Article
Oncology
Xingjie Ma, Weibo Qi, Fan Yang, Huan Pan
Summary: JOSD1 is significantly overexpressed in LUAD and stabilizes Snail protein through deubiquitination, thereby promoting LUAD metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Goeun Lee, Shinkyo Yoon, Bokyung Ahn, Hyeong-Ryul Kim, Se Jin Jang, Hee Sang Hwang
Summary: This study evaluated the prognostic role of blood vessel invasion (BVI) in 217 cases of surgically resected lung adenocarcinoma and found that BVI presence was significantly associated with higher pathologic stage, poor survival outcomes, and recurrence. Regardless of the location or type of involved blood vessels, the presence of BVI was consistently linked to poor prognosis, highlighting its importance as a predictive factor.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Shipeng Yang, Ying Liu, Chunxiao Tang, Anna Han, Zhenhua Lin, Jishu Quan, Yang Yang
Summary: Recent studies have shown that CPT1A plays a critical role in the metabolism and progression of pancreatic ductal adenocarcinoma (PAAD). Overexpression of CPT1A promotes cell proliferation and glycolytic metabolism in PAAD cells. Mechanistically, CPT1A binds to Snail and regulates its stability, thereby facilitating PAAD progression.
Article
Oncology
Kaiyi Tao, JinShi Liu, JinXiao Liang, XiaoFang Xu, LiWei Xu, WeiMin Mao
Summary: The study investigated the molecular mechanism of lung adenocarcinoma (LUAD) progression and the communication between cancer cells and vascular endothelial cells. The findings demonstrated that miR-30a-5p could be delivered from vascular endothelial cells to LUAD cells via exosomes to inhibit tumor progression.
Article
Multidisciplinary Sciences
Yoshihisa Shimada, Yusuke Yoshioka, Yujin Kudo, Takahiro Mimae, Yoshihiro Miyata, Hiroyuki Adachi, Hiroyuki Ito, Morihito Okada, Tatsuo Ohira, Jun Matsubayashi, Takahiro Ochiya, Norihiko Ikeda
Summary: This study aimed to identify EV-associated miRNAs related to LVI in early-stage lung adenocarcinoma (LADC) patients. The miR-30d-5p levels were significantly downregulated in the LVI-positive group and lower in healthy donors compared to LADC patients. Patients with high miR-30d-5p levels had a better survival rate. miR-30d-5p in EVs may serve as a promising biomarker for detecting LVI in early-stage LADC patients.
SCIENTIFIC REPORTS
(2023)
Article
Genetics & Heredity
Ruijie Zhang, Shengjin Li, Jian Lan, Changyi Li, Xianzhi Du, Weijie Dong, Qian Yu, Daoxin Wang
Summary: This study found that low-dose cisplatin can activate the EMT process and promote malignant progression of lung adenocarcinoma cells through upregulating CNTN-1.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Xingjie Ma, Weibo Qi, Fan Yang, Huan Pan
Summary: The expression of ubiquitin-conjugating enzyme E2 L3 (UBE2L3) is dramatically up-regulated in lung adenocarcinoma (LUAD). UBE2L3 overexpression is correlated with lymph node metastasis and shorter overall survival. It promotes cancer cell epithelial-mesenchymal transition and metastasis via the GSK-3β/Snail axis.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Linchun Wen, Lu Xu, Beibei Cai, Zihao Liu, Lixue Wang
Summary: This study found that NLRC5 promotes the invasion and metastasis of LUAD cells by activating the PI3K/AKT pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Zhipeng Jiang, Hao Hu, Wenli Hu, Zehui Hou, Wei Liu, Zhuomin Yu, Zhiqiang Liang, Shuang Chen
Summary: This study aimed to investigate the role of circ-RNF121 in colorectal cancer (CRC). The results showed that circ-RNF121 silencing inhibited cell proliferation, migration, invasion, and glycolysis while inducing cell apoptosis in CRC. Additionally, circ-RNF121 acted as a sponge for miR-1224-5p and was involved in tumor growth inhibition in vivo. This finding sheds new light on circRNA-mediated therapy for CRC.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Yin-Quan Chen, Chen-Yu Hung, Ming-Tzo Wei, Jean-Cheng Kuo, Muh-Hwa Yang, Han-Ying Cheng, Arthur Chiou
Summary: In this study, the researchers compared the biomolecular and biomechanical properties of lymph node (LN)-metastatic and non-metastatic cells in head and neck squamous cell carcinoma. They found that LN-metastatic cells had a higher level of Snail expression, which promoted cellular invasion capability in confined environments by increasing longitudinal strain of the cell nuclei through stronger cell traction force and softer nuclear stiffness. These biomechanical changes were correlated with a larger amount of focal adhesion and less amount of nuclear lamins. Overall, this study reveals the key process in LN metastasis by examining the biomechanical profiles and corresponding biomolecular expressions of LN-metastatic cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kailong Du, Shijie Sun, Tinghui Jiang, Tao Liu, Xiaofeng Zuo, Xing Xia, Xianjun Liu, Yitao Wang, Youquan Bu
Summary: This study elucidated the critical role of E2F2 in lung adenocarcinoma (LUAD) and the exquisite core transcription regulatory circuitry of E2F2/B-Myb/FOXM1 in LUAD progression.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Alice Yu, Yuanyuan Li, Irene Li, Michael G. Ozawa, Christine Yeh, Aaron E. Chiou, Winston L. Trope, Jonathan Taylor, Joseph Shrager, Sylvia K. Plevritis
Summary: The study introduces a graph-based algorithm REMI that predicts ligand-receptor (LR) interactions and reconstructs interactomes from RNA sequencing data. By leveraging single-cell transcriptomics data for cell type resolution and identifying LR prognostic signatures among tumor-stroma-immune subpopulations, the study confirmed an interaction associated with LUAD progression.
Article
Oncology
Jun Bai, Hongli Li, Xinlu Chen, Lin Chen, Yaqiong Hu, Lu Liu, Yanqiao Zhao, Wei Zuo, Baogang Zhang, Chonggao Yin
Summary: LncRNA-AC009948.5 is upregulated in lung adenocarcinoma tissues and cells, and its increased expression is associated with tumor size, lymph nodes, distant metastasis, histological grade, and poor prognosis. Knockdown of LncRNA-AC009948.5 inhibits cell proliferation, migration, and invasion in vitro, as well as tumorigenesis and metastasis in vivo. Mechanistically, LncRNA-AC009948.5 directly binds to miR-186-5p and suppresses the expression of the target gene NCAPG2.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yingyan Wang, Wen Lan, Mingxin Xu, Jing Song, Jun Mao, Chunyan Li, Xiaohui Du, Yunling Jiang, Encheng Li, Rui Zhang, Qi Wang
Summary: CAFs promote EMT in lung ADC through SDF-1, which enhances invasiveness and EMT by regulating CXCR4, beta-catenin, and PPAR delta. High expression of these proteins correlated with poor prognosis, suggesting targeting the SDF-1-mediated CXCR4 beta-catenin/PPAR delta cascade may be an effective approach for lung cancer treatment.
CELL DEATH & DISEASE
(2021)
Article
Oncology
Chunli Wu, Bo Dong, Lan Huang, Yafei Liu, Guanchao Ye, Shihao Li, Yu Qi
Summary: This study revealed that SPTBN2 was significantly upregulated in LUAD tissues compared to normal tissues. High expression of SPTBN2 in LUAD was associated with poor prognosis and could promote the proliferation, migration, and invasion of LUAD cells.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cell Biology
Nunu Huang, Fanying Li, Maolei Zhang, Huangkai Zhou, Zhipeng Chen, Xiaoyan Ma, Lixuan Yang, Xujia Wu, Jian Zhong, Feizhe Xiao, Xuesong Yang, Kun Zhao, Xixi Li, Xin Xia, Zexian Liu, Song Gao, Nu Zhang
Summary: The micropeptide MP31, encoded by the uORF of PTEN, acts as a circuit breaker in lactate metabolism by competing with mLDH for NAD(+). Knocking out the MP31 homolog in mice enhances global lactate metabolism, while knocking it out in mouse astrocytes initiates gliomagenesis. Recombinant MP31 inhibits GBM xenografts without neurological toxicity, suggesting its potential clinical application.
Article
Oncology
Yi Liu, Zhongjun Li, Maolei Zhang, Huangkai Zhou, Xujia Wu, Jian Zhong, Feizhe Xiao, Nunu Huang, Xuesong Yang, Rong Zeng, Lixuan Yang, Zhibo Xia, Nu Zhang
Summary: The study identified a novel EGFR variant, rtEGFR, encoded by circEGFR, which promotes GBM development by maintaining EGFR activation and inhibiting EGFR degradation, showing significant correlation with patient prognosis. Targeting rtEGFR could potentially enhance the efficacy of EGFR-targeting therapies in GBM treatment.
Article
Cell Biology
Xinya Gao, Xin Xia, Fanying Li, Maolei Zhang, Huangkai Zhou, Xujia Wu, Jian Zhong, Zheng Zhao, Kun Zhao, Dawei Liu, Feizhe Xiao, Qiang Xu, Tao Jiang, Bo Li, Shi-Yuan Cheng, Nu Zhang
Summary: The activation of EGFR signalling in GBM is driven by a newly discovered secretory E-cadherin protein variant called C-E-Cad encoded by circular RNA. This mechanism promotes tumorigenicity in glioma stem cells and provides a promising approach for treating EGFR-driven GBM by enhancing the efficacy of anti-EGFR strategies.
NATURE CELL BIOLOGY
(2021)
Review
Cell Biology
Zhong Deng, Huixue Wang, Jinlong Liu, Yuan Deng, Nu Zhang
Summary: Detachment is the critical step for cancer metastasis, exposing cells to different chemical and mechanical environments and multiple stresses. These stresses, including loss of growth stimuli and increased reactive oxygen species, have significant impacts on anchorage-independent survival and molecular signaling pathways, affecting cancer metastasis and treatment.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Jie Li, Xinya Gao, Zhanqiang Zhang, Yuanhui Lai, Xunxun Lin, Bo Lin, Maoguang Ma, Xiaoli Liang, Xixi Li, Weiming Lv, Ying Lin, Nu Zhang
Summary: A novel circRNA circCD44 is highly expressed in triple-negative breast cancer (TNBC) and promotes TNBC progression by sponging miR-502-5p and interacting with IGF2BP2, leading to enhanced cell proliferation, migration, invasion, and tumorigenesis. CircCD44 may serve as a potential diagnostic and therapeutic marker for TNBC patients.
Article
Biochemistry & Molecular Biology
Jin-Ling Duan, Wei Chen, Juan-Juan Xie, Mao-Lei Zhang, Run-Cong Nie, Hu Liang, Jie Mei, Kai Han, Zhi-Cheng Xiang, Feng-Wei Wang, Kai Teng, Ri-Xin Chen, Min-Hua Deng, Yi-Xin Yin, Nu Zhang, Dan Xie, Mu-Yan Cai
Summary: This study identified a highly expressed coding circRNA, circMAP3K4, in hepatocellular carcinoma (HCC), and showed that it protected HCC cells from cisplatin-induced apoptosis by encoding circMAP3K4-455aa. High levels of circMAP3K4 were also associated with adverse prognosis in HCC patients.
Editorial Material
Oncology
Xixi Li, Xinya Gao, Nu Zhang
CANCER BIOLOGY & MEDICINE
(2022)
Article
Oncology
Daqi Li, Qian Zhang, Lu Li, Kexin Chen, Junlei Yang, Deobrat Dixit, Ryan C. Gimple, Shusheng Ci, Chenfei Lu, Lang Hu, Jiancheng Gao, Danyang Shan, Yangqing Li, Junxia Zhang, Zhumei Shi, Danling Gu, Wei Yuan, Qiulian Wu, Kailin Yang, Linjie Zhao, Zhixin Qiu, Deguang Lv, Wei Gao, Hui Yang, Fan Lin, Qianghu Wang, Jianghong Man, Chaojun Li, Weiwei Tao, Sameer Agnihotri, Xu Qian, Yu Shi, Yongping You, Nu Zhang, Jeremy N. Rich, Xiuxing Wang
Summary: The study reveals the tumor-promoting functions of B2M in glioblastoma and suggests potential therapeutic strategies for targeting tumor cells and the immunosuppressive microenvironment. B2M activation leads to the maintenance of stem-like neoplastic populations and induces an anti-inflammatory state, while promoting the polarization of macrophages towards an M2-like phenotype. Inhibition of B2M could attenuate glioblastoma stem cell survival, self-renewal, and tumor growth.
