In-Depth Proteome Analysis Highlights HepaRG Cells as a Versatile Cell System Surrogate for Primary Human Hepatocytes

Wnt/β-Catenin Signaling in Liver Development, Homeostasis, and Pathobiology

(2018) Jacquelyn O. Russell et al.   Annual Review of Pathology-Mechanisms of Disease

Differential impacts of individual and combined exposures of deoxynivalenol and zearalenone on the HepaRG human hepatic cell proteome

(2018) Marie-Caroline Smith et al.   Journal of Proteomics

Penicillinase-resistant antibiotics induce non-immune-mediated cholestasis through HSP27 activation associated with PKC/P38 and PI3K/AKT signaling pathways

(2017) Audrey Burban et al.   Scientific Reports

Novel roles for AhR and ARNT in the regulation of alcohol dehydrogenases in human hepatic cells

(2016) Eléonore A. Attignon et al.   ARCHIVES OF TOXICOLOGY

Gene network activity in cultivated primary hepatocytes is highly similar to diseased mammalian liver tissue

(2016) Patricio Godoy et al.   ARCHIVES OF TOXICOLOGY

Differential proteomics reveals age-dependent liver oxidative costs of innate immune activation in mice

(2016) Marine I. Plumel et al.   Journal of Proteomics

In-depth quantitative analysis and comparison of the human hepatocyte and hepatoma cell line HepG2 proteomes

(2016) Jacek R. Wiśniewski et al.   Journal of Proteomics

NAFLD and diabetes mellitus

(2016) Herbert Tilg et al.   Nature Reviews Gastroenterology & Hepatology

Rho-kinase/myosin light chain kinase pathway plays a key role in the impairment of bile canaliculi dynamics induced by cholestatic drugs

(2016) Ahmad Sharanek et al.   Scientific Reports

Structural and functional hepatocyte polarity and liver disease

(2015) Paul Gissen et al.   JOURNAL OF HEPATOLOGY

Comparative Proteomic Analysis of Human Liver Tissue and Isolated Hepatocytes with a Focus on Proteins Determining Drug Exposure

(2015) Anna Vildhede et al.   JOURNAL OF PROTEOME RESEARCH

2016 update of the PRIDE database and its related tools

(2015) Juan Antonio Vizcaíno et al.   NUCLEIC ACIDS RESEARCH

Keap1 modulates the redox cycle and hepatocyte cell cycle in regenerating liver

(2014) Min Hu et al.   CELL CYCLE

DEPTOR Is a Stemness Factor That Regulates Pluripotency of Embryonic Stem Cells

(2014) Pooja Agrawal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Normalyzer: A Tool for Rapid Evaluation of Normalization Methods for Omics Data Sets

(2014) Aakash Chawade et al.   JOURNAL OF PROTEOME RESEARCH

Multi-enzyme digestion FASP and the ‘Total Protein Approach’-based absolute quantification of the Escherichia coli proteome

(2014) Jacek R. Wiśniewski et al.   Journal of Proteomics

A “Proteomic Ruler” for Protein Copy Number and Concentration Estimation without Spike-in Standards

(2014) Jacek R. Wiśniewski et al.   MOLECULAR & CELLULAR PROTEOMICS

USP7 Attenuates Hepatic Gluconeogenesis Through Modulation of FoxO1 Gene Promoter Occupancy

(2014) Jessica A. Hall et al.   MOLECULAR ENDOCRINOLOGY

MSDA, a proteomics software suite for in-depth Mass Spectrometry Data Analysis using grid computing

(2014) Christine Carapito et al.   PROTEOMICS

Different Dose-Dependent Mechanisms Are Involved in Early Cyclosporine A-Induced Cholestatic Effects in HepaRG Cells

(2014) Ahmad Sharanek et al.   TOXICOLOGICAL SCIENCES

Liver zonation: Novel aspects of its regulation and its impact on homeostasis

(2014) Rolf Gebhardt   WORLD JOURNAL OF GASTROENTEROLOGY

Manganese Superoxide Dismutase Regulates a Redox Cycle Within the Cell Cycle

(2013) Ehab H. Sarsour et al.   ANTIOXIDANTS & REDOX SIGNALING

Zonation of glucose and fatty acid metabolism in the liver: Mechanism and metabolic consequences

(2013) Brenda S. Hijmans et al.   BIOCHIMIE

What is the total number of protein molecules per cell volume? A call to rethink some published values

(2013) Ron Milo   BIOESSAYS

Long-term maintenance of HepaRG cells in serum-free conditions and application in a repeated dose study

(2013) Sebastian Klein et al.   JOURNAL OF APPLIED TOXICOLOGY

The role of hepatokines in metabolism

(2013) Norbert Stefan et al.   Nature Reviews Endocrinology

Aneuploidy, polyploidy and ploidy reversal in the liver

(2013) Andrew W. Duncan   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

1D and 2D annotation enrichment: a statistical method integrating quantitative proteomics with complementary high-throughput data

(2012) Juergen Cox et al.   BMC BIOINFORMATICS

Endoplasmic Reticulum Stress Induces the Expression of Fetuin-A to Develop Insulin Resistance

(2012) Horng-Yih Ou et al.   ENDOCRINOLOGY

The HepaRG cell line: a uniquein vitrotool for understanding drug metabolism and toxicology in human

(2012) Tommy B Andersson et al.   Expert Opinion on Drug Metabolism & Toxicology

Cingulin is dispensable for epithelial barrier function and tight junction structure, and plays a role in the control of claudin-2 expression and response to duodenal mucosa injury

(2012) L. Guillemot et al.   JOURNAL OF CELL SCIENCE

Cooperative Activation of PI3K by Ras and Rho Family Small GTPases

(2012) Hee Won Yang et al.   MOLECULAR CELL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

SREBP-1 Transcription Factors Regulate Skeletal Muscle Cell Size by Controlling Protein Synthesis through Myogenic Regulatory Factors

(2012) Kevin Dessalle et al.   PLoS One

The human hepatocyte cell lines IHH and HepaRG: models to study glucose, lipid and lipoprotein metabolism

(2012) Carolina Huaman Samanez et al.   ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY

CYP4F3B Expression Is Associated with Differentiation of HepaRG Human Hepatocytes and Unaffected by Fatty Acid Overload

(2011) S. Madec et al.   DRUG METABOLISM AND DISPOSITION

The HepaRG cell line is suitable for bioartificial liver application

(2011) Ruurdtje Hoekstra et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Andromeda: A Peptide Search Engine Integrated into the MaxQuant Environment

(2011) Jürgen Cox et al.   JOURNAL OF PROTEOME RESEARCH

Automated detection of hepatotoxic compounds in human hepatocytes using HepaRG cells and image-based analysis of mitochondrial dysfunction with JC-1 dye

(2011) K. Pernelle et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

On the beta-binomial model for analysis of spectral count data in label-free tandem mass spectrometry-based proteomics

(2009) Thang V. Pham et al.   BIOINFORMATICS

Role of transforming growth factor β signaling and expansion of progenitor cells in regenerating liver

(2009) Arun Thenappan et al.   HEPATOLOGY

Induction of avian musculoaponeurotic fibrosarcoma proteins by toxic bile acid inhibits expression of glutathione synthetic enzymes and contributes to cholestatic liver injury in mice

(2009) Heping Yang et al.   HEPATOLOGY

Histologic subtypes of hepatoblastoma are characterized by differential canonical Wnt and Notch pathway activation in DLK+ precursors

(2009) Dolores López-Terrada et al.   HUMAN PATHOLOGY

Hep G2 is a hepatoblastoma-derived cell line

(2009) Dolores López-Terrada et al.   HUMAN PATHOLOGY

Transcription dynamics in a physiological process: β-Catenin signaling directs liver metabolic zonation

(2009) Cyril Torre et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

(2008) K. P. Kanebratt et al.   DRUG METABOLISM AND DISPOSITION

Transcription factor HNF and hepatocyte differentiation

(2008) Masahito Nagaki et al.   HEPATOLOGY RESEARCH