4.7 Article

Comprehensive characterization of bioactive phenols from new Brazilian superfruits by LC-ESI-QTOF-MS, and their ROS and RNS scavenging effects and anti-inflammatory activity

Journal

FOOD CHEMISTRY
Volume 281, Issue -, Pages 178-188

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2018.12.106

Keywords

Native fruits; ROS and RNS; Anti-inflammatory activity; Antioxidant activity; Phenolic compounds

Funding

  1. State of Sao Paulo Research Foundation (FAPESP) [2013/13190-2, 2014/12606-3, 2016/02926, 2017/09898]
  2. National Council for Scientific and Technological Development (CNPq) [307893/2016-2]
  3. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior - Brasil (CAPES) [001]

Ask authors/readers for more resources

Brazilian native fruits (BNF) remain unexplored and underutilized resources with a high potential to improve human health and wellness. In our study, five new BNF (Eugenia stipitata, Sageretia elegans, Byrsonima arthropoda, Spondias mombin and Rubus rosaefolius) were evaluated for their phenolic composition by LC-ESI-QTOF-MS; and for their ROS and RNS scavenging effects (ROO center dot, O-2(center dot-), NO center dot, HOCl); in vivo anti-inflammatory activity (neutrophil migration); and in vivo acute toxicity in Galleria mellonella. Eighty-six phenolic compounds were identified, including hydroxybenzoic acids, hydroxycinnamic acids, flavonoids, anthocyanins and ellagitannins, several of which had never been reported in BNF. The BNF exhibited high antioxidant effects against biologically relevant radicals, and treated animals showed decreased neutrophil influx and NF-kB activation. Thus, these BNF are good sources of antioxidant and anti-inflammatory molecules that can be beneficial for human health as functional foods. Based on their bioactivity, they can be considered as new Brazilian superfruits.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Plant Sciences

A Systematic Review of the Potential Effects of Propolis Extracts on Experimentally-induced Diabetes

Gustavo Aparecido da Cunha, Paulo Fernando Carlstrom, Marcelo Franchin, Severino Matias Alencar, Masaharu Ikegaki, Pedro Luiz Rosalen

Summary: This systematic review evaluated the impact of propolis administration in diabetic animals. The study found that propolis administration resulted in a hypoglycemic effect in the treated animals, which may be attributed to the reduction of oxidative stress. Additionally, propolis administration restored endogenous antioxidant defenses and improved the lipid profile of the treated animals. However, the review also identified limitations in the studies, including a lack of randomization, blinding, and proper allocation of animals.

PLANTA MEDICA (2023)

Article Chemistry, Applied

Simulated gastrointestinal digestion/Caco-2 cell model to predict bioaccessibility and intestinal permeability of p-coumaric acid and p-coumaroyl derivatives in peanut

Adna Prado Massarioli, Alan Giovanini de Oliveira Sartori, Fernanda Francetto Juliano, Jose Eduardo Pedroso Gomes do Amaral, Roseane Cavalcanti dos Santos, Liziane Maria de Lima, Severino Matias de Alencar

Summary: This study predicts the bioaccessibility and intestinal permeability of major phenolics in peanuts using simulated digestion and Caco-2 cell model. The results show that the phenolics in peanuts undergo changes during digestion, but their antioxidant activity remains unchanged. Furthermore, peanuts are found to contain p-coumaric acid as a major phenolic compound.

FOOD CHEMISTRY (2023)

Article Cell Biology

PI3Kγ controls IL-17A expression and attenuates alveolar bone loss in an experimental periodontitis model

Marcelo Franchin, Thaise Mayumi Taira, Douglas da Silva Prado, Cesar Augusto Speck Hernandez, Fabio Bonifacio de Andrade, Henrique Ballassini Abdalla, Marcelo Henrique Napimoga, Thiago Mattar Cunha, Sandra Yasuyo Fukada, Pedro Luiz Rosalen

Summary: In this study, we investigated the modulatory effects of PI3K gamma on IL-17A expression and the progression of experimental periodontitis in vivo. Our results showed that PI3K gamma inhibitor can attenuate alveolar bone loss and downregulate IL-17A and Rankl gene expression.

INFLAMMATION RESEARCH (2023)

Article Dentistry, Oral Surgery & Medicine

Evaluation of efficacy of new chalcone-based endodontic irrigant against dual biofilm Enterococcus faecalis and Candida albicans: a study in vitro

Joice Graciani, Pedro Luiz Rosalen, Emmanuely de Oliveira Chaves dos Santos, Kellyth Andrade Pereira Rocha, Bruno Rafael Teixeira Balen, Mayara Aparecida Rocha Garcia, Josy Goldoni Lazarini, Diego Romario da Silva, Suzana Goncalves Carvalho, Luis Octavio Regasini, Marlus Chorilli, Janaina de Cassia Orlandi Sardi

Summary: The aim of this study was to develop a chalcone-based endodontic irrigant for cleaning and disinfecting root canals. The formulated irrigant showed significant antimicrobial activity against Candida albicans and Enterococcus faecalis, inhibiting biofilm formation and viability. Moreover, the formulation exhibited low toxicity to cells and insects in vitro and in vivo.

ODONTOLOGY (2023)

Article Chemistry, Applied

Dynamic gastrointestinal digestion/intestinal permeability of encapsulated and nonencapsulated Brazilian red propolis: Active compounds stability and bioactivity

Severino Matias de Alencar, Alan Giovanini de Oliveira Sartori, Damla Dag, Pollyanna Souza Batista, Pedro Luiz Rosalen, Masaharu Ikegaki, Fanbin Kong

Summary: The effect of dynamic gastrointestinal digestion/Caco-2 cell transport on the stability and activities of Brazilian red propolis extract (EEBRP) was investigated. Encapsulated EEBRP showed higher bioaccessibility and nonencapsulated EEBRP had higher Caco-2 cell transport. Nonencapsulated EEBRP exhibited higher ability to scavenge reactive oxygen species and decrease inflammation markers after cell transport. Further studies on encapsulation are encouraged for improving bioactivity and expanding food applications.

FOOD CHEMISTRY (2023)

Article Food Science & Technology

Application of spray drying, spray chilling and the combination of both methods to produce tucuma∼ oil microparticles: characterization, stability, and β-carotene bioaccessibility

Priscila Dayane de Freitas Santos, Pollyanna Souza Batista, Larissa Catelli Rocha Torres, Marcelo Thomazini, Severino Matias de Alencar, Carmen Silvia Favaro-Trindade

Summary: The aim of this study was to produce tucuma & SIM oil microparticles using different encapsulation methods and evaluate their properties. The results showed that the microparticles had attractive color, small mean diameter, and high & beta;-carotene content. However, some carotenoid loss was observed after encapsulation. After 90 days of storage, the microparticles produced by different methods showed different levels of degradation. The spray chilling method demonstrated high carotenoid retention and improved & beta;-carotene bioaccessibility.

FOOD RESEARCH INTERNATIONAL (2023)

Article Genetics & Heredity

Transcriptome profile of skeletal muscle using different sources of dietary fatty acids in male pigs

Simara Larissa Fanalli, Bruna Pereira Martins da Silva, Julia Dezen Gomes, Vivian Vezzoni de Almeida, Gabriel Costa Monteiro Moreira, Barbara Silva-Vignato, Juliana Afonso, Felipe Andre Oliveira Freitas, James Mark Reecy, James Eugene Koltes, Dawn Koltes, Dorian Garrick, Luciana Correia de Almeida Regitano, Julio Cesar de Carvalho Balieiro, Gerson Barreto Mourao, Luiz Lehmann Coutinho, Heidge Fukumasu, Mirele Daiana Poleti, Severino Matias de Alencar, Albino Luchiari Filho, Aline Silva Mello Cesar

Summary: This study evaluated the impact of different lipid sources on gene expression in porcine skeletal muscle tissue using RNA-Seq, and identified differentially expressed genes involved in metabolic pathways and biological processes. Addition of fish oil in pig diets resulted in intramuscular lipid with a higher composition of certain fatty acids. Blood parameters showed lower cholesterol and HDL content in the fish oil group compared to the other two groups. Enrichment analysis revealed differentially expressed genes related to lipid metabolism, metabolic diseases, and inflammation, as well as specific gene functions and altered blood parameters in each group.

FUNCTIONAL & INTEGRATIVE GENOMICS (2023)

Article Food Science & Technology

Anthocyanin bioaccessibility and anti-inflammatory activity of a grape-based 3D printed food for dysphagia

Alan Giovanini de Oliveira Sartori, Ana Sofia Martelli Chaib Saliba, Bruna Sousa Bitencourt, Jaqueline Souza Guedes, Larissa Catelli Rocha Torres, Severino Matias de Alencar, Pedro Esteves Duarte Augusto

Summary: The objective of this study was to develop 3D printable grape juice gels for dysphagia diets, and to evaluate their anthocyanin bioaccessibility and anti-inflammatory activity. The gels made with dry-heated starch showed the highest anthocyanin bio-accessibility. The study also showed that the dry heating treatment enhanced the chemical and biological properties of the 3D printable foods.

INNOVATIVE FOOD SCIENCE & EMERGING TECHNOLOGIES (2023)

Article Biochemistry & Molecular Biology

Hypoglycemic effect of Coffea arabica leaf extracts and major bioactive constituents

G. O. Nascimento, S. P. D. Marques, C. E. G. Maia, A. F. de Sousa, R. L. Cunha, M. R. Malta, R. W. Owen, M. K. A. Ferreira, A. W. da Silva, E. L. Reboucas, J. E. S. A. de Menezes, M. M. Marinho, E. S. Marinho, H. S. dos Santos, A. S. M. C. Saliba, A. P. Massarioli, S. M. Alencar, A. G. O. Sartori, M. T. S. Trevisan

Summary: The study investigated the properties of C. arabica leaf extracts, including antioxidant and antiglycation activity, digestive enzymes inhibition, bioaccessibility, and hypoglycemic effect. The extracts showed deactivation of various reactive oxygen species and strong inhibition of alpha-glucosidase and pancreatic lipase. They also exhibited a hypoglycemic effect in zebrafish. All compounds except rutin were detected during in vitro digestion. These findings suggest that C. arabica leaf extracts have potential antidiabetic and anti-obesity properties due to their main metabolites and synergistic action.

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS (2023)

Article Green & Sustainable Science & Technology

Ozone processing of peanut milk: Degradation of aflatoxins, impact on quality attributes and the potential effect on peanut allergens

Alessandra C. Romero, Alan G. O. Sartori, Maria E. Caetano-Silva, Severino M. de Alencar, Maria A. Calori, Pedro E. D. Augusto

Summary: The demand for plant-based products has been increasing, leading to the development of vegetable products analogous to conventional animal-products. This study focused on the ozonation process of peanut milk as an alternative to reduce allergens and mycotoxin contamination. The results showed that ozonation efficiently degraded the most toxic aflatoxins AFB1 and AFG1, while AFB2 and AFG2 were more resistant. Ozonation also showed the potential to reduce peanut allergens by approximately 80%, but it degraded fatty acids and produced off-flavours.

JOURNAL OF CLEANER PRODUCTION (2023)

Article Agriculture, Multidisciplinary

Cocoa powder and fermented jackfruit seed flour: A comparative cell-based study on their potential antioxidant and anti-inflammatory activities after simulated gastrointestinal digestion

Fernanda Papa Spada, Josy Goldoni Lazarini, Pollyanna Souza Batista, Alan Giovanini de Oliveira Sartori, Ana Sofia Martelli Chaib Saliba, Jose Eduardo Pedroso Gomes do Amaral, Eduardo Purgatto, Severino Matias de Alencar

Summary: The in vivo toxicity and in vitro antioxidant activity of fermented jackfruit seed flour (Fjs) and non-alkaline cocoa powder (Nac) were investigated in this study. The results showed that there were no significant differences in the antioxidant activity of Nac-D and Fjs-D after simulated gastrointestinal digestion. Furthermore, both Fjs and Nac exhibited beneficial effects in terms of cellular antioxidant activity and anti-inflammatory assay.

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE (2023)

Review Toxicology

Progress and promise of alternative animal and non-animal methods in biomedical research

Irlan Almeida Freires, David Fernando Colon Morelo, Lelio Fernando Ferreira Soares, Isabela Silva Costa, Leonardo Pereira de Araujo, Isadora Breseghello, Henrique Ballassini Abdalla, Josy Goldoni Lazarini, Pedro Luiz Rosalen, Suzane Cristina Pigossi, Marcelo Franchin

Summary: Cell culture and invertebrate animal models have revolutionized scientific research by providing reliable evidence for the physiopathology of diseases, drug screening, and toxicological tests, while minimizing the need for mammals.

ARCHIVES OF TOXICOLOGY (2023)

Article Chemistry, Applied

Food-grade delivery systems of Brazilian propolis from Apis mellifera: From chemical composition to bioactivities in vivo

Marcelo Franchin, Ana Sofia Martelli Chaib Saliba, Alan Giovanini de Oliveira Sartori, Sebastiao Orestes Pereira Neto, Bruna Benso, Masaharu Ikegaki, Kai Wang, Severino Matias de Alencar, Daniel Granato

Summary: Brazilian propolis from Apis mellifera is widely studied for its unique chemical composition and biological properties. This review explores the potential uses of propolis as a functional ingredient in food and pharmaceutical applications, providing a theoretical and practical basis for optimizing its bioactive properties.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

The first harmonised total diet study in Portugal: Vitamin D occurrence and intake assessment

M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira

Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

The digestion fates of lipids with different unsaturated levels in people with different age groups

Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu

Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Fabrication and characterization of chitosan-pectin emulsion-filled hydrogel prepared by cold-set gelation to improve bioaccessibility of lipophilic bioactive compounds

Hyunjong Yu, Huisu Kim, Pahn-Shick Chang

Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

The effect of lactic acid bacteria fermentation on physicochemical properties of starch from fermented proso millet flour

Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke

Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Novel competitive electrochemical impedance biosensor for the ultrasensitive detection of umami substances based on Pd/Cu-TCPP(Fe)

Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu

Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Identification and comparison of milk fat globule membrane and whey proteins from Selle Français, Welsh pony, and Tieling Draft horse mare's milk

Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang

Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Phenols and saliva effect on virgin olive oil aroma release: A chemical and sensory approach

Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales

Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Preparation and properties of pH-sensitive cationic starch nanoparticles

Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen

Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Direct seeding compromised the vitamin C content of baby vegetables and the glucosinolate content of mature vegetables in Asian leafy brassicas

Andrea Koo, Vinayak Ghate, Weibiao Zhou

Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

ACE inhibitory peptides from enzymatic hydrolysate of fermented black sesame seed: Random forest-based optimization, screening, and molecular docking analysis

Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie

Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Exploration of digestion-resistant immunodominant epitopes in shrimp (Penaeus vannamei) allergens

Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun

Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Effect of milling on in vitro Digestion-Induced release and bioaccessibility of active compounds in rice

Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan

Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Unraveling proteome changes of Sunit lamb meat in different feeding regimes and its relationship to flavor analyzed by TMT-labeled quantitative proteomic

Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin

Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Mechanism of aroma enhancement methods in accelerating Congou black tea acidification subjected to room temperature storage

Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni

Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.

FOOD CHEMISTRY (2024)

Article Chemistry, Applied

Immobilizing amyloglucosidase on inorganic hybrid nanoflowers to prepare time-temperature integrators for chilled pork quality monitoring

Lin Wang, Falai Ma, Zihan Li, Yan Zhang

Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.

FOOD CHEMISTRY (2024)