A switch in infected erythrocyte deformability at the maturation and blood circulation of Plasmodium falciparum transmission stages

(2012) M. Tiburcio et al.   BLOOD

Early gametocytes of the malaria parasitePlasmodium falciparumspecifically remodel the adhesive properties of infected erythrocyte surface

(2012) Marta Tibúrcio et al.   CELLULAR MICROBIOLOGY

Expression, Immunogenicity, Histopathology, and Potency of a Mosquito-Based Malaria Transmission-Blocking Recombinant Vaccine

(2012) D. K. Mathias et al.   INFECTION AND IMMUNITY

Regulating the Adaptive Immune Response to Blood-Stage Malaria: Role of Dendritic Cells and CD4+Foxp3+ Regulatory T Cells

(2012) Mary M. Stevenson et al.   International Journal of Biological Sciences

Expression of a type B RIFIN in Plasmodium falciparum merozoites and gametes

(2012) Steven B Mwakalinga et al.   MALARIA JOURNAL

The extravascular compartment of the bone marrow: a niche for Plasmodium falciparum gametocyte maturation?

(2012) Eric Farfour et al.   MALARIA JOURNAL

Production of non-glycosylated recombinant proteins inNicotiana benthamianaplants by co-expressing bacterial PNGase F

(2012) Tarlan Mamedov et al.   PLANT BIOTECHNOLOGY JOURNAL

Differential Adhesive Properties of Sequestered Asexual and Sexual Stages of Plasmodium falciparum on Human Endothelial Cells Are Tissue Independent

(2012) Francesco Silvestrini et al.   PLoS One

Algae-Produced Pfs25 Elicits Antibodies That Inhibit Malaria Transmission

(2012) James A. Gregory et al.   PLoS One

Mosquito Feeding Assays to Determine the Infectiousness of Naturally Infected Plasmodium falciparum Gametocyte Carriers

(2012) Teun Bousema et al.   PLoS One

Plasmodium vivax gametocyte protein Pvs230 is a transmission-blocking vaccine candidate

(2012) Mayumi Tachibana et al.   VACCINE

Directional gene expression and antisense transcripts in sexual and asexual stages of Plasmodium falciparum

(2011) María J López-Barragán et al.   BMC GENOMICS

N-Terminal Prodomain of Pfs230 Synthesized Using a Cell-Free System Is Sufficient To Induce Complement-Dependent Malaria Transmission-Blocking Activity

(2011) Mayumi Tachibana et al.   Clinical and Vaccine Immunology

A Plant-Produced Pfs230 Vaccine Candidate Blocks Transmission of Plasmodium falciparum

(2011) Christine E. Farrance et al.   Clinical and Vaccine Immunology

Epidemiology and Infectivity of Plasmodium falciparum and Plasmodium vivax Gametocytes in Relation to Malaria Control and Elimination

(2011) T. Bousema et al.   CLINICAL MICROBIOLOGY REVIEWS

Antibodies to plant-producedPlasmodium falciparumsexual stage protein Pfs25 exhibit transmission blocking activity

(2011) Christine E. Farrance et al.   Human vaccines & immunotherapeutics

PEXEL-independent trafficking of Plasmodium falciparum SURFIN4.2 to the parasite-infected red blood cell and Maurer's clefts

(2011) Jean Semé Fils Alexandre et al.   PARASITOLOGY INTERNATIONAL

Development and host cell modifications of Plasmodium falciparum blood stages in four dimensions

(2011) Christof Grüring et al.   Nature Communications

Identification of a major rif transcript common to gametocytes and sporozoites of Plasmodium falciparum

(2010) Christian W Wang et al.   MALARIA JOURNAL

Revisiting the circulation time of Plasmodium falciparum gametocytes: molecular detection methods to estimate the duration of gametocyte carriage and the effect of gametocytocidal drugs

(2010) Teun Bousema et al.   MALARIA JOURNAL

Protein Export Marks the Early Phase of Gametocytogenesis of the Human Malaria ParasitePlasmodium falciparum

(2010) Francesco Silvestrini et al.   MOLECULAR & CELLULAR PROTEOMICS

Three Members of the 6-cys Protein Family of Plasmodium Play a Role in Gamete Fertility

(2010) Melissa R. van Dijk et al.   PLoS Pathogens

Revisiting the Plasmodium falciparum RIFIN family: from comparative genomics to 3D-model prediction

(2009) Emanuele Bultrini et al.   BMC GENOMICS

Surface antigens of Plasmodium falciparum gametocytes—A new class of transmission-blocking vaccine targets?

(2009) Colin J. Sutherland   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A Potent Malaria Transmission Blocking Vaccine Based on Codon Harmonized Full Length Pfs48/45 Expressed in Escherichia coli

(2009) Debabani Roy Chowdhury et al.   PLoS One

Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?

(2009) Tobias Spielmann et al.   TRENDS IN PARASITOLOGY

Plasmodium berghei HAP2 induces strong malaria transmission-blocking immunity in vivo and in vitro

(2009) Andrew M. Blagborough et al.   VACCINE

The Plasmodium falciparum STEVOR Multigene Family Mediates Antigenic Variation of the Infected Erythrocyte

(2009) Makhtar Niang et al.   PLoS Pathogens

Sub-grouping and sub-functionalization of the RIFIN multi-copy protein family

(2008) Nicolas Joannin et al.   BMC GENOMICS

The conserved plant sterility gene HAP2 functions after attachment of fusogenic membranes in Chlamydomonas and Plasmodium gametes

(2008) Y. Liu et al.   GENES & DEVELOPMENT

Wheat Germ Cell-Free System-Based Production of Malaria Proteins for Discovery of Novel Vaccine Candidates

(2008) T. Tsuboi et al.   INFECTION AND IMMUNITY

SURFIN4.1, a schizont-merozoite associated protein in the SURFIN family of Plasmodium falciparum

(2008) Fingani A Mphande et al.   MALARIA JOURNAL

Plasmodium falciparum variant STEVOR antigens are expressed in merozoites and possibly associated with erythrocyte invasion

(2008) Ayman Khattab et al.   MALARIA JOURNAL

Reduction of transmission from malaria patients by artemisinin combination therapies: a pooled analysis of six randomized trials

(2008) Lucy C Okell et al.   MALARIA JOURNAL

PlasmoDB: a functional genomic database for malaria parasites

(2008) C. Aurrecoechea et al.   NUCLEIC ACIDS RESEARCH

Plasmodium falciparum Antigens on the Surface of the Gametocyte-Infected Erythrocyte

(2008) Maha Saeed et al.   PLoS One

Correctly folded Pfs48/45 protein of Plasmodium falciparum elicits malaria transmission-blocking immunity in mice

(2008) N. S. Outchkourov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA