The multifaceted roles of FOXM1 in pulmonary disease

Endothelial and Smooth Muscle Cell Interaction via FoxM1 Signaling Mediates Vascular Remodeling and Pulmonary Hypertension

(2018) Zhiyu Dai et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

How Many Foxs Are There on the Road to Pulmonary Hypertension?

(2018) Kurt R Stenmark et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

FABP4 induces asthmatic airway epithelial barrier dysfunction via ROS-activated FoxM1

(2018) Gaohui Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Long non-coding RNA LINC00339 facilitates the tumorigenesis of non-small cell lung cancer by sponging miR-145 through targeting FOXM1

(2018) Yuan Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

FOXM1 regulates radiosensitivity of lung cancer cell partly by upregulating KIF20A

(2018) Guanghong Xiu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

FOXM1 is a critical driver of lung fibroblast activation and fibrogenesis

(2018) Loka R. Penke et al.   JOURNAL OF CLINICAL INVESTIGATION

The FOXO3-FOXM1 axis: A key cancer drug target and a modulator of cancer drug resistance

(2018) Shang Yao et al.   SEMINARS IN CANCER BIOLOGY

FoxM1-dependent RAD51 and BRCA2 signaling protects idiopathic pulmonary fibrosis fibroblasts from radiation-induced cell death

(2018) Jintaek Im et al.   Cell Death & Disease

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Regulation of the master regulator FOXM1 in cancer

(2018) Guo-Bin Liao et al.   Cell Communication and Signaling

Smooth muscle cell-specific FoxM1 controls hypoxia-induced pulmonary hypertension

(2018) Jingbo Dai et al.   CELLULAR SIGNALLING

The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury

(2018) Zheng Cui et al.   MATRIX BIOLOGY

Upregulation of FoxM1 by MnSOD Overexpression Contributes to Cancer Stem-Like Cell Characteristics in the Lung Cancer H460 Cell Line

(2018) Zhimin Fu et al.   TECHNOLOGY IN CANCER RESEARCH & TREATMENT

FOXM1 promotes pulmonary artery smooth muscle cell expansion in pulmonary arterial hypertension

(2017) Alice Bourgeois et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

First-line ceritinib versus platinum-based chemotherapy in advanced ALK -rearranged non-small-cell lung cancer (ASCEND-4): a randomised, open-label, phase 3 study

(2017) Jean-Charles Soria et al.   LANCET

Should recommendations about starting inhaled corticosteroid treatment for mild asthma be based on symptom frequency: a post-hoc efficacy analysis of the START study

(2017) Helen K Reddel et al.   LANCET

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice

(2017) Lifeng Sun et al.   Science Signaling

DT-13 synergistically enhanced vinorelbine-mediated mitotic arrest through inhibition of FOXM1-BICD2 axis in non-small-cell lung cancer cells

(2017) Hongyang Li et al.   Cell Death & Disease

MicroRNA-134 reverses multidrug resistance in human lung adenocarcinoma cells by targeting FOXM1

(2017) Jipeng Li et al.   Oncology Letters

FOXM1 activates AGR2 and causes progression of lung adenomas into invasive mucinous adenocarcinomas

(2017) David Milewski et al.   PLoS Genetics

The FOXM1 inhibitor RCM-1 suppresses goblet cell metaplasia and prevents IL-13 and STAT6 signaling in allergen-exposed mice

(2017) Lifeng Sun et al.   Science Signaling

FoxM1 inhibition enhances chemosensitivity of docetaxel-resistant A549 cells to docetaxel via activation of JNK/mitochondrial pathway

(2016) Ke Wang et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

The Tumor Suppressive Role of MiRNA-509-5p by Targeting FOXM1 in Non-Small Cell Lung Cancer

(2016) Ning Ma et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Endothelial p110γPI3K Mediates Endothelial Regeneration and Vascular Repair After Inflammatory Vascular InjuryCLINICAL PERSPECTIVE

(2016) Xiaojia Huang et al.   CIRCULATION

β-catenin and Kras/Foxm1 signaling pathway are critical to restrict Sox9 in basal cells during pulmonary branching morphogenesis

(2016) Vladimir Ustiyan et al.   DEVELOPMENTAL DYNAMICS

Dupilumab: a potential new treatment for severe asthma

(2016) Kian Fan Chung   LANCET

COPD therapy: if two is good, is three better?

(2016) Peter M A Calverley   LANCET

Gene expression profile of oxidative stress and antioxidant defense in lung tissue of patients exposed to sulfur mustard

(2016) Eisa Tahmasbpour et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer

(2016) Hiroyuki Inoue et al.   Oncotarget

Foxm1 Regulates Resolution of Hyperoxic Lung Injury in Newborns

(2015) Hongping Xia et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

2nd ESMO Consensus Conference in Lung Cancer: locally advanced stage III non-small-cell lung cancer

(2015) W. E. E. Eberhardt et al.   ANNALS OF ONCOLOGY

Is there potential to target FOXM1 for ‘undruggable’ lung cancers?

(2015) Vladimir V Kalinichenko et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains

(2015) Maciej Cabanski et al.   INFLAMMATION RESEARCH

FOXM1 Promotes Lung Adenocarcinoma Invasion and Metastasis by Upregulating SNAIL

(2015) Ping Wei et al.   International Journal of Biological Sciences

A Novel Function of Molecular Chaperone HSP70

(2015) Marianna Halasi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Current concepts in targeting chronic obstructive pulmonary disease pharmacotherapy: making progress towards personalised management

(2015) Prescott G Woodruff et al.   LANCET

Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC

(2015) R. Nagel et al.   MOLECULAR CANCER THERAPEUTICS

CD44 is functionally crucial for driving lung cancer stem cells metastasis through Wnt/β-catenin-FoxM1-Twist signaling

(2015) Jie Su et al.   MOLECULAR CARCINOGENESIS

The prognostic landscape of genes and infiltrating immune cells across human cancers

(2015) Andrew J Gentles et al.   NATURE MEDICINE

Translating the transcriptome into tools for the early detection and prevention of lung cancer: Figure 1

(2015) Yaron B Gesthalter et al.   THORAX

Different expression of FoxM1 in human benign and malignant pleural effusion

(2014) Zhonghao Tang et al.   MEDICAL ONCOLOGY

Pro-proliferative and inflammatory signaling converge on FoxO1 transcription factor in pulmonary hypertension

(2014) Rajkumar Savai et al.   NATURE MEDICINE

Overexpression of FOXM1 is associated with EMT and is a predictor of poor prognosis in non-small cell lung cancer

(2014) FEI-FEI KONG et al.   ONCOLOGY REPORTS

FOXM1 Regulated by ERK Pathway MediatesTGF-β1-Induced EMT in NSCLC

(2014) Fei-Fei Kong et al.   ONCOLOGY RESEARCH

Endothelial FoxM1 Mediates Bone Marrow Progenitor Cell-Induced Vascular Repair and Resolution of Inflammation following Inflammatory Lung Injury

(2014) Yidan D. Zhao et al.   STEM CELLS

Involvement of FoxM1 in Non-Small Cell Lung Cancer Recurrence

(2013) Nuo Xu et al.   Asian Pacific Journal of Cancer Prevention

FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer

(2013) Chao Yang et al.   CANCER LETTERS

Foxm1 transcription factor is required for lung fibrosis and epithelial-to-mesenchymal transition

(2013) David Balli et al.   EMBO JOURNAL

How can we optimise concurrent chemoradiotherapy for inoperable stage III non-small cell lung cancer?

(2013) Neil Bayman et al.   LUNG CANCER

FOX(M1) News--It Is Cancer

(2013) M. Halasi et al.   MOLECULAR CANCER THERAPEUTICS

At the frontiers of lung fibrosis therapy

(2013)   NATURE BIOTECHNOLOGY

First-in-class guanylate cyclase stimulator approved for PAH

(2013) Malini Guha   NATURE BIOTECHNOLOGY

Foxm1 transcription factor is required for the initiation of lung tumorigenesis by oncogenic KrasG12D

(2013) I-C Wang et al.   ONCOGENE

FoxM1 mediated resistance to gefitinib in non-smallcell lung cancer cells

(2012) Nuo Xu et al.   ACTA PHARMACOLOGICA SINICA

Foxm1 transcription factor is critical for proliferation and differentiation of Clara cells during development of conducting airways

(2012) Vladimir Ustiyan et al.   DEVELOPMENTAL BIOLOGY

miR-134 inhibits epithelial to mesenchymal transition by targeting FOXM1 in non-small cell lung cancer cells

(2012) Jipeng Li et al.   FEBS LETTERS

Differential expression of forkhead box M1 and its downstream cyclin-dependent kinase inhibitors p27kip1 and p21waf1/cip1 in the diagnosis of pulmonary neuroendocrine tumours

(2012) Seung Yeon Ha et al.   HISTOPATHOLOGY

FoxM1 expression is significantly associated with cisplatin-based chemotherapy resistance and poor prognosis in advanced non-small cell lung cancer patients

(2012) Yu Wang et al.   LUNG CANCER

Foxm1 Mediates Cross Talk between Kras/Mitogen-Activated Protein Kinase and Canonical Wnt Pathways during Development of Respiratory Epithelium

(2012) I.-C. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

FOXM1 Promotes Allergen-Induced Goblet Cell Metaplasia and Pulmonary Inflammation

(2012) X. Ren et al.   MOLECULAR AND CELLULAR BIOLOGY

MnSOD Promotes Tumor Invasion via Upregulation of FoxM1–MMP2 Axis and Related with Poor Survival and Relapse in Lung Adenocarcinomas

(2012) Po-Ming Chen et al.   MOLECULAR CANCER RESEARCH

The potential of biologics for the treatment of asthma

(2012) Girolamo Pelaia et al.   NATURE REVIEWS DRUG DISCOVERY

Transgenic Expression of FoxM1 Promotes Endothelial Repair following Lung Injury Induced by Polymicrobial Sepsis in Mice

(2012) Xiaojia Huang et al.   PLoS One

Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation Is Controlled by Forkhead Box M1

(2011) Aarti Raghavan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Endothelial Cell-Specific Deletion of Transcription Factor FoxM1 Increases Urethane-Induced Lung Carcinogenesis

(2011) D. Balli et al.   CANCER RESEARCH

FoxM1 in Tumorigenicity of the Neuroblastoma Cells and Renewal of the Neural Progenitors

(2011) Z. Wang et al.   CANCER RESEARCH

A novel mode of FoxM1 regulation: Positive auto-regulatory loop

(2011) Marianna Halasi et al.   CELL CYCLE

The genetics of asthma and allergic disease: a 21st century perspective

(2011) Carole Ober et al.   IMMUNOLOGICAL REVIEWS

Role for miR-204 in human pulmonary arterial hypertension

(2011) Audrey Courboulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FoxM1 mediates the progenitor function of type II epithelial cells in repairing alveolar injury induced byPseudomonas aeruginosa

(2011) Yuru Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Mechanisms of disease: pulmonary arterial hypertension

(2011) Ralph T. Schermuly et al.   Nature Reviews Cardiology

A Randomized Clinical Trial of Hydroxymethylglutaryl– Coenzyme A Reductase Inhibition for Acute Lung Injury (The HARP Study)

(2010) Thelma R. Craig et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia

(2010) I-Ching Wang et al.   DEVELOPMENTAL BIOLOGY

FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of β-catenin expression

(2010) Muhammad K. Mirza et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Pharmacogenomics in non-small-cell lung cancer chemotherapy

(2009) Romano Danesi et al.   ADVANCED DRUG DELIVERY REVIEWS

Bone Marrow Progenitor Cells Induce Endothelial Adherens Junction Integrity by Sphingosine-1-Phosphate–Mediated Rac1 and Cdc42 Signaling

(2009) Yidan D. Zhao et al.   CIRCULATION RESEARCH

Forkhead box M1 transcriptional factor is required for smooth muscle cells during embryonic development of blood vessels and esophagus

(2009) Vladimir Ustiyan et al.   DEVELOPMENTAL BIOLOGY

FoxM1, a critical regulator of oxidative stress during oncogenesis

(2009) Hyun Jung Park et al.   EMBO JOURNAL

Forkhead box M1 expression in pulmonary squamous cell carcinoma: correlation with clinicopathologic features and its prognostic significance

(2009) Doo Kyung Yang et al.   HUMAN PATHOLOGY

Overexpression of hedgehog pathway molecules and FOXM1 in non-small cell lung carcinomas

(2009) Ioannis P. Gialmanidis et al.   LUNG CANCER

Deletion of Forkhead Box M1 Transcription Factor from Respiratory Epithelial Cells Inhibits Pulmonary Tumorigenesis

(2009) I-Ching Wang et al.   PLoS One

Inhibition of matrix metalloproteinase-2 enhances radiosensitivity by abrogating radiation-induced FoxM1-mediated G2/M arrest in A549 lung cancer cells

(2008) Chandramu Chetty et al.   INTERNATIONAL JOURNAL OF CANCER

Transcriptional up-regulation of FoxM1 in response to hypoxia is mediated by HIF-1

(2008) Li-Min Xia et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Transgenic expression of the forkhead box M1 transcription factor induces formation of lung tumors

(2008) I-C Wang et al.   ONCOGENE

Forkhead Box m1 transcription factor is required for perinatal lung function

(2008) T. V. Kalin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA