‘Beauty and the beast’ in infection: How immune–endocrine interactions regulate systemic metabolism in the context of infection

Diabetes and the occurrence of infection in primary care: a matched cohort study

(2018) Waseem Abu-Ashour et al.   BMC INFECTIOUS DISEASES

Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

(2018) Lucille C. Rankin et al.   CELL

Glucose Homeostasis Is Important for Immune Cell Viability during Candida Challenge and Host Survival of Systemic Fungal Infection

(2018) Timothy M. Tucey et al.   Cell Metabolism

CD2-associated Protein Contributes to Hepatitis C Virus Propagation and Steatosis by Disrupting Insulin Signaling

(2018) Huixia Zhang et al.   HEPATOLOGY

Virus-Induced Interferon-γ Causes Insulin Resistance in Skeletal Muscle and Derails Glycemic Control in Obesity

(2018) Marko Šestan et al.   IMMUNITY

Energy intake is associated with endotoxemia in apparently healthy men

(2018) Jacques Amar et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Cooperative Metabolic Adaptations in the Host Can Favor Asymptomatic Infection and Select for Attenuated Virulence in an Enteric Pathogen

(2018) Karina K. Sanchez et al.   CELL

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

(2018) Sue Tsai et al.   Cell Metabolism

Glycemic Control and Risk of Infections Among People With Type 1 or Type 2 Diabetes in a Large Primary Care Cohort Study

(2018) Julia A. Critchley et al.   DIABETES CARE

Mechanisms of Insulin Action and Insulin Resistance

(2018) Max C. Petersen et al.   PHYSIOLOGICAL REVIEWS

Glucose feeds the TCA cycle via circulating lactate

(2017) Sheng Hui et al.   NATURE

Osmolality and blood pressure stability during hemodialysis

(2017) Anika T. Singh et al.   SEMINARS IN DIALYSIS

Pathogen manipulation of host metabolism: A common strategy for immune evasion

(2017) Zachary Freyberg et al.   PLoS Pathogens

Salmonella Typhimurium disrupts Sirt1/AMPK checkpoint control of mTOR to impair autophagy

(2017) Raja Ganesan et al.   PLoS Pathogens

The relationship between pro-inflammatory cytokines and pain, appetite and fatigue in patients with advanced cancer

(2017) Ørnulf Paulsen et al.   PLoS One

PRKAA/AMPK restricts HBV replication through promotion of autophagic degradation

(2016) Na Xie et al.   Autophagy

The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia

(2016) Daniel Okin et al.   CELL

Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation

(2016) Andrew Wang et al.   CELL

Dysglycemia and Glucose Control During Sepsis

(2016) Mark P. Plummer et al.   CLINICS IN CHEST MEDICINE

CV Protection in the EMPA-REG OUTCOME Trial: A “Thrifty Substrate” Hypothesis

(2016) Ele Ferrannini et al.   DIABETES CARE

Stress resilience and subsequent risk of type 2 diabetes in 1.5 million young men

(2016) Casey Crump et al.   DIABETOLOGIA

Memory CD8 + T Cells Require Increased Concentrations of Acetate Induced by Stress for Optimal Function

(2016) Maria L. Balmer et al.   IMMUNITY

AMP-activated Kinase (AMPK) Promotes Innate Immunity and Antiviral Defense through Modulation of Stimulator of Interferon Genes (STING) Signaling

(2016) Daniel Prantner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Adult Critically Ill Patient

(2016) Stephen A. McClave et al.   JOURNAL OF PARENTERAL AND ENTERAL NUTRITION

Stress Induced Hyperglycemia and the Subsequent Risk of Type 2 Diabetes in Survivors of Critical Illness

(2016) Mark P. Plummer et al.   PLoS One

Metformin: Candidate host-directed therapy for tuberculosis in diabetes and non-diabetes patients

(2016) Blanca I. Restrepo   TUBERCULOSIS

Nonalcoholic fatty liver disease - A multisystem disease?

(2016) Ivana Mikolasevic et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Adiponectin: a versatile player of innate immunity

(2016) Yan Luo et al.   Journal of Molecular Cell Biology

Ceramide and sphingosine in pulmonary infections

(2015) Aaron P. Seitz et al.   BIOLOGICAL CHEMISTRY

Homeostasis, Inflammation, and Disease Susceptibility

(2015) Maya E. Kotas et al.   CELL

Non-traditional cytokines: How catecholamines and adipokines influence macrophages in immunity, metabolism and the central nervous system

(2015) Mark A. Barnes et al.   CYTOKINE

The “Big Bang” in obese fat: Events initiating obesity-induced adipose tissue inflammation

(2015) Felix M. Wensveen et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Acylcarnitines: potential implications for skeletal muscle insulin resistance

(2015) Céline Aguer et al.   FASEB JOURNAL

Hyperglycemia, p53, and mitochondrial pathway of apoptosis are involved in the susceptibility of diabetic models to ischemic acute kidney injury

(2015) Jianping Peng et al.   KIDNEY INTERNATIONAL

NK cells link obesity-induced adipose stress to inflammation and insulin resistance

(2015) Felix M Wensveen et al.   NATURE IMMUNOLOGY

Interactions between adipose tissue and the immune system in health and malnutrition

(2015) Felix M. Wensveen et al.   SEMINARS IN IMMUNOLOGY

Human adenovirus-36 is uncommon in type 2 diabetes and is associated with increased insulin sensitivity in adults in Sweden

(2014) Malin Almgren et al.   ANNALS OF MEDICINE

AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

The AMPK-PPARGC1A pathway is required for antimicrobial host defense through activation of autophagy

(2014) Chul-Su Yang et al.   Autophagy

Fasting: Molecular Mechanisms and Clinical Applications

(2014) Valter D. Longo et al.   Cell Metabolism

Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke

(2014) Alex Dregan et al.   CIRCULATION

Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways

(2014) S. R. Jacobs et al.   JOURNAL OF IMMUNOLOGY

Signaling by IL-6 promotes alternative activation of macrophages to limit endotoxemia and obesity-associated resistance to insulin

(2014) Jan Mauer et al.   NATURE IMMUNOLOGY

Brain glucose transporters: Implications for neurologic disease

(2014) E. E. Benarroch   NEUROLOGY

Profiling of the kinome of cytomegalovirus-infected cells reveals the functional importance of host kinases Aurora A, ABL and AMPK

(2013) Corina Hutterer et al.   ANTIVIRAL RESEARCH

Metabolic endotoxaemia

(2013) Milan K. Piya et al.   CURRENT OPINION IN LIPIDOLOGY

Increased intestinal permeability to oral chromium (51Cr)-EDTA in human Type 2 diabetes

(2013) F. Horton et al.   DIABETIC MEDICINE

Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding

(2013) N. Turner et al.   DIABETOLOGIA

Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages

(2013) Ari B. Molofsky et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of the LKB1-AMPK pathway by the Epstein-Barr virus-encoded LMP1 promotes proliferation and transformation of human nasopharyngeal epithelial cells

(2013) Angela Kwok-Fung Lo et al.   JOURNAL OF PATHOLOGY

Stress hyperlactataemia: present understanding and controversy

(2013) Mercedes Garcia-Alvarez et al.   Lancet Diabetes & Endocrinology

Hepatitis C virus inhibits AKT-tuberous sclerosis complex (TSC), the mechanistic target of rapamycin (MTOR) pathway, through endoplasmic reticulum stress to induce autophagy

(2012) He Huang et al.   Autophagy

Adipocytes Secrete Leukotrienes: Contribution to Obesity-Associated Inflammation and Insulin Resistance in Mice

(2012) I. Mothe-Satney et al.   DIABETES

Helicobacter pylori Infection Is Associated With an Increased Rate of Diabetes

(2012) C. Y. Jeon et al.   DIABETES CARE

The inflammation highway: metabolism accelerates inflammatory traffic in obesity

(2012) Amy R. Johnson et al.   IMMUNOLOGICAL REVIEWS

Endotoxin increase after fat overload is related to postprandial hypertriglyceridemia in morbidly obese patients

(2012) M. Clemente-Postigo et al.   JOURNAL OF LIPID RESEARCH

Prediabetes: a high-risk state for diabetes development

(2012) Adam G Tabák et al.   LANCET

A metagenome-wide association study of gut microbiota in type 2 diabetes

(2012) Junjie Qin et al.   NATURE

JNK Expression by Macrophages Promotes Obesity-Induced Insulin Resistance and Inflammation

(2012) M. S. Han et al.   SCIENCE

Relationship between hepatitis C virus infection and type 2 diabetes mellitus: Meta-analysis

(2012) Cho Naing   WORLD JOURNAL OF GASTROENTEROLOGY

High Fat Intake Leads to Acute Postprandial Exposure to Circulating Endotoxin in Type 2 Diabetic Subjects

(2011) A. L. Harte et al.   DIABETES CARE

The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue

(2011) Tim B. Koenen et al.   ENDOCRINOLOGY

Impact of time since last caloric intake on blood glucose levels

(2011) Susanne Moebus et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Adiponectin is a negative regulator of antigen-activated T cells

(2011) Sabrina Wilk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

Leptin Activates Human B Cells to Secrete TNF-α, IL-6, and IL-10 via JAK2/STAT3 and p38MAPK/ERK1/2 Signaling Pathway

(2011) Sudhanshu Agrawal et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Insulin resistance is associated with a higher risk of hepatocellular carcinoma in cirrhotic HIV/HCV-co-infected patients: Results from ANRS CO13 HEPAVIH

(2011) Dominique Salmon et al.   JOURNAL OF HEPATOLOGY

Hepatitis C Virus Infection Promotes Hepatic Gluconeogenesis through an NS5A-Mediated, FoxO1-Dependent Pathway

(2011) L. Deng et al.   JOURNAL OF VIROLOGY

National, regional, and global trends in fasting plasma glucose and diabetes prevalence since 1980: systematic analysis of health examination surveys and epidemiological studies with 370 country-years and 2·7 million participants

(2011) Goodarz Danaei et al.   LANCET

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Eosinophils Sustain Adipose Alternatively Activated Macrophages Associated with Glucose Homeostasis

(2011) D. Wu et al.   SCIENCE

Viral effects on metabolism: changes in glucose and glutamine utilization during human cytomegalovirus infection

(2011) Yongjun Yu et al.   TRENDS IN MICROBIOLOGY

Toward quantifying the usage costs of human immunity: Altered metabolic rates and hormone levels during acute immune activation in men

(2010) Michael P. Muehlenbein et al.   AMERICAN JOURNAL OF HUMAN BIOLOGY

Ceramide Is Increased in the Lower Airway Epithelium of People with Advanced Cystic Fibrosis Lung Disease

(2010) Malcolm Brodlie et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Review: Energy regulation and neuroendocrine-immune control in chronic inflammatory diseases

(2010) R. H. Straub et al.   JOURNAL OF INTERNAL MEDICINE

Human Cytomegalovirus Activates Glucose Transporter 4 Expression To Increase Glucose Uptake during Infection

(2010) Y. Yu et al.   JOURNAL OF VIROLOGY

Role of Leptin in the Activation of Immune Cells

(2010) Patricia Fernández-Riejos et al.   MEDIATORS OF INFLAMMATION

Prevalence of Infection With Adenovirus-36 in Belgium and Holland and Association With Obesity

(2010) Richard L. Atkinson   Obesity

Enhanced hepatitis C virus genome replication and lipid accumulation mediated by inhibition of AMP-activated protein kinase

(2010) J. Mankouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus

(2009) R. A. DeFronzo   DIABETES

Molecular physiology of weight regulation in mice and humans

(2009) R L Leibel   INTERNATIONAL JOURNAL OF OBESITY

Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: an analysis from the Whitehall II study

(2009) Adam G Tabák et al.   LANCET

Intensive versus Conventional Glucose Control in Critically Ill Patients

(2009)   NEW ENGLAND JOURNAL OF MEDICINE

Antiatherosclerotic and Anti-Insulin Resistance Effects of Adiponectin: Basic and Clinical Studies

(2009) Seung Hwan Han et al.   PROGRESS IN CARDIOVASCULAR DISEASES

The Role of Anorexia in Resistance and Tolerance to Infections in Drosophila

(2009) Janelle S. Ayres et al.   PLOS BIOLOGY

Four grams of glucose

(2008) David H. Wasserman   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

Energy Restriction Impairs Natural Killer Cell Function and Increases the Severity of Influenza Infection in Young Adult Male C57BL/6 Mice

(2008) Barry W. Ritz et al.   JOURNAL OF NUTRITION

Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy

(2008) Joshua Munger et al.   NATURE BIOTECHNOLOGY

Diabetes Mellitus Increases the Risk of Active Tuberculosis: A Systematic Review of 13 Observational Studies

(2008) Christie Y Jeon et al.   PLOS MEDICINE

Insulin Resistance in Chronic Hepatitis C: Association With Genotypes 1 and 4, Serum HCV RNA Level, and Liver Fibrosis

(2007) Rami Moucari et al.   GASTROENTEROLOGY