Chasing the FOXO3: Insights into Its New Mitochondrial Lair in Colorectal Cancer Landscape

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

(2019) Paul Laissue   Molecular Cancer

Meeting report from the joint IARC–NCI international cancer seminar series: a focus on colorectal cancer

(2019) M J Gunter et al.   ANNALS OF ONCOLOGY

Overexpression of Forkhead Box O3a and Its Association With Aggressive Phenotypes and Poor Prognosis in Human Hepatocellular Carcinoma

(2018) Hyein Ahn et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

Cancer statistics, 2018

(2018) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression

(2018) Marten Hornsveld et al.   CANCER RESEARCH

A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene

(2018) Evan E. Santo et al.   GENE

The longevity SNP rs2802292 uncovered: HSF1 activates stress-dependent expression of FOXO3 through an intronic enhancer

(2018) Valentina Grossi et al.   NUCLEIC ACIDS RESEARCH

Uncoupling FoxO3A mitochondrial and nuclear functions in cancer cells undergoing metabolic stress and chemotherapy

(2018) Valentina Celestini et al.   Cell Death & Disease

Estimation of The Percentage of US Patients With Cancer Who Benefit From Genome-Driven Oncology

(2018) John Marquart et al.   JAMA Oncology

Pleiotropic Effects of Metformin on Cancer

(2018) Hans-Juergen Schulten   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Foxo3a inhibits mitochondrial fission and protects against doxorubicin-induced cardiotoxicity by suppressing MIEF2

(2017) Luyu Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Overexpression of FoxO3a is associated with glioblastoma progression and predicts poor patient prognosis

(2017) Zhongrun Qian et al.   INTERNATIONAL JOURNAL OF CANCER

Functional precision cancer medicine—moving beyond pure genomics

(2017) Anthony Letai   NATURE MEDICINE

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification and characterization of two functional variants in the human longevity gene FOXO3

(2017) Friederike Flachsbart et al.   Nature Communications

The FoxO3 gene and cause-specific mortality

(2016) Bradley J. Willcox et al.   AGING CELL

An oncogenic role of miR-592 in tumorigenesis of human colorectal cancer by targeting Forkhead Box O3A (FoxO3A)

(2016) Qi Fu et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Evaluation of the potential synergism of imatinib-related poly kinase inhibitors using growth factor stimulated proteoglycan synthesis as a model response

(2016) Rebekah Bernard et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Longevity-AssociatedFOXO3Genotype and its Impact on Coronary Artery Disease Mortality in Japanese, Whites, and Blacks: A Prospective Study of Three American Populations

(2016) Bradley J. Willcox et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Precision oncology: origins, optimism, and potential

(2016) Vinay Prasad et al.   LANCET ONCOLOGY

Downregulation of Foxo3 and TRIM31 by miR-551b in side population promotes cell proliferation, invasion, and drug resistance of ovarian cancer

(2016) Zhentong Wei et al.   MEDICAL ONCOLOGY

Perspective: The precision-oncology illusion

(2016) Vinay Prasad   NATURE

Proteogenomics connects somatic mutations to signalling in breast cancer

(2016) Philipp Mertins et al.   NATURE

Limits to Personalized Cancer Medicine

(2016) Ian F. Tannock et al.   NEW ENGLAND JOURNAL OF MEDICINE

Precision oncology: a strategy we were not ready to deploy

(2016) Tito Fojo   SEMINARS IN ONCOLOGY

FOXO3a promotes gastric cancer cell migration and invasion through the induction of cathepsin L

(2016) Shan Yu et al.   Oncotarget

Repurposing metformin for cancer treatment: current clinical studies

(2016) Young Kwang Chae et al.   Oncotarget

No Solid Evidence, Only Hollow Argument for Universal Tumor Sequencing

(2016) Howard (Jack) West   JAMA Oncology

Methylation by Set9 modulates FoxO3 stability and transcriptional activity

(2016) Daniel R. Calnan et al.   Aging-US

Expression and Prognostic Implications of FOXO3a and Ki67 in Lung Adenocarcinomas

(2015) Hong-Bin Liu et al.   Asian Pacific Journal of Cancer Prevention

In Silico Prescription of Anticancer Drugs to Cohorts of 28 Tumor Types Reveals Targeting Opportunities

