Article
Multidisciplinary Sciences
Anke Schumann, Marion Brutsche, Monique Havermans, Sarah C. Gruenert, Stefan Koelker, Olaf Gross, Luciana Hannibal, Ute Spiekerkoetter
Summary: Methylmalonic aciduria (MMA-uria) is a condition caused by a lack of the enzyme methylmalonyl-CoA mutase (MUT) in mitochondria. It affects energy generation from certain amino acids, fatty acids, and cholesterol. Chronic kidney disease (CKD) is a known complication of MMA-uria. Research has shown that MMA-uria cells have increased creatinine levels and decreased antioxidant defense. Mitochondrial homeostasis is disrupted, with changes in metabolites and impaired energy generation from fatty acid oxidation. Potentially toxic metabolite methylcitrate is increased under high protein and isoleucine/valine conditions. Mitophagy is disabled, while autophagy is active, especially under high protein and isoleucine/valine conditions. Mitochondrial dynamics shift towards fission and the stress-resistance protein Sirtuin1 is down-regulated. Overall, these findings highlight the role of protein toxicity and provide insight into how accumulating toxic organic acids may contribute to CKD in MMA-uria.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Chaohua Tang, Shuang Li, Kai Zhang, Jing Li, Yunsheng Han, Qingyu Zhao, Xiaoqing Guo, Yuchang Qin, Jingdong Yin, Junmin Zhang
Summary: A study using a pig model investigates the effects of selenium deficiency on the heart. The study reveals that selenium deficiency leads to cardiac oxidative stress, disordered energy production, lipid metabolic vulnerabilities, and inflammation initiation pathways. These findings provide potential targets for treating cardiac diseases induced by redox imbalance.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Biochemical Research Methods
Peijie Shen, Suyi Gu, Dou Jin, Yu Su, Hongxuan Wu, Qingchen Li, Jinhua Yang, Wenjin He, Jianzhong Huang, Feng Qi
Summary: In this study, an optimized heterologous serotonin biosynthetic pathway was engineered in E. coli, coupled with the biosynthetic and regeneration modules of tetrahydrobiopterin (BH4). By further metabolic engineering efforts, an adequate endogenous BH4 supply was ensured. Using the optimized fed-batch fermentation, a high level of serotonin production was achieved, demonstrating the potential of E. coli for industrial applications.
ACS SYNTHETIC BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiapeng Hu, Ruiwei Ding, Shaozhuang Liu, Jia Wang, Jianjun Li, Yunxiao Shang
Summary: This study found that RNF125 gene expression was downregulated in the bronchial epithelium of asthma patients and mice, and this low expression was caused by hypermethylation of the Rnf125 gene. Furthermore, it was found that RNF125 could inhibit autophagy and oxidative stress, and protect the epithelial barrier. This study revealed that the hypermethylation of the Rnf125 gene reduced its expression, thereby promoting autophagy-induced oxidative stress in asthma by increasing HMGB1 stability.
Article
Medicine, Research & Experimental
Mithilesh Kumar Jha, Joseph Passero, Atul Rawat, Xanthe Heifetz Ament, Fang Yang, Svetlana Vidensky, Samuel L. Collins, Maureen R. Horton, Ahmet Hoke, Guy A. Rutter, Alban Latremoliere, Jeffrey D. Rothstein, Brett M. Morrison
Summary: Macrophages play a critical role in peripheral nerve response to injury, with their metabolism dependent on genes like MCT1 influencing nerve regeneration speed. Manipulating macrophage metabolism through MCT1 may enhance recovery from peripheral nerve injuries, potentially offering new therapeutic approaches where approved medical therapies are lacking.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Koichiro Kawaguchi, Kaori Komoda, Ryuta Mikawa, Azusa Asai, Masataka Sugimoto
Summary: Research has found that cellular senescence can promote the metastatic development of melanoma through seCad, suggesting that seCad may serve as a potential diagnostic marker and therapeutic target for metastatic lung cancer.
Article
Biochemistry & Molecular Biology
Kyeoung-Hwa Kim, Kyung-Ah Lee
Summary: This study identified the effects of human placenta-derived mesenchymal stem cell therapy on aging, including weight loss, increased insulin-like growth factor-I levels, altered metabolites and protein levels, and the therapeutic targeting of serotonin for reversing aging-associated liver degeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Chih-Ming Chen, Chien-Chen Wu, Chin-Lin Huang, Min-Yu Chang, Shih-Hsuan Cheng, Ching-Ting Lin, Ying-Chieh Tsai
Summary: This study demonstrated that Lactobacillus plantarum PS128 can promote intestinal motility, increase mucin production, and regulate serotonin signal transduction, leading to a laxative effect in mice.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2022)
Article
Endocrinology & Metabolism
Chia-Chu Liu, Shu-Pin Huang, Yung-Chin Lee, Cheng-Hsueh Lee, Tsung-Yi Huang, Jiun-Hung Geng, Che-Wei Chang, Chung-Yu Lin, Yung-Shun Juan, Wen-Jeng Wu, Tusty-Jiuan Hsieh
Summary: The study found an association between metabolic dysfunction-associated fatty liver disease (MAFLD) and testosterone deficiency (TD) in aging Taiwanese men, particularly in those without metabolic syndrome (MetS). This suggests that MAFLD could serve as an early predictor of TD, facilitating the identification of high-risk individuals and enabling timely interventions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Gastroenterology & Hepatology
Yuta Sugiyama, Yumiko Mori, Misaki Nara, Yusuke Kotani, Emiko Nagai, Hiroki Kawada, Mayu Kitamura, Rika Hirano, Hiromi Shimokawa, Akira Nakagawa, Hiromichi Minami, Aina Gotoh, Mikiyasu Sakanaka, Noriho Iida, Takashi Koyanagi, Takane Katayama, Shigefumi Okamoto, Shin Kurihara
Summary: Gut microbiota can produce aromatic amines, which are different from dietary sources. The production of these aromatic amines is related to the activity of aadc in gut bacteria and may have an impact on diseases such as osteoporosis and irritable bowel syndrome. Human AADC inhibitors can inhibit the production of aromatic amines in gut bacteria.
Article
Multidisciplinary Sciences
Leandro R. Soria, Georgios Makris, Alfonso M. D'Alessio, Angela De Angelis, Iolanda Boffa, Veronica M. Pravata, Veronique Rufenacht, Sergio Attanasio, Edoardo Nusco, Paola Arena, Andrew T. Ferenbach, Debora Paris, Paola Cuomo, Andrea Motta, Matthew Nitzahn, Gerald S. Lipshutz, Ainhoa Martinez-Pizarro, Eva Richard, Lourdes R. Desviat, Johannes Haeberle, Daan M. F. van Aalten, Nicola Brunetti-Pierri
Summary: Hyperammonemia, a life-threatening condition, occurs in liver diseases affecting ureagenesis. This study demonstrates that increased liver UDP-GlcNAc during hyperammonemia leads to O-GlcNAcylation of CPS1, enhancing ureagenesis and ammonia detoxification. The authors also find that pharmacological increase of protein O-GlcNAcylation reduces hyperammonemia in mouse models of liver disease. These findings suggest that hepatic O-GlcNAcylation of CPS1 could be a novel target for therapy of hyperammonemia in both genetic and acquired liver diseases.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Katsunori Nonogaki
Summary: Central and peripheral serotonin play a regulatory role in feeding signals and energy metabolism. Disruption of central 5-HT signaling leads to hyperphagia and metabolic diseases. High-fat and high-carbohydrate diets increase plasma 5-HT and FGF21 levels. Upregulation of peripheral 5-HT is associated with the development of metabolic diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Egle Danileviciute, Ni Zeng, Christophe M. Capelle, Nicole Paczia, Mark A. Gillespie, Henry Kurniawan, Mohaned Benzarti, Myriam P. Merz, Djalil Coowar, Sabrina Fritah, Daniela Maria Vogt Weisenhorn, Gemma Gomez Giro, Melanie Grusdat, Alexandre Baron, Coralie Guerin, Davide G. Franchina, Cathy Leonard, Olivia Domingues, Sylvie Delhalle, Wolfgang Wurst, Jonathan D. Turner, Jens Christian Schwamborn, Johannes Meiser, Rejko Krueger, Jeff Ranish, Dirk Brenner, Carole L. Linster, Rudi Balling, Markus Ollert, Feng Q. Hefeng
Summary: In this study, the researchers found that the protein DJ-1 plays a crucial role in regulating PDH activity in T-reg cells, especially in aged mice. This discovery provides new insights into the regulation of the PDH complex and suggests the DJ-1-PDHB axis as a potential target for maintaining or re-establishing T-reg homeostasis.
Article
Oncology
Shuai Zhang, Zhi-Mei Cheng, Jia-L Yu, Kai Lu, Sheng-Jie Xu, Yuan Lu, Ting Liu, Bai-Juan Xia, Zhi Huang, Xu-Ya Zhao, Wei He, Jun-Xiang Li, Wei Cao, Yu Huang, Ling Wang, Zhu Zeng, Xun Zou, Rong Liu, Yu-Sui Zhang, Xiao-Ping Wu, Tian-Peng Jiang, Shi Zhou
Summary: The study found that ME2 plays an oncogenic role in HCC by promoting cell growth and migration, as well as increasing triglyceride production. Inhibition of ME2 can slow down the progression of HCC.
Article
Biochemistry & Molecular Biology
Weiyun Wang, Shaofang Ren, Yunkun Lu, Xi Chen, Juanjuan Qu, Xiaojie Ma, Qian Deng, Zhensheng Hu, Yan Jin, Ziyu Zhou, Wenyan Ge, Yibing Zhu, Nannan Yang, Qin Li, Jiaqi Pu, Guo Chen, Cunqi Ye, Hao Wang, Xiaoyang Zhao, Zhiqiang Liu, Saiyong Zhu
Summary: Inhibition of spleen tyrosine kinase (Syk) by R406 enhances mouse chemical reprogramming by upregulating glycine level and transsulfuration cysteine biosynthesis, promoting cysteine metabolism and cellular hydrogen sulfide (H2S) production, which leads to decreased oxidative phosphorylation and ROS levels, ultimately enhancing the efficiency of chemical reprogramming.
Article
Pharmacology & Pharmacy
Yangyang Yu, Zhenhe Huang, Zhuo Mao, Yarui Zhang, Meiling Jin, Wenwen Chen, Wei Zhang, Bo Yu, Weizhen Zhang, Hang Yung Alaster Lau
EUROPEAN JOURNAL OF PHARMACOLOGY
(2016)
Article
Cell Biology
Meiling Jin, Bo Yu, Weizhen Zhang, Wei Zhang, Zhangang Xiao, Zhuo Mao, Yihong Lai, Dongxu Lin, Qiang Ma, En Pan, Yarui Zhang, Yangyang Yu
INTEGRATIVE BIOLOGY
(2016)
Article
Medicine, Research & Experimental
Meiling Jin, Sun Young Park, Qian Shen, Yihong Lai, Xingmei Ou, Zhuo Mao, Dongxu Lin, Yangyang Yu, Weizhen Zhang
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Zhuo Mao, Weizhen Zhang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Cell Biology
Jia Li, Zhuo Mao, Jiandong Huang, Jun Xia
MOLECULAR BIOLOGY OF THE CELL
(2018)
Article
Multidisciplinary Sciences
Xiumao Li, Zhuo Mao, Min Wu, Jun Xia
SCIENTIFIC REPORTS
(2013)
Article
Biochemistry & Molecular Biology
Mian Cao, Zhuo Mao, Chuen Kam, Nan Xiao, Xiaoxing Cao, Chong Shen, Kenneth K. Y. Cheng, Aimin Xu, Kwong-Man Lee, Liwen Jiang, Jun Xia
Review
Cell Biology
Wen Su, Zhuo Mao, Yiao Liu, Xiaoyan Zhang, Weizhen Zhang, Jan-Ake Gustafsson, Youfei Guan
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Cell Biology
Zhuo Mao, Qing Yang, Wenzhen Yin, Wen Su, Hui Lin, Mingji Feng, Ke Pan, Yue Yin, Weizhen Zhang
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Zhuo Mao, Mingji Feng, Zhuoran Li, Minsi Zhou, Langning Xu, Ke Pan, Shaoxiang Wang, Wen Su, Weizhen Zhang
Summary: ETV5, identified as a novel transcription factor, plays a crucial role in regulating hepatic fatty acid metabolism by enhancing PPAR signaling and fatty acid degradation pathways. Depletion of ETV5 leads to increased lipid accumulation in the liver, suggesting ETV5 may serve as a therapeutic target for hepatic steatosis.
Article
Pharmacology & Pharmacy
Wen Su, Mingji Feng, Yuan Liu, Rong Cao, Yiao Liu, Junyao Tang, Ke Pan, Rongfeng Lan, Zhuo Mao
Summary: Deficiency of ZnT8 in mice alleviates APAP-induced liver injury by inhibiting oxidative stress and promoting hepatocyte proliferation.
FRONTIERS IN PHARMACOLOGY
(2021)