Eukaryotic G protein-coupled receptors as descendants of prokaryotic sodium-translocating rhodopsins

Cation-Specific Conformations in a Dual-Function Ion-Pumping Microbial Rhodopsin

(2015) Giordano F. Z. da Silva et al.   BIOCHEMISTRY

Ancient systems of sodium/potassium homeostasis as predecessors of membrane bioenergetics

(2015) D. V. Dibrova et al.   BIOCHEMISTRY-MOSCOW

Structural Insights into the Dynamic Process of β 2 -Adrenergic Receptor Signaling

(2015) Aashish Manglik et al.   CELL

Structural basis for Na+ transport mechanism by a light-driven Na+ pump

(2015) Hideaki E. Kato et al.   NATURE

Buried ionizable networks are an ancient hallmark of G protein-coupled receptor activation

(2015) Daniel G. Isom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Light-driven ion-translocating rhodopsins in marine bacteria

(2015) Keiichi Inoue et al.   TRENDS IN MICROBIOLOGY

Generic GPCR residue numbers – aligning topology maps while minding the gaps

(2015) Vignir Isberg et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MicRhoDE: a curated database for the analysis of microbial rhodopsin diversity and evolution

(2015) Dominique Boeuf et al.   Database-The Journal of Biological Databases and Curation

Light-Driven Na+ Pump from Gillisia limnaea: A High-Affinity Na+ Binding Site Is Formed Transiently in the Photocycle

(2014) Sergei P. Balashov et al.   BIOCHEMISTRY

Mechanistic Insights into the Allosteric Modulation of Opioid Receptors by Sodium Ions

(2014) Yi Shang et al.   BIOCHEMISTRY

The Evolution of the GPCR Signaling System in Eukaryotes: Modularity, Conservation, and the Transition to Metazoan Multicellularity

(2014) Alex de Mendoza et al.   Genome Biology and Evolution

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain

(2014) Andrew S. Doré et al.   NATURE

Molecular control of δ-opioid receptor signalling

(2014) Gustavo Fenalti et al.   NATURE

The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

(2014) Jennifer L. Miller-Gallacher et al.   PLoS One

Structure of signaling-competent neurotensin receptor 1 obtained by directed evolution inEscherichia coli

(2014) Pascal Egloff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nature's toolkit for microbial rhodopsin ion pumps

(2014) O. Beja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Class C GPCR Metabotropic Glutamate Receptor 1 Bound to an Allosteric Modulator

(2014) H. Wu et al.   SCIENCE

Allosteric sodium in class A GPCR signaling

(2014) Vsevolod Katritch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Light-Induced Movement of the Transmembrane Helix B in Channelrhodopsin-2

(2013) Thomas Sattig et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism divergence in microbial rhodopsins

(2013) John L. Spudich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Molecular and evolutionary aspects of microbial sensory rhodopsins

(2013) Keiichi Inoue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Eubacterial rhodopsins — Unique photosensors and diverse ion pumps

(2013) Leonid S. Brown   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Large Deformation of Helix F during the Photoreaction Cycle of Pharaonis Halorhodopsin in Complex with Azide

(2013) Taichi Nakanishi et al.   BIOPHYSICAL JOURNAL

Microbial and Animal Rhodopsins: Structures, Functions, and Molecular Mechanisms

(2013) Oliver P. Ernst et al.   CHEMICAL REVIEWS

The transporter-opsin-G protein-coupled receptor (TOG) superfamily

(2013) Daniel C. Yee et al.   FEBS Journal

Structural differences between the closed and open states of channelrhodopsin-2 as observed by EPR spectroscopy

(2013) Nils Krause et al.   FEBS LETTERS

Do Plants Contain G Protein-Coupled Receptors?

(2013) B. Taddese et al.   PLANT PHYSIOLOGY

Relocating the active-site lysine in rhodopsin and implications for evolution of retinylidene proteins

(2013) E. L. Devine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into the proton pumping by unusual proteorhodopsin from nonmarine bacteria

(2013) I. Gushchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial, archaeal and viral-like rhodopsins from the Red Sea

(2013) Alon Philosof et al.   Environmental Microbiology Reports

A light-driven sodium ion pump in marine bacteria

(2013) Keiichi Inoue et al.   Nature Communications

Structure-Function of the G Protein–Coupled Receptor Superfamily

(2012) Vsevolod Katritch et al.   Annual Review of Pharmacology and Toxicology

Proteorhodopsin genes in giant viruses

(2012) Natalya Yutin et al.   Biology Direct

Crystal structure of the µ-opioid receptor bound to a morphinan antagonist

(2012) Aashish Manglik et al.   NATURE

Crystal structure of the channelrhodopsin light-gated cation channel

(2012) Hideaki E. Kato et al.   NATURE

High-resolution crystal structure of human protease-activated receptor 1

(2012) Cheng Zhang et al.   NATURE

The RCSB Protein Data Bank: new resources for research and education

(2012) Peter W. Rose et al.   NUCLEIC ACIDS RESEARCH

Origin of first cells at terrestrial, anoxic geothermal fields

(2012) A. Y. Mulkidjanian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Allosteric Regulation of GPCRs by Sodium Ions

(2012) W. Liu et al.   SCIENCE

GPCR-MPredictor: multi-level prediction of G protein-coupled receptors using genetic ensemble

(2011) Muhammad Naveed et al.   AMINO ACIDS

Halotolerant CyanobacteriumAphanothece halophyticaContains an Na+-dependent F1F0-ATP Synthase with a Potential Role in Salt-stress Tolerance

(2011) Kanteera Soontharapirakkul et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Active State of Sensory Rhodopsin II: Structural Determinants for Signal Transfer and Proton Pumping

(2011) Ivan Gushchin et al.   JOURNAL OF MOLECULAR BIOLOGY

Independent HHsearch, Needleman-Wunsch-Based, and Motif Analyses Reveal the Overall Hierarchy for Most of the G Protein-Coupled Receptor Families

(2011) K. J. V. Nordstrom et al.   MOLECULAR BIOLOGY AND EVOLUTION

A Knockout Mutation of a Constitutive GPCR in Tetrahymena Decreases Both G-Protein Activity and Chemoattraction

(2011) Thomas J. Lampert et al.   PLoS One

Characterization of the N-ATPase, a distinct, laterally transferred Na+-translocating form of the bacterial F-type membrane ATPase

(2010) Daria V. Dibrova et al.   BIOINFORMATICS

Pre-calculated protein structure alignments at the RCSB PDB website: Fig. 1.

(2010) Andreas Prlić et al.   BIOINFORMATICS

An improved classification of G-protein-coupled receptors using sequence-derived features

(2010) Zhen-Ling Peng et al.   BMC BIOINFORMATICS

Comparative genomics uncovers novel structural and functional features of the heterotrimeric GTPase signaling system

(2010) Vivek Anantharaman et al.   GENE

Structural divergence and functional versatility of the rhodopsin superfamily

(2010) Tsutomu Kouyama et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

7TMRmine: a Web server for hierarchical mining of 7TMR proteins

(2009) Guoqing Lu et al.   BMC GENOMICS

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

High-resolution structure of the rotor ring of a proton-dependent ATP synthase

(2009) Denys Pogoryelov et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Evolution of phototaxis

(2009) G. Jekely   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Co-evolution of primordial membranes and membrane proteins

(2009) Armen Y. Mulkidjanian et al.   TRENDS IN BIOCHEMICAL SCIENCES

The past and present of sodium energetics: May the sodium-motive force be with you

(2008) Armen Y. Mulkidjanian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Evolutionary primacy of sodium bioenergetics

(2008) Armen Y Mulkidjanian et al.   Biology Direct

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

Crystallographic structure of xanthorhodopsin, the light-driven proton pump with a dual chromophore

(2008) H. Luecke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA