Article
Nutrition & Dietetics
Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire
Summary: “Calorie restriction (CR) is the only nutritional strategy proven to extend lifespan, prevent age-related diseases, and delay functional decline. The effects of CR when started early in life are not well understood. This study found that young female rats treated with CR showed similar expression patterns of key genes/pathways associated with healthy aging compared to old animals treated with CR, while in male rats these effects were reduced.”
Article
Nutrition & Dietetics
Ana Teofilovic, Milos Vrataric, Natasa Velickovic, Danijela Vojnovic Milutinovic, Aleksandra Mladenovic, Milica Prvulovic, Ana Djordjevic
Summary: Late-onset calorie restriction has a positive impact on lipid metabolism but a negative impact on inflammation in the liver of old rats. It can restore age-related imbalance in lipid metabolism but does not improve expression of antioxidant enzymes and leads to progression of age-related inflammation in the liver.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Sai Krupa Das, Rachel E. Silver, Alistair Senior, Cheryl H. Gilhooly, Manjushri Bhapkar, David Le Couteur
Summary: This study used the Geometric Framework for Nutrition to examine the impact of macronutrient composition on adherence to calorie restriction (CR) and its effect on cardiometabolic markers of healthspan. The study found that a higher percentage of reported energy intake from protein and carbohydrate, and lower fat intake, were associated with greater adherence to CR. However, there was no significant correlation between macronutrient composition and cardiometabolic risk factors in the CR group. This study suggests that individual macronutrients have an interactive role in CR adherence, but further research is needed to understand the effect of different macronutrient compositions on adherence to CR and cardiometabolic risk factors.
Article
Multidisciplinary Sciences
Libia Alejandra Garcia-Flores, Cara L. Green, Sharon E. Mitchell, Daniel E. L. Promislow, David Lusseau, Alex Douglas, John R. Speakman
Summary: Caloric restriction affects the metabolome in a tissue-specific manner, with only a small number of common metabolic features responding in the same way across all tissues. The top modulated pathways were related to biosynthesis and degradation processes, suggesting each tissue has its own unique way of coping with reduced energy intake, supporting the clean cupboards hypothesis over the disposable soma interpretation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Geriatrics & Gerontology
Satchidananda Panda, Geraldine Maier, Dennis T. Villareal
Summary: With the rise in obesity across age groups, engaging in physical activity and mobility in older adults has become difficult. Calorie restriction (CR) up to 25% has been used for obesity management, but its safety in older adults is not fully understood. There are challenges in adopting and complying with CR, and concerns about the negative effects on sarcopenia, osteopenia, and frailty. Time-Restricted Feeding/Eating (TRF/TRE), which optimizes circadian rhythm and combines with CR, may reduce weight and improve health.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Nutrition & Dietetics
Emiliana Giacomello, Luana Toniolo
Summary: Aging is a biological process influenced by multiple cellular mechanisms leading to functional decline. The growth of the elderly population and their susceptibility to diseases drive the search for anti-aging interventions, with calorie restriction identified as an effective approach.
Article
Cell Biology
Kavitha Kurup, Stephanie Matyi, Cory B. Giles, Jonathan D. Wren, Kenneth Jones, Aaron Ericsson, Daniel Raftery, Lu Wang, Daniel Promislow, Arlan Richardson, Archana Unnikrishnan
Summary: The study shows that calorie restriction has significant effects on the microbiome, fecal metabolome, and colon transcriptome of mice, maintaining a more youthful state of the gastrointestinal system, which may lead to a more diverse and youthful microbiome.
Review
Cell Biology
Begun Erbaba, Ayca Arslan-Ergul, Michelle M. Adams
Summary: Caloric restriction is a non-genetic intervention that extends lifespan and healthspan by promoting cell survival, reducing cell proliferation, inducing stem cell quiescence, and preserving stem cell reserve for extreme needs. This protective mechanism induced by diet may involve downregulation of crucial cell cycle-related transcription activators and could offer new targets for treatments against neurodegenerative diseases.
AGEING RESEARCH REVIEWS
(2021)
Review
Food Science & Technology
Mehedy Hasan Abir, A. G. M. Sofi Uddin Mahamud, Sadia Haque Tonny, Mithila Saha Anu, K. H. Sabbir Hossain, Ismam Ahmed Protic, Md Shihab Uddine Khan, Artho Baroi, Akhi Moni, Md Jamal Uddin
Summary: Aging and aging-related chronic disorders are leading causes of death globally. Lycopene, a carotenoid found in various fruits and vegetables, has antioxidative properties and has shown potential in treating aging disorders. Lycopene-rich foods have been found to prevent or alleviate aging disorders.
FOOD SCIENCE & NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Alisa B. Beydogan, Zeynep M. Coskun Yazici, Sema Bolkent
Summary: The study aimed to investigate the effects of lipopolysaccharide (LPS) alone and in combination with calorie restriction (CR) on the pancreatic tissues in C57BL/6 mice modeled with pancreatic ductal adenocarcinoma (PDAC). The combination of low-dose LPS and 40% CR was found to be more effective in PDAC model mice.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Cell Biology
Christopher Minteer, Marco Morselli, Margarita Meer, Jian Cao, Albert Higgins-Chen, Sabine M. Lang, Matteo Pellegrini, Qin Yan, Morgan E. Levine
Summary: This study demonstrates that physiologically relevant aging changes can be induced in vitro and used to uncover mechanistic insights into epigenetic aging.
Article
Cell Biology
David G. Le Couteur, Samantha M. Solon-Biet, Benjamin L. Parker, Tamara Pulpitel, Amanda E. Brandon, Nicholas J. Hunt, Jibran A. Wali, Rahul Gokarn, Alistair M. Senior, Gregory J. Cooney, David Raubenheimer, Victoria C. Cogger, David E. James, Stephen J. Simpson
Summary: Diet composition has a significant impact on the hepatic proteome, influencing not only metabolic pathways but also fundamental processes like mitochondrial function and RNA splicing.
Article
Cell Biology
Dennis Mangan
Summary: Iron is essential for living organisms, but excessive accumulation can lead to health issues, age-related diseases, and shortened lifespan. Blocking iron absorption can extend lifespan, while controlling body iron stores may be an important intervention for health and longevity.
Review
Biochemistry & Molecular Biology
Patrick C. Bradshaw
Summary: Acetyl-CoA plays important roles in regulating gene expression and promoting longevity, with decreased cytoplasmic levels potentially contributing to longevity and increased nuclear levels aiding in histone acetylation and lifespan extension. Future research should focus on the role of nuclear acetyl-CoA and histone acetylation in controlling hypothalamic inflammation, a key driver of organismal aging.
Article
Nutrition & Dietetics
Shanlin Ke, Sarah J. Mitchell, Michael R. MacArthur, Alice E. Kane, David A. Sinclair, Emily M. Venable, Katia S. Chadaideh, Rachel N. Carmody, Francine Grodstein, James R. Mitchell, Yangyu Liu
Summary: The study found that calorie restriction can significantly reduce the rate of increase in the frailty index (FI), showing that CR can slow down the aging process. Significant alterations in diversity and compositional patterns of the mouse gut microbiota were also observed during the aging process. The gut microbial features of 21-month-old mice can predict the healthy aging of 30-month-old mice with reasonable accuracy.
Article
Geriatrics & Gerontology
Jin Young Lee, Brian K. Kennedy, Chen-Yu Liao
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2020)
Article
Multidisciplinary Sciences
Katherine H. Schreiber, Sebastian I. Arriola Apelo, Deyang Yu, Jacqueline A. Brinkman, Michael C. Velarde, Faizan A. Syed, Chen-Yu Liao, Emma L. Baar, Kathryn A. Carbaja, Dawn S. Sherman, Denise Ortiz, Regina Brunauer, Shany E. Yang, Stelios T. Tzannis, Brian K. Kennedyl, Dudley W. Lamming
NATURE COMMUNICATIONS
(2019)
Article
Geriatrics & Gerontology
Chen-Yu Liao, Oona M. P. Kummert, Amanda M. Bair, Nora Alavi, Josef Alavi, Delana M. Miller, Isha Bagga, Anja M. Schempf, Yueh-Mei Hsu, Bruce D. Woods, Stephen M. Brown Mayfield, Angelina N. Mitchell, Gabriella Tannady, Aislinn R. Talbot, Aaron M. Dueck, Ricardo Barrera Ovando, Heather D. Parker, Junying Wang, Jane K. Schoeneweis, Brian K. Kennedy
Summary: The study shows that spermidine affects systemic metabolism through various mechanistic pathways, including increasing FGF21 expression in the liver and enhancing lipolysis in visceral fat to counteract high-fat diet-induced obesity.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)