Immunohistochemical Characterization of Procaspase-3 Overexpression as a Druggable Target With PAC-1, a Procaspase-3 Activator, in Canine and Human Brain Cancers

Current trends in mouse models of glioblastoma

(2017) Masafumi Miyai et al.   JOURNAL OF NEURO-ONCOLOGY

Expression and function of ABCG2 and XIAP in glioblastomas

(2017) Ivette F. Emery et al.   JOURNAL OF NEURO-ONCOLOGY

Frameless stereotactic radiotherapy alone and combined with temozolomide for presumed canine gliomas

(2017) M. Dolera et al.   Veterinary and Comparative Oncology

Expression and activity of the urokinase plasminogen activator system in canine primary brain tumors

(2017) John H Rossmeisl et al.   OncoTargets and Therapy

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

(2017) Avadhut D. Joshi et al.   Oncotarget

Survival in glioblastoma: a review on the impact of treatment modalities

(2016) P. D. Delgado-López et al.   Clinical & Translational Oncology

Perfusion and Volume Response of Canine Brain Tumors to Stereotactic Radiosurgery and Radiotherapy

(2016) A.L. Zwingenberger et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Creation of an NCI comparative brain tumor consortium: informing the translation of new knowledge from canine to human brain tumor patients

(2016) Amy K. LeBlanc et al.   NEURO-ONCOLOGY

World Health Organization Grade II Meningioma: A 10-Year Retrospective Study for Recurrence and Prognostic Factor Assessment

(2016) Charles Champeaux et al.   World Neurosurgery

Brain Invasion in Meningiomas: Incidence and Correlations with Clinical Variables and Prognosis

(2016) Dorothee Cäcilia Spille et al.   World Neurosurgery

Small-Molecule Procaspase-3 Activation Sensitizes Cancer to Treatment with Diverse Chemotherapeutics

(2016) Rachel C. Botham et al.   ACS Central Science

Molecular Mechanisms of Apoptosis and Roles in Cancer Development and Treatment

(2015) Samira Goldar et al.   Asian Pacific Journal of Cancer Prevention

Atypical meningioma: Randomized trials are required to resolve contradictory retrospective results regarding the role of adjuvant radiotherapy

(2015) MustafaK Baskaya et al.   Journal of Cancer Research and Therapeutics

Caspase-3 Deficiency Results in Disrupted Synaptic Homeostasis and Impaired Attention Control

(2015) S.-C. Lo et al.   JOURNAL OF NEUROSCIENCE

Safety and feasibility of the NanoKnife system for irreversible electroporation ablative treatment of canine spontaneous intracranial gliomas

(2015) John H. Rossmeisl et al.   JOURNAL OF NEUROSURGERY

Systematic Review of Brain Tumor Treatment in Dogs

(2015) H. Hu et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Canine brain tumours: a model for the human disease?

(2015) J. Hicks et al.   Veterinary and Comparative Oncology

PAC-1 and isatin derivatives are weak matrix metalloproteinase inhibitors

(2014) Stian Sjøli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Distinctive effects of the cellular inhibitor of apoptosis protein c-IAP2 through stabilization by XIAP in glioblastoma multiforme cells

(2014) Wensheng Yang et al.   CELL CYCLE

Local Pruning of Dendrites and Spines by Caspase-3-Dependent and Proteasome-Limited Mechanisms

(2014) A. Erturk et al.   JOURNAL OF NEUROSCIENCE

Dual Small-Molecule Targeting of Procaspase-3 Dramatically Enhances Zymogen Activation and Anticancer Activity

(2014) Rachel C. Botham et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Advances in Diagnostic and Treatment Modalities for Intracranial Tumors

(2014) P.J. Dickinson   JOURNAL OF VETERINARY INTERNAL MEDICINE

Bioengineered 3D Brain Tumor Model To Elucidate the Effects of Matrix Stiffness on Glioblastoma Cell Behavior Using PEG-Based Hydrogels

(2014) Christine Wang et al.   MOLECULAR PHARMACEUTICS

Historical benchmarks for medical therapy trials in surgery- and radiation-refractory meningioma: a RANO review

(2014) T. Kaley et al.   NEURO-ONCOLOGY

High-grade meningiomas

(2013) Matthias Preusser et al.   CURRENT OPINION IN NEUROLOGY

Postmortem Evaluation of 435 Cases of Intracranial Neoplasia in Dogs and Relationship of Neoplasm with Breed, Age, and Body Weight

(2013) R.B. Song et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

New Agents for Targeting of IL-13RA2 Expressed in Primary Human and Canine Brain Tumors

(2013) Waldemar Debinski et al.   PLoS One

Toward 3D Biomimetic Models to Understand the Behavior of Glioblastoma Multiforme Cells

(2013) Shreyas S. Rao et al.   TISSUE ENGINEERING PART B-REVIEWS

Frameless stereotactic radiosurgery for the treatment of primary intracranial tumours in dogs

(2013) C. L. Mariani et al.   Veterinary and Comparative Oncology

Clinicopathological evaluation of cyclooxygenase-2 expression in meningioma: immunohistochemical analysis of 76 cases of low and high-grade meningioma

(2012) Yasutaka Kato et al.   Brain Tumor Pathology

Survival time following hospital discharge in dogs with palliatively treated primary brain tumors

(2012) John H. Rossmeisl et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Differential Effects of Procaspase-3 Activating Compounds in the Induction of Cancer Cell Death

(2012) Diana C. West et al.   MOLECULAR PHARMACEUTICS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

What drives intense apoptosis resistance and propensity for necrosis in glioblastoma? A role for Bcl2L12 as a multifunctional cell death regulator

(2011) Alexander H. Stegh et al.   CELL CYCLE

Apoptosis in cancer: from pathogenesis to treatment

(2011) Rebecca SY Wong   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Sphingosine Kinase 1 Regulates the Akt/FOXO3a/Bim Pathway and Contributes to Apoptosis Resistance in Glioma Cells

(2011) Hongyu Guan et al.   PLoS One

TP53 Mutations in Canine Brain Tumors

(2011) D. York et al.   VETERINARY PATHOLOGY

Pharmacokinetics and derivation of an anticancer dosing regimen for PAC-1, a preferential small molecule activator of procaspase-3, in healthy dogs

(2010) Pamela W. Lucas et al.   INVESTIGATIONAL NEW DRUGS

Canine spontaneous glioma: A translational model system for convection-enhanced delivery

(2010) P. J. Dickinson et al.   NEURO-ONCOLOGY

Mitotic Count, Brain Invasion, and Location Are Independent Predictors of Recurrence-Free Survival in Primary Atypical and Malignant Meningiomas: A Study of 86 Patients

(2010) Andrej Vranic et al.   NEUROSURGERY

Neuronal caspase-3 signaling: not only cell death

(2009) M D'Amelio et al.   CELL DEATH AND DIFFERENTIATION

Procaspase-3 Activation as an Anti-Cancer Strategy: Structure−Activity Relationship of Procaspase-Activating Compound 1 (PAC-1) and Its Cellular Co-Localization with Caspase-3

(2009) Quinn P. Peterson et al.   JOURNAL OF MEDICINAL CHEMISTRY

PAC-1 Activates Procaspase-3 in Vitro through Relief of Zinc-Mediated Inhibition

(2009) Quinn P. Peterson et al.   JOURNAL OF MOLECULAR BIOLOGY

Endoscopic-Assisted Intracranial Tumor Removal in Dogs and Cats: Long-Term Outcome of 39 Cases

(2009) L.S. Klopp et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Cyclooxygenase-2 (COX-2) expression in canine intracranial meningiomas

(2009) J. H. Rossmeisl et al.   Veterinary and Comparative Oncology

Expression of the Tumor Suppressor Genes NF2, 4.1B, and TSLC1 in Canine Meningiomas

(2009) P. J. Dickinson et al.   VETERINARY PATHOLOGY

Anti-Apoptosis Mechanisms in Malignant Gliomas

(2008) David S. Ziegler et al.   JOURNAL OF CLINICAL ONCOLOGY

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Preliminary analysis of genomic abnormalities in canine meningiomas

(2008) C. Courtay-Cahen et al.   Veterinary and Comparative Oncology

Atypical and anaplastic meningiomas: prognostic implications of clinicopathological features

(2007) S-Y Yang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY