Investigating the Complex Arrhythmic Phenotype Caused by the Gain-of-Function Mutation KCNQ1-G229D

From ionic to cellular variability in human atrial myocytes: an integrative computational and experimental study

(2018) Anna Muszkiewicz et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Human Atrial Arrhythmogenesis and Sinus Bradycardia in KCNQ1-Linked Short QT Syndrome: Insights From Computational Modelling

(2018) Dominic G. Whittaker et al.   Frontiers in Physiology

Computational analysis of the human sinus node action potential: model development and effects of mutations

(2017) Alan Fabbri et al.   JOURNAL OF PHYSIOLOGY-LONDON

In silico investigation of a KCNQ1 mutation associated with short QT syndrome

(2017) Ismail Adeniran et al.   Scientific Reports

Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions

(2016) Louie Cardone-Noott et al.   EUROPACE

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

(2016) Elisa Passini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Computational simulations of the effects of the G229D KCNQ1 mutation on human atrial fibrillation

(2016) Indana Zulfa et al.   Journal of Physiological Sciences

Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm

(2016) Anna Muszkiewicz et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

A newKCNQ1mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome

(2015) Cristina Moreno et al.   CARDIOVASCULAR RESEARCH

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesNovelty and Significance

(2015) Xin Zhou et al.   CIRCULATION RESEARCH

LQT1-phenotypes in hiPSC: Are we measuring the right thing?

(2015) Torsten Christ et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular mechanisms underlying the increased disease severity seen for patients with long QT syndrome caused by compound mutations in KCNQ1

(2014) Stephen C. Harmer et al.   BIOCHEMICAL JOURNAL

Mouse models of arrhythmogenic cardiovascular disease: challenges and opportunities

(2014) Jeanne M Nerbonne   CURRENT OPINION IN PHARMACOLOGY

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

(2014) Carlos Sánchez et al.   PLoS One

Overlapping Cardiac Phenotype Associated with a Familial Mutation in the Voltage Sensor of the KCNQ1 Channel

(2013) Ulrike Henrion et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels

(2013) Kanae Hasegawa et al.   HEART RHYTHM

In silico investigation of a KCNQ1 mutation associated with familial atrial fibrillation

(2013) J.C. Hancox et al.   JOURNAL OF ELECTROCARDIOLOGY

A KCNQ1 mutation causes age-dependant bradycardia and persistent atrial fibrillation

(2013) Chang-Seok Ki et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Altered HCN4 channel C-linker interaction is associated with familial tachycardia–bradycardia syndrome and atrial fibrillation

(2012) Nana Duhme et al.   EUROPEAN HEART JOURNAL

AKCNQ1Mutation Causes a High Penetrance for Familial Atrial Fibrillation

(2012) DANIEL C. BARTOS et al.   JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY

Pro-arrhythmogenic effects of the S140GKCNQ1mutation in human atrial fibrillation - insights from modelling

(2012) Sanjay Kharche et al.   JOURNAL OF PHYSIOLOGY-LONDON

Human Atrial Action Potential and Ca 2+ Model

(2011) Eleonora Grandi et al.   CIRCULATION RESEARCH

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

A Coupled SYSTEM of Intracellular Ca 2+ Clocks and Surface Membrane Voltage Clocks Controls the Timekeeping Mechanism of the Heart’s Pacemaker

(2010) Edward G. Lakatta et al.   CIRCULATION RESEARCH

R231C mutation in KCNQ1 causes long QT syndrome type 1 and familial atrial fibrillation

(2010) Daniel C. Bartos et al.   HEART RHYTHM

Characterization of a Binding Site for Anionic Phospholipids on KCNQ1

(2010) Alison M. Thomas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K+ current changes account for the rate dependence of the action potential in the human atrial myocyte

(2009) Mary M. Maleckar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Chaste: A test-driven approach to software development for biological modelling

(2009) Joe Pitt-Francis et al.   COMPUTER PHYSICS COMMUNICATIONS

Mutation in the S3 segment of KCNQ1 results in familial lone atrial fibrillation

(2009) Saumya Das et al.   HEART RHYTHM

Mechanisms of cardiac arrhythmias and sudden death in transgenic rabbits with long QT syndrome

(2008) Michael Brunner et al.   JOURNAL OF CLINICAL INVESTIGATION