Review
Cell & Tissue Engineering
Shiying Niu, Yueying Zhang
Summary: RILI, a common complication of radiotherapy, lacks effective therapeutic strategies. Studies show that MSCs can enhance tissue regeneration, modulate inflammatory response, and inhibit fibrotic cytokines, providing new potential therapeutic options for RILI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Satya Prakash Shukla, Aaron Raymond, Vineeta Rustagi, Samanth R. Kedika, Olivia Tran, Liye Wang, Bin Guo, D. Gomika Udugamasooriya
Summary: The study identified a highly specific peptidomimetic PCS2D1.2 that displayed highly specific cytotoxicity towards CSCs, effectively blocking colony formation and cell migration of CSCs without affecting non-CSCs. Furthermore, PCS2D1.2 reduced plectin expression and/or plectin-rich CSCs in both in vitro and in vivo studies, showing potential as a highly CSC specific drug candidate for combination therapy with current anti-cancer drugs.
BIOORGANIC CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Wookyeom Yang, Dasol Kim, Dae Kyoung Kim, Kyung Un Choi, Dong Soo Suh, Jae Ho Kim
Summary: Ovarian cancer is a fatal gynecological malignancy, and its treatment remains a challenge. Cancer stem cells (CSCs) play a key role in cancer relapse and treatment resistance, with their malignancy regulated by cell surface receptors and intracellular factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Win Sen Heng, Frank A. E. Kruyt, Shiau-Chuen Cheah
Summary: Lung cancer, one of the deadliest cancers, can be effectively reduced through prevention measures, though treatment improvements are still needed to address therapeutic resistance caused by cancer stem cells; phytochemicals in plant-based diets are believed to have efficacy in targeting lung cancer stem cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yuanyuan Ma, Xiaodan Yang, Wei Zhao, Yue Yang, Zhiqian Zhang
Summary: Research has identified a subpopulation of TICs in non-small cell lung carcinoma (NSCLC) that can be specifically defined by the voltage-gated calcium channel alpha 2 delta 1 subunit, demonstrating stem cell-like properties and resistance to conventional chemotherapy. This discovery suggests that targeting alpha 2 delta 1 to prevent calcium influx provides a novel strategy for targeted therapy against TICs in NSCLC.
CELL DEATH & DISEASE
(2021)
Review
Medicine, Research & Experimental
Hector Mayani, Antonieta Chavez-Gonzalez, Karla Vazquez-Santillan, Jorge Contreras, Monica L. Guzman
Summary: This review article summarizes the biology of cancer stem cells (CSCs) and their significance in tumor development. CSCs are not only capable of initiating tumor growth, but also drive tumor progression and metastasis, exhibit resistance to cancer drugs, and are responsible for cancer relapse. Therefore, CSCs are attractive targets for the development of more effective oncologic treatments.
ARCHIVES OF MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Yeon-Jee Kahm, Rae-Kwon Kim
Summary: BIRC5, also known as survivin, is a protein that negatively regulates apoptosis by inhibiting caspase activation. Its overexpression enables cancer cells to survive and divide. BIRC5 is highly expressed in stem cells and may be involved in the regulation of cancer stem cells (CSCs). The study shows that BIRC5 is a key factor in CSCs and epithelial to mesenchymal transition (EMT) regulation, and it regulates the secretion of plasminogen activator inhibitor-1 (PAI-1), which is involved in signaling mechanisms regulating CSCs and EMT.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Plant Sciences
Chunqing Fu, Keyu Zhang, Manyuan Wang, Feng Qiu
Summary: This study demonstrated the cytotoxicity of A. annua active components CAS and CHD in NSCLC cells, identified the mechanism by which these compounds induce apoptosis, and discovered potential targets for DNA damage pathways in NSCLC cells.
Article
Pharmacology & Pharmacy
Xiaobin Zeng, Chengxiao Liu, Jie Yao, Haoqiang Wan, Guoqing Wan, Yingpeng Li, Nianhong Chen
Summary: Both hereditary and sporadic breast cancer may stem from a subcomponent of stem cells with dysregulated self-renewal pathways. Cancer stem cells play a crucial role in treatment resistance and tumor initiation, highlighting the importance of therapeutic strategies targeting these cells.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Oncology
Sarah E. Mudra, Pritam Sadhukhan, M. Talha Ugurlu, Shorna Alam, Mohammad O. Hoque
Summary: Resistance to cancer therapy is a significant obstacle, with cancer stem cells (CSCs) playing a key role in resistance and the need for novel targeted agents to combat CSCs.
Article
Biochemistry & Molecular Biology
Xue Liu, Shiyao Cui, Caiyun Dan, Wenle Li, Hongqing Xie, Conghui Li, Liangen Shi
Summary: This study identified the composition of Phellinus baumii polyphenol (PBP) and investigated its antitumor effects on lung cancer cells. The results showed that PBP induces apoptosis and cell cycle arrest, accumulates reactive oxygen species, and decreases mitochondrial membrane potential in A549 cells, exerting its antitumor effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Nan Jing, Wei-Qiang Gao, Yu-Xiang Fang
Summary: Cancer stem cells have been proposed as key players in tumorigenesis and progression, regulated by genetic and epigenetic factors and influenced by the tumor microenvironment. Therapeutic strategies targeting CSCs involve regulating key factors in formation, stemness maintenance, and therapeutic resistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Integrative & Complementary Medicine
Xue-li Wang, Xiao-zheng Cao, Dao-yuan Wang, Ye-bei Qiu, Kai-yu Deng, Jian-guo Cao, Shao-qiang Lin, Yong Xu, Kai-qun Ren
Summary: This study found that casticin effectively inhibits stemness in cancer stem-like cells (CCSLCs) from human cervical cancer by suppressing the activation of DNA methyltransferase 1 (DNMT1). This suggests that casticin may be a promising preventive and therapeutic candidate for cervical cancer.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Review
Chemistry, Multidisciplinary
Samjhana Shrestha, Asmita Banstola, Jee-Heon Jeong, Ji Hae Seo, Simmyung Yook
Summary: Cancer stem cells (CSCs) are a subpopulation of tumor cells with the ability to self renew, differentiate, and proliferate. Conventional chemotherapy agents have failed to eliminate CSCs, leading to cancer relapse and drug resistance. Therefore, it is crucial to develop an efficient strategy targeting CSCs through differentiation therapy or targeted drug delivery in order to achieve long-lasting clinical responses and prevent cancer recurrence. CSCs overexpress specific biomarkers, which can be utilized as targets for the development of new diagnostic and treatment approaches. The use of nanostructured particles improves the detection, imaging, and targeting of CSCs, overcoming the limitations of current cancer therapies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Ji Hyeon Kim, Soeun Park, Eunsun Jung, Jinwoo Shin, Yoon-Jae Kim, Ji Young Kim, Jonathan L. Sessler, Jae Hong Seo, Jong Seung Kim
Summary: Chemotherapy rarely eradicates cancer stem cells (CSCs) that drive metastatic recurrence. A prodrug, Nic-A, was developed to target triple-negative breast cancer (TNBC) CSCs and inhibit their characteristics. Nic-A showed effectiveness in inhibiting both proliferating TNBC cells and CSCs, leading to decreased stem-like subpopulations and tumor growth. This study highlights a potential strategy for addressing CSC-based cancer recurrence.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)