The origins and functions of hepatic polyploidy

Polyploidy in tissue homeostasis and regeneration

(2018) Jan Inge Øvrebø et al.   DEVELOPMENT

Myocardial Polyploidization Creates a Barrier to Heart Regeneration in Zebrafish

(2018) Juan Manuel González-Rosa et al.   DEVELOPMENTAL CELL

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

(2018) Shuyuan Zhang et al.   DEVELOPMENTAL CELL

Distributed hepatocytes expressing telomerase repopulate the liver in homeostasis and injury

(2018) Shengda Lin et al.   NATURE

Chromosome Segregation Fidelity in Epithelia Requires Tissue Architecture

(2018) Kristin A. Knouse et al.   CELL

Cholangiocytes act as facultative liver stem cells during impaired hepatocyte regeneration

(2017) Alexander Raven et al.   NATURE

The evolutionary significance of polyploidy

(2017) Yves Van de Peer et al.   NATURE REVIEWS GENETICS

Fueling the Cell Division Cycle

(2017) María Salazar-Roa et al.   TRENDS IN CELL BIOLOGY

Metabolic zonation of the liver: The oxygen gradient revisited

(2017) Thomas Kietzmann   Redox Biology

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent–induced mitotic arrest

(2017) Yasuo Tsuda et al.   Scientific Reports

Evolutionary consequences of polyploidy in prokaryotes and the origin of mitosis and meiosis

(2016) Alexander V. Markov et al.   Biology Direct

Dynamic zonation of liver polyploidy

(2016) Sivan Tanami et al.   CELL AND TISSUE RESEARCH

MicroRNA-122 regulates polyploidization in the murine liver

(2016) Shu-hao Hsu et al.   HEPATOLOGY

The Yeast Cyclin-Dependent Kinase Routes Carbon Fluxes to Fuel Cell Cycle Progression

(2016) Jennifer C. Ewald et al.   MOLECULAR CELL

Mfsd2a+ hepatocytes repopulate the liver during injury and regeneration

(2016) Wenjuan Pu et al.   Nature Communications

Hybrid Periportal Hepatocytes Regenerate the Injured Liver without Giving Rise to Cancer

(2015) Joan Font-Burgada et al.   CELL

Polyploidy in Amphibia

(2015) Michael Schmid et al.   CYTOGENETIC AND GENOME RESEARCH

Functional Reprogramming of Polyploidization in Megakaryocytes

(2015) Marianna Trakala et al.   DEVELOPMENTAL CELL

Hepatocyte homeostasis for chromosome ploidization and liver function is regulated by Ssu72 protein phosphatase

(2015) Se-Hyuk Kim et al.   HEPATOLOGY

The expanding implications of polyploidy

(2015) Kevin P. Schoenfelder et al.   JOURNAL OF CELL BIOLOGY

Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease

(2015) Géraldine Gentric et al.   JOURNAL OF CLINICAL INVESTIGATION

The number of polyploid giant cancer cells and epithelial-mesenchymal transition-related proteins are associated with invasion and metastasis in human breast cancer

(2015) Fei Fei et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Bursty Gene Expression in the Intact Mammalian Liver

(2015) Keren Bahar Halpern et al.   MOLECULAR CELL

Self-renewing diploid Axin2+ cells fuel homeostatic renewal of the liver

(2015) Bruce Wang et al.   NATURE

Polyploidy can drive rapid adaptation in yeast

(2015) Anna M. Selmecki et al.   NATURE

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence

(2015) Grazyna Mosieniak et al.   NEOPLASIA

Nonadditive Gene Expression in Polyploids

(2014) Mi-Jeong Yoo et al.   Annual Review of Genetics

TALEN-Mediated Somatic Mutagenesis in Murine Models of Cancer

(2014) S. Zhang et al.   CANCER RESEARCH

Cytokinesis Failure Triggers Hippo Tumor Suppressor Pathway Activation

(2014) Neil J. Ganem et al.   CELL

Identification of Transcriptional and Metabolic Programs Related to Mammalian Cell Size

(2014) Teemu P. Miettinen et al.   CURRENT BIOLOGY

Reversal of hepatocyte senescence after continuousin vivocell proliferation

(2014) Min-Jun Wang et al.   HEPATOLOGY

Clonal tracing of Sox9+liver progenitors in mouse oval cell injury

(2014) Branden D. Tarlow et al.   HEPATOLOGY

Single cell sequencing reveals low levels of aneuploidy across mammalian tissues

(2014) Kristin A. Knouse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence against a Stem Cell Origin of New Hepatocytes in a Common Mouse Model of Chronic Liver Injury

(2014) Johanna R. Schaub et al.   Cell Reports

Polyploidization in Liver Tissue

(2013) Géraldine Gentric et al.   AMERICAN JOURNAL OF PATHOLOGY

Abnormal mitosis triggers p53-dependent cell cycle arrest in human tetraploid cells

(2013) Christian Kuffer et al.   CHROMOSOMA

Liver repopulation and regeneration

(2013) Andrew W. Duncan et al.   Current Opinion in Organ Transplantation

Polyploidy in Animals: Effects of Gene Expression on Sex Determination, Evolution and Ecology

(2013) B. Wertheim et al.   CYTOGENETIC AND GENOME RESEARCH

Evolutionary Consequences, Constraints and Potential of Polyploidy in Plants

(2013) H. Weiss-Schneeweiss et al.   CYTOGENETIC AND GENOME RESEARCH

Unusual chromatin status and organization of the inactive X chromosome in murine trophoblast giant cells

(2013) C. Corbel et al.   DEVELOPMENT

Hepatic loss of survivin impairs postnatal liver development and promotes expansion of hepatic progenitor cells in mice

(2013) Dan Li et al.   HEPATOLOGY

p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver

(2013) Svitlana Kurinna et al.   HEPATOLOGY

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells

(2013) B. Rengstl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polyploids Exhibit Higher Potassium Uptake and Salinity Tolerance in Arabidopsis

(2013) D.-Y. Chao et al.   SCIENCE

Aneuploidy, polyploidy and ploidy reversal in the liver

(2013) Andrew W. Duncan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Telomere-Driven Tetraploidization Occurs in Human Cells Undergoing Crisis and Promotes Transformation of Mouse Cells

(2012) Teresa Davoli et al.   CANCER CELL

Hypertrophy and Unconventional Cell Division of Hepatocytes Underlie Liver Regeneration

(2012) Yuichiro Miyaoka et al.   CURRENT BIOLOGY

Aneuploidy as a mechanism for stress-induced liver adaptation

(2012) Andrew W. Duncan et al.   JOURNAL OF CLINICAL INVESTIGATION

Absolute quantification of somatic DNA alterations in human cancer

(2012) Scott L Carter et al.   NATURE BIOTECHNOLOGY

Canonical and atypical E2Fs regulate the mammalian endocycle

(2012) Hui-Zi Chen et al.   NATURE CELL BIOLOGY

E2F8 is essential for polyploidization in mammalian cells

(2012) Shusil K. Pandit et al.   NATURE CELL BIOLOGY

Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration

(2012) M. K. Diril et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Causes and Consequences of Polyploidy in Normal Development and Cancer

(2011) Teresa Davoli et al.   Annual Review of Cell and Developmental Biology

Correcting for cancer genome size and tumour cell content enables better estimation of copy number alterations from next-generation sequence data

(2011) Arief Gusnanto et al.   BIOINFORMATICS

Embryonic Ductal Plate Cells Give Rise to Cholangiocytes, Periportal Hepatocytes, and Adult Liver Progenitor Cells

(2011) Rodolphe Carpentier et al.   GASTROENTEROLOGY

Frequent Aneuploidy Among Normal Human Hepatocytes

(2011) Andrew W. Duncan et al.   GASTROENTEROLOGY

Ancestral polyploidy in seed plants and angiosperms

(2011) Yuannian Jiao et al.   NATURE

Cyclin G1 regulates the outcome of taxane-induced mitotic checkpoint arrest

(2011) P Russell et al.   ONCOGENE

Persistent Telomere Damage Induces Bypass of Mitosis and Tetraploidy

(2010) Teresa Davoli et al.   CELL

Polyploidy and liver proliferation: Central role of insulin signaling

(2010) Séverine Celton-Morizur et al.   CELL CYCLE

Regulation of Cardiomyocyte Polyploidy and Multinucleation by CyclinG1

(2010) Zhipei Liu et al.   CIRCULATION RESEARCH

Death effector domain–containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice

(2010) Mayumi Mori et al.   JOURNAL OF CLINICAL INVESTIGATION

The ploidy conveyor of mature hepatocytes as a source of genetic variation

(2010) Andrew W. Duncan et al.   NATURE

Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine

(2010) Kenichiro Furuyama et al.   NATURE GENETICS

Aneuploid Chromosomes Are Highly Unstable during DNA Transformation ofCandida albicans

(2009) Kelly Bouchonville et al.   EUKARYOTIC CELL

Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer

(2009) W Brian Dalton et al.   Future Oncology

Aberrant Cell Cycle Progression and Endoreplication in Regenerating Livers of Mice That Lack a Single E-Type Cyclin

(2009) Yulia A. Nevzorova et al.   GASTROENTEROLOGY

Endoreplication: polyploidy with purpose

(2009) H. O. Lee et al.   GENES & DEVELOPMENT

Megakaryocyte endomitosis is a failure of late cytokinesis related to defects in the contractile ring and Rho/Rock signaling

(2008) L. Lordier et al.   BLOOD

Differentiation of trophoblast stem cells into giant cells is triggered by p57/Kip2 inhibition of CDK1 activity

(2008) Z. Ullah et al.   GENES & DEVELOPMENT

Cell fusion is a physiological process in mouse liver

(2008) Francesca Faggioli et al.   HEPATOLOGY