MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies
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Title
MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies
Authors
Keywords
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Journal
ONCOGENE
Volume 35, Issue 13, Pages 1609-1618
Publisher
Springer Nature
Online
2015-06-29
DOI
10.1038/onc.2015.216
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Related references
Note: Only part of the references are listed.- MicroRNAs as regulators and mediators of c-MYC function
- (2015) Rene Jackstadt et al. Biochimica et Biophysica Acta-Gene Regulatory Mechanisms
- Organoid Models of Human and Mouse Ductal Pancreatic Cancer
- (2015) Sylvia F. Boj et al. CELL
- Plasticity and Dedifferentiation within the Pancreas: Development, Homeostasis, and Disease
- (2015) Sapna Puri et al. Cell Stem Cell
- Whole genomes redefine the mutational landscape of pancreatic cancer
- (2015) Nicola Waddell et al. NATURE
- c-MYC and SIRT1 locked in a vicious cycle
- (2015) Oncotarget
- Drugging MYCN through an Allosteric Transition in Aurora Kinase A
- (2014) William Clay Gustafson et al. CANCER CELL
- Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States
- (2014) L. Rahib et al. CANCER RESEARCH
- Loss of Fbw7 Reprograms Adult Pancreatic Ductal Cells into α, δ, and β Cells
- (2014) Rocio Sancho et al. Cell Stem Cell
- Pancreatic cancer genomics
- (2014) David K Chang et al. CURRENT OPINION IN GENETICS & DEVELOPMENT
- Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase
- (2014) S. Peter et al. EMBO Molecular Medicine
- USP22 is a positive regulator of NFATc2 on promoting IL2 expression
- (2014) Yayi Gao et al. FEBS LETTERS
- A modular and flexible ESC-based mouse model of pancreatic cancer
- (2014) M. Saborowski et al. GENES & DEVELOPMENT
- A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression
- (2014) N. Okada et al. GENES & DEVELOPMENT
- miR-494 acts as an anti-oncogene in gastric carcinoma by targeting c-myc
- (2014) Weiling He et al. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
- Therapeutic Effects of an Anti-Myc Drug on Mouse Pancreatic Cancer
- (2014) Dimitris Stellas et al. JNCI-Journal of the National Cancer Institute
- BET Bromodomain Inhibitors Block Growth of Pancreatic Cancer Cells in Three-Dimensional Collagen
- (2014) V. Sahai et al. MOLECULAR CANCER THERAPEUTICS
- Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles
- (2014) Susanne Walz et al. NATURE
- A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
- (2014) Nina Schönhuber et al. NATURE MEDICINE
- The interaction of MYC with the trithorax protein ASH2L promotes gene transcription by regulating H3K27 modification
- (2014) A. Ullius et al. NUCLEIC ACIDS RESEARCH
- MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib
- (2014) Matthias Wirth et al. NUCLEIC ACIDS RESEARCH
- Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas
- (2014) Irene Ischenko et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- miR-34 Cooperates with p53 in Suppression of Prostate Cancer by Joint Regulation of Stem Cell Compartment
- (2014) Chieh-Yang Cheng et al. Cell Reports
- Oncogenic Mechanisms in Burkitt Lymphoma
- (2014) R. Schmitz et al. Cold Spring Harbor Perspectives in Medicine
- Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven Cancers
- (2014) S. Cermelli et al. Cold Spring Harbor Perspectives in Medicine
- Therapeutic Strategies to Inhibit MYC
- (2014) M. R. McKeown et al. Cold Spring Harbor Perspectives in Medicine
- MYC Activation Is a Hallmark of Cancer Initiation and Maintenance
- (2014) M. Gabay et al. Cold Spring Harbor Perspectives in Medicine
- An Overview of MYC and Its Interactome
- (2014) M. Conacci-Sorrell et al. Cold Spring Harbor Perspectives in Medicine
- miRNA dysregulation in cancer: towards a mechanistic understanding
- (2014) Jayanth Kumar Palanichamy et al. Frontiers in Genetics
- Inhibition of oncogenic Pim-3 kinase modulates transformed growth and chemosensitizes pancreatic cancer cells to gemcitabine
- (2013) Dapeng Xu et al. CANCER BIOLOGY & THERAPY
- Small Molecule Inhibitors of Aurora-A Induce Proteasomal Degradation of N-Myc in Childhood Neuroblastoma
- (2013) Markus Brockmann et al. CANCER CELL
- Discovery and Characterization of Super-Enhancer-Associated Dependencies in Diffuse Large B Cell Lymphoma
- (2013) Bjoern Chapuy et al. CANCER CELL
- Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer
- (2013) W.-c. Lin et al. CANCER RESEARCH
- Efficacy of BET Bromodomain Inhibition in Kras-Mutant Non-Small Cell Lung Cancer
- (2013) T. Shimamura et al. CLINICAL CANCER RESEARCH
- Roles for KRAS in Pancreatic Tumor Development and Progression
- (2013) Marina Pasca di Magliano et al. GASTROENTEROLOGY
- Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice
- (2013) L. Soucek et al. GENES & DEVELOPMENT
- Signatures of mutational processes in human cancer
- (2013) Ludmil B. Alexandrov et al. NATURE
- Pan-cancer patterns of somatic copy number alteration
- (2013) Travis I Zack et al. NATURE GENETICS
- Emerging landscape of oncogenic signatures across human cancers
- (2013) Giovanni Ciriello et al. NATURE GENETICS
- miRNA and mRNA cancer signatures determined by analysis of expression levels in large cohorts of patients
- (2013) S. Zadran et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Role of MIZ-1 in MYC-Dependent Tumorigenesis
- (2013) K. E. Wiese et al. Cold Spring Harbor Perspectives in Medicine
- Neuroblastoma and MYCN
- (2013) M. Huang et al. Cold Spring Harbor Perspectives in Medicine
- Role of MYC in Medulloblastoma
- (2013) M. F. Roussel et al. Cold Spring Harbor Perspectives in Medicine
- BET bromodomain inhibition targets both c-Myc and IL7R in high-risk acute lymphoblastic leukemia
- (2012) C. J. Ott et al. BLOOD
- Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family
- (2012) Panagis Filippakopoulos et al. CELL
- MYC expression and distribution in normal mature lymphoid cells
- (2012) Giorgio Cattoretti JOURNAL OF PATHOLOGY
- Dual inhibition of Janus and Src family kinases by novel indirubin derivative blocks constitutively-activated Stat3 signaling associated with apoptosis of human pancreatic cancer cells
- (2012) Sangkil Nam et al. Molecular Oncology
- Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
- (2012) Andrew V. Biankin et al. NATURE
- Deregulated MYC expression induces dependence upon AMPK-related kinase 5
- (2012) Lidan Liu et al. NATURE
- Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB
- (2012) K Ogami et al. ONCOGENE
- Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
- (2011) Georg Feldmann et al. CANCER BIOLOGY & THERAPY
- BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
- (2011) Jake E. Delmore et al. CELL
- Immunology in the clinic review series; focus on cancer: multiple roles for the immune system in oncogene addiction
- (2011) P. Bachireddy et al. CLINICAL AND EXPERIMENTAL IMMUNOLOGY
- MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors
- (2011) Hiroshi Tazawa et al. EXPERT OPINION ON BIOLOGICAL THERAPY
- Genome profiling of pancreatic adenocarcinoma
- (2011) David J. Birnbaum et al. GENES CHROMOSOMES & CANCER
- Pancreatic ductal adenocarcinoma and acinar cells: a matter of differentiation and development?
- (2011) Ilse Rooman et al. GUT
- Acinar-to-ductal metaplasia accompanies c-myc-induced exocrine pancreatic cancer progression in transgenic rodents
- (2011) Paul J. Grippo et al. INTERNATIONAL JOURNAL OF CANCER
- Disruption of a Nuclear NFATc2 Protein Stabilization Loop Confers Breast and Pancreatic Cancer Growth Suppression by Zoledronic Acid
- (2011) Shiv K. Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Origin of pancreatic ductal adenocarcinoma from atypical flat lesions: a comparative study in transgenic mice and human tissues
- (2011) Michaela Aichler et al. JOURNAL OF PATHOLOGY
- RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
- (2011) Johannes Zuber et al. NATURE
- miR-34 miRNAs provide a barrier for somatic cell reprogramming
- (2011) Yong Jin Choi et al. NATURE CELL BIOLOGY
- Key contribution of CPEB4-mediated translational control to cancer progression
- (2011) Elena Ortiz-Zapater et al. NATURE MEDICINE
- Mutant K-Ras increases GSK-3β gene expression via an ETS-p300 transcriptional complex in pancreatic cancer
- (2011) J-S Zhang et al. ONCOGENE
- Multiple Wnt/ß-Catenin Responsive Enhancers Align with the MYC Promoter through Long-Range Chromatin Loops
- (2011) Gregory S. Yochum PLoS One
- c-Myc Regulates Transcriptional Pause Release
- (2010) Peter B. Rahl et al. CELL
- Virtual Ligand Screening of the p300/CBP Histone Acetyltransferase: Identification of a Selective Small Molecule Inhibitor
- (2010) Erin M. Bowers et al. CHEMISTRY & BIOLOGY
- Suppression of Aurora-A oncogenic potential by c-Myc downregulation
- (2010) Shangbin Yang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Regulator of Calcineurin 1 Controls Growth Plasticity of Adult Pancreas
- (2010) Grzegorz T. Gurda et al. GASTROENTEROLOGY
- The interaction between Myc and Miz1 is required to antagonize TGF -dependent autocrine signaling during lymphoma formation and maintenance
- (2010) J. van Riggelen et al. GENES & DEVELOPMENT
- Sequential Activation of NFAT and c-Myc Transcription Factors Mediates the TGF-β Switch from a Suppressor to a Promoter of Cancer Cell Proliferation
- (2010) Garima Singh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Selective inhibition of BET bromodomains
- (2010) Panagis Filippakopoulos et al. NATURE
- Curcumin and Gemcitabine in Patients With Advanced Pancreatic Cancer
- (2010) Ron Epelbaum et al. NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
- Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
- (2010) D. Yang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma
- (2010) P. K. Mazur et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- p38 MAPK/MK2-mediated induction of miR-34c following DNA damage prevents Myc-dependent DNA replication
- (2010) I. G. Cannell et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- MYC-Induced Cancer Cell Energy Metabolism and Therapeutic Opportunities
- (2009) C. V. Dang et al. CLINICAL CANCER RESEARCH
- Conditional inactivation of Myc impairs development of the exocrine pancreas
- (2008) H. Nakhai et al. DEVELOPMENT
- Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice
- (2008) Claire Bonal et al. GASTROENTEROLOGY
- Myc's broad reach
- (2008) M. Eilers et al. GENES & DEVELOPMENT
- LY2109761, a novel transforming growth factor receptor type I and type II dual inhibitor, as a therapeutic approach to suppressing pancreatic cancer metastasis
- (2008) D. Melisi et al. MOLECULAR CANCER THERAPEUTICS
- Modelling Myc inhibition as a cancer therapy
- (2008) Laura Soucek et al. NATURE
- miR-34a repression of SIRT1 regulates apoptosis
- (2008) M. Yamakuchi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses
- (2008) S. Jones et al. SCIENCE
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