Human and Murine Hematopoietic Stem Cell Aging Is Associated with Functional Impairments and Intrinsic Megakaryocytic/Erythroid Bias

Age-dependent modulation of vascular niches for haematopoietic stem cells

(2016) Anjali P. Kusumbe et al.   NATURE

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

(2016) Amit Grover et al.   Nature Communications

BubbleGUM: automatic extraction of phenotype molecular signatures and comprehensive visualization of multiple Gene Set Enrichment Analyses

(2015) Lionel Spinelli et al.   BMC GENOMICS

Ensembl 2016

(2015) Andrew Yates et al.   NUCLEIC ACIDS RESEARCH

Prospective isolation of human erythroid lineage-committed progenitors

(2015) Yasuo Mori et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct routes of lineage development reshape the human blood hierarchy across ontogeny

(2015) F. Notta et al.   SCIENCE

Aging Impairs Long-Term Hematopoietic Regeneration after Autologous Stem Cell Transplantation

(2014) Carolien M. Woolthuis et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Epigenomic Profiling of Young and Aged HSCs Reveals Concerted Changes during Aging that Reinforce Self-Renewal

(2014) Deqiang Sun et al.   Cell Stem Cell

Reduced Lymphoid Lineage Priming Promotes Human Hematopoietic Stem Cell Expansion

(2014) Peter van Galen et al.   Cell Stem Cell

Platelet count and aging

(2014) C. L. Balduini et al.   HAEMATOLOGICA

Advances in Geroscience: Impact on Healthspan and Chronic Disease

(2014) J. B. Burch et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Concise Review: Hematopoietic Stem Cell Aging and the Prospects for Rejuvenation

(2014) Martin Wahlestedt et al.   Stem Cells Translational Medicine

An epigenetic component of hematopoietic stem cell aging amenable to reprogramming into a young state

(2013) M. Wahlestedt et al.   BLOOD

Heterogeneity of young and aged murine hematopoietic stem cells revealed by quantitative clonal analysis using cellular barcoding

(2013) E. Verovskaya et al.   BLOOD

Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging

(2013) Isabel Beerman et al.   Cell Stem Cell

Platelet-biased stem cells reside at the apex of the haematopoietic stem-cell hierarchy

(2013) Alejandra Sanjuan-Pla et al.   NATURE

BANK1 and BLK Act through Phospholipase C Gamma 2 in B-Cell Signaling

(2013) Manuel Bernal-Quirós et al.   PLoS One

Age- And Sex-Related Variations in Platelet Count in Italy: A Proposal of Reference Ranges Based on 40987 Subjects' Data

(2013) Ginevra Biino et al.   PLoS One

The Gracefully Aging Immune System

(2013) D. Boraschi et al.   Science Translational Medicine

Reduced repression of cytokine signaling ameliorates age-induced decline in hematopoietic stem cell function

(2012) Gudmundur L. Norddahl et al.   AGING CELL

Prognostic Factors Affecting Outcome after Allogeneic Transplantation for Hematological Malignancies from Unrelated Donors: Results from a Randomized Trial

(2012) Jürgen Finke et al.   BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION

Aging of the Microenvironment Influences Clonality in Hematopoiesis

(2012) Virag Vas et al.   PLoS One

Age-related changes in human hematopoietic stem/progenitor cells

(2011) Klaudia Kuranda et al.   AGING CELL

Stem cell aging: Survival of the laziest?

(2011) Christa Muller-Sieburg et al.   CELL CYCLE

Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells

(2011) Brad Dykstra et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age

(2011) W. W. Pang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isolation of Single Human Hematopoietic Stem Cells Capable of Long-Term Multilineage Engraftment

(2011) F. Notta et al.   SCIENCE

Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment

(2010) Yohei Morita et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functionally distinct hematopoietic stem cells modulate hematopoietic lineage potential during aging by a mechanism of clonal expansion

(2010) I. Beerman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages

(2008) H. Karsunky et al.   BLOOD

A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells

(2008) R. H. Cho et al.   BLOOD

Aging and erythropoiesis: Current state of knowledge

(2008) Elizabeth A. Price   BLOOD CELLS MOLECULES AND DISEASES

Stems Cells and the Pathways to Aging and Cancer

(2008) Derrick J. Rossi et al.   CELL

Distinct changes in adult lymphopoiesis in Rag2−/− mice fully reconstituted by α4-deficient adult bone marrow cells

(2008) Ena R. Banerjee et al.   EXPERIMENTAL HEMATOLOGY

Age and stress related phenotypical changes in bone marrow CD34+cells

(2008) Eli Taraldsrud et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION

Anemia of Aging: The Role of Chronic Inflammation and Cancer

(2008) Luigi Ferrucci et al.   SEMINARS IN HEMATOLOGY

CD61 enriches long-term repopulating hematopoietic stem cells

(2007) Terumasa Umemoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS