Universal influenza virus vaccines: what needs to happen next?

Neuraminidase as an influenza vaccine antigen: a low hanging fruit, ready for picking to improve vaccine effectiveness

(2018) Maryna C Eichelberger et al.   CURRENT OPINION IN IMMUNOLOGY

Human monoclonal antibodies neutralizing influenza virus A/H1N1pdm09 and seasonal A/H1N1 strains – Distinct Ig gene repertoires with a similar action mechanism

(2018) Satoshi Hiroi et al.   IMMUNOBIOLOGY

Matrix-M™ adjuvant enhances immunogenicity of both protein- and modified vaccinia virus Ankara-based influenza vaccines in mice

(2018) Sofia E. Magnusson et al.   IMMUNOLOGIC RESEARCH

Comparison of Heterosubtypic Protection in Ferrets and Pigs Induced by a Single-Cycle Influenza Vaccine

(2018) Barbara Holzer et al.   JOURNAL OF IMMUNOLOGY

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

An immuno-assay to quantify influenza virus hemagglutinin with correctly folded stalk domains in vaccine preparations

(2018) Madhusudan Rajendran et al.   PLoS One

Towards a universal influenza vaccine: different approaches for one goal

(2018) Giuseppe A. Sautto et al.   Virology Journal

Universal Vaccines and Vaccine Platforms to Protect against Influenza Viruses in Humans and Agriculture

(2018) Daniela S. Rajão et al.   Frontiers in Microbiology

The Hurdles From Bench to Bedside in the Realization and Implementation of a Universal Influenza Vaccine

(2018) Sophie A. Valkenburg et al.   Frontiers in Immunology

Novel Platforms for the Development of a Universal Influenza Vaccine

(2018) Arun Kumar et al.   Frontiers in Immunology

Mini-hemagglutinin vaccination induces cross-reactive antibodies in pre-exposed NHP that protect mice against lethal influenza challenge

(2018) Joan E. M. van der Lubbe et al.   npj Vaccines

The Pathway to a Universal Influenza Vaccine

(2017) Catharine I. Paules et al.   IMMUNITY

Workshop report: Immunoassay standardisation for “universal” influenza vaccines

(2017) Sophia Pavlova et al.   Influenza and Other Respiratory Viruses

One Step Forward in the Road Toward a Universal Influenza Vaccine

(2017) Octavio Ramilo et al.   JOURNAL OF INFECTIOUS DISEASES

Chimeric Hemagglutinin Constructs Induce Broad Protection against Influenza B Virus Challenge in the Mouse Model

(2017) Megan E. Ermler et al.   JOURNAL OF VIROLOGY

Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques

(2017) Frank Liang et al.   MOLECULAR THERAPY

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site

(2017) Eva-Maria Strauch et al.   NATURE BIOTECHNOLOGY

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains

(2017) Seth J. Zost et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Do antibody responses to the influenza vaccine persist year-round in the elderly? A systematic review and meta-analysis

(2017) Barnaby Young et al.   VACCINE

Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

(2017) Henning Jacobsen et al.   mBio

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccine

(2017) Nicholas C. Wu et al.   PLoS Pathogens

Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines

(2017) Johannes Lutz et al.   npj Vaccines

A universal influenza virus vaccine candidate confers protection against pandemic H1N1 infection in preclinical ferret studies

(2017) Raffael Nachbagauer et al.   npj Vaccines

Protective efficacy of influenza group 2 hemagglutinin stem-fragment immunogen vaccines

(2017) Troy C. Sutton et al.   npj Vaccines

A modified vaccinia Ankara vaccine vector expressing a mosaic H5 hemagglutinin reduces viral shedding in rhesus macaques

(2017) Nicholas W. Florek et al.   PLoS One

Heads, stalks and everything else: how can antibodies eradicate influenza as a human disease?

(2016) Karlynn E Neu et al.   CURRENT OPINION IN IMMUNOLOGY

M2-based influenza vaccines: recent advances and clinical potential

(2016) Annasaheb Kolpe et al.   Expert Review of Vaccines

Epidemiology of influenza B in Australia: 2001-2014 influenza seasons

(2016) Aye M. Moa et al.   Influenza and Other Respiratory Viruses

Effects of egg-adaptation on receptor-binding and antigenic properties of recent influenza A (H3N2) vaccine viruses

(2016) Lauren Parker et al.   JOURNAL OF GENERAL VIROLOGY

Aerosol Delivery of a Candidate Universal Influenza Vaccine Reduces Viral Load in Pigs Challenged with Pandemic H1N1 Virus

(2016) Sophie B. Morgan et al.   JOURNAL OF IMMUNOLOGY

Unmasking Stem-Specific Neutralizing Epitopes by Abolishing N-Linked Glycosylation Sites of Influenza Virus Hemagglutinin Proteins for Vaccine Design

(2016) Wen-Chun Liu et al.   JOURNAL OF VIROLOGY

Design and Characterization of a Computationally Optimized Broadly Reactive Hemagglutinin Vaccine for H1N1 Influenza Viruses

(2016) Donald M. Carter et al.   JOURNAL OF VIROLOGY

Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge

(2016) Diletta Magini et al.   PLoS One

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent protection against H5N1 and H7N9 influenza via childhood hemagglutinin imprinting

(2016) Katelyn M. Gostic et al.   SCIENCE

Generation of influenza A viruses as live but replication-incompetent virus vaccines

(2016) L. Si et al.   SCIENCE

Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets

(2016) Andrew J. Broadbent et al.   VACCINE

Comparability of neuraminidase inhibition antibody titers measured by enzyme-linked lectin assay (ELLA) for the analysis of influenza vaccine immunogenicity

(2016) Maryna C. Eichelberger et al.   VACCINE

Universal influenza vaccines: Shifting to better vaccines

(2016) Francesco Berlanda Scorza et al.   VACCINE

Influenza B virus M2 protein can functionally replace its influenza A virus counterpart in promoting virus replication

(2016) Asawin Wanitchang et al.   VIROLOGY

Development and applications of single-cycle infectious influenza A virus (sciIAV)

(2016) Aitor Nogales et al.   VIRUS RESEARCH

Fifteen years of epidemiologic, virologic and syndromic influenza surveillance: A focus on type B virus and the effects of vaccine mismatch in Liguria region, Italy

(2016) Cecilia Trucchi et al.   Human Vaccines & Immunotherapeutics

Self-assembling protein nanoparticles in the design of vaccines

(2016) Jacinto López-Sagaseta et al.   Computational and Structural Biotechnology Journal

Stalking influenza by vaccination with pre-fusion headless HA mini-stem

(2016) Sophie A. Valkenburg et al.   Scientific Reports

Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study

(2015) Andrew C. Hayward et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The pandemic potential of avian influenza A(H7N9) virus: a review

(2015) W. D. TANNER et al.   EPIDEMIOLOGY AND INFECTION

Flucelvax (Optaflu) for seasonal influenza

(2015) Ilaria Manini et al.   Expert Review of Vaccines

Antibody to Influenza Virus Neuraminidase: An Independent Correlate of Protection

(2015) Arnold S. Monto et al.   JOURNAL OF INFECTIOUS DISEASES

Human Influenza A Virus–Specific CD8+ T-Cell Response Is Long-lived

(2015) Carolien E. van de Sandt et al.   JOURNAL OF INFECTIOUS DISEASES

Sequential Infection in Ferrets with Antigenically Distinct Seasonal H1N1 Influenza Viruses Boosts Hemagglutinin Stalk-Specific Antibodies

(2015) Greg A. Kirchenbaum et al.   JOURNAL OF VIROLOGY

Induction of Broad-Based Immunity and Protective Efficacy by Self-amplifying mRNA Vaccines Encoding Influenza Virus Hemagglutinin

(2015) Michela Brazzoli et al.   JOURNAL OF VIROLOGY

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

(2015) Hadi M Yassine et al.   NATURE MEDICINE

Advances in the development of influenza virus vaccines

(2015) Florian Krammer et al.   NATURE REVIEWS DRUG DISCOVERY

A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen

(2015) A. Impagliazzo et al.   SCIENCE

Development of a Mouse-Adapted Live Attenuated Influenza Virus That PermitsIn VivoAnalysis of Enhancements to the Safety of Live Attenuated Influenza Virus Vaccine

(2015) Andrew Cox et al.   JOURNAL OF VIROLOGY

An Anti-Influenza Virus Antibody Inhibits Viral Infection by Reducing Nucleus Entry of Influenza Nucleoprotein

(2015) Aerin Yoon et al.   PLoS One

Continuing challenges in influenza

(2014) Robert G. Webster et al.   Annals of the New York Academy of Sciences

An optimized enzyme-linked lectin assay to measure influenza A virus neuraminidase inhibition antibody titers in human sera

(2014) Laura Couzens et al.   JOURNAL OF VIROLOGICAL METHODS

Modified Vaccinia Virus Ankara Encoding Influenza Virus Hemagglutinin Induces Heterosubtypic Immunity in Macaques

(2014) N. W. Florek et al.   JOURNAL OF VIROLOGY

Flow Cytometry Reveals that H5N1 Vaccination Elicits Cross-Reactive Stem-Directed Antibodies from Multiple Ig Heavy-Chain Lineages

(2014) J. R. R. Whittle et al.   JOURNAL OF VIROLOGY

Influenza Virus Reservoirs and Intermediate Hosts: Dogs, Horses, and New Possibilities for Influenza Virus Exposure of Humans

(2014) Colin R. Parrish et al.   JOURNAL OF VIROLOGY

Priming by a novel universal influenza vaccine (Multimeric-001)—A gateway for improving immune response in the elderly population

(2014) Jacob Atsmon et al.   VACCINE

Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins

(2014) A.V. Vasin et al.   VIRUS RESEARCH

In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen

(2014) Teddy Wohlbold et al.   Viruses-Basel

Characterization of a Novel Influenza Virus in Cattle and Swine: Proposal for a New Genus in the Orthomyxoviridae Family

(2014) B. M. Hause et al.   mBio

Self-replicating Replicon-RNA Delivery to Dendritic Cells by Chitosan-nanoparticles for Translation In Vitro and In Vivo

(2014) Kenneth C McCullough et al.   Molecular Therapy-Nucleic Acids

Universal anti-neuraminidase antibody inhibiting all influenza A subtypes

(2013) Tracey M. Doyle et al.   ANTIVIRAL RESEARCH

Correlates of protection against influenza infection in humans—on the path to a universal vaccine?

(2013) Chris Ka-fai Li et al.   CURRENT OPINION IN IMMUNOLOGY

Immunological assessment of influenza vaccines and immune correlates of protection

(2013) Adrian Reber et al.   Expert Review of Vaccines

Antibody Correlates and Predictors of Immunity to Naturally Occurring Influenza in Humans and the Importance of Antibody to the Neuraminidase

(2013) Robert B. Couch et al.   JOURNAL OF INFECTIOUS DISEASES

Molecular Basis for Broad Neuraminidase Immunity: Conserved Epitopes in Seasonal and Pandemic H1N1 as Well as H5N1 Influenza Viruses

(2013) H. Wan et al.   JOURNAL OF VIROLOGY

H3N2 Influenza Virus Infection Induces Broadly Reactive Hemagglutinin Stalk Antibodies in Humans and Mice

(2013) I. Margine et al.   JOURNAL OF VIROLOGY

Hemagglutinin Stalk-Based Universal Vaccine Constructs Protect against Group 2 Influenza A Viruses

(2013) I. Margine et al.   JOURNAL OF VIROLOGY

Chimeric Hemagglutinin Influenza Virus Vaccine Constructs Elicit Broadly Protective Stalk-Specific Antibodies

(2013) F. Krammer et al.   JOURNAL OF VIROLOGY

Clinical Assessment of a Novel Recombinant Simian Adenovirus ChAdOx1 as a Vectored Vaccine Expressing Conserved Influenza A Antigens

(2013) Richard D Antrobus et al.   MOLECULAR THERAPY

Coadministration of Seasonal Influenza Vaccine and MVA-NP+M1 Simultaneously Achieves Potent Humoral and Cell-Mediated Responses

(2013) Richard D Antrobus et al.   MOLECULAR THERAPY

Cellular immune correlates of protection against symptomatic pandemic influenza

(2013) Saranya Sridhar et al.   NATURE MEDICINE

A Recombinant Viruslike Particle Influenza A (H7N9) Vaccine

(2013) Louis F. Fries et al.   NEW ENGLAND JOURNAL OF MEDICINE

Influenza A penetrates host mucus by cleaving sialic acids with neuraminidase

(2013) Miriam Cohen et al.   Virology Journal

Natural history of highly pathogenic avian influenza H5N1

(2013) Stephanie Sonnberg et al.   VIRUS RESEARCH

New World Bats Harbor Diverse Influenza A Viruses

(2013) Suxiang Tong et al.   PLoS Pathogens

Rapidly produced SAM® vaccine against H7N9 influenza is immunogenic in mice

(2013) Armin Hekele et al.   Emerging Microbes & Infections

Pandemic influenza vaccine: characterization of A/California/07/2009 (H1N1) recombinant hemagglutinin protein and insights into H1N1 antigen stability

(2012) Elena Feshchenko et al.   BMC BIOTECHNOLOGY

Preliminary Assessment of the Efficacy of a T-Cell–Based Influenza Vaccine, MVA-NP+M1, in Humans

(2012) Patrick J. Lillie et al.   CLINICAL INFECTIOUS DISEASES

Understanding the immune response to seasonal influenza vaccination in older adults: a systems biology approach

(2012) Nathaniel D Lambert et al.   Expert Review of Vaccines

Virus-like Particles Containing Multiple M2 Extracellular Domains Confer Improved Cross-protection Against Various Subtypes of Influenza Virus

(2012) Min-Chul Kim et al.   MOLECULAR THERAPY

Cross-neutralization of influenza A viruses mediated by a single antibody loop

(2012) Damian C. Ekiert et al.   NATURE

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

A distinct lineage of influenza A virus from bats

(2012) S. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hemagglutinin stalk antibodies elicited by the 2009 pandemic influenza virus as a mechanism for the extinction of seasonal H1N1 viruses

(2012) N. Pica et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Highly Conserved Protective Epitopes on Influenza B Viruses

(2012) C. Dreyfus et al.   SCIENCE

Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled Phase I trial

(2012) Olga Pleguezuelos et al.   VACCINE

The rationale for quadrivalent influenza vaccines

(2012) Christopher S. Ambrose et al.   Human Vaccines & Immunotherapeutics

Re-Engaging Cross-Reactive Memory B Cells: The Influenza Puzzle

(2012) Ali H. Ellebedy et al.   Frontiers in Immunology

A potential role for monoclonal antibodies in prophylactic and therapeutic treatment of influenza

(2011) Nicasio Mancini et al.   ANTIVIRAL RESEARCH

Improving influenza vaccine virus selectionReport of a WHO informal consultation held at WHO headquarters, Geneva, Switzerland, 14-16 June 2010

(2011) et al.   Influenza and Other Respiratory Viruses

Cold-Adapted Influenza and Recombinant Adenovirus Vaccines Induce Cross-Protective Immunity against pH1N1 Challenge in Mice

(2011) Mark R. Soboleski et al.   PLoS One

Safety and immunogenicity of a recombinant M2e–flagellin influenza vaccine (STF2.4xM2e) in healthy adults

(2011) Christine B. Turley et al.   VACCINE

Original Article: Highly conserved cross-reactive CD4+ T-cell HA-epitopes of seasonal and the 2009 pandemic influenza viruses

(2010) Venkata R. S. K. Duvvuri et al.   Influenza and Other Respiratory Viruses

Differentiation of Influenza B Virus Lineages Yamagata and Victoria by Real-Time PCR

(2010) B. Biere et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Universal Vaccine Based on Ectodomain of Matrix Protein 2 of Influenza A: Fc Receptors and Alveolar Macrophages Mediate Protection

(2010) K. El Bakkouri et al.   JOURNAL OF IMMUNOLOGY

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

(2010) C.-J. Wei et al.   SCIENCE

Influenza Virus Vaccine Based on the Conserved Hemagglutinin Stalk Domain

(2010) J. Steel et al.   mBio

Universal M2 ectodomain-based influenza A vaccines: preclinical and clinical developments

(2009) Michael Schotsaert et al.   Expert Review of Vaccines

Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses

(2009) Jianhua Sui et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

(2009) R. J. Garten et al.   SCIENCE

A high dosage influenza vaccine induced significantly more neuraminidase antibody than standard vaccine among elderly subjects

(2009) Thomas R. Cate et al.   VACCINE