Deuterated Curcuminoids: Synthesis, Structures, Computational/Docking and Comparative Cell Viability Assays against Colorectal Cancer

Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

(2018) Panchanan Maiti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Novel fluorinated curcuminoids and their pyrazole and isoxazole derivatives: Synthesis, structural studies, Computational/Docking and in-vitro bioassay

(2018) Kenneth K. Laali et al.   JOURNAL OF FLUORINE CHEMISTRY

Curcumin induces apoptosis and cell cycle arrest via the activation of reactive oxygen species–independent mitochondrial apoptotic pathway in Smad4 and p53 mutated colon adenocarcinoma HT29 cells

(2018) Ayushi Agarwal et al.   NUTRITION RESEARCH

Synthesis, Computational Docking Study, and Biological Evaluation of a Library of Heterocyclic Curcuminoids with Remarkable Antitumor Activity

(2018) Kenneth K. Laali et al.   ChemMedChem

GPNMB methylation: a new marker of potentially carcinogenic colon lesions

(2018) Hassan Ashktorab et al.   BMC CANCER

Curcuminoid Demethylation as an Alternative Metabolism by Human Intestinal Microbiota

(2017) Supawadee Burapan et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Structural analyses of human thymidylate synthase reveal a site that may control conformational switching between active and inactive states

(2017) Dan Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis of deuterium-enriched and fluorine-substituted plinabulin derivatives and evaluation of their antitumor activities

(2017) Zhongpeng Ding et al.   MOLECULAR DIVERSITY

B(C6F5)3-Catalyzed Regioselective Deuteration of Electron-Rich Aromatic and Heteroaromatic Compounds

(2017) Wu Li et al.   ORGANIC LETTERS

Fluoro-curcuminoids and curcuminoid-BF 2 adducts: Synthesis, X-ray structures, bioassay, and computational/docking study

(2016) Kenneth K. Laali et al.   JOURNAL OF FLUORINE CHEMISTRY

Design and Performance Validation of a Conductively Heated Sealed-Vessel Reactor for Organic Synthesis

(2016) David Obermayer et al.   JOURNAL OF ORGANIC CHEMISTRY

Deuterated drugs draw heavier backing

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

RAF inhibitors that evade paradoxical MAPK pathway activation

(2015) Chao Zhang et al.   NATURE

Biological and therapeutic activities, and anticancer properties of curcumin

(2015) DONATELLA PERRONE et al.   Experimental and Therapeutic Medicine

SHELXT– Integrated space-group and crystal-structure determination

(2015) George M. Sheldrick   Acta Crystallographica A-Foundation and Advances

Curcumin Suppresses Proliferation of Colon Cancer Cells by Targeting CDK2

(2014) T.-G. Lim et al.   Cancer Prevention Research

Deuterated drugs: where are we now?

(2014) Graham S Timmins   EXPERT OPINION ON THERAPEUTIC PATENTS

Standing the test of time: targeting thymidylate biosynthesis in cancer therapy

(2014) Peter M. Wilson et al.   Nature Reviews Clinical Oncology

Recent developments in chemistry and biology of curcumin analogues

(2014) Khemraj Bairwa et al.   RSC Advances

Dissecting the Pharmacophore of Curcumin. Which Structural Element Is Critical for Which Action?

(2013) Alberto Minassi et al.   JOURNAL OF NATURAL PRODUCTS

Design and Synthesis of Curcumin Analogues for in Vivo Fluorescence Imaging and Inhibiting Copper-Induced Cross-Linking of Amyloid Beta Species in Alzheimer’s Disease

(2013) Xueli Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

(2013) Andrew J Souers et al.   NATURE MEDICINE

Curcumin Modulates DNA Methylation in Colorectal Cancer Cells

(2013) Alexander Link et al.   PLoS One

Curcumin Analogues with Potent and Selective Anti-proliferative Activity on Acute Promyelocytic Leukemia: Involvement of Accumulated Misfolded Nuclear Receptor Co-repressor (N-CoR) Protein as a Basis for Selective Activity

(2012) Kheng-Lin Tan et al.   ChemMedChem

Multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects

(2012) Adrian L Lopresti et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Molecular conformations, interactions, and properties associated with drug efficiency and clinical performance among VEGFR TK inhibitors

(2012) M. McTigue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Analysis of the Mechanism of Inhibition and Allosteric Activation of the Kinase Domain of HER2 Protein

(2011) Kathleen Aertgeerts et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

Optimization of a series of dipeptides with a P3 threonine residue as non-covalent inhibitors of the chymotrypsin-like activity of the human 20S proteasome

(2010) Christopher Blackburn et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin Inhibits the Proteasome Activity in Human Colon Cancer Cells In vitro and In vivo

(2008) V. Milacic et al.   CANCER RESEARCH

Anti cancer effects of curcumin: cycle of life and death

(2008) Gaurisankar Sa et al.   Cell Division