Article
Cardiac & Cardiovascular Systems
Alexandra Rhoden, Thomas Schulze, Niels Pietsch, Torsten Christ, Arne Hansen, Thomas Eschenhagen
Summary: The study found that the effects of OM on contractility and diastolic tension are complex and influenced by concentration, time, species, and loading conditions. Further research is needed to explore the effects on mitochondrial function.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biology
Jialing Qi, Annegret Rittershaus, Rashmi Priya, Shivani Mansingh, Didier Y. R. Stainier, Christian S. M. Helker, Victoria L. Bautch
Summary: This study reveals that endocardial cells interact with cardiomyocytes through dynamic membrane protrusions, which is essential for trabeculation. Loss of Apelin signaling, a peptide derived from cardiomyocytes, or its receptor in endocardial cells leads to reduced endocardial sprouting and hypotrabeculation.
Article
Medicine, General & Internal
Ke Qian, Jie Tang, Yue-Juan Ling, Ming Zhou, Xin-Xin Yan, Yu Xie, Lu-Jia Zhu, Koju Nirmala, Kang-Yun Sun, Zheng-Hong Qin, Rui Sheng
Summary: NADPH exhibits positive inotropic effects and improves energy metabolism via SIRT3 in pathological cardiac hypertrophy and heart failure.
Article
Pharmacology & Pharmacy
Yu-wei Wang, Qian-wen Gao, Yu-jie Xiao, Xiao-jia Zhu, Li Gao, Wen -hui Zhang, Rong -rong Wang, Ke-su Chen, Fu-ming Liu, Hui -li Huang, Long Chen
Summary: The study found that Bay 60-7550 increases rat heart contractility and decreases peripheral arterial resistance by increasing phosphorylation of phospholamban and dilating peripheral vessels. This suggests that PDE2 inhibitors could be a potential target for developing treatments for heart failure by inducing a positive inotropic effect and decreasing peripheral resistance.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Maria Koivisto, Milad Mosallaei, Tarja Toimela, Sampo Tuukkanen, Tuula Heinonen
Summary: This study developed a method for measuring cardiac contraction force using a dual-axis piezoelectric force sensor and human cell-based cardiac tissue constructs. The system was able to detect both positive and negative inotropic effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Zuzana Tatarkova, Maria Bencurova, Jan Lehotsky, Peter Racay, Monika Kmetova Sivonova, Dusan Dobrota, Peter Kaplan
Summary: This study aimed to investigate how impaired Ca2+ handling in the sarcoplasmic reticulum (SR) contributes to cardiac dysfunction in hyperhomocysteinemia (HHcy). The results showed that the altered protein contents in SR Ca2+-handling proteins are associated with the impaired cardiac contractile function caused by HHcy, while oxidative damage is not involved.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Bo Pang, Yin-Ru Jiang, Jia-Yao Xu, Dong-Xue Shao, Li-Ying Hao
Summary: Heart failure is a major public health problem faced by medical researchers worldwide, and pathological cardiac hypertrophy is considered a potential risk factor for heart failure. This review focuses on the apelin/ELABELA-APJ system as a novel therapeutic target for cardiac hypertrophy, exploring its role and intricate mechanisms. The review also discusses the latest breakthroughs in the development of agonists and antagonists for APJ.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Denisa Miklankova, Irena Markova, Martina Huttl, Iveta Zapletalova, Martin Poruba, Hana Malinska
Summary: Metformin can reduce cardiovascular risk independently of glycemic control, with non-glycemic benefits such as improved lipid and fatty acid metabolism and lower blood pressure. In a rat model, metformin treatment reduced accumulation of neutral lipids in the myocardium and showed associations with gene expression and enzyme activity. Additionally, metformin improved fatty acid composition in the heart muscle and had positive effects on arachidonic acid metabolism and related metabolites.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
He-qiang Zhang, Jia-le Lin, Lei Pan, Liang Mao, Jing-long Pang, Qian Yuan, Gui-yang Li, Gang-si Yi, Yang-bin Lin, Bao-long Feng, Yun-da Li, Yan Wang, Ling-jun Jie, Yan-hui Zhang
Summary: This study found that enzastaurin prolongs QT interval in cancer patients and investigated its mechanism of action. The results showed that enzastaurin inhibits the conduction of rapid delayed rectifier potassium current (IKr) by binding to the human Ether-`a-go-go-Related gene (hERG) channel in both open and closed states. Additionally, enzastaurin moderately inhibits the slow delayed rectifier potassium current (IKs) and impairs cardiac function.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Peeraya Jungtanasomboon, Surunchana Nussaro, Hathaichanok Winwan, Patcharapol Suebthawinkul, Pakit Boonpala, Van Nhut Khanh Dong, Nakkawee Saengklub, Sarawut Kumphune, Yaowalak Panyasing, Anusak Kijtawornrat
Summary: The study aimed to investigate the effects of the sGC stimulator Vericiguat on cardiac function, blood pressure, cardiac mitochondrial quality, and fibrosis in rat models of chronic mitral regurgitation. The results showed that Vericiguat preserved cardiac function and structure and significantly reduced systolic blood pressure. It also improved mitochondrial quality by reducing ROS production, depolarization, and swelling, and decreased fibrosis area.