(2015) Carlota Rubio-Perez et al.   CANCER CELL

FOXO3: A Major Gene for Human Longevity - A Mini-Review

(2015) Brian J. Morris et al.   GERONTOLOGY

The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression

(2015) Arnav Mehta et al.   IMMUNITY

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

Paclitaxel targets FOXM1 to regulate KIF20A in mitotic catastrophe and breast cancer paclitaxel resistance

(2015) P Khongkow et al.   ONCOGENE

Myristoylation confers noncanonical AMPK functions in autophagy selectivity and mitochondrial surveillance

(2015) Jiyong Liang et al.   Nature Communications

PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer

(2015) Huanan Wang et al.   Oncotarget

Micro-RNA-155 is induced by K-Ras oncogenic signal and promotes ROS stress in pancreatic cancer

(2015) Peng Wang et al.   Oncotarget

Redox regulation of FoxO transcription factors

(2015) Lars-Oliver Klotz et al.   Redox Biology

Sp1-mediated microRNA-182 expression regulates lung cancer progression

(2015) Wen-Bin Yang et al.   Oncotarget

Effects of metformin and other biguanides on oxidative phosphorylation in mitochondria

(2014) Hannah R. Bridges et al.   BIOCHEMICAL JOURNAL

Characterization of the rs2802292 SNP identifies FOXO3Aas a modifier locus predicting cancer risk in patients with PJS and PHTS hamartomatous polyposis syndromes

(2014) Giovanna Forte et al.   BMC CANCER

Ischemia in Tumors Induces Early and Sustained Phosphorylation Changes in Stress Kinase Pathways but Does Not Affect Global Protein Levels

(2014) Philipp Mertins et al.   MOLECULAR & CELLULAR PROTEOMICS

The clinical development of MEK inhibitors

(2014) Yujie Zhao et al.   Nature Reviews Clinical Oncology

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

(2014) William W Wheaton et al.   eLife

Targeted therapy against chemoresistant colorectal cancers: Inhibition of p38α modulates the effect of cisplatin in vitro and in vivo through the tumor suppressor FoxO3A

(2013) Aldo Germani et al.   CANCER LETTERS

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome

(2013) Teresa Davoli et al.   CELL

The estrogen receptor α is the key regulator of the bifunctional role of FoxO3a transcription factor in breast cancer motility and invasiveness

(2013) Diego Sisci et al.   CELL CYCLE

A novel AMPK-dependent FoxO3A-SIRT3 intramitochondrial complex sensing glucose levels

(2013) Alessia Peserico et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage

(2013) Anne H.H. Tseng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Serotonin promotes the proliferation of serum-deprived hepatocellular carcinoma cells via upregulation of FOXO3a

(2013) Chao Liang et al.   Molecular Cancer

Mutational heterogeneity in cancer and the search for new cancer-associated genes

(2013) Michael S. Lawrence et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

FOXOs: signalling integrators for homeostasis maintenance

(2013) Astrid Eijkelenboom et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Oncodrive-CIS: A Method to Reveal Likely Driver Genes Based on the Impact of Their Copy Number Changes on Expression

(2013) David Tamborero et al.   PLoS One

Foxo3a Expression Is a Prognostic Marker in Breast Cancer

(2013) Ying Jiang et al.   PLoS One

Decreased Expression of the FOXO3a Gene Is Associated with Poor Prognosis in Primary Gastric Adenocarcinoma Patients

(2013) Xiao-bo Yang et al.   PLoS One

Cancer Genome Landscapes

(2013) B. Vogelstein et al.   SCIENCE

Sorafenib inhibits p38α activity in colorectal cancer cells and synergizes with the DFG-in inhibitor SB202190 to increase apoptotic response

(2012) Valentina Grossi et al.   CANCER BIOLOGY & THERAPY

Dependency of Colorectal Cancer on a TGF-β-Driven Program in Stromal Cells for Metastasis Initiation

(2012) Alexandre Calon et al.   CANCER CELL

Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models

(2012) Fulvio Chiacchiera et al.   CANCER LETTERS

IKK-β mediates chemoresistance by sequestering FOXO3; A critical factor for cell survival and death

(2012) Tugsan Tezil et al.   CELLULAR SIGNALLING

SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression

(2012) Kristi Muldoon Jacobs et al.   International Journal of Biological Sciences

Mitochondrial localization of the Forkhead box class O transcription factor FOXO3a in brain

(2012) Aurelien Caballero-Caballero et al.   JOURNAL OF NEUROCHEMISTRY

Phosphosignature Predicts Dasatinib Response in Non-small Cell Lung Cancer

(2012) Martin Klammer et al.   MOLECULAR & CELLULAR PROTEOMICS

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Comprehensive genomic characterization of squamous cell lung cancers

(2012)   NATURE

Regulation of FoxO transcription factors by acetylation and protein–protein interactions

(2011) Hiroaki Daitoku et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FoxO transcription factors; Regulation by AKT and 14-3-3 proteins

(2011) Guri Tzivion et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

FOXO3a nuclear localisation is associated with good prognosis in luminal-like breast cancer

(2011) Hany Onsy Habashy et al.   BREAST CANCER RESEARCH AND TREATMENT

FoxO family members in cancer

(2011) Yuqing Zhang et al.   CANCER BIOLOGY & THERAPY

Resist or die: FOXO transcription factors determine the cellular response to chemotherapy

(2011) Ana R. Gomes et al.   CELL CYCLE

FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

(2011) E C Ferber et al.   CELL DEATH AND DIFFERENTIATION

FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

(2011) Kim Steen Jensen et al.   EMBO JOURNAL

Phosphorylation of FOXO3a on Ser-7 by p38 Promotes Its Nuclear Localization in Response to Doxorubicin

(2011) Ka-Kei Ho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer

(2011) C T Karadedou et al.   ONCOGENE

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during Stress

(2010) Hyun-Seok Kim et al.   CANCER CELL

The AMPK-FoxO3A axis as a target for cancer treatment

(2010) Fulvio Chiacchiera et al.   CELL CYCLE

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

(2010) Gideon Bollag et al.   NATURE

Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

(2010) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Quantitative Phosphoproteomics Reveals Widespread Full Phosphorylation Site Occupancy During Mitosis

(2010) J. V. Olsen et al.   Science Signaling

Inhibition of p38α unveils an AMPK-FoxO3A axis linking autophagy to cancer-specific metabolism

(2009) Fulvio Chiacchiera et al.   Autophagy

AMPKα1 regulates the antioxidant status of vascular endothelial cells

(2009) Sergio L. Colombo et al.   BIOCHEMICAL JOURNAL

Low expression of Foxo3a is Associated with Poor Prognosis in Ovarian Cancer Patients

(2009) Min Fei et al.   CANCER INVESTIGATION

p38α blockade inhibits colorectal cancer growth in vivo by inducing a switch from HIF1α- to FoxO-dependent transcription

(2009) F Chiacchiera et al.   CELL DEATH AND DIFFERENTIATION

Global Effects of Kinase Inhibitors on Signaling Networks Revealed by Quantitative Phosphoproteomics

(2009) Cuiping Pan et al.   MOLECULAR & CELLULAR PROTEOMICS

FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases

(2009) P. Storz et al.   MOLECULAR AND CELLULAR BIOLOGY

Gefitinib (Iressa) represses FOXM1 expression via FOXO3a in breast cancer

(2009) U. B. McGovern et al.   MOLECULAR CANCER THERAPEUTICS

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor

(2009) Miguel F. Segura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association ofFOXO3Avariation with human longevity confirmed in German centenarians

(2009) Friederike Flachsbart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of the FOXO3A Locus with Extreme Longevity in a Southern Italian Centenarian Study

(2009) Chiara Viviani Anselmi et al.   REJUVENATION RESEARCH

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70

(2008) N. R. Sundaresan et al.   MOLECULAR AND CELLULAR BIOLOGY

FOXO3a mediates the cytotoxic effects of cisplatin in colon cancer cells

(2008) Silvia Fernández de Mattos et al.   MOLECULAR CANCER THERAPEUTICS

Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor

(2008) S.-C. Weng et al.   MOLECULAR CANCER THERAPEUTICS

Doxorubicin activates FOXO3a to induce the expression of multidrug resistance gene ABCB1 (MDR1) in K562 leukemic cells

(2008) R. C-Y. Hui et al.   MOLECULAR CANCER THERAPEUTICS

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

(2008) Jer-Yen Yang et al.   NATURE CELL BIOLOGY

The FoxO code

(2008) D R Calnan et al.   ONCOGENE

FOXOs, cancer and regulation of apoptosis

(2008) Z Fu et al.   ONCOGENE

FOXO3A genotype is strongly associated with human longevity

(2008) B. J. Willcox et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unravelling the tumor-suppressive functions of FOXO proteins

(2008) Tobias B. Dansen et al.   TRENDS IN CELL BIOLOGY