Correction
Biochemistry & Molecular Biology
Xin Xia, Xixi Li, Fanying Li, Xujia Wu, Maolei Zhang, Huangkai Zhou, Nunu Huang, Xuesong Yang, Feizhe Xiao, Dawei Liu, Lixuan Yang, Nu Zhang
Article
Multidisciplinary Sciences
Jian Zhong, Xuesong Yang, Junju Chen, Kejun He, Xinya Gao, Xujia Wu, Maolei Zhang, Huangkai Zhou, Feizhe Xiao, Lele An, Xiuxing Wang, Yu Shi, Nu Zhang
Summary: This study revealed that the overexpression of EZH2-92aa in Glioblastoma leads to immune evasion of the tumor cells from NK cells. EZH2-92aa directly binds and represses the transcription of MICA/B, and indirectly represses ULBP transcription by stabilizing EZH2. Knockdown of EZH2-92aa enhances NK cell-mediated eradication of GSCs and synergizes with anti-PD1 therapy.
NATURE COMMUNICATIONS
(2022)
Article
Biotechnology & Applied Microbiology
Haohan Liu, Deliang Fang, Chaoyue Zhang, Zirui Zhao, Yinan Liu, Shaoji Zhao, Nu Zhang, Jianbo Xu
Summary: The aim of this study was to identify an undiscovered protein encoded by circRNA and explore its key role and molecular mechanism in gastric cancer progression. A downregulated circRNA with coding potential, circMTHFD2L, was found to encode a protein named CM-248aa. CM-248aa was significantly downregulated in gastric cancer and its low expression was associated with advanced tumor-node-metastasis stage and histopathological grade. Low expression of CM-248aa could be an independent risk factor for poor prognosis.
Article
Cell Biology
Rongjie Cheng, Fanying Li, Maolei Zhang, Xin Xia, Jianzhuang Wu, Xinya Gao, Huangkai Zhou, Zhi Zhang, Nunu Huang, Xuesong Yang, Yaliang Zhang, Shunli Shen, Tiebang Kang, Zexian Liu, Feizhe Xiao, Hongwei Yao, Jianbo Xu, Chao Yan, Nu Zhang
Summary: This study identifies RASON as a positive regulator of oncogenic RAS signaling and reveals its aberrant overexpression in pancreatic ductal adenocarcinoma. RASON promotes tumor cell proliferation and tumor growth by sustaining the hyperactive state of KRAS through inhibiting GTP hydrolysis. Deprivation of RASON sensitizes KRAS mutant pancreatic cancer cells to EGFR inhibitors.
Article
Clinical Neurology
Xiaofang He, Wenbin Zhao, Jianwen Huang, Jia Xu, Shaoqing Niu, Qun Zhang, Nu Zhang, Huawei Jin, Guoping Shen
Summary: This study analyzed the characteristics and trends of globally registered glioma trials in the past decades. The findings suggest that meaningful effective treatments for glioma are difficult to find, but Bayesian adaptive platform trials may accelerate clinical research in this field.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Medicine, Research & Experimental
Jin-Zhu Wang, Hong Zhu, Pu You, Hui Liu, Wei-Kang Wang, Xiaojuan Fan, Yun Yang, Keren Xu, Yingfeng Zhu, Qunyi Li, Ping Wu, Chao Peng, Catherine C. L. Wong, Kaicheng Li, Yufeng Shi, Nu Zhang, Xiuxing Wang, Rong Zeng, Ying Huang, Liusong Yang, Zefeng Wang, Jingyi Hui
Summary: In this study, the researchers found that overexpression of YB-1 protein is associated with activation of the mTOR signaling pathway in glioblastoma. YB-1 promotes the translation of CCT4, leading to mTOR activation, and also autoregulates its own translation to sustain mTOR signaling. Targeting YB-1 with RNA decoy therapy slows tumor growth and improves survival.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biotechnology & Applied Microbiology
Xujia Wu, Songhua Xiao, Maolei Zhang, Lixuan Yang, Jian Zhong, Bo Li, Fanying Li, Xin Xia, Xixi Li, Huangkai Zhou, Dawei Liu, Nunu Huang, Xuesong Yang, Feizhe Xiao, Nu Zhang
Summary: This study identifies SMO-193a.a. encoded by circ-SMO as a critical component for Hedgehog signaling activation in glioblastoma, playing a key role in tumorigenesis. The positive feedback loop involving Shh/Gli1/FUS/SMO-193a.a. sustains Hedgehog signaling in glioblastoma, with higher expression of SMO-193a.a. predicting worse overall survival in patients, highlighting its potential prognostic value.