Article
Multidisciplinary Sciences
Yosuke Nakadate, Akiko Kawakami, Hiroaki Sato, Tamaki Sato, Takeshi Oguchi, Keisuke Omiya, Toru Matsuoka, Thomas Schricker, Takashi Matsukawa
Summary: Insulin has dose-dependent positive inotropic effects on cardiac muscle, mediated by the PI3K/Akt pathway. However, high doses of insulin temporarily enhance cardiac tissue function and cause tachyphylaxis.
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Zhipeng Yan, Ni Zeng, Jieting Li, Tao Liao, Guoxin Ni
Summary: The study revealed that the effect of treadmill exercise training on cardiac hypertrophy is intensity dependent, with high-intensity running potentially leading to cardiomyocyte injury and increased risk of pathological development. Different exercise intensities showed variations in myocardial tissue structure, fiber deposition, and cTnI levels, with high-intensity running displaying more detrimental effects compared to low and medium intensities. Additionally, the ERK signaling pathway was found to be involved in compensatory hypertrophy but may be attenuated with long-term exercise.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Summary: The study found that Apelin rejuvenated AMSCs by activating AMPK, promoting autophagy, and enhancing cardiac protection following myocardial infarction in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Junli Hu, Shuhua Huo, Shiying Dou, Wei Jiang, Yongjun Li
Summary: The study analyzed the protective effect and mechanism of Apelin on LPS-induced myocardial dysfunction, showing that it can reverse the decrease of cardiac function and increase of inflammatory factors induced by LPS. Endogenous Apelin may have a protective effect, and exogenous administration can inhibit inflammation through a specific pathway.
GENERAL PHYSIOLOGY AND BIOPHYSICS
(2021)
Article
Medicine, Research & Experimental
Balint Andras Barta, Mihaly Ruppert, Klemens Erwin Frohlich, Miguel Cosenza-Contreras, Attila Olah, Alex Ali Sayour, Krisztian Kovacs, Gellert Balazs Karvaly, Martin Biniossek, Bela Merkely, Oliver Schilling, Tamas Radovits
Summary: Sex-specific alterations in systolic and diastolic function were observed shortly after ischemia, with significant differences in protein levels between males and females, particularly involving transcriptional regulation, cytoskeletal organization, and mitochondrial function.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Giovanni Pacini, Bo Ahren
Summary: Tirzepatide stimulates both insulin secretion and glucose effectiveness, with stimulation of glucose effectiveness being the prominent process to reduce glucose.
Article
Biochemistry & Molecular Biology
Si -yu Wang, Yu-zhe Zhang, Xiao-han Liu, Xue-ci Guo, Xiao-fang Wang, Feng-tong Han, Yao Zhang, Chang -lin Wang
Summary: In the formalin pain test, the EM-2 analogs EM-2-Me, EM-2-Et, and EM-2-Bu showed significant analgesic effects with reduced tolerance and gastrointestinal side effects. These effects were mediated through central opioid mechanisms, with EM-2-Me possibly involving dynorphin A release and EM-2-Bu directly activating multiple opioid receptors.