Improving glucocorticoid replacement profiles in adrenal insufficiency

Circadian rhythm of glucocorticoid administration entrains clock genes in immune cells: a DREAM trial ancillary study

(2018) Mary Anna Venneri et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adrenal disease: Imitating the cortisol profile improves the immune system

(2018) Lisa Müller et al.   Nature Reviews Endocrinology

Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man

(2018) K. Kalafatakis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of once-daily, modified-release hydrocortisone versus standard glucocorticoid therapy on metabolism and innate immunity in patients with adrenal insufficiency (DREAM): a single-blind, randomised controlled trial

(2018) Andrea M Isidori et al.   Lancet Diabetes & Endocrinology

Higher glucocorticoid replacement doses are associated with increased mortality in patients with pituitary adenoma

(2017) Casper Hammarstrand et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Primary adrenal insufficiency is associated with impaired natural killer cell function: a potential link to increased mortality

(2017) Irina Bancos et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Ultradian glucocorticoid exposure directs gene-dependent and tissue-specific mRNA expression patterns in vivo

(2017) Charlotte L. George et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Stress-Related and Circadian Secretion and Target Tissue Actions of Glucocorticoids: Impact on Health

(2017) Nicolas C. Nicolaides et al.   Frontiers in Endocrinology

Prednisolone has the same cardiovascular risk profile as hydrocortisone in glucocorticoid replacement

(2017) David J F Smith et al.   Endocrine Connections

Low-dose hydrocortisone replacement is associated with improved arterial stiffness index and blood pressure dynamics in severely adrenocorticotrophin-deficient hypopituitary male patients

(2016) Lucy-Ann Behan et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Dynamic Pituitary-Adrenal Interactions in Response to Cardiac Surgery*

(2015) Ben Gibbison et al.   CRITICAL CARE MEDICINE

Glucocorticoids entrain molecular clock components in human peripheral cells

(2015) Marc Cuesta et al.   FASEB JOURNAL

Adrenal Insufficiency in Australia: Is it Possible that the Use of Lower Dose, Short-Acting Glucocorticoids has Increased the Risk of Adrenal Crises?

(2015) R. Rushworth et al.   HORMONE AND METABOLIC RESEARCH

A Phase 2 Study of Chronocort, a Modified-Release Formulation of Hydrocortisone, in the Treatment of Adults With Classic Congenital Adrenal Hyperplasia

(2015) Ashwini Mallappa et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High Incidence of Adrenal Crisis in Educated Patients With Chronic Adrenal Insufficiency: A Prospective Study

(2015) Stefanie Hahner et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Subcutaneous pulsatile glucocorticoid replacement therapy

(2014) Georgina M. Russell et al.   CLINICAL ENDOCRINOLOGY

Continuous Subcutaneous Hydrocortisone Infusion Therapy in Addison's Disease: A Randomized, Placebo-Controlled Clinical Trial

(2014) Lucia Gagliardi et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Continuous Subcutaneous Hydrocortisone Infusion versus Oral Hydrocortisone Replacement for Treatment of Addison's Disease: A Randomized Clinical Trial

(2014) Marianne Øksnes et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Adrenal insufficiency

(2014) Evangelia Charmandari et al.   LANCET

Deconvolution of Serum Cortisol Levels by Using Compressed Sensing

(2014) Rose T. Faghih et al.   PLoS One

The importance of dynamic signalling for endocrine regulation and drug development: relevance for glucocorticoid hormones

(2014) Stafford Lightman et al.   Lancet Diabetes & Endocrinology

An oral multiparticulate, modified-release, hydrocortisone replacement therapy that provides physiological cortisol exposure

(2013) Martin J. Whitaker et al.   CLINICAL ENDOCRINOLOGY

Exposure to Shift Work as a Risk Factor for Diabetes

(2013) Timothy H. Monk et al.   JOURNAL OF BIOLOGICAL RHYTHMS

The Origin of Glucocorticoid Hormone Oscillations

(2012) Jamie J. Walker et al.   PLOS BIOLOGY

Improved Cortisol Exposure-Time Profile and Outcome in Patients with Adrenal Insufficiency: A Prospective Randomized Trial of a Novel Hydrocortisone Dual-Release Formulation

(2011) G. Johannsson et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Peripheral CLOCK Regulates Target-Tissue Glucocorticoid Receptor Transcriptional Activity in a Circadian Fashion in Man

(2011) Evangelia Charmandari et al.   PLoS One

Stress Responsiveness Varies over the Ultradian Glucocorticoid Cycle in a Brain-Region-Specific Manner

(2010) Ratna A. Sarabdjitsingh et al.   ENDOCRINOLOGY

The crucial role of pulsatile activity of the HPA axis for continuous dynamic equilibration

(2010) Stafford L. Lightman et al.   NATURE REVIEWS NEUROSCIENCE

Origin of ultradian pulsatility in the hypothalamic-pituitary-adrenal axis

(2010) J. J. Walker et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Hypothalamic-Pituitary-Adrenal Axis Activation in Obstructive Sleep Apnea: The Effect of Continuous Positive Airway Pressure Therapy

(2009) David E. Henley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ACTH Deficiency, Higher Doses of Hydrocortisone Replacement, and Radiotherapy Are Independent Predictors of Mortality in Patients with Acromegaly

(2009) M. Sherlock et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Ultradian hormone stimulation induces glucocorticoid receptor-mediated pulses of gene transcription

(2009) Diana A. Stavreva et al.   NATURE CELL BIOLOGY