Article
Pharmacology & Pharmacy
Bin Pan, Lin Zheng, Jiawei Fang, Ye Lin, Hehuan Lai, Jiawei Gao, Wenzheng Pan, Yejin Zhang, Kainan Ni, Chao Lou, Dengwei He
Summary: Azilsartan inhibits osteoclastogenesis by reducing ROS production and may serve as a novel treatment strategy for osteoporosis caused by osteoclast overactivation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Xiaohui Su, Wanyi Guo, Bei Yuan, Dong Wang, Liling Liu, Xuan Wu, Yanqiong Zhang, Xiangying Kong, Na Lin
Summary: Artesunate (ARS) acts as an effective antioxidant by inhibiting ROS production and activating the Nrf2/p62 signaling pathway, which can suppress osteoclastogenesis and ameliorate arthritic bone erosion.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Nanoscience & Nanotechnology
Bolin Bao, Hanghang Liu, Yaobao Han, Liyao Xu, Wei Xing, Zhen Li
Summary: In this study, we have discovered that PVP-stabilized and quercetin-functionalized ultrasmall Cu2-xSe nanoparticles (CSPQ NPs) can effectively eliminate excess reactive oxygen species (ROS) and activate nuclear factor erythroid 2-related factor 2 (Nrf2) protein, leading to reduced cellular oxidative stress and improved renal function. These ultrasmall nanoparticles demonstrate great biocompatibility, allowing for rapid accumulation in the injured kidney. This research highlights the potential of simultaneous elimination of ROS and activation of intracellular Nrf2 in the treatment of acute kidney injury (AKI).
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biochemistry & Molecular Biology
Qimeng Wang, Xuyun Peng, Yifan Chen, Xiaoyan Tang, Yunfei Qin, Mian He, Wenjie Chen, Hui Chen
Summary: Acetaminophen (APAP) overdose is the leading cause of acute liver failure (ALF) in developed countries and has limited treatment options. The study found that APAP upregulated the expression of Piezo1, a mechanosensitive cation channel, in both an APAP-induced acute liver injury (ALI) animal model and a mouse hepatocyte cell line. Activating Piezo1 with its activator Yoda1 reduced APAP-induced liver toxicity and oxidative stress. Mechanistically, Piezo1 activation led to the accumulation of the antioxidant regulator Nrf2 and upregulation of its target genes Nqo1 and Gsta1. Inhibition of Piezo1 downregulated this pathway. Injection of Yoda1 decreased liver injury and improved liver function in the APAP-induced ALI mouse model. These findings reveal a previously unknown protective role of Piezo1 in APAP-induced ALI and provide a potential new therapeutic target.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Hiroko P. Indo, Daisuke Masuda, Sompong Sriburee, Hiromu Ito, Ikuo Nakanishi, Ken-ichiro Matsumoto, Samlee Mankhetkorn, Moragot Chatatikun, Sirirat Surinkaew, Lunla Udomwech, Fumitaka Kawakami, Takafumi Ichikawa, Hirofumi Matsui, Jitbanjong Tangpong, Hideyuki J. Majima
Summary: This study aims to prove that mitochondrial reactive oxygen species (mtROS) can be released from mitochondria and initiate cellular signals in the nucleus. By comparing two cell lines with different levels of mtROS, the researchers found differential expression of various cellular signal proteins. Transfection of human MnSOD in the cell line with higher mtROS levels resulted in a decrease in the expression of these signal proteins, suggesting the involvement of mtROS in cellular signals in the nucleus.
Review
Endocrinology & Metabolism
Jie Han, Kuan Yang, Jinyang An, Na Jiang, Songbo Fu, Xulei Tang
Summary: Bone metabolism is closely related to oxidative stress, and NRF2, as a core regulatory factor, plays a complex and controversial role in bone homeostasis. Moderate activation of NRF2 promotes increased bone mass, while hyperactivation may cause damage to bone formation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Yeonjin Ko, Mannkyu Hong, Seungbeom Lee, Manoj Kumar, Lara Ibrahim, Kayla Nutsch, Caroline Stanton, Braddock Sandoval, Phillip Sondermann, Maya L. Bulos, Jonathan Iaconelli, Arnab K. Chatterjee, R. Luke Wiseman, Peter G. Schultz, Michael J. Bollong
Summary: sAKZ692, a small molecule, activates the transcriptional activity of NRF2 in cells by inhibiting the pyruvate kinase enzyme. This leads to the accumulation of glyceraldehyde 3-phosphate, which modifies cysteine residues of KEAP1, resulting in increased NRF2-dependent transcription.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Marine & Freshwater Biology
Dongwu Liu, Xue Wu, Cun Hu, Yujie Zeng, Qiuxiang Pang
Summary: In this study, zebrafish were exposed to different concentrations of neodymium for four weeks. The results showed that neodymium accumulated in fish gill and affected the balance of nutrient elements. Neodymium decreased antioxidant enzymes' activity and gene expression, but increased the generation of reactive oxygen species. In addition, neodymium treatments inhibited Nrf2 signaling in gill. Interfering gsk-3 beta gene in zebrafish under neodymium exposure induced Nrf2 signaling and the expression and activity of antioxidant enzymes in fish gill. Overall, neodymium could accumulate in fish gill and GSK-3 beta/Nrf2 signaling was involved in regulating ROS generation under neodymium treatments.
AQUATIC TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaohan Yang, Chao Li, Gongchang Yu, Lei Sun, Sumei Guo, Linlin Sai, Cunxiang Bo, Caihong Xing, Hua Shao, Cheng Peng, Qiang Jia
Summary: This study identified the underlying molecular mechanism of benzene-induced hematopoietic toxicity. The results showed that hydroquinone (HQ) activates aryl hydrocarbon receptor (AhR), leading to DNA damage and apoptosis in human lymphocytes. Additionally, the study revealed that HQ-induced AhR activation and its toxic effects can be mitigated by antioxidant N-acetyl-L-cysteine (NAC).
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, Research & Experimental
Yusuf Hussain, Jyoti Singh, Waseem Raza, Abha Meena, Sangam Rajak, Rohit Anthony Sinha, Suaib Luqman
Summary: The study explored the antioxidative mechanism of purpurin under the influence of alcohol, demonstrating its ability to reduce ROS levels and restore antioxidant enzyme activity. Purpurin alleviated alcohol-induced liver toxicity by activating antioxidant signaling pathways and suppressing oxidative stress.
Article
Environmental Sciences
Yuan Wen, Zhaowei Wang, Yonghui Cai, Mengxi Song, Kemin Qi, Xiaoyun Xie
Summary: This study successfully prepared a highly efficient BiVO4/CQDs/beta-FeOOH photocatalyst and revealed its mechanism. The photocatalyst showed significantly improved removal efficiency of ofloxacin under visible-light irradiation and exhibited good reusability. Additionally, the study also reported for the first time the phenomenon of directional transformation of reactive groups in the photocatalysis process under different pH conditions.
Article
Chemistry, Multidisciplinary
Zilong Li, Qianwen Zhao, Yunjie Lu, Yangxi Zhang, Luyang Li, Min Li, Xuemin Chen, Donglin Sun, Yunfei Duan, Yong Xu
Summary: This study elucidates a novel mechanism by which BRG1 regulates ROS accumulation, identifying DDIT4 as a transcriptional target of BRG1 and showing that it drives ROS production through facilitating the assembly of the p38-MAPK signaling complex via S-nitrosylation. Additionally, bioactive compounds interacting with DDIT4 are identified and confirmed to attenuate hepatic ROS production and ameliorate liver injury by influencing DDIT4 S-nitrosylation. Moreover, a positive correlation between ROS levels and BRG1/DDIT4/S-nitrosylated DDIT4 levels is observed in human liver biopsy specimens.
Article
Biochemistry & Molecular Biology
Dong-Gyun Hong, Ga Yeon Song, Cheol Bin Eom, Jae-Hee Ahn, Sun Myoung Kim, Aeri Shim, Yong-Hyun Han, Yoon-Seok Roh, Chang Yeob Han, Eun Ju Bae, Hyun-Jeong Ko, Yoon Mee Yang
Summary: This study reveals the increased expression of ERdj5 in alcoholic liver disease patients and mice. Mice lacking Dnajc10 are more susceptible to alcohol-induced liver injury and hepatic steatosis. Additionally, Dnajc10 depletion worsens oxidative stress and decreases Nrf2 pathway and glutathione contents, providing protection against liver damage.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Paula Rhana, Guilherme Mendes Barros, Vinicius Cisneiros de Oliveira Santos, Alexandre Dantas Costa, Danillo Menezes dos Santos, Weslley Fernandes-Braga, Aimee Obolari Durco, Marcio Roberto Viana Santos, Danilo Roman-Campos, Carla Maria Lins de Vasconcelos, Jader Santos Cruz, Diego Santos Souza
Summary: This study aimed to investigate the cardioprotective effects of s-limonene in an isoproterenol-induced myocardial infarction (MI) animal model and the underlying mechanisms. The results showed that s-limonene attenuated isoproterenol-induced MI injury by inhibiting increased Ca2+ and attenuating oxidative stress through the CaMKII pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Review
Agronomy
Rupal Singh Tomar, Sunita Kataria, Anjana Jajoo
Summary: This article explores the recent research on signaling and mechanisms for salt tolerance in plants, focusing on the role of the salt overly sensitive system (SOS) and related antiporters proteins and mitogen-activated protein kinase cascades under salt stress. It also highlights the differential expression of various antioxidative enzymes in C3, C4 and CAM plants.
JOURNAL OF AGRONOMY AND CROP SCIENCE
(2021)
Article
Toxicology
Jianping Mao, Wenbin Dai, Shuya Zhang, Lanlan Sun, Hanxun Wang, Yinli Gao, Jian Wang, Fengjiao Zhang
ARCHIVES OF TOXICOLOGY
(2019)
Article
Medicine, Legal
Hao Wu, Huan Wang, Feng Xu, Jiepeng Chen, Lili Duan, Fengjiao Zhang
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2019)
Review
Pharmacology & Pharmacy
Baichun Hu, Xiaoming Zheng, Ying Wang, Jian Wang, Fengjiao Zhang
CURRENT DRUG TARGETS
(2020)
Article
Biochemistry & Molecular Biology
Ying Wang, Johnson Joseph, Yinli Gao, Baichun Hu, Xiaohui Geng, Di Wu, Jian Wang, Fengjiao Zhang
Summary: The study investigated the interaction modes between 5-HT2A receptor and its antagonists, and identified potential dual-target molecules, providing new insights for the development of anti-psychotic drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Pharmacology & Pharmacy
Tingting Zhang, Miaomiao Zhou, Danxia Huang, Zhaohui Sun, Bi Ao, Feng Xu, Fengjiao Zhang
Summary: This study investigates the involvement of progesterone (P4) injections in the adverse local effects observed during assisted reproduction. The results suggest that repeated vehicle oil injections can lead to nociception-related behaviors, induration formation, and dorsal root ganglion (DRG) damage. Interestingly, P4 injections cause more nociception-related behaviors and induration occurrence, which can be relieved by ketoprofen (Ket). Furthermore, P4 significantly elevates inflammatory factor levels and upregulates Na(v)1.8 in DRG, indicating its role in stimulating inflammation and DRG damage.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2023)
Article
Chemistry, Medicinal
Ying Wang, Huan Wang, Yupeng Zhang, Feng Xu, Jian Wang, Fengjiao Zhang
Summary: This study utilized a computational strategy to investigate the cleavage events of Nattokinase (NK) and identified thrombin as a novel biological substrate of NK. This discovery expands our understanding of the comprehensive antithrombus mechanism of NK and provides support for the development of feature drugs.
JOURNAL OF CHEMICAL INFORMATION AND MODELING
(2022)
Article
Chemistry, Medicinal
Jianping Mao, Dong Wang, Ping Xu, Ying Wang, Haoyu Zhang, Shiyu Wang, Feng Xu, Jian Wang, Fengjiao Zhang
Summary: This study revealed the role of CYP1B1 in Taxol resistance and cancer migration/invasion, and also contributed to the discovery of CYP1B1-targeted anticancer drugs.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Hao Wu, Qian Zhang, Pu Xu, Jiepeng Chen, Lili Duan, Feng Xu, Fengjiao Zhang
Summary: The therapeutic potential of nattokinase (NK) in treating post-stroke cognitive impairment (PSCI) is explored in this study. The research demonstrates that NK protects against acute ischemic stroke and promotes neurogenesis in rat models, leading to improved cognitive functions. The study highlights the role of the blood factor irisin as a novel target of NK and its potential impact on the peripheral blood-to-brain axis.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Haoyu Zhang, Ping Xu, Ting Wang, Shiyu Wang, Weixia Li, Jianping Mao, Jian Wang, Fengjiao Zhang, Maosheng Cheng
Summary: In this study, a highly potent and selective CYP1B1 inhibitor C9 was obtained by structural modification, with an inhibitory activity of 2.7 nM against CYP1B1, and more than 37037 and 7407 fold selectivity over CYP1A1 and 1A2, respectively. Furthermore, C9 effectively restored the sensitivity of Taxol to A549/Taxol cells and inhibited cell migration. Molecular docking and molecular dynamics simulations showed that C9 formed necessary interactions in binding to CYP1B1 and could remain relatively stable.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Jianping Mao, Dong Wang, Ping Xu, Ying Wang, Haoyu Zhang, Shiyu Wang, Feng Xu, Jian Wang, Fengjiao Zhang
Summary: The overexpression of CYP1B1 in Taxol-resistant cells and its correlation with AKT/ERK1/2 and focal adhesion pathways suggest its important role in drug resistance and cancer migration/invasion. The novel CYP1B1-selective inhibitors show potential in reversing Taxol resistance and inhibiting cell migration/invasion.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Physical
Ying Wang, Baichun Hu, Yupeng Zhang, Dong Wang, Zhaohu Luo, Jian Wang, Fengjiao Zhang
Summary: The study found that the selectivity between CYP1A1 and CYP1B1 mainly depends on the sustainability of pi-pi stacking interactions with phenylalanine residues. Structural flexibility of protein domains orchestrates this interaction, determining binding selectivity. Modification of naphthoflavone compounds to satisfy pi-pi stacking interactions of key phenylalanine residues in CYP1B1 could improve inhibitory selectivity.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Multidisciplinary
Yi Zhao, Ying Wang, Huibin Wang, Baichun Hu, Zhaohu Luo, Fengjiao Zhang
Summary: The study revealed the structural differences between CB1 and CB2 receptors, highlighting the importance of binding pocket shape in determining ligand selectivity. Strategies to improve selectivity towards CB2, such as increasing molecular size and optimizing hydrogen bond interactions, were proposed based on the key residues that determine receptor selectivity. This information provides a promising foundation for the future design of selective inhibitors targeting CB2.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Xiaohui Geng, Ying Wang, Huibin Wang, Baichun Hu, Junhao Huang, Yiheng Wu, Jian Wang, Fengjiao Zhang
Summary: 5-HT2AR and 5-HT2CR, widely expressed in the brain, are important targets for antipsychotic and addiction medications, as well as depression and addiction treatments. Analysis of their structure and chemical properties revealed key residues contributing to selectivity, providing insights for designing selective inhibitors.
MOLECULAR SYSTEMS DESIGN & ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Huibin Wang, Ying Wang, Chunshi Li, Hanxun Wang, Xiaohui Geng, Baichun Hu, Rui Wen, Jian Wang, Fengjiao Zhang
Summary: The PI3K alpha and beta isoforms share a similar ATP binding site but have different effects on tumor growth. By studying the interaction modes of selective inhibitors, it was found that certain amino acids play a significant role in determining the selective inhibition mechanism of PI3K alpha and beta. This research sheds light on potential strategies for designing selective inhibitors for PI3K alpha and beta.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sotirios P. Fortis, Anthimia Batrinou, Hara T. Georgatzakou, Ioannis Tsamesidis, Grigorios Alvanidis, Effie G. Papageorgiou, Kontantinos Stamoulis, Dimitrios Gkiliopoulos, Georgia K. Pouroutzidou, Anna Theocharidou, Eleana Kontonasaki, Anastasios G. Kriebardis
Summary: This study evaluated the compatibility of human blood cells with silica-based mesoporous nanomaterials (MSNs) manufactured using the solgel method, with Ca and Ce as doping elements. The results showed that these nanomaterials had no impact on the viability of lymphocytes and monocytes, but reduced the viability of granulocytes. Additionally, the expression of Pselectin in platelets and the level of internal reactive oxygen species increased when exposed to MSNs. The presence of Ce in the MSNs improved their hemocompatibility to some extent. Further research is needed to understand how MSNs may affect different blood components and design safe and effective MSNs for biomedical applications.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Retraction
Biochemistry & Molecular Biology
Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini Zhao
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yuting Chen, Lin Chen, Shiheng Zhu, Hui Yang, Zhongming Ye, Huanhuan Wang, Haipeng Wu, Yao Wu, Qian Sun, Xiaoshan Liu, Hairong Liang, Huanwen Tang
Summary: This study investigates the impact of exosomal derived miR-1246 from HQ-transformed cells on cell-to-cell communication in recipient TK6 cells. The results show that exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuping Yu, Yaming Mu, Kai Wang, Ling Wang, Chunying Wang, Zexin Yang, Yu Liu, Shuxian Li, Meihua Zhang
Summary: Fetal growth restriction (FGR) is a common complication in obstetrics, and its exact cause is unknown. In this study, we constructed 1-NP exposed pregnant mice models and found that 1-NP induced FGR. Additionally, we observed significant ferroptosis in placental trophoblasts from 1-NP exposed mice and human FGR patients. Using in vitro cell models, we demonstrated that 1-NP impaired trophoblast biological function and induced cellular ferroptosis. We also identified the ERK signaling pathway and CYP1B1 as key regulators of 1-NP-induced ferroptosis. This study provides new insights into the aetiology of FGR and the reproductive toxicity of environmental pollutants.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Lei Hou, Yingying Zhao, Shiyu Zhao, Xuexia Zhang, Xia Yao, Jianjun Yang, Ziteng Wang, Shuaibing Liu
Summary: This study systematically characterized the UGTs enzymes involved in the formation of M4 and the inhibitory effects of ciprofol and its metabolite M4 on P450s enzymes. In vitro-in vivo extrapolation and PBPK simulations were performed to predict potential drug-drug interactions caused by ciprofol.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Disheng Liu, Lu Wang, Wuhua Ha, Kan Li, Rong Shen, Degui Wang
Summary: Renal fibrosis is a common outcome of renal injuries, characterized by structural destruction and functional decline of the kidneys. Hypoxia induces the activation of HIF-1 alpha, which regulates cellular metabolism, proliferation, apoptosis, and inflammation, contributing to the development of renal fibrosis. Understanding the regulation and cascade reactions mediated by HIF-1 alpha can provide new insights for studying the mechanism of renal fibrosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Sheng Chen, Hanqing Xu, Yi He, Chen Meng, Yunhui Fan, Yunkun Qu, Yingguang Wang, Wei Zhou, Xiaojian Huang, Hongbo You
Summary: Osteoarthritis is a heterogeneous disease that affects the entire joint. This study found that Carveol can reverse the inflammatory state of macrophages, promote their anti-inflammatory effects, and protect cartilage by activating the NRF2/HO-1/NQO1 pathway and reducing ROS clearance. The results also showed that Carveol can alleviate the pathological changes of osteoarthritis in mice, suggesting its potential therapeutic efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Liyi Wei, Tingting Wang, Mingcui Luo, Shuai Zhang, Mengxi Lu, Xinli Zhou, Xuelei Cheng, Hui Wang, Dan Xu
Summary: This study found that azithromycin during pregnancy may have toxic effects on fetal hippocampal development, especially in the late pregnancy, high dose, and multi-course situation. The results also suggest that the SOX2/Wnt signaling pathway may be involved in this toxicity.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Di Wu, Faheem Ahmed Khan, Kejia Zhang, Nuruliarizki Shinta Pandupuspitasari, Windu Negara, Kaifeng Guan, Fei Sun, Chunjie Huang
Summary: Retinoic acid (RA) is a signaling molecule derived from vitamin A/retinol, with implications in various aspects of health and disease. It regulates cell functioning through both transcriptional and non-genomic mechanisms, influencing cell-fate determination, neurogenesis, visual function, inflammatory responses, and gametogenesis commitment.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Review
Biochemistry & Molecular Biology
Bilal Murtaza, Lili Wang, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Aisha Khatoon, Xu Yongping
Summary: Mycotoxins in food pose significant concerns for food safety and public health, potentially causing a range of adverse symptoms and cancer development. Deoxynivalenol (DON) is particularly worrisome due to its harm to vital organs. Altered mycotoxins present possible risks to the environment and well-being, necessitating further research into their adverse consequences. Accurately assessing the risk posed by modified mycotoxins remains challenging.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Emine Toraman, Buesra Budak, Cemil Bayram, Selma Sezen, Behzad Mokhtare, Ahmet Hacimueftueoglu
Summary: The study suggests that parthenolide (PTL) may have therapeutic effects in treating testicular toxicity caused by paclitaxel (PTX) through reducing oxidative stress and increasing glutathione levels. PTL also promotes the expression of genes involved in reproduction and sperm production.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Correction
Biochemistry & Molecular Biology
Cuicui Zhuang, Hui Huo, Wanfa Fu, Wanyue Huang, Lulu Han, Miao Song, Yanfei Li
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Taotao Zhao, Jia Lv, Mingyuan Peng, Jiahui Mi, Shaosan Zhang, Jie Liu, Tong Chen, Zilong Sun, Ruiyan Niu
Summary: This study explores the protective effects of fecal microbiota transplantation (FMT) and short-chain fatty acids (SCFAs) supplementation on learning and memory impairment caused by fluoride exposure in mice. The results show that FMT and SCFAs can improve memory deficits and alleviate pathological damages caused by fluoride, possibly by activating the BDNF-PI3K/AKT pathway. Furthermore, the disordered gut microbiome caused by fluoride can be restored through frequent FMT.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Biochemistry & Molecular Biology
Yong Liu, Zhaofei Pang, Yadong Wang, Jichang Liu, Guanghui Wang, Jiajun Du
Summary: This study reveals that silencing PKD2 promotes ferroptosis in LUAD by increasing reactive oxygen species, malondialdehyde accumulation, intracellular iron content and cell death. Overexpression of PKD2 prevents autophagic degradation of ferritin and promotes proliferation, migration and invasion of LUAD cells. Moreover, targeting PKD2 enhances the efficacy of carboplatin through ferroptosis and apoptosis in LUAD.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)