Article
Medical Laboratory Technology
Xinlei Zou, Ziyue Huang, Canghai Guan, Wujiang Shi, Jianjun Gao, Jiangang Wang, Yunfu Cui, Mei Wang, Yi Xu, Xiangyu Zhong
Summary: Pancreatic cancer (PC) is highly aggressive with a poor prognosis. The tumor microenvironment (TME) of PC is complex and diverse. Various cellular components in the microenvironment secrete different substances that promote tumor development. These substances can be released via exosomes, which are abundant extracellular vesicles (EVs) capable of carrying factors and enabling intercellular communication. MiRNAs are involved in regulating pathological and physiological processes and can be transported by exosomes to regulate the TME. Exosomal miRNAs hold promise as future targets for PC diagnosis and prognosis, offering potential new treatment strategies.
CLINICA CHIMICA ACTA
(2023)
Review
Oncology
Xinyao Chang, Xingchen Liu, Haoze Wang, Xuan Yang, Yan Gu
Summary: Metabolic reprogramming, specifically the switch from oxidative phosphorylation to glycolysis, promotes the malignant behavior of pancreatic cancer and affects tumor microenvironments. Glycolysis is critical for cancer cells to maintain biosynthesis and promotes tumor initiation, invasion, angiogenesis, and metastasis to distant organs.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Masaya Higashiguchi, Hirotomo Murakami, Hirofumi Akita, Shogo Kobayashi, Shokichi Takahama, Yoshifumi Iwagami, Daisaku Yamada, Yoshito Tomimaru, Takehiro Noda, Kunihito Gotoh, Yuichiro Doki, Takuya Yamamoto, Hidetoshi Eguchi
Summary: This study found that individual differences in cancer-associated fibroblasts (CAFs) can affect the malignancy of pancreatic cancer (PC). It was also discovered that the senescence of CAFs has an impact on the malignancy of PC by suppressing PC cell proliferation. The results of this study suggest that p53-mediated cellular senescence and SASP of CAFs may be related to the proliferation potential of PC.
Article
Oncology
Kelly Boelaars, Laura Goossens-Kruijssen, Di Wang, Charlotte M. de Winde, Ernesto Rodriguez, Dimitri Lindijer, Babet Springer, Irene van der Haar avila, Aram de Haas, Laetitia Wehry, Louis Boon, Reina E. Mebius, Nadine van Montfoort, Manfred Wuhrer, Joke M. M. den Haan, Sandra J. van Vliet, Yvette van Kooyk
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer, and immunotherapy has been unsuccessful in its treatment. This study shows that tumor-derived sialic acids play a critical role in shaping the immune landscape of PDAC. The absence of sialic acids allows for better infiltration of T cells into the tumor, resulting in improved response to immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Xudong Zhu, Rongpu Liang, Tianyun Lan, Dongbing Ding, Shengxin Huang, Jun Shao, Zongheng Zheng, Tufeng Chen, Yong Huang, Jianpei Liu, Janak L. Pathak, Hongbo Wei, Bo Wei
Summary: This study found that the specific localization of CD155(+) TAMs in CRC tissue could become a potential therapeutic target for CRC treatment, as it is responsible for M2-phenotype transition, immunosuppression, and tumor progression in CRC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Jian Yang, Yongzheng Li, Zhaowei Sun, Hanxiang Zhan
Summary: This review summarizes recent advances in understanding the origin, distribution, and polarization of macrophages in pancreatic cancer, as well as their role in carcinogenesis and development, and potential therapeutic value. Macrophages play a crucial role in creating an immunosuppressive tumor microenvironment, ultimately facilitating tumor initiation and progression in pancreatic cancer.
Review
Immunology
Zeyu Wu, Xiao Yu, Shuijun Zhang, Yuting He, Wenzhi Guo
Summary: This article summarizes the mechanisms underlying aberrant circRNA expression in the TME of digestive system cancers, including immune surveillance, angiogenesis, EMT, and ECM remodelling. The regulation of the TME by circRNA is expected to be a new therapeutic method.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Samuel A. Kerk, Lin Lin, Amy L. Myers, Damien J. Sutton, Anthony Andren, Peter Sajjakulnukit, Li Zhang, Yaqing Zhang, Jennifer A. Jimenez, Barbara S. Nelson, Brandon Chen, Anthony Robinson, Galloway Thurston, Samantha B. Kemp, Nina G. Steele, Megan T. Hoffman, Hui-Ju Wen, Daniel Long, Sarah E. Ackenhusen, Johanna Ramos, Xiaohua Gao, Zeribe C. Nwosu, Stefanie Galban, Christopher J. Halbrook, David B. Lombard, David R. Piwnica-Worms, Haoqiang Ying, Marina Pasca di Magliano, Howard C. Crawford, Yatrik M. Shah, Costas A. Lyssiotis
Summary: Mitochondrial glutamate-oxaloacetate transaminase 2 (GOT2) is a key component of glutamine metabolism in pancreatic ductal adenocarcinoma (PDA). Loss of GOT2 disrupts redox homeostasis and halts proliferation of PDA cells in vitro, but has no effect on tumor growth in vivo due to metabolic plasticity of PDA cells.
Article
Biochemistry & Molecular Biology
Wanning Liu, Boda Wang, Mingzhen Zhou, Dan Liu, Fulin Chen, Xiaodi Zhao, Yuanyuan Lu
Summary: Redox dysregulation leads to ROS accumulation, causing oxidative stress and cellular damage. ROS play a dual role in cancer development and survival. Recent studies have shown that ROS impact the behavior of cancer cells and tumor-associated stromal cells in the TME, and these cells have developed complex systems to adapt to high ROS environments.
ANTIOXIDANTS & REDOX SIGNALING
(2023)
Article
Oncology
Francesco De Sanctis, Alessia Lamolinara, Federico Boschi, Chiara Musiu, Simone Caligola, Rosalinda Trovato, Alessandra Fiore, Cristina Frusteri, Cristina Anselmi, Ornella Poffe, Tiziana Cestari, Stefania Cane, Silvia Sartoris, Rosalba Giugno, Giulia Del Rosario, Barbara Zappacosta, Francesco Del Pizzo, Matteo Fassan, Erica Dugnani, Lorenzo Piemonti, Emanuela Bottani, Ilaria Decimo, Salvatore Paiella, Roberto Salvia, Rita Teresa Lawlor, Vincenzo Corbo, Youngkyu Park, David A. Tuveson, Claudio Bassi, Aldo Scarpa, Manuela Iezzi, Stefano Ugel, Vincenzo Bronte
Summary: PDAC tumors exhibit strong immunosuppressive characteristics that limit the success of immunotherapy. Research shows that reprogramming the tumor microenvironment by intervening in RNS production can enhance the efficacy of immune-based treatments.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, General & Internal
Minsung Kim, Il Tae Son, Gyoung Tae Noh, So-Youn Woo, Ryung-Ah Lee, Bo Young Oh
Summary: This study investigated the role of colon cancer-cell-derived exosomes in colon cancer. The results showed that exosome treatment significantly increased cancer cell proliferation, altered cell adhesion molecule expression, enhanced cell motility, and had an impact on the gene regulation of cancer-associated fibroblasts.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Ying Li, Jing Wang, Haiyan Wang, Shaoqiang Zhang, Yingxin Wei, Shanglong Liu
Summary: In pancreatic cancer, there are interactions between immune cells, inflammatory cells, chemokines, and cytokines, leading to the establishment of an inflammatory tumor microenvironment. Inflammation is closely associated with immunity, and immune cells play a role in both inflammation and immune response. Tumor-promoting inflammation and tumor-suppressive immunity are the main characteristics of the tumor microenvironment in pancreatic cancer. However, the mechanisms of inflammation and immune response in pancreatic cancer development are still not fully understood due to the dual role of certain cytokines and the complex crosstalk between tumor and stromal components in the microenvironment. This review outlines the principal cytokines and stromal cells involved in the tumor-promoting and immunosuppressive effects of inflammation in the pancreatic tumor microenvironment and discusses the interaction between inflammation and stromal components in pancreatic cancer progression. Moreover, clinical approaches targeting the tumor microenvironment in pancreatic cancer are summarized. Defining the mechanisms of interplay between inflammation and stromal components is crucial for the further development of anti-cancer therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yixin Liu, Sheng Tian, Biao Ning, Tianhe Huang, Yi Li, Yongchang Wei
Summary: Advances in psychoneuroimmunology have shown that stress and cancer are closely linked. Chronic stress accelerates tumorigenesis and progression, while interventions can help reduce psychological disorders and improve quality of life.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Qinglin Zhang, He Nie, Jiadong Pan, Haoran Xu, Qiang Zhan
Summary: This study analyzed the expression, prognostic value, and immunological correlation of FMNL3 in multiple cancers, with a focus on pancreatic cancer (PAAD). The results showed positive correlations between FMNL3 and immunomodulators as well as tumor-infiltrating immune cells in several cancer types, including PAAD. Additionally, FMNL3 was associated with immune-related microbiota and genes. Therefore, FMNL3 could potentially serve as an indicator for high immunogenicity in PAAD.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Anita Rogic, Ila Pant, Luca Grumolato, Ruben Fernandez-Rodriguez, Andrew Edwards, Suvendu Das, Aaron Sun, Shen Yao, Rui Qiao, Shabnam Jaffer, Ravi Sachidanandam, Guray Akturk, Rosa Karlic, Mihaela Skobe, Stuart A. Aaronson
Summary: Inflammatory breast cancer (IBC) is an aggressive form of breast cancer with a poor prognosis. The characterization of a human IBC cell line in this study suggests that the high level of CCL2 is implicated in macrophage infiltration and tumor progression.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Estefania Carrasco-Garcia, Lidia Lopez, Veronica Moncho-Amor, Fernando Carazo, Paula Aldaz, Manuel Collado, Donald Bell, Ayman Gaafar, Eva Karamitopoulou, Alexandar Tzankov, Manuel Hidalgo, Angel Rubio, Manuel Serrano, Charles H. Lawrie, Robin Lovell-Badge, Ander Matheu
Summary: The study shows that SOX9 plays a crucial role in the progression and metastasis of pancreatic cancer by regulating stemness and EMT processes. High levels of SOX9 are associated with metastases in clinical samples.
Article
Medicine, Research & Experimental
David A. Gross, Henry S. Cheng, Rulin Zhuang, Michael G. McCoy, Daniel Perez-Cremades, Zachary Salyers, A. K. M. Khyrul Wara, Stefan Haemmig, Terence E. Ryan, Mark W. Feinberg
Summary: SNHG12 is a dysregulated long noncoding RNA (lncRNA) in atherosclerosis, and it plays a significant role in the regulation of vascular senescence and angiogenic response. The deficiency of SNHG12 reduces cell proliferation, migration, and endothelial sprouting, while overexpression promotes these angiogenic functions. SNHG12 may exert its effects through interacting with proteins like IGF2BP3, and it is involved in cell cycle regulation and signaling pathways related to Wnt, Notch, and angiopoietin signaling pathways.
Article
Multidisciplinary Sciences
Antonio Rodriguez-Calero, John Gallon, Dilara Akhoundova, Sina Maletti, Alison Ferguson, Joanna Cyrta, Ursula Amstutz, Andrea Garofoli, Viola Paradiso, Scott A. Tomlins, Ekkehard Hewer, Vera Genitsch, Achim Fleischmann, Erik Vassella, Elisabeth J. Rushing, Rainer Grobholz, Ingeborg Fischer, Wolfram Jochum, Gieri Cathomas, Adeboye O. Osunkoya, Lukas Bubendorf, Holger Moch, George Thalmann, Charlotte K. Y. Ng, Silke Gillessen, Salvatore Piscuoglio, Mark A. Rubin
Summary: Improved therapies for prostate cancer have led to an increase in brain metastases. By studying the genetic alterations in brain metastases from prostate cancer patients, researchers have found higher mutational burden and enrichment of homologous recombination deficiency mutational signature. Some patients may benefit from PARP inhibitors.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Oncology
Eva Karamitopoulou
Article
Oncology
Eva Karamitopoulou, Andreas Andreou, Anna Silvia Wenning, Beat Gloor, Aurel Perren
Summary: This study links tumor mutational burden (TMB) levels with immune pathway activation and intratumoral immune responses in pancreatic adenocarcinoma (PDAC). The results show that TMB-high cases frequently belong to specific PDAC subsets with prolonged survival and display strong anti-tumor immune responses.
EUROPEAN JOURNAL OF CANCER
(2022)
Article
Clinical Neurology
Kirsten Guse, Nina Hagemann, Lisa Thiele, Jana Remlinger, Anke Salmen, Robert Hoepner, Irene Keller, Patricia Meyer, Denis Grandgirard, Stephen L. Leib, Erik Vassella, Giuseppe Locatelli, Dirk M. Hermann, Andrew Chan
Summary: This study investigates the mutual and combined interactions between autoimmune neuroinflammation and cerebral ischemia. It found that mice with severe autoimmune disease showed a reduction in infarct size after ischemia, indicating a protective influence of CNS autoantigen-specific autoimmunity on primary tissue damage. These findings suggest the involvement of myeloid cell-driven anti-inflammatory mechanisms in mitigating ischemic injury in the acute phase of autoimmune disease.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Review
Oncology
Elham Kashani, Erik Vassella
Summary: GBM is a highly heterogeneous tumor with dynamic oncogenic pathways driving subclonal alterations. PP2A can target multiple key inducers of these pathways and modulate the response of GBM cells, potentially serving as an adjunct therapy. This review emphasizes the importance of PP2A modulation in the context of GBM.
Article
Cell Biology
Konstantin Braeutigam, Stefan Reinhard, Martin Wartenberg, Stefan Forster, Karen Greif, Massimo Granai, Hans Boesmueller, Karin Klingel, Christian M. Schuerch
Summary: COVID-19 has had significant effects on global healthcare, resulting in millions of deaths. In this study, the expression of 10 known and novel virus entry molecules was investigated using immunohistochemistry. The results showed that ACE2, ASGR1, or KREMEN1 was expressed in the majority of lung tissues, indicating their potential role in SARS-CoV-2 entry. Furthermore, the expression of these molecules was observed in alveolar macrophages, suggesting their involvement in intra-alveolar virus transmission. The study also revealed the relevance of certain molecules in different anatomical sites.
Article
Multidisciplinary Sciences
L. Paige Ferguson, Jovylyn Gatchalian, Matthew L. McDermott, Mari Nakamura, Kendall Chambers, Nirakar Rajbhandari, Nikki K. Lytle, Sara Brin Rosenthal, Michael Hamilton, Sonia Albini, Martin Wartenberg, Inti Zlobec, Jose A. Galvan, Eva Karamitopoulou, Vera Vavinskaya, Alexis Wascher, Andrew M. Lowy, Christian M. Schuerch, Pier Lorenzo Puri, Benoit G. Bruneau, Diana C. Hargreaves, Tannishtha Reya
Summary: Pancreatic cancer is highly resistant to traditional therapies, posing challenges for clinical management. Researchers have identified SMARCD3 as an epigenetic regulator that plays a role in pancreatic cancer stem cells. SMARCD3, although often considered a tumor suppressor, is amplified in cancer and enriched in pancreatic cancer stem cells. Deletion of Smarcd3 improves survival in established tumors, particularly when combined with chemotherapy, and it acts in conjunction with FOXA1 to regulate lipid metabolism, which is associated with therapy resistance and poor prognosis in cancer.
NATURE COMMUNICATIONS
(2023)
Article
Endocrinology & Metabolism
Matthias S. S. Dettmer, Sandra Huerlimann, Lukas Scheuble, Erik Vassella, Aurel Perren, Corinna Wicke
Summary: A 44-year-old female patient with familial adenomatous polyposis (FAP) had a diagnosis of cribriform morular thyroid carcinoma (CMTC). Next generation sequencing revealed a homozygous APC mutation and a TERT promoter mutation in both components. TP53 mutation was exclusive to the CMTC part, while the poorly differentiated component showed clonal evolution with an activating PIK3CA mutation and copy number gains of BRCA2, FGF23, FGFR1, and PIK3CB alterations typically seen in squamous cell carcinoma. The patient, after total thyroidectomy and radioiodine ablation, remained disease-free with no residual tumor burden on 2-year follow-up.
ENDOCRINE PATHOLOGY
(2023)
Article
Pathology
Theoni Maragkou, Stefan Reinhard, Patric Jungo, Baptiste Pasquier, Maja Neuenschwander, Philippe Schucht, Erik Vassella, Ekkehard Hewer
Summary: This study evaluated the utility of MTAP and p16 immunostainings as surrogate markers for CDKN2A/B HD in diffuse gliomas, and investigated the prognostic value of MTAP in different histological tumor grades and IDH mutation status. The results showed that MTAP immunostaining has excellent correlation with CDKN2A/B status, while p16 should be used cautiously.
Article
Multidisciplinary Sciences
Paulo Sampaio, Maria Lopez-Antuna, Federico Storni, Jonatan Wicht, Greta Soekeland, Martin Wartenberg, Pablo Marquez-Neila, Daniel Candinas, Brice-Olivier Demory, Aurel Perren, Raphael Sznitman
Summary: This study investigates the potential of Muller matrix polarimetry (MMP) for analyzing fresh pancreatic tissue samples. By measuring the Muller matrices of ex-vivo unfixed human pancreatic tissue and leveraging the feature-learning capabilities of a machine-learning model, accurate differentiation between normal and abnormal pancreatic tissue is achieved.
SCIENTIFIC REPORTS
(2023)
Article
Pathology
Martin Wartenberg, Sara-Lynn Hool, Andrea Marrazzini, Roland Giger, Niels J. Rupp
Summary: We report a case of an unusual NUT carcinoma in the maxillary sinus, which showed extensive well-differentiated, papillary squamous morphology. Immunohistochemical and molecular studies revealed a NUT::NSD3 gene fusion and (speckled-type) immunopositivity of NUT in the tumor cells.
HEAD & NECK PATHOLOGY
(2023)
Article
Oncology
Jonas Galli, Roland Giger, Olgun Elicin, Martin Wartenberg, Lukas Anschuetz, Lluis Nisa
Summary: This study evaluated the ability of MRI and PET/CT to detect occult lymph node metastases in patients with recurrent LSCC. The results showed that both imaging modalities had high negative predictive values and could effectively assist in nodal staging, reducing unnecessary surgeries.
JOURNAL OF CANCER METASTASIS AND TREATMENT
(2022)
Meeting Abstract
Biotechnology & Applied Microbiology
Michael Boyd, Stefan Haemmig, Jake Cosgrove, Ge Tan, Jenifer Kaplan, Ranjith Munigunti, Nancy Lewicki, Edward J. Oakeley, Joel Jenzer, Samuel Aeschlimann, Samuel Mount, Sophie Dessus-Babus, Olga Slack, Hon-Ren Huang
Article
Pathology
Juliana Mota Siqueira, Yoshitsugu Mitani, Camilla Oliveira Hoff, Flavia Bonini, Luana Guimaraes de Sousa, Mario L. Marques-Piubelli, Anurag Purushothaman, Mutsumi Mitani, Hui Dai, Shiaw-Yih Lin, Michael T. Spiotto, Ehab Y. Hanna, Daniel J. McGrail, Adel K. El-Naggar, Renata Ferrarotto
Summary: B7-H4 expression pattern varies among different types of salivary gland carcinomas, and high B7-H4 expression is associated with poor prognosis in adenoid cystic carcinoma.
Article
Pathology
Basile Tessier-Cloutier, Felix K. F. Kommoss, David L. Kolin, Kristyna Nemejcova, Dupreez Smith, Jennifer Pors, Colin J. R. Stewart, W. Glenn Mccluggage, William D. Foulkes, Andreas von Deimling, Martin Kobel, Cheng-Han Lee
Summary: This study provides a detailed analysis of the clinical, pathological, immunohistochemical, and molecular features of DDOC/UDOC. The majority of patients presented with extraovarian disease and had rapid disease progression resulting in high mortality rate.
Review
Pathology
Sophia J. Wagner, Christian Matek, Sayedali Shetab Boushehri, Melanie Boxberg, Lorenz Lamm, Ario Sada, Dominik J. E. Winter, Carsten Marr, Tingying Peng
Summary: Computational pathology research driven by deep learning faces challenges in reproducibility and reusability. Codebase with good documentation and robustness and generalizability of models are crucial. The reuse of computational pathology algorithms is limited, and their application in clinical settings is even rarer. This study evaluates 160 peer-reviewed articles, providing criteria for data and code availability and statistical analysis of results.
Article
Pathology
Andres M. Acosta, Lynette M. Sholl, Fiona Maclean, Chia-Sui Kao, Thomas M. Ulbright
Summary: This study assessed the clinicopathologic and genomic features of 14 cases of testicular sex cord-stromal tumors. The results showed that CTNNB1 mutations are rare in these tumors, and most of them have genomic alterations similar to testicular sex cord-stromal tumors with pure or predominant spindle cell components.
Article
Pathology
Toru Odate, Kaishi Satomi, Takashi Kubo, Yuko Matsushita, Toshihide Ueno, Akira Kurose, Kohei Shomori, Tokiko Nakai, Reiko Watanabe, Keiko Segawa, Shusa Ohshika, Naritomo Miyake, Sayaka Kudo, Tatsunori Shimoi, Eisuke Kobayashi, Motokiyo Komiyama, Seiichi Yoshimoto, Fumihiko Nakatani, Akira Kawai, Yasushi Yatabe, Shinji Kohsaka, Koichi Ichimura, Hitoshi Ichikawa, Akihiko Yoshida
Summary: Inflammatory rhabdomyoblastic tumors (IRMTs) are newly recognized skeletal muscle tumors with uncertain malignant potential. This study investigated 13 IRMTs using clinicopathologic, genetic, and epigenetic methods. The results showed specific histologic features and genetic mutations in these tumors, and most of them exhibited benign behavior.
Article
Pathology
Dale L. Davis, Adam C. Lechner, David B. Chapel, Jonathan C. Slack, Chrystalle Katte Carreon, Bradley J. Quade, Carlos Parra-Herran
Summary: The Amsterdam Consensus Statement introduced the term maternal vascular malperfusion (MVM) to classify a group of findings related to impaired maternal-placental circulation. The study found that features such as low placental weight, accelerated villous maturation, decidual arteriopathy, and infarcts are associated with adverse obstetrical outcomes, while the role of other features like distal villous hypoplasia, excess multinucleated trophoblast, and retroplacental hemorrhage needs further research.
Review
Pathology
Alain C. Borczuk
Summary: COVID-19 is an acute respiratory illness that can progress to acute respiratory distress syndrome. While most patients recover completely, some may experience persistent respiratory dysfunction, known as long COVID. The pathogenesis involves immune and cellular disturbances.
Article
Pathology
Annikka Weissferdt, Cheuk H. Leung, Heather Lin, Boris Sepesi, William N. William, Stephen G. Swisher, Tina Cascone, J. Jack Lee, Abujiang Pataer
Summary: Neoadjuvant treatment of non-small cell lung cancer challenges traditional processing of pathology specimens, and accurate evaluation of residual tumor is crucial for assessing treatment efficacy.