Apelin peptides linked to anti‐serum albumin domain antibodies retain affinity in vitro and are efficacious receptor agonists in vivo

Basic & Clinical Pharmacology & Toxicology Policy for Experimental and Clinical studies

(2018) Pernille Tveden-Nyborg et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Cardiac action of the first G protein biased small molecule apelin agonist

(2016) Cai Read et al.   BIOCHEMICAL PHARMACOLOGY

Discovery and Structure–Activity Relationship of a Bioactive Fragment of ELABELA that Modulates Vascular and Cardiac Functions

(2016) Alexandre Murza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart

(2015) Ábel Perjés et al.   BASIC RESEARCH IN CARDIOLOGY

GSK2374697, a long duration glucagon-like peptide-1 (GLP-1) receptor agonist, reduces postprandial circulating endogenous total GLP-1 and peptide YY in healthy subjects

(2015) J. Lin et al.   DIABETES OBESITY & METABOLISM

Design, Characterization, and First-In-Human Study of the Vascular Actions of a Novel Biased Apelin Receptor Agonist

(2015) A. L. Brame et al.   HYPERTENSION

C-Terminal Modifications of Apelin-13 Significantly Change Ligand Binding, Receptor Signaling, and Hypotensive Action

(2015) Alexandre Murza et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacokinetic and Pharmacodynamic Characterisation of an Anti-Mouse TNF Receptor 1 Domain Antibody Formatted for In Vivo Half-Life Extension

(2015) Laura J. Goodall et al.   PLoS One

Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

(2015) Peiran Yang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Stability and degradation patterns of chemically modified analogs of apelin-13 in plasma and cerebrospinal fluid

(2014) Alexandre Murza et al.   BIOPOLYMERS

GSK2374697, a Novel Albumin-Binding Domain Antibody (AlbudAb), Extends Systemic Exposure of Exendin-4: First Study in Humans—PK/PD and Safety

(2014) R L O’Connor-Semmes et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Effect of apelin on the cardiac hemodynamics in hypertensive rats with heart failure

(2014) HUI PANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Biased Signaling Favoring Giover β-Arrestin Promoted by an Apelin Fragment Lacking the C-terminal Phenylalanine

(2014) Emilie Ceraudo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apelin Increases Cardiac Contractility via Protein Kinase Cε- and Extracellular Signal-Regulated Kinase-Dependent Mechanisms

(2014) Ábel Perjés et al.   PLoS One

Toddler: An Embryonic Signal That Promotes Cell Movement via Apelin Receptors

(2014) A. Pauli et al.   SCIENCE

Novel fusion of GLP-1 with a domain antibody to serum albumin prolongs protection against myocardial ischemia/reperfusion injury in the rat

(2013) Weike Bao et al.   Cardiovascular Diabetology

ELABELA: A Hormone Essential for Heart Development Signals via the Apelin Receptor

(2013) Serene C. Chng et al.   DEVELOPMENTAL CELL

Cardiovascular effects of a PEGylated apelin

(2012) Z.Q. Jia et al.   PEPTIDES

Elucidation of the Structure-Activity Relationships of Apelin: Influence of Unnatural Amino Acids on Binding, Signaling, and Plasma Stability

(2011) Alexandre Murza et al.   ChemMedChem

Cardioprotective Effect of Apelin-13 on Cardiac Performance and Remodeling in End-Stage Heart Failure

(2011) Wataru Koguchi et al.   CIRCULATION JOURNAL

By Interacting with the C-terminal Phe of Apelin, Phe255and Trp259in Helix VI of the Apelin Receptor Are Critical for Internalization

(2010) Xavier Iturrioz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apelin decreases myocardial injury and improves right ventricular function in monocrotaline-induced pulmonary hypertension

(2009) Inês Falcão-Pires et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

[Pyr 1 ]Apelin-13 Identified as the Predominant Apelin Isoform in the Human Heart

(2009) Janet J. Maguire et al.   HYPERTENSION

Vascular Effects of Apelin In Vivo in Man

(2008) Alan G. Japp et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

(2008) Pál Pacher et al.   Nature Protocols

Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs

(2008) L. J. Holt et al.   PROTEIN ENGINEERING DESIGN & SELECTION