Sirt1 Promotes a Thermogenic Gene Program in Bone Marrow Adipocytes: From Mice to (Wo)Men

High-Fat Diet-Induced Obesity Promotes Expansion of Bone Marrow Adipose Tissue and Impairs Skeletal Stem Cell Functions in Mice

(2018) Michaela Tencerova et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults

(2018) Christopher R. Martens et al.   Nature Communications

Osteocytic oxygen sensing controls bone mass through epigenetic regulation of sclerostin

(2018) Steve Stegen et al.   Nature Communications

PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ

(2018) Bo Yu et al.   Cell Stem Cell

Exercise Decreases Marrow Adipose Tissue Through ß-Oxidation in Obese Running Mice

(2017) Maya Styner et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis

(2017) Heather Fairfield et al.   JOURNAL OF CELLULAR PHYSIOLOGY

SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2

(2017) Kayvan Zainabadi et al.   PLoS One

Marrow Adipose Tissue: Skeletal Location, Sexual Dimorphism, and Response to Sex Steroid Deficiency

(2017) Beata Lecka-Czernik et al.   Frontiers in Endocrinology

SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

(2017) Kayvan Zainabadi et al.   PLoS One

Leptin Receptor Promotes Adipogenesis and Reduces Osteogenesis by Regulating Mesenchymal Stromal Cells in Adult Bone Marrow

(2016) Rui Yue et al.   Cell Stem Cell

Sclerostin Enhances Adipocyte Differentiation in 3T3-L1 Cells

(2016) Mayumi Ukita et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Reduced Sirtuin1 expression at the femoral neck in women who sustained an osteoporotic hip fracture

(2016) M. El-Haj et al.   OSTEOPOROSIS INTERNATIONAL

Bone Marrow Adipose Tissue: A New Player in Cancer Metastasis to Bone

(2016) Emma V. Morris et al.   Frontiers in Endocrinology

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis

(2015) Mikael Rydén et al.   Cell Metabolism

Brown and Beige Fat: Physiological Roles beyond Heat Generation

(2015) Shingo Kajimura et al.   Cell Metabolism

Skeletal stem cells

(2015) P. Bianco et al.   DEVELOPMENT

SIRT1 activation ameliorates hyperglycaemia by inducing a torpor-like state in an obese mouse model of type 2 diabetes

(2015) Richard E. Gilbert et al.   DIABETOLOGIA

Exercise Regulation of Marrow Fat in the Setting of PPARγ Agonist Treatment in Female C57BL/6 Mice

(2015) Maya Styner et al.   ENDOCRINOLOGY

The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells

(2015) Irina Gurt et al.   PLoS One

Creatine Inhibits Adipogenesis by Downregulating Insulin-Induced Activation of the Phosphatidylinositol 3-Kinase Signaling Pathway

(2015) Nayeon Lee et al.   STEM CELLS AND DEVELOPMENT

Region-specific variation in the properties of skeletal adipocytes reveals regulated and constitutive marrow adipose tissues

(2015) Erica L. Scheller et al.   Nature Communications

What's the matter with MAT? Marrow adipose tissue, metabolism, and skeletal health

(2014) Erica L. Scheller et al.   Annals of the New York Academy of Sciences

Gene expression and protein secretion during human mesenchymal cell differentiation into adipogenic cells

(2014) Paola Romina Amable et al.   BMC CELL BIOLOGY

Bone Marrow Adipose Tissue Is an Endocrine Organ that Contributes to Increased Circulating Adiponectin during Caloric Restriction

(2014) William P. Cawthorn et al.   Cell Metabolism

Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow

(2014) Bo O. Zhou et al.   Cell Stem Cell

Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues

(2014) Cheng Xu et al.   DIABETES

The Sirtuin1 Activator SRT3025 Down-Regulates Sclerostin and Rescues Ovariectomy-Induced Bone Loss and Biomechanical Deterioration in Female Mice

(2014) Hanna Artsi et al.   ENDOCRINOLOGY

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

Marrow Fat and Bone—New Perspectives

(2013) Pouneh K. Fazeli et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

The meaning, the sense and the significance: translating the science of mesenchymal stem cells into medicine

(2013) Paolo Bianco et al.   NATURE MEDICINE

A withanolide coagulin-L inhibits adipogenesis modulating Wnt/β-catenin pathway and cell cycle in mitotic clonal expansion

(2013) Muheeb Beg et al.   PHYTOMEDICINE

Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism

(2013) M. Gertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Resveratrol Exerts Dosage and Duration Dependent Effect on Human Mesenchymal Stem Cell Development

(2012) Lindsay Peltz et al.   PLoS One

Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes

(2011) A. Krings et al.   BONE

The WTX Tumor Suppressor Regulates Mesenchymal Progenitor Cell Fate Specification

(2011) Annie Moisan et al.   DEVELOPMENTAL CELL

Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor

(2011) Einav Cohen-Kfir et al.   ENDOCRINOLOGY

Nicotinamide phosphoribosyltransferase (Nampt) affects the lineage fate determination of mesenchymal stem cells: A possible cause for reduced osteogenesis and increased adipogenesis in older individuals

(2011) Yan Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats

(2010) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Short-Term Re-Feeding of Previously Energy-Restricted C57BL/6 Male Mice Restores Body Weight and Body Fat and Attenuates the Decline in Natural Killer Cell Function after Primary Influenza Infection

(2010) Jonathan F. Clinthorne et al.   JOURNAL OF NUTRITION

Adiponectin and AdipoR1 regulate PGC-1α and mitochondria by Ca2+ and AMPK/SIRT1

(2010) Masato Iwabu et al.   NATURE

SIRT1 Controls the Transcription of the Peroxisome Proliferator-activated Receptor-γ Co-activator-1α (PGC-1α) Gene in Skeletal Muscle through the PGC-1α Autoregulatory Loop and Interaction with MyoD

(2009) Ramon Amat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased Bone Marrow Fat in Anorexia Nervosa

(2009) Miriam A. Bredella et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment

(2009) Olaia Naveiras et al.   NATURE

Sclerostin Antibody Treatment Increases Bone Formation, Bone Mass, and Bone Strength in a Rat Model of Postmenopausal Osteoporosis*

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH